Burdur Mehmet Akif Ersoy Üniversitesi

Freshwater mussels of the Order Unionida provide important ecosystem functions and services, yet many of their populations are in decline. We comprehensively review the status of the 16 currently recognized species in Europe, collating for the first time their life-history traits, distribution, conservation status, habitat preferences, and main threats in order to suggest future management actions. In northern, central, and eastern Europe, a relatively homogeneous species composition is found in most basins. In southern Europe, despite the lower species richness, spatially restricted species make these basins a high conservation priority. Information on freshwater mussels in Europe is unevenly distributed with considerable differences in data quality and quantity among countries and species. To make conservation more effective in the future, we suggest greater international cooperation using standardized protocols and methods to monitor and manage European freshwater mussel diversity. Such an approach will not only help conserve this vulnerable group but also, through the protection of these important organisms, will offer wider benefits to freshwater ecosystems.

Invasive species can displace natives, and thus identifying the traits that make aliens successful is crucial for predicting and preventing biodiversity loss. Pathogens may play an important role in the invasive process, facilitating colonization of their hosts in new continents and islands. According to the Novel Weapon Hypothesis, colonizers may out-compete local native species by bringing with them novel pathogens to which native species are not adapted. In contrast, the Enemy Release Hypothesis suggests that flourishing colonizers are successful because they have left their pathogens behind. To assess the role of avian malaria and related haemosporidian parasites in the global spread of a common invasive bird, we examined the prevalence and genetic diversity of haemosporidian parasites (order Haemosporida, genera Plasmodium and Haemoproteus) infecting house sparrows (Passer domesticus). We sampled house sparrows (N = 1820) from 58 locations on 6 continents. All the samples were tested using PCR-based methods; blood films from the PCR-positive birds were examined microscopically to identify parasite species. The results show that haemosporidian parasites in the house sparrows' native range are replaced by species from local host-generalist parasite fauna in the alien environments of North and South America. Furthermore, sparrows in colonized regions displayed a lower diversity and prevalence of parasite infections. Because the house sparrow lost its native parasites when colonizing the American continents, the release from these natural enemies may have facilitated its invasion in the last two centuries. Our findings therefore reject the Novel Weapon Hypothesis and are concordant with the Enemy Release Hypothesis.

Fermentation is thought to be born in the Fertile Crescent, and since then, almost every culture has integrated fermented foods into their dietary habits. Originally used to preserve foods, fermentation is now applied to improve their physicochemical, sensory, nutritional, and safety attributes. Fermented dairy, alcoholic beverages like wine and beer, fermented vegetables, fruits, and meats are all highly valuable due to their increased storage stability, reduced risk of food poisoning, and enhanced flavor. Over the years, scientific research has associated the consumption of fermented products with improved health status. The fermentation process helps to break down compounds into more easily digestible forms. It also helps to reduce the amount of toxins and pathogens in food. Additionally, fermented foods contain probiotics, which are beneficial bacteria that help the body to digest food and absorb nutrients. In today's world, non-communicable diseases such as cardiovascular disease, type 2 diabetes, cancer, and allergies have increased. In this regard, scientific investigations have demonstrated that shifting to a diet that contains fermented foods can reduce the risk of non-communicable diseases. Moreover, in the last decade, there has been a growing interest in fermentation technology to valorize food waste into valuable by-products. Fermentation of various food wastes has resulted in the successful production of valuable by-products, including enzymes, pigments, and biofuels.

