Childrens Brittle Bone Foundation

Catalytic building blocks: Chiral porous zirconium phosphonates containing Ru-binap moieties are synthesized by a molecular building-block approach, and characterized by a variety of techniques. These hybrid solids are used for enantioselective heterogeneous asymmetric hydrogenation of β-keto esters with ee values of up to 95 % (see picture). Ready tunability of such a molecular building-block approach promises to lead to useful heterogeneous asymmetric catalysts.

Rehabilitation therapy is an important aspect of recovery after volumetric muscle loss. However, the traditional rehabilitation approach involves a period of rest and passive loading followed by gradual active loading. Extracellular matrix is a naturally occurring material consisting of structural proteins that provide mechanical strength, structural support, and functional molecules with diverse bioactive properties. There is evidence to suggest that the addition of aggressive regenerative rehabilitation protocols immediately after surgical implantation of an extracellular matrix scaffold to an area of volumetric muscle loss has significant benefits for extracellular matrix remodeling. Rehabilitation exercises likely provide the needed mechanical signals to encourage cell migration and site-specific differentiation in the temporal framework required for constructive remodeling. Herein, the authors review the literature and present an example of an aggressive rehabilitation program implemented immediately after extracellular matrix transplantation into a severely injured quadriceps muscle.

Jianqiang Ma, Erhard Hinrichs. Proceedings of the 53rd Annual Meeting of the Association for Computational Linguistics and the 7th International Joint Conference on Natural Language Processing (Volume 1: Long Papers). 2015.

The exotic disease white pine blister rust (caused by Cronartium ribicola) damages and kills whitebark pine (Pinus albicaulis), even in the extreme environments of alpine treeline communities. We surveyed P. albicaulis trees and tree islands for blister rust in 2 distinct alpine treeline communities in Montana, USA, and examined meso- and microtopographic factors potentially related to the climatic requirements for blister rust infection. For each of 60 sampling plots, we created high-resolution digital elevation models, derived microtopography variables, and compared these and distance to water feature variables with blister rust occurrence and intensity (number of cankers per infected tree) for every sampled P. albicaulis tree. Infection rates were 19% (of 328 sampled trees) and 24% (of 585 sampled trees) at the 2 sites. Tree island P. albicaulis had higher infection percentages than solitary trees. Using Bayesian analysis and a zero-inflated Poisson regression model, we determined that solar radiation and moisture-related variables correlated with both presence and number of blister rust cankers on P. albicaulis. Site factors that influence moisture, such as local topography, hydrology, and climate, differed between the 2 treeline study areas, which may account for the model variability.

The identity of putative oxytocin receptors visualized in autoradiographic studies of primate brain is unclear because the ligand used is much less selective in primate than rodent brains. This study tests the feasibility of utilizing a new monoclonal antibody (MoAb) developed against human uterine OTRs to visualize OTRs in primate brain. A block containing ventral hypothalamus of cynomolgus macaque brain, paraformaldehyde, glutaraldehyde-fixed and paraffin-embedded, and positive control tissue (human endometrium) were sectioned at 8 microm and studied with immunohistochemistry. OTRs were located in fibers in septal nucleus and in both cell bodies and fibers of preoptic area. These results indicate that OTRs in primate brain may be visualized with this MoAb, and are located in primate brain sites linked to the regulation of social behavior.

7 Львiвський нацiональний унiверситет iменi Iвана Франка, 79000, Львiв, Україна 8 Нацiональний унiверситет "Львiвська полiтехнiка", 79013, Львiв, Україна (Отримано 19 грудня 2006 р.

Ecological systems are facing major diversity losses in this century owing to Anthropogenic effects. Habitat loss, overexploitation of resources, invasion and pollution are rapidly jeopardizing the survival of whole communities. It has been recently suggested that a potential approach to flatten the curve of species extinction and prevent catastrophic shifts would involve the engineering of one selected species within one of these communities. Such possibility has started to become part of potential intervention scenarios to preserve biodiversity. Despite its potential, very little is known about the actual dynamic responses of complex ecological networks to the introduction of a synthetic strains derived from a resident species. In this paper, we address this problem by modelling the response of a community to the addition of a synthetic strain derived from a member of a stable ecosystem. We show that the community interaction matrix largely limits the spread of the engineered strain, thus suggesting that species diversity acts as an ecological firewall. The implications for future scenarios of ecosystem engineering are outlined. This article is part of the theme issue 'Ecological complexity and the biosphere: the next 30 years'.

