Centrale Lyon ENISE

BACKGROUND: The health benefits of 150 min a week of moderate-to-vigorous-intensity physical activity (MVPA) in older adults, as currently recommended, are well established, but the suggested dose in older adults is often not reached. OBJECTIVES: We aimed to determine whether a lower dose of MVPA was effective in reducing mortality, in participants older than 60 years. METHODS: The PubMed and Embase databases were searched from inception to February 2015. Only prospective cohorts were included. Risk ratios of death were established into four doses based on weekly Metabolic Equivalent of Task (MET)-minutes, defined as inactive (reference), low (1-499), medium (500-999) or high (≥1000). Data were pooled and analysed through a random effects model using comprehensive meta-analysis software. RESULTS: Of the 835 reports screened, nine cohort studies remained, totalling 122 417 participants, with a mean follow-up of 9.8±2.7 years and 18 122 reported deaths (14.8%). A low dose of MVPA resulted in a 22% reduction in mortality risk (RR=0.78 (95% CI 0.71 to 0.87) p<0.0001). MVPA beyond this threshold brought further benefits, reaching a 28% reduction in all-cause mortality in older adults who followed the current recommendations (RR=0.72 (95% CI 0.65 to 0.80) p<0.0001) and a 35% reduction beyond 1000 MET-min per week (RR=0.65 (95% CI 0.61 to 0.70) p<0.0001). CONCLUSIONS: A dose of MVPA below current recommendations reduced mortality by 22% in older adults. A further increase in physical activity dose improved these benefits in a linear fashion. Older adults should be encouraged to include even low doses of MVPA in their daily lives.

This review summarizes recent advances in the area of tribology based on the outcome of a Lorentz Center workshop surveying various physical, chemical and mechanical phenomena across scales. Among the main themes discussed were those of rough surface representations, the breakdown of continuum theories at the nano- and microscales, as well as multiscale and multiphysics aspects for analytical and computational models relevant to applications spanning a variety of sectors, from automotive to biotribology and nanotechnology. Significant effort is still required to account for complementary nonlinear effects of plasticity, adhesion, friction, wear, lubrication and surface chemistry in tribological models. For each topic, we propose some research directions.

Unsteady cavitation in a Venturi-type section was simulated by two-dimensional computations of viscous, compressible, and turbulent cavitating flows. The numerical model used an implicit finite volume scheme (based on the SIMPLE algorithm) to solve Reynolds-averaged Navier-Stokes equations, associated with a barotropic vapor/liquid state law that strongly links the density variations to the pressure evolution. To simulate turbulence effects on cavitating flows, four different models were implemented (standard k-ε RNG; modified k-ε RNG; k-ω with and without compressibility effects), and numerical results obtained were compared to experimental ones. The standard models k-ε RNG and k-ω without compressibility effects lead to a poor description of the self-oscillation behavior of the cavitating flow. To improve numerical simulations by taking into account the influence of the compressibility of the two-phase medium on turbulence, two other models were implemented in the numerical code: a modified k-ε model and the k-ω model including compressibility effects. Results obtained concerning void ratio, velocity fields, and cavitation unsteady behavior were found in good agreement with experimental ones. The role of the compressibility effects on turbulent two-phase flow modeling was analyzed, and it seemed to be of primary importance in numerical simulations.

Recent literature supports the importance of horizontal ground reaction force (GRF) production for sprint acceleration performance. Modeling and clinical studies have shown that the hip extensors are very likely contributors to sprint acceleration performance. We experimentally tested the role of the hip extensors in horizontal GRF production during short, maximal, treadmill sprint accelerations. Torque capabilities of the knee and hip extensors and flexors were assessed using an isokinetic dynamometer in 14 males familiar with sprint running. Then, during 6-s sprints on an instrumented motorized treadmill, horizontal and vertical GRF were synchronized with electromyographic (EMG) activity of the vastus lateralis, rectus femoris, biceps femoris, and gluteus maximus averaged over the first half of support, entire support, entire swing and end-of-swing phases. No significant correlations were found between isokinetic or EMG variables and horizontal GRF. Multiple linear regression analysis showed a significant relationship (P = 0.024) between horizontal GRF and the combination of biceps femoris EMG activity during the end of the swing and the knee flexors eccentric peak torque. In conclusion, subjects who produced the greatest amount of horizontal force were both able to highly activate their hamstring muscles just before ground contact and present high eccentric hamstring peak torque capability.