BACKGROUND: The recent geographical expansion of phlebotomine vectors of Leishmania infantum in the Mediterranean subregion has been attributed to ongoing climate changes. At these latitudes, the activity of sand flies is typically seasonal; because seasonal phenomena are also sensitive to general variations in climate, current phenological data sets can provide a baseline for continuing investigations on sand fly population dynamics that may impact on future scenarios of leishmaniasis transmission. With this aim, in 2011-2013 a consortium of partners from eight Mediterranean countries carried out entomological investigations in sites where L. infantum transmission was recently reported. METHODS/PRINCIPAL FINDINGS: A common protocol for sand fly collection included monthly captures by CDC light traps, complemented by sticky traps in most of the sites. Collections were replicated for more than one season in order to reduce the effects of local weather events. In each site, the trapping effort was left unchanged throughout the survey to legitimate inter-seasonal comparisons. Data from 99,000 collected specimens were analyzed, resulting in the description of seasonal dynamics of 56,000 sand flies belonging to L. infantum vector species throughout a wide geographical area, namely P. perniciosus (Portugal, Spain and Italy), P. ariasi (France), P. neglectus (Greece), P. tobbi (Cyprus and Turkey), P. balcanicus and P. kandelakii (Georgia). Time of sand fly appearance/disappearance in collections differed between sites, and seasonal densities showed variations in each site. Significant correlations were found between latitude/mean annual temperature of sites and i) the first month of sand fly appearance, that ranged from early April to the first half of June; ii) the type of density trend, varying from a single peak in July/August to multiple peaks increasing in magnitude from May through September. A 3-modal trend, recorded for P. tobbi in Cyprus, represents a novel finding for a L. infantum vector. Adults ended the activity starting from mid September through November, without significant correlation with latitude/mean annual temperature of sites. The period of potential exposure to L.infantum in the Mediterranean subregion, as inferred by adult densities calculated from 3 years, 37 sites and 6 competent vector species, was associated to a regular bell-shaped density curve having a wide peak center encompassing the July-September period, and falling between early May to late October for more than 99% of values. Apparently no risk for leishmaniasis transmission took place from December through March in the years considered. We found a common pattern of nocturnal females activity, whose density peaked between 11 pm and 2 am. CONCLUSIONS: Despite annual variations, multiple collections performed over consecutive years provided homogeneous patterns of the potential behavior of leishmaniasis vectors in selected sites, which we propose may represent sentinel areas for future monitoring. In the investigated years, higher potential risk for L. infantum transmission in the Mediterranean was identified in the June-October period (97% relative vector density), however such risk was not equally distributed throughout the region, since density waves of adults occurred earlier and were more frequent in southern territories.

The aim of this study examines the relationship between quality of life, satisfaction with life and multidimensional perceived social support in people aged 65 years and older. The implementation part of the study was carried out with elderly people living in the city center of Burdur, Turkey. Data were collected in March 2018 from 517 participants and then assessed. The results of the analyses revealed that perceived social support explained 11.7% of the total variance in the satisfaction with life, 22.1% of the total variance in the quality of life. In addition to, the perceived social support and the quality of life explained 28.6% of the total variance in the satisfaction with life. And the quality of life was the most influential variable on the satisfaction with life. The findings of this study suggest that making improvements to the elderly people social support and quality of life will increase their satisfaction with life.

By sequencing 727 ancient individuals from the Southern Arc (Anatolia and its neighbors in Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic period and Bronze Age (about 5000 to 1000 BCE), when extensive gene flow entangled it with the Eurasian steppe. Two streams of migration transmitted Caucasus and Anatolian/Levantine ancestry northward, and the Yamnaya pastoralists, formed on the steppe, then spread southward into the Balkans and across the Caucasus into Armenia, where they left numerous patrilineal descendants. Anatolia was transformed by intra-West Asian gene flow, with negligible impact of the later Yamnaya migrations. This contrasts with all other regions where Indo-European languages were spoken, suggesting that the homeland of the Indo-Anatolian language family was in West Asia, with only secondary dispersals of non-Anatolian Indo-Europeans from the steppe.

In this work, reduced graphene oxide (rGO) based electrode materials were developed to achieve a hybrid supercapacitor (SC) function. Therefore, several synthesis methods were developed to prepare a cost effective and environmentally friendly rGO. Additionally, to maintain the high surface area, spinel lithium titanate (sLTO) nanoparticles (NPs) were synthesized and deposited on the rGO surface to inhibit the restacking of the rGO layers on graphite. Furthermore, the adequate Fe-doping of sLTO increased the ionic conductivity and the intercalation capacity, which is necessary for a SC performance. The sLTO/rGO-composites were electrochemically analysed by chronopotentiometry and electrochemical impedance spectroscopy (EIS) to determine the stability during charge/discharge cycling and the capacity, respectively. To overcome the drawback of LTO's low conductivity values, its value has been drastically increased by Fe-doping. The results demonstrated the remarkable cycling performance of the Fe:LTO/rGO composite as well as a higher capacity compared to LTO/rGO and pure rGO-electrodes. The thermal stability, degradation and weight loss of the sLTO/rGO in the temperature range between 20 °C and 800 °C were investigated by thermogravimetry (TG)/DTA. As a conclusion, it can be stated that, increasing the ionic conductivity by Fe-doping drastically increases the hybrid capacity of the SC electrodes.

= 5.96). The study's findings indicated that meaning in life and psychological flexibility mediated the effect of coronavirus stress on student well-being. Psychological flexibility also mitigated the effect of stress on meaning in life. The study findings offer implications for mental health professionals and officials responding to COVID-19 and provide insights into future planning and preparedness for disasters of this scale that may occur in future years.

