Bridge University

Graphene is the two-dimensional building block for carbon allotropes of every other dimensionality. We show that its electronic structure is captured in its Raman spectrum that clearly evolves with the number of layers. The D peak second order changes in shape, width, and position for an increasing number of layers, reflecting the change in the electron bands via a double resonant Raman process. The G peak slightly down-shifts. This allows unambiguous, high-throughput, nondestructive identification of graphene layers, which is critically lacking in this emerging research area.

Multiple imputation by chained equations is a flexible and practical approach to handling missing data. We describe the principles of the method and show how to impute categorical and quantitative variables, including skewed variables. We give guidance on how to specify the imputation model and how many imputations are needed. We describe the practical analysis of multiply imputed data, including model building and model checking. We stress the limitations of the method and discuss the possible pitfalls. We illustrate the ideas using a data set in mental health, giving Stata code fragments.

Abstract This paper discusses the influence of surface energy on the contact between elastic solids. Equations are derived for its effect upon the contact size and the force of adhesion between two lightly loaded spherical solid surfaces. The theory is supported by experiments carried out on the contact of rubber and gelatine spheres.

A finite-size particle scheme for the numerical solution of twoand three-dimensional gasdynamic problems of astronomical interest is described and tested. The scheme is then applied to the fission problem for optically thick protostars. Results are given, showing the evolution of one such protostar from an initial state as a single rotating star to a final state as a triple system whose components contain 60% of the original mass. The decisiveness of this numerical test of the fission hypothesis and its relevance to observed binaries are briefly discussed.

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is thatthere is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure flux through the autophagy pathway (i.e., the completeprocess including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defined as increasedautophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in manycases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as forreviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multipleassays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation, it is imperative to target by gene knockout or RNA interference more than one autophagyrelated protein. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways implying that not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular assays, we hope to encourage technical innovation in the field.

An investigation is made of the merits of various emission-line intensity ratios for classifying the spectra of extragalactic objects. It is shown empirically that several combinations of easily-measured lines can be used to separate objects into one of four categories according to the principal excitation mechanism: normal H II regions, planetary nebulae, objects photoionized by a power-law continuum, and objects excited by shock-wave heating. A two-dimensional quantitative classification scheme is suggested.

Abstract: The exhaustivity of document descriptions and the specificity of index terms are usually regarded as independent. It is suggested that specificity should be interpreted statistically, as a function of term use rather than of term meaning. The effects on retrieval of variations in term specificity are examined, experiments with three test collections showing, in particular, that frequently-occurring terms are required for good overall performance. It is argued that terms should be weighted according to collection frequency, so that matches on less frequent, more specific, terms are of greater value than matches on frequent terms. Results for the test collections show that considerable improvements in performance are obtained with this very simple procedure. Exhaustivity and specificity We are familiar with the notions of exhaustivity and specificity: exhaustivity is a property of index descriptions, and specificity one of index terms. They are most clearly illustrated by a simple keyword or descriptor system. In this case the exhaustivity of a document description is the coverage of its various topics given by the terms assigned to it; and the specificity of an individual term is the level of detail at which a given concept is represented.