A model for coupled radiation transfer and thermal diffusion is proposed, which provides a local temperature field. Single-line scanning of a laser beam over a thin layer of metallic powder placed on a dense substrate of the same material is studied. Both the laser beam diameter and the layer thickness are about 50 μm. The typical scanning velocity is in the range of 10–20 cm/s. An effective volumetric heat source is estimated from laser radiation scattering and absorption in a powder layer. A strong difference in thermal conductivity between the powder bed and dense material is taken into account. The above conditions correspond to the technology of selective laser melting that is applied to build objects of complicated shape from metallic powder. Complete remelting of the powder in the scanned zone and its good adhesion to the substrate ensure fabrication of functional parts with mechanical properties close to the ones of the wrought material. Experiments with single-line melting indicate that an interval of scanning velocities exists, where the remelted tracks are uniform. The tracks become “broken” if the scanning velocity is outside this interval. This is extremely undesirable and referred to as the “balling” effect. The size and the shape of the melt pool and the surface of the metallurgical contact of the remelted material to the substrate are analyzed in relation to the scanning velocity. The modeling results are compared with experimental observation of laser tracks. The experimentally found balling effect at scanning velocities above ∼20 cm/s can be explained by the Plateau–Rayleigh capillary instability of the melt pool. Two factors destabilize the process with increasing the scanning velocity: increasing the length-to-width ratio of the melt pool and decreasing the width of its contact with the substrate.

Selective Laser Melting (SLM) is a powder-based additive manufacturing capable to produce parts layer-by-layer from a 3D CAD model. Currently there is a growing interest in industry for applying this technology for generating objects with high geometrical complexity. To introduce SLM process into industry for manufacturing real components, high mechanical properties of final product must be achieved. Properties of the manufactured parts depend strongly on each single laser-melted track and each single layer, as well as the strength of the connections between them. In this study, effects of the processing parameters such as hatch distance on surface morphology are analyzed.

To up-grade SLM process for manufacturing real components, high mechanical properties of final product must be achieved. The properties of a part produced by SLM technology depend strongly on the properties of each single track and each single layer. In this study, effects of the processing parameters such as laser power, scanning speed and powder layer thickness on the single tracks formation are analyzed. It is shown that, by choosing an optimal technological window and appropriate strategy of SLM, it is possible to manufacture highly complex parts with mechanical properties comparable to those of wrought material.

Abstract A 2D numerical model is proposed to simulate unsteady cavitating flows. The Reynolds‐averaged Navier–Stokes equations are solved for the mixture of liquid and vapour, which is considered as a single fluid with variable density. The vapourization and condensation processes are controlled by a barotropic state law that relates the fluid density to the pressure variations. The numerical resolution is a pressure‐correction method derived from the SIMPLE algorithm, with a finite volume discretization. The standard scheme is slightly modified to take into account the cavitation phenomenon. That numerical model is used to calculate unsteady cavitating flows in two Venturi type sections. The choice of the turbulence model is discussed, and the standard RNG k–εmodel is found to lead to non‐physical stable cavities. A modified k–εmodel is proposed to improve the simulation. The influence of numerical and physical parameters is presented, and the numerical results are compared to previous experimental observations and measurements. The proposed model seems to describe the unsteady cavitation behaviour in 2D geometries well. Copyright © 2003 John Wiley &amp; Sons, Ltd.

