Department of the Premier and Cabinet

Large Language Models (LLMs) have recently demonstrated remarkable capabilities in natural language processing tasks and beyond. This success of LLMs has led to a large influx of research contributions in this direction. These works encompass diverse topics such as architectural innovations, better training strategies, context length improvements, fine-tuning, multimodal LLMs, robotics, datasets, benchmarking, efficiency, and more. With the rapid development of techniques and regular breakthroughs in LLM research, it has become considerably challenging to perceive the bigger picture of the advances in this direction. Considering the rapidly emerging plethora of literature on LLMs, it is imperative that the research community is able to benefit from a concise yet comprehensive overview of the recent developments in this field. This article provides an overview of the literature on a broad range of LLM-related concepts. Our self-contained comprehensive overview of LLMs discusses relevant background concepts along with covering the advanced topics at the frontier of research in LLMs. This review article is intended to provide not only a systematic survey but also a quick, comprehensive reference for the researchers and practitioners to draw insights from extensive, informative summaries of the existing works to advance the LLM research.

BACKGROUND: Randomized trials and meta-analyses have reached conflicting conclusions about the role of thrombolytic therapy for the treatment of acute pulmonary embolism. METHODS AND RESULTS: We performed a meta-analysis of all randomized trials comparing thrombolytic therapy with heparin in patients with acute pulmonary embolism. Eleven trials, involving 748 patients, were included. Compared with heparin, thrombolytic therapy was associated with a nonsignificant reduction in recurrent pulmonary embolism or death (6.7% versus 9.6%; OR 0.67, 95% CI 0.40 to 1.12, P for heterogeneity=0.48), a nonsignificant increase in major bleeding (9.1% versus 6.1%; OR 1.42, 95% CI 0.81 to 2.46), and a significant increase in nonmajor bleeding (22.7% versus 10.0%; OR 2.63, 95% CI 1.53 to 4.54; number needed to harm=8). Thrombolytic therapy compared with heparin was associated with a significant reduction in recurrent pulmonary embolism or death in trials that also enrolled patients with major (hemodynamically unstable) pulmonary embolism (9.4% versus 19.0%; OR 0.45, 95% CI 0.22 to 0.92; number needed to treat=10) but not in trials that excluded these patients (5.3% versus 4.8%; OR 1.07, 95% CI 0.50 to 2.30), with significant heterogeneity between these 2 groups of trials (P=0.10). CONCLUSIONS: Currently available data provide no evidence for a benefit of thrombolytic therapy compared with heparin for the initial treatment of unselected patients with acute pulmonary embolism. A benefit is suggested in those at highest risk of recurrence or death. The number of patients enrolled in randomized trials to date is modest, and further evaluation of the efficacy and safety of thrombolytic therapy for the treatment of high-risk patients with acute pulmonary embolism appears warranted.

BACKGROUND: There is a lack of consensus regarding the best option for the treatment of acute Achilles tendon rupture. Treatment can be broadly classified as operative (open or percutaneous) or nonoperative (casting or functional bracing). Postoperative splinting can be performed with a rigid cast (proximal or distal to the knee) or a more mobile functional brace. The aim of this meta-analysis was to identify and summarize the evidence from randomized, controlled trials on the effectiveness of different interventions for the treatment of acute Achilles tendon ruptures. METHODS: We searched multiple databases (including EMBASE, CINAHL, and MEDLINE) as well as reference lists of articles and contacted authors. Keywords included Achilles tendon, rupture, and tendon injuries. Three reviewers extracted data and independently assessed trial quality with use of a ten-item scale. RESULTS: Twelve trials involving 800 patients were included. There was a variable level of methodological rigor and reporting of outcomes. Open operative treatment was associated with a lower risk of rerupture compared with nonoperative treatment (relative risk, 0.27; 95% confidence interval, 0.11 to 0.64). However, it was associated with a higher risk of other complications, including infection, adhesions, and disturbed skin sensibility (relative risk, 10.60; 95% confidence interval, 4.82 to 23.28). Percutaneous repair was associated with a lower complication rate compared with open operative repair (relative risk, 2.84; 95% confidence interval, 1.06 to 7.62). Patients who had been managed with a functional brace postoperatively (allowing for early mobilization) had a lower complication rate compared with those who had been managed with a cast (relative risk, 1.88; 95% confidence interval, 1.27 to 2.76). Because of the small number of patients involved, no definitive conclusions could be made regarding different nonoperative treatment regimens. CONCLUSIONS: Open operative treatment of acute Achilles tendon ruptures significantly reduces the risk of rerupture compared with nonoperative treatment, but operative treatment is associated with a significantly higher risk of other complications. Operative risks may be reduced by performing surgery percutaneously. Postoperative splinting with use of a functional brace reduces the overall complication rate. LEVEL OF EVIDENCE: Therapeutic Level I.