Abstract Aims Ellenberg‐type indicator values are expert‐based rankings of plant species according to their ecological optima on main environmental gradients. Here we extend the indicator‐value system proposed by Heinz Ellenberg and co‐authors for Central Europe by incorporating other systems of Ellenberg‐type indicator values (i.e., those using scales compatible with Ellenberg values) developed for other European regions. Our aim is to create a harmonized data set of Ellenberg‐type indicator values applicable at the European scale. Methods We collected European data sets of indicator values for vascular plants and selected 13 data sets that used the nine‐, ten‐ or twelve‐degree scales defined by Ellenberg for light, temperature, moisture, reaction, nutrients and salinity. We compared these values with the original Ellenberg values and used those that showed consistent trends in regression slope and coefficient of determination. We calculated the average value for each combination of species and indicator values from these data sets. Based on species’ co‐occurrences in European vegetation plots, we also calculated new values for species that were not assigned an indicator value. Results We provide a new data set of Ellenberg‐type indicator values for 8908 European vascular plant species (8168 for light, 7400 for temperature, 8030 for moisture, 7282 for reaction, 7193 for nutrients, and 7507 for salinity), of which 398 species have been newly assigned to at least one indicator value. Conclusions The newly introduced indicator values are compatible with the original Ellenberg values. They can be used for large‐scale studies of the European flora and vegetation or for gap‐filling in regional data sets. The European indicator values and the original and taxonomically harmonized regional data sets of Ellenberg‐type indicator values are available in the Supporting Information and the Zenodo repository.

The concept of intellectual capital was popularized by Tom Stewart in 1991 when Fortune Magazine published his article “Brainpower: How intellectual capital is becoming Americas’ most valuable asset”. It can be described as the difference between a firm's market value and the cost of replacing its assets. Today innovation is considered as a necessity for every company due to the terminating competition in market, globalization and rapid development of technology. Innovation is defined as “implementing new ideas that create value”. Strategy is the outcome of decisions made to guide an organization with respect to environment, structure and processes that influence its firm performance. The organizational literature that improved business performance requires an organizational structure, information systems and management style that are related to a specific-firm strategy. Firm performance can be measured in a variety of ways, including financial performance, product performance and market performance. The purpose of this study is to research the relationships between intellectual capital, innovation, organizational strategy and firm performance. The main contribution of this study is to investigate the effects of intellectual capital, innovation and organizational strategy on performance of firms operating in Antalya, Turkey.

Abstract Colon cancer is one of the most common cancer around the world. Exopolysaccharides (EPSs) produced by lactobacilli as potential prebiotics have been found to have an anti-tumor effect. In this study, lyophilized EPSs of four Lactobacillus spp. for their impact on apoptosis in colon cancer cells (HT-29) was evaluated using flow cytometry. The relationship between capability of a lactobacilli-EPS to induce apoptosis and their monosaccharide composition, molecular weight (MW), and linkage type was investigated by HPLC, SEC, and NMR, respectively. Changes in apoptotic-markers were examined by qPCR and Western Blotting. EPSs were capable of inhibiting proliferation in a time-dependent manner and induced apoptosis via increasing the expression of Bax, Caspase 3 and 9 while decreasing Bcl-2 and Survivin. All EPSs contained mannose, glucose, and N-acetylglucosamine with different relative proportions. Some contained arabinose or fructose. MW ranged from 10 2 –10 4 Da with two or three fractions. EPS of L. delbrueckii ssp. bulgaricus B3 having the highest amount of mannose and the lowest amount of glucose, showed the highest apoptosis induction. In conclusion, lactobacilli-EPSs inhibit cell proliferation in HT-29 via apoptosis. Results suggest that a relationship exists between the ability of EPS to induce apoptosis and its mannose and glucose composition.

COVID-19, a novel infectious disease, caused by SARS-CoV-2, affected millions of people around the world with a high mortality rate. Although SARS-CoV-2 mainly causes lung infection, gastrointestinal symptoms described in COVID-19 patients and detection of the viral RNA in feces of infected patients drove attentions to a possible fecal-oral transmission route of SARS-CoV-2. However, not only the viral RNA but also the infectious viral particles are required for the viral infection and no proof has been demonstrated the transmission of the infectious virus particles via the fecal-oral route yet. Growing evidence indicates the crosstalk between gut microbiota and lung, that maintains host homeostasis and disease development with the association of immune system. This gut-lung interaction may influence the COVID-19 severity in patients with extrapulmonary conditions. Severity of COVID-19 has mostly associated with old ages and underlying medical conditions. Since the diversity in the gut microbiota decreases during aging, dysbiosis could be the reason for older adults being at high risk for severe illness from COVID-19. We believe that gut microbiota contributes to the course of COVID-19 due to its bidirectional relationship with immune system and lung. Dysbiosis in gut microbiota results in gut permeability leading to secondary infection and multiple organ failure. Conversely, disruption of the gut barrier integrity due to dysbiosis may lead to translocation of SARS-CoV-2 from the lung into the intestinal lumen via circulatory and lymphatic system. This review points out the role of dysbiosis of the gut microbiota involving in sepsis, on the severity of SARS-CoV-2 infection. Additionally, this review aims to clarify the ambiguity in fecal-oral transmission of SARS- CoV-2.