Probabilistic finite-state machines are used today in a variety of areas in pattern recognition, or in fields to which pattern recognition is linked: computational linguistics, machine learning, time series analysis, circuit testing, computational biology, speech recognition, and machine translation are some of them. In Part I of this paper, we survey these generative objects and study their definitions and properties. In Part II, we will study the relation of probabilistic finite-state automata with other well-known devices that generate strings as hidden Markov models and n-grams and provide theorems, algorithms, and properties that represent a current state of the art of these objects.

Abstract This paper presents and exercises a general structure for an object‐oriented‐enriched finite element code. The programming environment provides a robust tool for extended finite element (XFEM) computations and a modular and extensible system. The programme structure has been designed to meet all natural requirements for modularity, extensibility, and robustness. To facilitate mesh–geometry interactions with hundreds of enrichment items, a mesh generator and mesh database are included. The salient features of the programme are: flexibility in the integration schemes (subtriangles, subquadrilaterals, independent near‐tip, and discontinuous quadrature rules); domain integral methods for homogeneous and bi‐material interface cracks arbitrarily oriented with respect to the mesh; geometry is described and updated by level sets, vector level sets or a standard method; standard and enriched approximations are independent; enrichment detection schemes: topological, geometrical, narrow‐band, etc.; multi‐material problem with an arbitrary number of interfaces and slip‐interfaces; non‐linear material models such as J2 plasticity with linear, isotropic and kinematic hardening. To illustrate the possible applications of our paradigm, we present 2D linear elastic fracture mechanics for hundreds of cracks with local near‐tip refinement, and crack propagation in two dimensions as well as complex 3D industrial problems. Copyright © 2007 John Wiley &amp; Sons, Ltd.

The frictional properties of a rough contact interface are controlled by its area of real contact, the dynamical variations of which underlie our modern understanding of the ubiquitous rate-and-state friction law. In particular, the real contact area is proportional to the normal load, slowly increases at rest through aging, and drops at slip inception. Here, through direct measurements on various contacts involving elastomers or human fingertips, we show that the real contact area also decreases under shear, with reductions as large as 30[Formula: see text], starting well before macroscopic sliding. All data are captured by a single reduction law enabling excellent predictions of the static friction force. In elastomers, the area-reduction rate of individual contacts obeys a scaling law valid from micrometer-sized junctions in rough contacts to millimeter-sized smooth sphere/plane contacts. For the class of soft materials used here, our results should motivate first-order improvements of current contact mechanics models and prompt reinterpretation of the rate-and-state parameters.

Abstract Discrete and smeared crack models for concrete fracture are discussed in a historical perspective. It is argued that these two computational approaches, originally conceived as very different, can be brought together by exploiting the partition‐of‐unity property of finite element shape functions. The cohesive segments method, which exploits this partition‐of‐unity property, exhibits advantages of both the discrete and smeared crack approaches, and is capable of describing the transition from distributed micro‐cracking to a dominant crack. The versatility of the cohesive methodology is shown by incorporating water diffusion and ion transport into the formulation. Copyright © 2004 John Wiley &amp; Sons, Ltd.

Abstract A two‐scale numerical model is developed for fluid flow in fractured, deforming porous media. At the microscale the flow in the cavity of a fracture is modelled as a viscous fluid. From the micromechanics of the flow in the cavity, coupling equations are derived for the momentum and the mass couplings to the equations for a fluid‐saturated porous medium, which are assumed to hold on the macroscopic scale. The finite element equations are derived for this two‐scale approach and integrated over time. By exploiting the partition‐of‐unity property of the finite element shape functions, the position and direction of the fractures is independent from the underlying discretization. The resulting discrete equations are non‐linear due to the non‐linearity of the coupling terms. A consistent linearization is given for use within a Newton–Raphson iterative procedure. Finally, examples are given to show the versatility and the efficiency of the approach, and show that faults in a deforming porous medium can have a significant effect on the local as well as on the overall flow and deformation patterns. Copyright © 2006 John Wiley &amp; Sons, Ltd.

