Cabot (United States)

Background Web-based cognitive-behavioral therapeutic (CBT) apps have demonstrated efficacy but are characterized by poor adherence. Conversational agents may offer a convenient, engaging way of getting support at any time. Objective The objective of the study was to determine the feasibility, acceptability, and preliminary efficacy of a fully automated conversational agent to deliver a self-help program for college students who self-identify as having symptoms of anxiety and depression. Methods In an unblinded trial, 70 individuals age 18-28 years were recruited online from a university community social media site and were randomized to receive either 2 weeks (up to 20 sessions) of self-help content derived from CBT principles in a conversational format with a text-based conversational agent (Woebot) (n=34) or were directed to the National Institute of Mental Health ebook, “Depression in College Students,” as an information-only control group (n=36). All participants completed Web-based versions of the 9-item Patient Health Questionnaire (PHQ-9), the 7-item Generalized Anxiety Disorder scale (GAD-7), and the Positive and Negative Affect Scale at baseline and 2-3 weeks later (T2). Results Participants were on average 22.2 years old (SD 2.33), 67% female (47/70), mostly non-Hispanic (93%, 54/58), and Caucasian (79%, 46/58). Participants in the Woebot group engaged with the conversational agent an average of 12.14 (SD 2.23) times over the study period. No significant differences existed between the groups at baseline, and 83% (58/70) of participants provided data at T2 (17% attrition). Intent-to-treat univariate analysis of covariance revealed a significant group difference on depression such that those in the Woebot group significantly reduced their symptoms of depression over the study period as measured by the PHQ-9 (F=6.47; P=.01) while those in the information control group did not. In an analysis of completers, participants in both groups significantly reduced anxiety as measured by the GAD-7 (F1,54= 9.24; P=.004). Participants’ comments suggest that process factors were more influential on their acceptability of the program than content factors mirroring traditional therapy. Conclusions Conversational agents appear to be a feasible, engaging, and effective way to deliver CBT.

Nutrient additions to intensive agricultural systems range from inadequate to excessive—and both extremes have substantial human and environmental costs.

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was purified and identified by sequencing as beta-catenin, a protein that binds to the cell adhesion molecule E-cadherin. An antibody specific to beta-catenin also recognized the 95-kilodalton protein in the immunoprecipitates. These results suggest that APC is involved in cell adhesion.

Abstract In the past few years, an enormous amount of work has been reported on the progress in the application of conventional fillers and the development of new products to improve the reinforcement of rubber, dynamic properties in particular. While all agree that the filler as one of the main components of the filled-rubber composite, has a very important role in improving the dynamic performances of the rubber products; many new ideas, theories, practices, phenomena, and observations about how and especially why the filler alters the dynamic stress-strain response have been presented. This, of course, suggests that not only is the real world of the filled rubber complex and sophisticated but also multiple mechanisms may be involved. However, it must be admitted that the possibility exists for explaining the effect of all fillers on rubber properties ultimately in similar and relatively nonspecific terms, i.e. , the phenomenon related to all filler parameters should follow a general rule or principle. It is the author's belief that, with regard to the effect of filler on the dynamic properties of a given polymer and cure system, filler networking, both its architecture and strength, is the main (although not only) parameter to govern the behavior of the filled rubber. From the thermodynamic and kinetic points of view, filler network formation is especially related to filler-filler, polymer-filler, as well as polymer-polymer interactions. As mentioned in the introduction, this paper is an attempt to review the effect of filler characteristics on dynamic properties in connection with processing conditions and additives. Since the polymer-filler interaction is not only affected by filler, what is also important are the characteristics of polymers such as chemical composition, chain microstructure including molecular weight and molecular weight distribution, configuration, stereoregularity, monomer unit distribution and sequence, and their functionality. All of these have a substantial influence on the physical and/or chemical interactions with other additives and filler surfaces, as well as on the interaction between polymer molecules themselves, which would impact not only the filler network formation but also the viscoelastic response of the polymer matrix. In addition, the polymer network structure which was formed during vulcanization and characterized by crosslink density, crosslink structure, and chain modification, is equally important in contributing to the overall dynamic properties of the filled rubber. In this paper, only some of these aspects have been discussed relative to their effect on filler network formation. Further discussion of these parameters is beyond the subject of the present paper. However, some guidance to these important topics is given in a handbook that was recently published.