We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:mn>1</a:mn><a:mtext> </a:mtext><a:mtext> </a:mtext><a:msub><a:mrow><a:mi>M</a:mi></a:mrow><a:mrow><a:mo stretchy="false">⊙</a:mo></a:mrow></a:msub></a:mrow></a:math> during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (<d:math xmlns:d="http://www.w3.org/1998/Math/MathML" display="inline"><d:mi>O</d:mi><d:mn>1</d:mn></d:math>), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (<f:math xmlns:f="http://www.w3.org/1998/Math/MathML" display="inline"><f:mi>O</f:mi><f:mn>2</f:mn></f:math>), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star inspiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between <h:math xmlns:h="http://www.w3.org/1998/Math/MathML" display="inline"><h:mrow><h:msubsup><h:mrow><h:mn>18.6</h:mn></h:mrow><h:mrow><h:mo>−</h:mo><h:mn>0.7</h:mn></h:mrow><h:mrow><h:mo>+</h:mo><h:mn>3.2</h:mn></h:mrow></h:msubsup><h:mtext> </h:mtext><h:mtext> </h:mtext><h:msub><h:mrow><h:mi>M</h:mi></h:mrow><h:mrow><h:mo stretchy="false">⊙</h:mo></h:mrow></h:msub></h:mrow></h:math> and <k:math xmlns:k="http://www.w3.org/1998/Math/MathML" display="inline"><k:msubsup><k:mn>84.4</k:mn><k:mrow><k:mo>−</k:mo><k:mn>11.1</k:mn></k:mrow><k:mrow><k:mo>+</k:mo><k:mn>15.8</k:mn></k:mrow></k:msubsup><k:mtext> </k:mtext><k:mtext> </k:mtext><k:msub><k:mrow><k:mi>M</k:mi></k:mrow><k:mrow><k:mo stretchy="false">⊙</k:mo></k:mrow></k:msub></k:math> and range in distance between <n:math xmlns:n="http://www.w3.org/1998/Math/MathML" display="inline"><n:msubsup><n:mn>320</n:mn><n:mrow><n:mo>−</n:mo><n:mn>110</n:mn></n:mrow><n:mrow><n:mo>+</n:mo><n:mn>120</n:mn></n:mrow></n:msubsup></n:math> and <p:math xmlns:p="http://www.w3.org/1998/Math/MathML" display="inline"><p:mrow><p:msubsup><p:mrow><p:mn>2840</p:mn></p:mrow><p:mrow><p:mo>−</p:mo><p:mn>1360</p:mn></p:mrow><p:mrow><p:mo>+</p:mo><p:mn>1400</p:mn></p:mrow></p:msubsup><p:mtext> </p:mtext><p:mtext> </p:mtext><p:mi>Mpc</p:mi></p:mrow></p:math>. No neutron star–black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of <r:math xmlns:r="http://www.w3.org/1998/Math/MathML" display="inline"><r:mrow><r:mn>110</r:mn><r:mo>−</r:mo><r:mn>3840</r:mn><r:mtext> </r:mtext><r:mtext> </r:mtext><r:msup><r:mrow><r:mi>Gpc</r:mi></r:mrow><r:mrow><r:mo>−</r:mo><r:mn>3</r:mn></r:mrow></r:msup><r:mtext> </r:mtext><r:msup><r:mrow><r:mi mathvariant="normal">y</r:mi></r:mrow><r:mrow><r:mo>−</r:mo><r:mn>1</r:mn></r:mrow></r:msup></r:mrow></r:math> for binary neutron stars and <u:math xmlns:u="http://www.w3.org/1998/Math/MathML" display="inline"><u:mrow><u:mn>9.7</u:mn><u:mo>−</u:mo><u:mn>101</u:mn><u:mtext> </u:mtext><u:mtext> </u:mtext><u:msup><u:mrow><u:mi>Gpc</u:mi></u:mrow><u:mrow><u:mo>−</u:mo><u:mn>3</u:mn></u:mrow></u:msup><u:mtext> </u:mtext><u:msup><u:mrow><u:mi mathvariant="normal">y</u:mi></u:mrow><u:mrow><u:mo>−</u:mo><u:mn>1</u:mn></u:mrow></u:msup></u:mrow></u:math> for binary black holes assuming fixed population distributions and determine a neutron star–black hole merger rate 90% upper limit of <x:math xmlns:x="http://www.w3.org/1998/Math/MathML" display="inline"><x:mrow><x:mn>610</x:mn><x:mtext> </x:mtext><x:mtext> </x:mtext><x:msup><x:mrow><x:mi>Gpc</x:mi></x:mrow><x:mrow><x:mo>−</x:mo><x:mn>3</x:mn></x:mrow></x:msup><x:mtext> </x:mtext><x:msup><x:mrow><x:mi mathvariant="normal">y</x:mi></x:mrow><x:mrow><x:mo>−</x:mo><x:mn>1</x:mn></x:mrow></x:msup></x:mrow></x:math>. Published by the American Physical Society 2019

We present a Raman study of Ar(+)-bombarded graphene samples with increasing ion doses. This allows us to have a controlled, increasing, amount of defects. We find that the ratio between the D and G peak intensities, for a given defect density, strongly depends on the laser excitation energy. We quantify this effect and present a simple equation for the determination of the point defect density in graphene via Raman spectroscopy for any visible excitation energy. We note that, for all excitations, the D to G intensity ratio reaches a maximum for an interdefect distance ∼3 nm. Thus, a given ratio could correspond to two different defect densities, above or below the maximum. The analysis of the G peak width and its dispersion with excitation energy solves this ambiguity.