Novel species of fungi described in this study include those from various countries as follows: Australia : Apiognomonia lasiopetali on Lasiopetalum sp., Blastacervulus eucalyptorum on Eucalyptus adesmophloia , Bullanockia australis (incl. Bullanockia gen. nov.) on Kingia australis , Caliciopsis eucalypti on Eucalyptus marginata , Celerioriella petrophiles on Petrophile teretifolia , Coleophoma xanthosiae on Xanthosia rotundifolia , Coniothyrium hakeae on Hakea sp., Diatrypella banksiae on Banksia formosa , Disculoides corymbiae on Corymbia calophylla , Elsinoë eelemani on Melaleuca alternifolia , Elsinoë eucalyptigena on Eucalyptus kingsmillii , Elsinoë preissianae on Eucalyptus preissiana , Eucasphaeria rustici on Eucalyptus creta , Hyweljonesia queenslandica (incl. Hyweljonesia gen. nov.) on the cocoon of an unidentified microlepidoptera, Mycodiella eucalypti (incl. Mycodiella gen. nov.) on Eucalyptus diversicolor , Myrtapenidiella sporadicae on Eucalyptus sporadica , Neocrinula xanthorrhoeae (incl. Neocrinula gen. nov.) on Xanthorrhoea sp., Ophiocordyceps nooreniae on dead ant, Phaeosphaeriopsis agavacearum on Agave sp., Phlogicylindrium mokarei on Eucalyptus sp., Phyllosticta acaciigena on Acacia suaveolens , Pleurophoma acaciae on Acacia glaucoptera , Pyrenochaeta hakeae on Hakea sp., Readeriella lehmannii on Eucalyptus lehmannii , Saccharata banksiae on Banksia grandis , Saccharata daviesiae on Daviesia pachyphylla , Saccharata eucalyptorum on Eucalyptus bigalerita , Saccharata hakeae on Hakea baxteri , Saccharata hakeicola on Hakea victoria , Saccharata lambertiae on Lambertia ericifolia , Saccharata petrophiles on Petrophile sp., Saccharata petrophilicola on Petrophile fastigiata , Sphaerellopsis hakeae on Hakea sp., and Teichospora kingiae on Kingia australis . Brazil : Adautomilanezia caesalpiniae (incl. Adautomilanezia gen. nov.) on Caesalpina echinata , Arthrophiala arthrospora (incl. Arthrophiala gen. nov.) on Sagittaria montevidensis , Diaporthe caatingaensis (endophyte from Tacinga inamoena ), Geastrum ishikawae on sandy soil, Geastrum pusillipilosum on soil, Gymnopus pygmaeus on dead leaves and sticks, Inonotus hymenonitens on decayed angiosperm trunk, Pyricularia urashimae on Urochloa brizantha , and Synnemellisia aurantia on Passiflora edulis . Chile : Tubulicrinis australis on Lophosoria quadripinnata . France : Cercophora squamulosa from submerged wood, and Scedosporium cereisporum from fluids of a wastewater treatment plant. Hawaii : Beltraniella acaciae , Dactylaria acaciae , Rhexodenticula acaciae , Rubikia evansii and Torula acaciae (all on Acacia koa ). India : Lepidoderma echinosporum on dead semi-woody stems, and Rhodocybe rubrobrunnea from soil. Iran : Talaromyces kabodanensis from hypersaline soil. La Réunion : Neoco

The interpretation of magnetic field data at low magnetic latitudes is difficult because the vector nature of the magnetic field increases the complexity of anomalies from magnetic rocks. The most obvious approach to this problem is to reduce the data to the magnetic pole (RTP), where the presumably vertical magnetisation vector will simplify observed anomalies. However, RTP requires special treatment of north-south features in data observed in low magnetic latitudes due to high amplitude corrections of such features. Furthermore, RTP requires the assumption of induced magnetisation with the result that anomalies from remanently and anisotropically magnetised bodies can be severely disturbed.The amplitude of the 3-D analytic signal of the total magnetic field produces maxima over magnetic contacts regardless of the direction of magnetisation. The absence of magnetisation direction in the shape of analytic signal anomalies is a particularly attractive characteristic for the interpretation of magnetic field data near the magnetic equator. Although the amplitude of the analytic signal is dependent on magnetisation strength and the direction of geological strike with respect to the magnetisation vector, this dependency is easier to deal with in the interpretation of analytic signal amplitude than in the original total field data or pole-reduced magnetic field. It is also straightforward to determine the depth to sources from the distance between inflection points of analytic signal anomalies.