Commercially improved crop performance under drought conditions has been challenging because of the complexity of the trait and the multitude of factors that influence yield. Here we report the results of a functional genomics approach that identified a transcription factor from the nuclear factor Y (NF-Y) family, AtNF-YB1, which acts through a previously undescribed mechanism to confer improved performance in Arabidopsis under drought conditions. An orthologous maize transcription factor, ZmNF-YB2, is shown to have an equivalent activity. Under water-limited conditions, transgenic maize plants with increased ZmNF-YB2 expression show tolerance to drought based on the responses of a number of stress-related parameters, including chlorophyll content, stomatal conductance, leaf temperature, reduced wilting, and maintenance of photosynthesis. These stress adaptations contribute to a grain yield advantage to maize under water-limited environments. The application of this technology has the potential to significantly impact maize production systems that experience drought.

A process has been developed for the in situ formation of the mineral phase of bone. Inorganic calcium and phosphate sources are combined to form a paste that is surgically implanted by injection. Under physiological conditions, the material hardens in minutes concurrent with the formation of dahllite. After 12 hours, dahllite formation was nearly complete, and an ultimate compressive strength of 55 megapascals was achieved. The composition and crystal morphology of the dahllite formed are similar to those of bone. Animal studies provide evidence that the material is remodeled in vivo. A novel approach to skeletal repair is being tested in human trials for various applications; in one of the trials the new biomaterial is being percutaneously placed into acute fractures. After hardening, it serves as internal fixation to maintain proper alignment while healing occurs.

Utopia should be understood as a method rather than a goal. This book rehabilitates utopia as a repressed dimension of the sociological and in the process produces the Imaginary Reconstitution of Soci

As one of the most comprehensive machine learning texts around, this book does justice to the field's incredible richness, but without losing sight of the unifying principles. Peter Flach's clear, example-based approach begins by discussing how a spam filter works, which gives an immediate introduction to machine learning in action, with a minimum of technical fuss. Flach provides case studies of increasing complexity and variety with well-chosen examples and illustrations throughout. He covers a wide range of logical, geometric and statistical models and state-of-the-art topics such as matrix factorisation and ROC analysis. Particular attention is paid to the central role played by features. The use of established terminology is balanced with the introduction of new and useful concepts, and summaries of relevant background material are provided with pointers for revision if necessary. These features ensure Machine Learning will set a new standard as an introductory textbook.

The renewability, biocompatibility, and mechanical properties of cellulose nanocrystals (CNCs) have made them an attractive material for numerous composite, biomedical, and rheological applications. However, for CNCs to shift from a laboratory curiosity to commercial applications, researchers must transition from CNCs extracted on the bench scale to material produced on an industrial scale. There are a number of companies currently producing kilogram to ton per day quantities of sulfuric acid-hydrolyzed CNCs as well as other nanocelluloses, as described herein. With the recent intensification of industrially produced CNCs and the variety of cellulose sources, hydrolysis methods, and purification procedures, the characterization of these materials becomes critical. This has further been justified by the past two decades of research that demonstrate that the CNC stability and behavior are highly dependent on the surface chemistry, surface charge density, and particle size. This work outlines key test methods that should be employed to characterize these properties to ensure a "known" starting material and consistent performance. Of the sulfuric acid-extracted CNCs examined, industrially produced material compared well with laboratory-made CNCs, exhibiting similar charge density, colloidal and thermal stability, crystallinity, morphology, and self-assembly behavior. In addition, it was observed that further purification of CNCs using Soxhlet extraction in ethanol had minimal impact on the nanoparticle properties and is unlikely to be necessary for many applications. Overall, the current standing of industrially produced CNCs is positive, suggesting that the evolution to commercial-scale applications will not be hindered by CNC production.