PURPOSE: To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair. METHODS: Fifteen rats were distributed to three groups: MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldner's trichrome. RESULTS: The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect. CONCLUSION: The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.

The purpose of the present paper consists in proposing and discussing a double probabilistic representation for a porous media equation in the whole space perturbed by a multiplicative colored noise. For almost all random realizations $ω$, one associates a stochastic differential equation in law with random coefficients, driven by an independent Brownian motion. The key ingredient is a uniqueness lemma for a linear SPDE of Fokker-Planck type with measurable bounded (possibly degenerated) random coefficients.

УДК 66.014 Оценка биопотенциала дикорастущей облепихи и перспектив ее комплексного использования Д-р техн.наук О. я.МЕЗЕНОВА 1 , д-р наук Й.-Т.

We present a discourse annotation study, in which an annotation method based on Questions under Discussion (QuD) is applied to Italian data.The results of our inter-annotator agreement analysis show that the QUD-based approach, originally spelled out for English and German, can successfully be transferred cross-linguistically, supporting good agreement for the annotation of central information structure notions such as focus and non-at-issueness.Our annotation and interannotator agreement study on Italian authentic data confirms the cross-linguistic applicability of the QuD-based approach.

Some time lag, however small between time of death or the discovery of the body (and pending medicolegal autopsy), would appear to be indispensible and justified in each case for reasons of investigation. This time interval is reduced to a required minimum, depending upon the competency of crime investigative machinery and the concern of well-intentioned individuals. In a developing country like India, this can cause serious problems. The time lag interval between the discovery of the body and the autopsy is often very long in India, and may be attributed to reasons which are outside the legitimate needs of investigation, ranging from outright incompetence to cool callousness, willful omissions, or machinations based on unfair motivations and political compulsion. Long distances, proper communication, and availability of transportation all play their parts in the need for proper indentification and autopsy examination. In addition to delays in performing the autopsies, there are numerous instances of unnatural, sudden, and suspicious deaths, where postmortem examination is never done. These reasons range from those that are seemingly innocent to those which are grossly unfair or dishonest. The medicolegal postmortem index can vary between 20 and 80% in different areas of India.

My book Cosmopolitan Islanders derives from the Inaugural Lecture I delivered in 2008 as Regius Professor of Modern History in Cambridge. The brief of such a lecture is a tricky one – you have to say something about yourself, something about your field, and something about the discipline of History, and you have to appeal both to colleagues and to the wider world. In addition, in both Oxford and Cambridge, the only two universities with Regius Chairs of History, there have been many famous Inaugurals, by historians as varied as J. B. Bury, Hugh Trevor-Roper and, most famous of all, Lord Acton. In some universities, where professors are all-powerful, the Inaugural has served as a means of laying down the law about how the subject should be taught and researched. But in recent times this has been rare, and it has never really been true in Oxford or Cambridge; the one time that an Oxford Regius, the seventeenth-century specialist Sir Charles Firth, tried this, he ran into a huge amount of trouble and was more or less ostracised in the Faculty for the rest of his career.

Abstract In this work, we synthesized and studied the spectroscopic properties of (NH4)2(SO4)2Y­(H2O)6 (Y = Ni, Mg) crystals doped with AgNO3 or H3BO3. These crystals constitute a series of hexahydrated salts known as Tutton salts. We investigated the influence of dopants on the vibrational modes of the tetrahedral ligands NH4 and SO4, octahedral complexes Mg­(H2O)6 and Ni­(H2O)6, and H2O molecules present in these crystals through Raman and infrared spectroscopies. We were able to identify bands that are attributed to the presence of Ag and B dopants, as well as band shifts caused by the presence of these dopants in the crystal lattice. A detailed study of the crystal degradation processes was performed by thermogravimetric measurements, where there was an increase in the initial temperature of crystal degradation due to the presence of dopants in the crystal lattice. Raman spectroscopy of the crystal residues after the thermogravimetric measurements helped us to elucidate the degradation processes occurring after the crystal pyrolysis process.