BACKGROUND: The use of springs in craniofacial surgery originated at Sahlgrenska University Hospital in 1997 as a way of remodeling the cranial vault postoperatively. METHODS: The hospital records of the first 100 operations involving spring placement were analyzed retrospectively. Demographic, perioperative, and postoperative data were recorded. RESULTS: Two hundred forty-six springs were used in 96 patients. Results for sagittal, metopic, bicoronal, multiple synostoses, and midface surgery are presented. In total, five patients (5 percent) required further surgery because of undercorrection. There were no major complications. Spring dislodgement (5 percent) was the most common complication in early cases. Raised intracranial pressure resulted in a protocol change with the use of compressive springs. The data compare favorably with those of standard craniofacial procedures performed in the same unit. CONCLUSIONS: This therapeutic modality in craniofacial surgery has allowed minimization of the extent of surgery without compromising clinical outcomes. Springs have now become part of the authors' treatment protocol for craniosynostosis and midface surgery. The authors have shown the use of these techniques to be safe and, in selected situations, to offer significant advantages over other methods of treatment.

In 26 patients with features of reflex sympathetic dystrophy, venous blood was collected from painful and unaffected limbs. Levels of plasma adrenaline, noradrenaline and its intracellular metabolite, 3,4-dihydroxyphenylethyleneglycol (DHPG), were measured by combined gas chromatography/mass spectrometry. Plasma DHPG was lower on the painful side. Concentration of plasma noradrenaline was also lower on the painful side in patients with widespread allodynia, and in those with hyperhidrosis in the affected hand or foot. These findings do not support the widely held view that autonomic disturbances in reflex sympathetic dystrophy are due to sympathetic overactivity. Rather, they suggest that sweating and changes in peripheral blood flow result from supersensitivity to sympathetic neurotransmitters. After injury, supersensitivity to noradrenaline may also contribute to spontaneous pain and allodynia by disrupting efferent sympathetic modulation of sensation. This would explain why pain and allodynia are relieved by sympathetic blockade, and why noradrenaline rekindles pain in sympathectomized skin.

Peer Reviewed

The furcation entrance diameter of first permanent molar teeth has been investigated in a sample of 114 maxillary and 103 mandibular teeth, and found to be smaller than the blade face width of commonly used periodontal curettes in 58% of the furcations examined. It is suggested that because of this size disparity curettes when used alone may not be suitable for root preparation in this area as part of periodontal therapy. Alternative methods of instrumentation require clinical appraisal before recommendation. The buccal furcation entrance diameters of the maxillary first molar teeth examined tended to be smaller than either the mesiopalatal or distopalatal. Similarly the buccal entrance diameter in the mandibular first molar teeth examined tended to be smaller than the linqual. The mesiodistal widths at the cementoenamel junction of both maxillary and mandibular first molar teeth were found to have very low correlation with their furcation entrance diameters. Large teeth therefore do not necessarily have large furcation entrance diameters.

INTRODUCTION: This pilot study tested the feasibility and effectiveness of using Mindfulness-Based Childbirth Education (MBCE), a novel integration of mindfulness meditation and skills-based childbirth education, for mental health promotion with pregnant women. The MBCE protocol aimed to reduce fear of birth, anxiety, and stress and improve maternal self-efficacy. This pilot study also aimed to determine the acceptability and feasibility of the MBCE protocol. METHODS: A single-arm pilot study of the MBCE intervention using a repeated-measures design was used to analyze data before and after the MBCE intervention to determine change trends with key outcome variables: mindfulness; depression, anxiety, and stress; childbirth self-efficacy; and fear of childbirth. Pregnant women (18-28 weeks' gestation) and their support companions attended weekly MBCE group sessions over 8 weeks in an Australian community setting. RESULTS: Of the 18 women who began and completed the intervention, missing data allowed for complete data from 12 participants to be analyzed. Statistically significant improvements and large effect sizes were observed for childbirth self-efficacy and fear of childbirth. Improvements in depression, mindfulness, and birth outcome expectations were underpowered. At postnatal follow-up significant improvements were found in anxiety, whereas improvements in mindfulness, stress, and fear of birth were significant at a less conservative alpha level. DISCUSSION: This pilot study demonstrated that a blended mindfulness and skills-based childbirth education intervention was acceptable to women and was associated with improvements in women's sense of control and confidence in giving birth. Previous findings that low self-efficacy and high childbirth fear are linked to greater labor pain, stress reactivity, and trauma suggest the observed improvements in these variables have important implications for improving maternal mental health and associated child health outcomes. Ways in which these outcomes can be achieved through improved childbirth education are discussed.