Purpose Properties of the parts manufactured by selective laser melting (SLM) depend strongly on the each single laser‐melted track and each single layer, as well as the strength of the connections between them. The purpose of this paper to establish links between the principal SLM parameters (laser power density, scanning speed, layer thickness), properties of the powder and geometrical characteristics of single tracks. This study will provide a theoretical and technical basis for production of parts from metal powders. Design/methodology/approach This paper discusses the SLM parameters affecting on geometrical characteristics of the synthesized single tracks. Granulomorphometric characteristics of powders were studied in detail. A Greco‐Latin square design was used to control geometrical characteristics of the tracks. Analysis of variance (ANOVA) permitted to establish a statistically significant influence of the SLM process parameters on geometry of the single laser‐melted track. Findings The behavior of individual tracks and their geometric characteristics depend on the process parameters, and physical‐chemical and granulomorphometrical properties of the powder. Each powder shows peculiar behavior in the process of single track formation. For stainless steel grade 904L powders with different particle size it was found that the most influencing parameter is the laser power (the following values were applied: 25, 37.5, 50 W), and then, in order of decreasing importance, are the powder layer thickness (60, 90, 120 μm), the scanning speed (0.05, 0.10, 0.15 m/s), and, finally, the particle size. Originality/value The proposed hierarchy of the process parameters is a new systematic study presented by the authors, developed for selective laser melting. Obtained data can be used in surface structuring and micro‐manufacturing characterized by a small number of layers within a part and, thus, sensible to the geometric dimensions and shape of the individual tracks.

This paper considers the use of electromagnetic pulses (EMP) to inject transient faults into the calculations of a hardware and a software AES. A pulse generator and a 500 um-diameter magnetic coil were used to inject the localized EMP disturbances without any physical contact with the target. EMP injections were performed against a software AES running on a CPU, and a hardware AES (with and without countermeasure) embedded in a FPGA. The purpose of this work was twofold: (a) reporting actual faults injection induced by EMPs in our targets and describing their main properties, (b) explaining the coupling mechanism between the antenna used to produce the EMP and the targeted circuit, which causes the faults. The obtained results revealed a localized effect of the EMP since the injected faults were found dependent on the spatial position of the antenna on top of the circuit's surface. The assumption that EMP faults are related to the violation of the target's timing constraints was also studied and ascertained thanks to the use of a countermeasure based on monitoring such timing violations.

Obtaining uniform single vectors well attached to the substrate is necessary and sufficient for fabrication of complex-shape parts of high quality by selective laser melting. The temperature distribution in the laser/powder interaction zone and the shape of the melt pool is numerically calculated by the proposed model of coupled radiation and heat transfer applicable to single vectors. The analysis of the capillary stability of the segmental cylinder applied to the calculated melt pool estimates the stability of the process depending on the scanning velocity, powder layer thickness, and the material optical and thermal properties.

BACKGROUND/PURPOSE: Knowledge of the mechanical properties of the human skin is very important for cosmetic and clinical research. Objective and quantitative measurements are essential to compare studies performed by different experimenters in different centres. The aim of this paper is to present a method to measure the viscoelastic properties of human skin in vivo using dynamic indentation. METHODS: A complete device to assess the stiffness and damping of skin has been developed. The frequency and strain amplitude range from 10 to 60 Hz and from 1 to 10 mum. Tests on pure elastic inert materials have been performed to validate the device. An in vivo study including dynamic indentation, suction test, hydration measurement and topographic analysis has been performed on 46 subjects aged from 18 to 70 years, divided into three groups. RESULTS: Results on inert materials show the validity of the device developed. The mechanical behaviour of the skin can be described by a Kelvin-Voight model under dynamic indentation. A comparison with a suction test, hydration and topographic measurements shows that the stiffness and the damping measured by dynamic indentation correspond mainly to the natural tense state of the skin on the body due to the dermis. A weak correlation has been found between dynamic indentation and suction parameters. The complex modulus measured by dynamic indentation at 10 Hz frequency stress ranges from 7.2 +/- 2.1 kPa for the oldest group to 10.7 +/- 2.6 kPa for the youngest group. CONCLUSION: The device presented gives convincing results. The measurement of stiffness and damping complements the viscoelastic phenomenological parameters of the suction test.