Lexical preferences encoded as association metrics have been shown to improve performance on structural ambiguities that are still challenging for modern parsers.This paper introduces a mechanism to include lexical preferences into a neural transition-based dependency parser for German.We compare pointwise mutual information (PMI) and embedding-based scores.Both the PMI-based model and the embedding-based model outperform the baseline significantly.The best model is PMI-based and increases overall performance by 0.26 LAS points over the baseline.

Different topics are bringing the meaning of whole in physics.They are: nature tendency for conglomerates, confinement and complexity.Thus, one should investigate on a whole gauge symmetry.For this, a set of fields transforming under a common gauge parameter is considered.A systemic approach to gauge symmetry is studied.Different fields are introduced in a same abelian group, where their association is given through polynomial transformations.Consequently, new fields strength are introduced under such systemic gauge symmetry.It also introduces the possibility of a mass term without requiring Higgs mechanism.A systemic non-linear abelian Lagrangean is proposed.It is candidate for analysing an electromagnetic systemic phenomena.

The secretagogue effect of histamine on calcitonin secretion has been studied in 15 patients with medullary thyroid carcinoma and compared with known stimuli: glucagon and calcium in combination with pentagastrin. The effect of concomitant histamine H2-receptor blockade on these responses has been studied in the same patients. Seven patients with undetectable basal plasma calcitonin concentrations had measurable responses to calcium/pentagastrin but not to histamine or glucagon. In the remaining eight subjects, significant responses were seen to all three test substances, calcium/pentagastrin proving to be the most potent secretagogue. Establishment of H2-receptor blockade with cimetidine had no effect on basal calcitonin concentrations and did not suppress responses to histamine, calcium or pentagastrin. The variable secretagogue effect of histamine could be mediated through H1-receptors, through nonspecific vascular dilation "washing out" preformed calcitonin, or through its destruction to varying degrees by histaminase, present in most medullary thyroid tumors. Histamine is unlikely to replace calcium/pentagastrin as the most discriminative, provocative diagnostic agent in medullary thyroid carcinoma, but correlation of secretory responses with tissue histaminase concentrations and attempted blockade with differing antihistamines will further our understanding of this tumor.

Abstract This study systematically investigates two multi-fidelity strategies used to train machine-learned force fields (MLFFs)—pre-training/fine-tuning and multi-headed training—and elucidates the mechanisms underpinning their success. For pre-training and fine-tuning, we uncover a log–log linear relationship between pre-trained and fine-tuned accuracies that holds across model architectures, model sizes, and quantum-chemical methods. The success of this approach hinges on the quantity and quality of available pre-training data, and, critically, the inclusion of force labels. We demonstrate that pre-trained representations are inherently method-specific, requiring adaptation of the model backbone during fine-tuning. In contrast, multi-headed models learn method-independent backbone representations, where again the heads’ accuracies are log–log linearly related. Relative to pre-training and fine-tuning, these shared representations marginally reduce model performance in most cases. However, this trade-off is offset by practical advantages: multi-headed training extends naturally to multiple labelling methods and enables partial replacement of expensive labels with cheaper alternatives, paving the way towards cost-efficient universal MLFFs.

SÍNDROME DE BURNOUT NA ENFERMAGEM changes due to stress levels due to work overload, night shifts, low wages, poor working conditions, difficulties in interpersonal relationships in the work environment, physical and emotional exhaustion , which ends up leading the professional to a loss of motivation and impairing the performance of tasks, and not treated in a timely manner, has high levels of suicidal behavior.Through a bibliographical and systematic review of the literature, we observed that its etiology was clarified and that the treatment should be carried out in a multidisciplinary way.This is a literature review study with a narrative approach.

We develop conditions for the coding of a Bratteli-Vershik system according to initial path segments to be periodic, equivalently for a constructive symbolic recursive scheme corresponding to a cutting and stacking process to produce a periodic sequence. This is a step toward understanding when a Bratteli-Vershik system can be essentially faithfully represented by means of a natural coding as a subshift on a finite alphabet.