ABSTRACT We extend the standard finance model of the firm's dividend/investment/financing decisions by allowing the firm's managers to know more than outside investors about the true state of the firm's current earnings. The extension endogenizes the dividend (and financing) announcement effects amply documented in recent research. But once trading of shares is admitted to the model along with asymmetric information, the familiar Fisherian criterion for optimal investment becomes time inconsistent: the market's belief that the firm is following the Fisher rule creates incentives to violate the rule. We show that an informationally consistent signalling equilibrium exists under asymmetric information and the trading of shares that restores the time consistency of investment policy, but leads in general to lower levels of investment than the optimum achievable under full information and/or no trading. Contractual provisions that change the information asymmetry or the possibility of profiting from it could eliminate both the time inconsistency and the inefficiency in investment policies, but these contractual provisions too are likely to involve dead‐weight costs. Establishing which route or combination of routes serves in practice to maintain consistency remains for future research.

We report a method to convert discrete representations of molecules to and from a multidimensional continuous representation. This model allows us to generate new molecules for efficient exploration and optimization through open-ended spaces of chemical compounds. A deep neural network was trained on hundreds of thousands of existing chemical structures to construct three coupled functions: an encoder, a decoder, and a predictor. The encoder converts the discrete representation of a molecule into a real-valued continuous vector, and the decoder converts these continuous vectors back to discrete molecular representations. The predictor estimates chemical properties from the latent continuous vector representation of the molecule. Continuous representations of molecules allow us to automatically generate novel chemical structures by performing simple operations in the latent space, such as decoding random vectors, perturbing known chemical structures, or interpolating between molecules. Continuous representations also allow the use of powerful gradient-based optimization to efficiently guide the search for optimized functional compounds. We demonstrate our method in the domain of drug-like molecules and also in a set of molecules with fewer that nine heavy atoms.

Resolving the spatial distribution of the human proteome at a subcellular level can greatly increase our understanding of human biology and disease. Here we present a comprehensive image-based map of subcellular protein distribution, the Cell Atlas, built by integrating transcriptomics and antibody-based immunofluorescence microscopy with validation by mass spectrometry. Mapping the in situ localization of 12,003 human proteins at a single-cell level to 30 subcellular structures enabled the definition of the proteomes of 13 major organelles. Exploration of the proteomes revealed single-cell variations in abundance or spatial distribution and localization of about half of the proteins to multiple compartments. This subcellular map can be used to refine existing protein-protein interaction networks and provides an important resource to deconvolute the highly complex architecture of the human cell.

Extensive data of the strength and dilatancy of 17 sands in axisymmetric or plane strain at different densities and confining pressures are collated. The critical state angle of shearing resistance of soil which is shearing at constant volume is principally a function of mineralogy and can readily be determined experimentally within a margin of about 1°, being roughly 33° for quartz and 40° for feldspar. The extra angle of shearing of ‘dense’ soil is correlated to its rate of dilation and thence to its relative density and mean effective stress, combined in a new relative dilatancy index. The data of ø′ max – ø′ crit in triaxial or plane strain are separately fitted within a typical margin of about 2°, though the streneth of certain sands is underpredicted in the 1000–10000 kN/m 2 range owing to the continued dilation of their crush-resistant grains. The practical consequences of these new correlations are assessed, with regard to both laboratory and field testing procedures. L'auteur analyse de nombreuses données concernant la résistance et la dilatance de 17 sables sous déformation plane ou axisymétrique pour différentes densités et pressions d'étreinte. L'angle de résistance au cisaillement dans l'état critique d'un sol soumis au cisaillement à volume constant est principalement une fonction de la minéralogie et peut se déterminer facilement à 1° près, comme ayant une valeur d'environ 33° pour le quartz et 40° pour le feldspath. L'angle supplémentaire de cisaillement d'un sol dense dépend à sa vitesse de dilation donc de sa densité relative et de la contrainte effective moyenne, combinées dans un nouvel indice de dilatance relative. Les données de ø′ max – ø′ crit en déformation plane ou triaxiale sent separées par une marge de 2° approximativement, bien que la résistance de certains sables soit sousestimée dans une fourchette de 1000 – 10000 kN/m 2 en raison de la poursuite de la provoquée par l'écrasement de leurs grains résistants. L'article évalue les conséquences pratiques de ces nouvelles corrélations en ce qui concerne les méthodes d'essai en laboratoire et in-situ.