The mechanisms involved in the mechanical loading-induced increase in bone formation remain unclear. In this study, we showed that cyclic strain (CS) (10 min, 1% stretch at 0.25 Hz) stimulated the proliferation of overnight serum-starved ROS 17/2.8 osteoblast-like cells plated on type I collagen-coated silicone membranes. This increase was blocked by MEK inhibitor PD-98059. Signaling events were then assessed 0 min, 30 min, and 4 h after one CS period with Western blotting and coimmunoprecipitation. CS rapidly and time-dependently promoted phosphorylation of both ERK2 at Tyr-187 and focal adhesion kinase (FAK) at Tyr-397 and Tyr-925, leading to the activation of the Ras/Raf/MEK pathway. Cell transfection with FAK mutated at Tyr-397 completely blocked ERK2 Tyr-187 phosphorylation. Quantitative immunofluorescence analysis of phosphotyrosine residues showed an increase in focal adhesion plaque number and size in strained cells. CS also induced both Src-Tyr-418 phosphorylation and Src to FAK association. Treatment with the selective Src family kinase inhibitor pyrazolopyrimidine 2 did not prevent CS-induced FAK-Tyr-397 phosphorylation suggesting a Src-independent activation of FAK. CS also activated proline-rich tyrosine kinase 2 (PYK2), a tyrosine kinase highly homologous to FAK, at the 402 phosphorylation site and promoted its association to FAK in a time-dependent manner. Mutation of PYK2 at the Tyr-402 site prevented the ERK2 phosphorylation only at 4 h. Intra and extracellular calcium chelators prevented PYK2 activation only at 4 h. In summary, our data showed that osteoblast response to mitogenic CS was mediated by MEK pathway activation. The latter was induced by ERK2 phosphorylation under the control of FAK and PYK2 phosphorylation orchestrated in a time-dependent manner.

As animals vocalize, their vocal organ transforms motor commands into vocalizations for social communication. In birds, the physical mechanisms by which vocalizations are produced and controlled remain unresolved because of the extreme difficulty in obtaining in vivo measurements. Here, we introduce an ex vivo preparation of the avian vocal organ that allows simultaneous high-speed imaging, muscle stimulation and kinematic and acoustic analyses to reveal the mechanisms of vocal production in birds across a wide range of taxa. Remarkably, we show that all species tested employ the myoelastic-aerodynamic (MEAD) mechanism, the same mechanism used to produce human speech. Furthermore, we show substantial redundancy in the control of key vocal parameters ex vivo, suggesting that in vivo vocalizations may also not be specified by unique motor commands. We propose that such motor redundancy can aid vocal learning and is common to MEAD sound production across birds and mammals, including humans.

BACKGROUND/PURPOSE: Various analyses have been performed to identify the mechanical properties of the human skin tissue in vivo. They generally use different approaches and hypotheses (behavior laws as well as mechanical tests) and the obtained results are consequently difficult to analyze and compare. In this paper, an inverse method that can be adapted to any kind of mechanical tests and behavior laws is presented. METHOD: A suction deformation performed on the volar aspect of the forearm of a subject is considered. This test is modeled with the finite element method to compare the experimental and simulated curves using an inverse method that allows the skin mechanical parameters identification. This process is based on two optimization algorithms, Kalman's filter and Gauss-Newton's methods. To account for the nonlinear behavior of the skin, a specific nonlinear elastic law, which is then compared with standard linear elastic and neo-Hookean's mechanical behaviors, was developed. RESULTS: The obtained results first prove that neither linear elasticity nor neo-Hookean's laws can be used to model the skin. On the contrary, the nonlinear elastic model presents a relevant fit of the experimental curves. The skin thickness is also proved to be another key point to be taken into consideration. CONCLUSIONS: The obtained results are successfully compared with literature and the reliability of the proposed method is underlined with the identification of 300 additional experimental curves. The different works we are currently focusing on are finally introduced.