Literature on Quality of Work Life (QWL) is limited and several studies commonly correlates with some variables but no study on QWL has associated with work engagement. This research investigates the association between quality of work life and work engagement. The objectives of this study are: (a) to investigate and determine relationships between QWL and work engagement; (b) to compare the work engagement of blue collar employees and white collar employees; (c) to compare the QWL perceptions of blue collar employees and white collar employees in a large sized Turkish marble firm toward this topic. In this context, study conducted in a marble factory in Burdur which is one of the greatest export firm of Turkey. Results showed that there was significant relations between dimension of QWL and work engagement. Accordingly; (a) QWL affect work engagement; (b) work engagement level of blue-collar employees differentiates from white-collar employees; (c) blue collar employees’ perceptions of QWL differentiates from white collar employees.

Abstract School belonging is associated with a range of positive educational and developmental outcomes, including psychosocial health and wellbeing, prosocial behaviour and academic achievement, and transition into adulthood. However, an increasing number of students worldwide report not feeling a sense of belonging to their school. There is growing research evidence that strong student–teacher relationships can promote school belonging, however creating these relationships within highly complex educational systems can be challenging. Further, only a few interventions focusing specifically on belonging that are available in schools have been found to be effective. This chapter highlights the importance of teacher support for a student’s sense of school belonging, discusses challenges associated with student–teacher relationships, and points to strategies for building strong relationships. We highlight the role that school leaders play in fostering strong relationships, and consider extensions within higher education, and future directions. Considering the importance of student–teacher relationships towards a student’s sense of school belonging, and the empirical base that points to both short- and long-term outcomes, implications for widespread benefits are possible for schools that prioritize and value positive relationships between staff and students.

Objective: In the world, the COVID-19 pandemic has led to public mental health stress, anxiety, panic, and behavioural disorders. The purpose of the present study was to examine whether meaning in life and optimism-pessimism mediated the relationship between coronavirus stress and depressive symptoms and whether the mediating effect of meaning in life on depressive symptoms was moderated by optimism. Method: The sample of the study included 475 undergraduate students attending a public university in an urban city of Turkey. They were 69.2% female, ranged in age between 18 and 34 years (M = 20.63, SD = 1.99). Results: Results from the study showed that meaning in life and optimism-pessimism mediated the relationship between coronavirus stress and depressive symptoms. Optimism and pessimism additionally mediated the relationship between meaning in life and depressive symptoms. Furthermore, optimism moderated the mediating effect of meaning in life in the relationship between coronavirus stress and depressive symptoms. Conclusions: These results indicate that the relationship between coronavirus stress and depressive symptoms can be better understood by meaning in life and optimism. Optimism might play a protective factor to mitigate the impact of stress on individuals' psychological health and is an important aspect of implementing meaning - centred intervention services. What is already known about this topic: Meaningful living and optimism are important psychological constructs for psychological health, not only at an empirical level but also at a theoretical level. A high level of optimism improves youth well-being and mental health Stress has adverse impacts on individuals' well-being and is a risk factor for developing psychological problems What this topic adds: The present study highlights the importance of school meaning-based preventions and interventions targeting to promote mental health during and after the COVID-19 pandemic. Optimism is an important mechanism that may help to explain the effect of coronavirus stress on psychological health of individuals. The study outcomes suggest there is a need to design a more comprehensive prevention and intervention approach for improving people's psychological health in the context of the pandemic.

Loneliness is a serious risk factor for healthy development and flourishing. Although loneliness has been revealed to play an important role in psychological health and well-being, little is known about moderating and mitigating mechanisms underlying this association, especially during adverse experiences (e.g., COVID-19 pandemic). The current study purposed to explore whether subjective vitality mediated the association of loneliness with psychological adjustment and whether college belongingness moderated the mediating effect of subjective vitality on students’ adjustment in the context of loneliness. The study sample comprised 333 undergraduate students (69% female) from a public university in Turkey. They ranged in age between 19 and 41 years (M= 21.94, SD= 4.15). Findings from mediation analysis revealed that loneliness had a significant predictive effect on subjective vitality and psychological adjustment challenges. Subjective vitality also mediated the effect of loneliness on the psychological adjustment of college students. Further, college belongingness moderated the mediating effect of subjective vitality on adjustment and had a protective effect on the association between loneliness and subjective vitality in college students. These results indicate that subjective vitality and college belongingness are important mechanisms that may help develop prevention and intervention strategies to foster students’ psychological health and well-being in university settings.