Raman spectroscopy is a standard characterization technique for any carbon system. Here we review the Raman spectra of amorphous, nanostructured, diamond-like carbon and nanodiamond. We show how to use resonant Raman spectroscopy to determine structure and composition of carbon films with and without nitrogen. The measured spectra change with varying excitation energy. By visible and ultraviolet excitation measurements, the G peak dispersion can be derived and correlated with key parameters, such as density, sp(3) content, elastic constants and chemical composition. We then discuss the assignment of the peaks at 1150 and 1480 cm(-1) often observed in nanodiamond. We review the resonant Raman, isotope substitution and annealing experiments, which lead to the assignment of these peaks to trans-polyacetylene.

On 17 August 2017, the LIGO and Virgo observatories made the first direct detection of gravitational waves from the coalescence of a neutron star binary system. The detection of this gravitational-wave signal, GW170817, offers a novel opportunity to directly probe the properties of matter at the extreme conditions found in the interior of these stars. The initial, minimal-assumption analysis of the LIGO and Virgo data placed constraints on the tidal effects of the coalescing bodies, which were then translated to constraints on neutron star radii. Here, we expand upon previous analyses by working under the hypothesis that both bodies were neutron stars that are described by the same equation of state and have spins within the range observed in Galactic binary neutron stars. Our analysis employs two methods: the use of equation-of-state-insensitive relations between various macroscopic properties of the neutron stars and the use of an efficient parametrization of the defining function p(ρ) of the equation of state itself. From the LIGO and Virgo data alone and the first method, we measure the two neutron star radii as R_{1}=10.8_{-1.7}^{+2.0} km for the heavier star and R_{2}=10.7_{-1.5}^{+2.1} km for the lighter star at the 90% credible level. If we additionally require that the equation of state supports neutron stars with masses larger than 1.97 M_{⊙} as required from electromagnetic observations and employ the equation-of-state parametrization, we further constrain R_{1}=11.9_{-1.4}^{+1.4} km and R_{2}=11.9_{-1.4}^{+1.4} km at the 90% credible level. Finally, we obtain constraints on p(ρ) at supranuclear densities, with pressure at twice nuclear saturation density measured at 3.5_{-1.7}^{+2.7}×10^{34} dyn cm^{-2} at the 90% level.

Hundreds of individual human cancer genome sequences are expected to be published in 2010, and thousands per year after that. The International Cancer Genome Consortium (ICGC) was launched with the aim of keeping track of the data relating to large-scale cancer genome studies of all major cancers in adults and children — a total of 50 different cancer types and/or subtypes. In this issue the ICGC team ( http://www.icgc.org ) spells out the policies and planning for the project. The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

This study is about the principles for constructing polite speech. We describe and account for some remarkable parallelisms in the linguistic construction of utterances with which people express themselves in different languges and cultures. A motive for these parallels is isolated - politeness, broadly defined to include both polite friendliness and polite formality - and a universal model is constructed outlining the abstract principles underlying polite usages. This is based on the detailed study of three unrelated languages and cultures: the Tamil of south India, the Tzeltal spoken by Mayan Indians in Chiapas, Mexico, and the English of the USA and England, supplemented by examples from other cultures. Of general interest is the point that underneaath the apparent diversity of polite behaviour in different societies lie some general pan-human principles of social interaction, and the model of politenss provides a tool for analysing the quality of social relations in any society.

Journal Article Regional economic resilience, hysteresis and recessionary shocks Get access Ron Martin Ron Martin **Department of Geography, University of Cambridge, Cambridge, UK. email <rlm1@cam.ac.uk> Search for other works by this author on: Oxford Academic Google Scholar Journal of Economic Geography, Volume 12, Issue 1, January 2012, Pages 1–32, https://doi.org/10.1093/jeg/lbr019 Published: 07 September 2011 Article history Received: 03 January 2011 Accepted: 30 June 2011 Published: 07 September 2011

IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

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