This conceptual review article provides a critical appraisal of Sustainable Consumption and Production research, which is currently framed by two generic positions. First, the 'reformist' position, which focuses on firms pursuing green eco-innovations and consumers buying eco-efficient products, represents the political and academic orthodoxy. Second, the 'revolutionary' position, which is a radical critique of the mainstream, advocates the abolishment of capitalism, materialism, and consumerism, and promotes values such as frugality, sufficiency, and localism. We find this dichotomous debate problematic, because it is intellectually stifling and politically conservative (in its outcomes). To move beyond this dichotomy, we propose a third position, 'reconfiguration', which focuses on transitions in socio-technical systems and daily life practices and accommodates new conceptual frameworks. For each of the three positions, we discuss: (1) the scale and type of change, (2) views on consumption and production in exemplary approaches, (3) underlying theoretical, epistemological and normative orientations, (4) policy implications, and (5) critical appraisal. The conclusion compares the three positions, provides arguments for the fruitfulness of the reconfiguration-position and offers four critical reflections about future Sustainable Consumption and Production research agendas.

In public debates about the volume of food that is currently wasted by UK households, there exists a tendency to blame the consumer or individualise responsibilities for affecting change. Drawing on ethnographic examples, this article explores the dynamics of domestic food practices and considers their consequences in terms of waste. Discussions are structured around the following themes: (1) feeding the family; (2) eating ‘properly’; (3) the materiality of ‘proper’ food and its intersections with the socio-temporal demands of everyday life and (4) anxieties surrounding food safety and storage. Particular attention is paid to the role of public health interventions in shaping the contexts through which food is at risk of wastage. Taken together, I argue that household food waste cannot be conceptualised as a problem of individual consumer behaviour and suggest that policies and interventions might usefully be targeted at the social and material conditions in which food is provisioned.

Highly-skilled professionals, who circulate within and between transnational corporations as inter-company transferees (ICTs), are important constituents of the global economic system. In Castells' 'Network Society', such labour is referred to as 'managerial elites' but what remains invisible in this meta-narrative is their transnational existence. The aim of this paper, therefore, is to unpack further our understanding of transnational managerial elites by drawing upon a study of British highly-skilled ICTs who were posted from London to New York in the late 1990s. The paper is divided into four parts. Following a discussion of transnational managerial elites in globalisation, the paper highlights the transnational organisational and social networks of these ICTs in New York. The paper then revisits the conceptualisation of transnational managerial elites, suggesting that individual career paths, physical mobility and cross-border connections, ties and business/social networks (both physical and virtual) are key factors which reproduce traits of 'transnationalism' in the city. The paper concludes that major constituents of the transnationalism of managerial elites are the organisational and social networks that stretch across national boundaries, grounded in the translocal of the city.

Nanomaterials continue to bring promising advances to science and technology. In concert have come calls for increased regulatory oversight to ensure their appropriate identification and evaluation, which has led to extensive discussions about nanomaterial definitions. Numerous nanomaterial definitions have been proposed by government, industry, and standards organizations. We conducted a comprehensive comparative assessment of existing nanomaterial definitions put forward by governments to highlight their similarities and differences. We found that the size limits used in different definitions were inconsistent, as were considerations of other elements, including agglomerates and aggregates, distributional thresholds, novel properties, and solubility. Other important differences included consideration of number size distributions versus weight distributions and natural versus intentionally-manufactured materials. Overall, the definitions we compared were not in alignment, which may lead to inconsistent identification and evaluation of nanomaterials and could have adverse impacts on commerce and public perceptions of nanotechnology. We recommend a set of considerations that future discussions of nanomaterial definitions should consider for describing materials and assessing their potential for health and environmental impacts using risk-based approaches within existing assessment frameworks. Our intent is to initiate a dialogue aimed at achieving greater clarity in identifying those nanomaterials that may require additional evaluation, not to propose a formal definition.

Epicuticular wax forms a layer of hydrophobic material on plant aerial organs, which constitutes a protective barrier between the plant and its environment. We report here the identification of WIN1, an Arabidopsis thaliana ethylene response factor-type transcription factor, which can activate wax deposition in overexpressing plants. We constitutively expressed WIN1 in transgenic Arabidopsis plants, and found that leaf epidermal wax accumulation was up to 4.5-fold higher in these plants than in control plants. A significant increase was also found in stems. Interestingly, approximately 50% of the additional wax could only be released by complete lipid extractions, suggesting that not all of the wax is superficial. Gene expression analysis indicated that a number of genes, such as CER1, KCS1, and CER2, which are known to be involved in wax biosynthesis, were induced in WIN1 overexpressors. This observation indicates that induction of wax accumulation in transgenic plants is probably mediated through an increase in the expression of genes encoding enzymes of the wax biosynthesis pathway.