The current study investigated whether there are significant relationships between life satisfaction and meaning in life, hope and COVID-19 fear and the extent to which life satisfaction is predicted by these variables. The study group of this research consists of 1,186 adults with the mean age of 41.04. Study group participants are consists of different cities of different regions of Turkey. As the data collection tools, the life satisfaction scale, the meaning in life scale, the dispositional hope scale and the COVID-19 fear scale were used. The results of the analyses have revealed that meaning in life, hope (actuating thinking and alternative ways thinking) are significant predictors of life satisfaction as positively. Besides, it is seen COVID-19 fear, age, gender and the presence of people infected with COVID-19 around aren't significant predictors of life satisfaction in adults.

Dysfunction of motile monocilia, altering the leftward flow at the embryonic node essential for determination of left-right body asymmetry, is a major cause of laterality defects. Laterality defects are also often associated with reduced mucociliary clearance caused by defective multiple motile cilia of the airway and are responsible for destructive airway disease. Outer dynein arms (ODAs) are essential for ciliary beat generation, and human respiratory cilia contain different ODA heavy chains (HCs): the panaxonemally distributed γ-HC DNAH5, proximally located β-HC DNAH11 (defining ODA type 1), and the distally localized β-HC DNAH9 (defining ODA type 2). Here we report loss-of-function mutations in DNAH9 in five independent families causing situs abnormalities associated with subtle respiratory ciliary dysfunction. Consistent with the observed subtle respiratory phenotype, high-speed video microscopy demonstrates distally impaired ciliary bending in DNAH9 mutant respiratory cilia. DNAH9-deficient cilia also lack other ODA components such as DNAH5, DNAI1, and DNAI2 from the distal axonemal compartment, demonstrating an essential role of DNAH9 for distal axonemal assembly of ODAs type 2. Yeast two-hybrid and co-immunoprecipitation analyses indicate interaction of DNAH9 with the ODA components DNAH5 and DNAI2 as well as the ODA-docking complex component CCDC114. We further show that during ciliogenesis of respiratory cilia, first proximally located DNAH11 and then distally located DNAH9 is assembled in the axoneme. We propose that the β-HC paralogs DNAH9 and DNAH11 achieved specific functional roles for the distinct axonemal compartments during evolution with human DNAH9 function matching that of ancient β-HCs such as that of the unicellular Chlamydomonas reinhardtii.

In this study, the effect of weld parameters on mechanical properties, such as lap shear fracture load, of friction stir spot welded dissimilar lap joints was studied. The effects of the plate positioning, the plunge depth and the dwell time as well as the tool tilt angle on the joint strength were investigated. The experimental results showed that the positioning of the sheets played an important role on the strength of the joints. The joint strength was higher when AA 5754 sheet is placed on the top, whereas lower strength values were displayed by dissimilar joints produced by placing AA 2024 as the upper sheet. It was also observed that the plunge depth, dwell time and tool tilt angle had a strong effect on the failure mode of the friction stir spot welded lap joints produced. The joints exhibited two different fracture modes, namely cross and pullout nugget under lap shear tensile testing conditions.

Biomass is defined as organic matter from living organisms represented in all kingdoms. It is recognized to be an excellent source of proteins, polysaccharides and lipids and, as such, embodies a tailored feedstock for new products and processes to apply in green industries. The industrial processes focused on the valorization of terrestrial biomass are well established, but marine sources still represent an untapped resource. Oceans and seas occupy over 70% of the Earth’s surface and are used intensively in worldwide economies through the fishery industry, as logistical routes, for mining ores and exploitation of fossil fuels, among others. All these activities produce waste. The other source of unused biomass derives from the beach wrack or washed-ashore organic material, especially in highly eutrophicated marine ecosystems. The development of high-added-value products from these side streams has been given priority in recent years due to the detection of a broad range of biopolymers, multiple nutrients and functional compounds that could find applications for human consumption or use in livestock/pet food, pharmaceutical and other industries. This review comprises a broad thematic approach in marine waste valorization, addressing the main achievements in marine biotechnology for advancing the circular economy, ranging from bioremediation applications for pollution treatment to energy and valorization for biomedical applications. It also includes a broad overview of the valorization of side streams in three selected case study areas: Norway, Scotland, and the Baltic Sea.