Abstract The term dynamic properties as applied to elastomers refers to the response to periodic or transient forces which do not cause failure or appreciable fatigue (permanent change of properties) during the investigation. Generally this is limited to vulcanizates subjected to deformations not exceeding about 25%; and generally the dynamic properties are measured after several cycles or (in a transient experiment such as resilience) after several preconditioning transients, so that the Mullins effect or difference between first and second strain cycles is not of consequence. Thus, dynamic properties represent the viscoelastic properties of vulcanizates at deformations below about 25%, after reaching a pseudo-equilibrium state. The dynamic properties of rubber are altered tremendously by the addition of a filler. The scope of this article is restricted to the dynamic properties of rubber vulcanizates with carbon black as a filler. The effect covered in this article are important in designing rubber compounds to be used under dynamic conditions, such as tires, power transmission belts, vibration isolation mountings, etc . However, the engineering application of dynamic properties, which has been treated in detail elsewhere, is outside the scope of this review. A certain amount of background material is needed. We will first define the terms used in describing dynamic properties. The methods and instruments used for measuring these properties will be described briefly, and the nature of carbon black will be reviewed. Finally, some historical material is given, together with the dynamic behavior of typical compounds, as a preface to the review of more recent work in this field.

The soil actinomycete causing formation of nitrogen-fixing symbiotic nodules on roots of the woody angiosperm Comptonia peregrina (L.) Coult. (Myricaceae) has been isolated from surface-sterilized root nodules after incubation and enzyme maceration. The filamentous bacterium grows slowly in pure culture on a yeast extract medium, producing sporogenous bodies which form large numbers of ovoid spores. Reinfection of sand-grown or aeroponically grown seedlings of Comptonia was achieved repeatedly with inocula prepared from suspensions of the Comptonia isolate. The same actinomycete has been reisolated from these seedling nodules. The induced nodules are highly active in the acetylene-reduction assay, and plants grow vigorously without an exogenous supply of fixed nitrogen.

Some scientifically well-established results—such as the fact that emission of greenhouse gases produces global warming—are rejected by sizable proportions of the population in the United States and other countries. Rejection of scientific findings is mostly driven by motivated cognition: People tend to reject findings that threaten their core beliefs or worldview. At present, rejection of scientific findings by the U.S. public is more prevalent on the political right than the left. Yet the cognitive mechanisms driving rejection of science, such as the superficial processing of evidence toward the desired interpretation, are found regardless of political orientation. General education and scientific literacy do not mitigate rejection of science but, rather, increase the polarization of opinions along partisan lines. In contrast, specific knowledge about the mechanisms underlying a scientific result—such as human-made climate change—can increase the acceptance of that result.

Social Politics: International Studies in Gender, State and Society - Volume 12, Number 3, Fall 2005

Multiple imputation is becoming increasingly established as the leading practical approach to modelling partially observed data, under the assumption that the data are missing at random. However, many medical and social datasets are multilevel, and this structure should be reflected not only in the model of interest, but also in the imputation model. In particular, the imputation model should reflect the differences between level 1 variables and level 2 variables (which are constant across level 1 units). This led us to develop the <b>REALCOM-IMPUTE</b> software, which we describe in this article. This software performs multilevel multiple imputation, and handles ordinal and unordered categorical data appropriately. It is freely available on-line, and may be used either as a standalone package, or in conjunction with the multilevel software <b>MLwiN</b> or Stata.

Increasing numbers of comparative survey datasets span multiple waves. Moving beyond purely cross-sectional analyses, multilevel longitudinal analyses of such datasets should generate substantively important insights into the political, social and economic correlates of many individual-level outcomes of interest (attitudes, behaviors, etc.). This article describes two simple techniques for extracting such insights, which allow change over time in y to be a function of change over time in x and/or of a time-invariant x. The article presents results from simulation studies that assess the techniques in the presence of complications that are likely to arise with real-world data, and concludes with applications to the issues of generalized social trust and postmaterialist values, using data from World/European Values Surveys.