Abstract Cool smoke treatments were applied to unmined Eucalyptus marginata (jarrah) forest soils, rehabilitated bauxite mine soils, and broadcast seed to determine if enhancement in germination could be effected with a view toward maximizng the establishment of species in bauxite mines in Western Australia. Forest sites showed a 48‐fold increase in total germinants from the soil seed bank when treated with aerosol smoke. Newly returned bauxite mine soils showed a greater than threefold increase in total germinants after the same treatment. There were also significant increases in the number of species germinating in response to the aerosol smoke treatment in both the forest and the mined soils. Similarly, application of smoked water to the soil seed bank in previously mined sites elicited a significant positive germination response, increasing total germinants and species numbers by 56 and 33%, respectively. Treatment of mixed seed lots with aerosol smoke before broadcast resulted in highly significant improvement in germination when compared to untreated seed. Both total number of germinants, and number of species emerging from mined sites were positively influenced (85% and 34% increases, respectively). Ten target species were used to determine the relative effectiveness of different methods of smoke treatment on the germination of broadcast seed. Nine of the species involved displayed a promotive effect with at least two of the treatments. Generally, however, aerosol smoking of seed before broadcast proved to be the more effective approach. As a result of these findings, all broadcast seed for use in Alcoa's bauxite mined areas in the southwest of Western Australia is now routinely smoke treated before application.

The incidence of natural scrapie in sheep is associated with polymorphisms of the PrP gene, particularly those at codons 136, 154 and 171. In many breeds, the PrP allele encoding valine at codon 136 confers an extremely high risk of scrapie, but in Suffolk sheep this allele is vanishingly rare. In this study of a single closed flock of Suffolk sheep in Scotland, scrapie occurred primarily in animals which were homozygous for glutamine at codon 171, a genotype which was significantly less frequent in healthy flockmates. However, the apparent linkage between glutamine at codon 171 and scrapie was not completely recessive because two of 64 scrapie cases were heterozygous glutamine/arginine. These results suggest that breeding for increased resistance to scrapie in Suffolks by the selection of animals according to their PrP genotype is a feasible option.

BACKGROUND: The Mesopsychidae is an extinct family of Mecoptera, comprising eleven described genera from Upper Permian to Lower Cretaceous deposits. In 2009, several well-preserved mesopsychids with long proboscides were reported from the mid Mesozoic of Northeastern China, suggesting the presence of pollination mutualisms with gymnosperm plants and highlighting their elevated genus-level diversity. Since that time, additional mesopsychid taxa have been described. However, the phylogeny of genera within Mesopsychidae has not been studied formally, attributable to the limited number of well-preserved fossils. RESULTS: Here, we describe two new species, Lichnomesopsyche prochorista sp. nov. and Vitimopsyche pristina sp. nov. and revise the diagnosis of Lichnomesopsyche daohugouensis Ren, Labandeira and Shih, 2010, based on ten specimens from the latest Middle Jurassic Jiulongshan Formation of Inner Mongolia, China. After compiling data from these new fossil species and previously reported representative taxa, we conducted phylogenetic analyses and geometric morphometric studies that now shed light on the taxonomy and phylogeny of Mesopsychidae. We also evaluate the recurring origin of the siphonate proboscis in the Mecoptera and propose an evolutionary developmental model for its multiple origins. CONCLUSIONS: Phylogenetic and geometric morphometric results confirm the establishment of two new species, each to Lichnomesopsyche and Vitimopsyche. Vitimopsyche pristina sp. nov. extends the existence of the genus Vitimopsyche Novokshonov and Sukacheva, 2001, from the mid Lower Cretaceous to the latest Middle Jurassic. Two methods of analyses indicate an affiliation of Mesopsyche dobrokhotovae Novokshonov, 1997 with Permopsyche Bashkuev, 2011. A phylogenetic analysis of the Mesopsychidae supports: 1), Mesopsychidae as a monophyletic group; 2), Mesopsyche as a paraphyletic group, to be revised pending future examination of additional material; and 3), the independent origin of the proboscis in the Pseudopolycentropodidae, its subsequent loss in earliest Mesopsychidae such as Epicharmesopsyche, its re-origination in the common ancestor (or perhaps independently) in the Vitimopsyche and Lichnomesopsyche clades of the Mesopsychidae. The third conclusion indicates that the proboscis originated four or five times within early Mecoptera, whose origin is explained by an evolutionary developmental model.

OBJECTIVE: This treatment concept paper introduces a risk assessment tool, the Implant Disease Risk Assessment, (IDRA) which estimates the risk for a patient to develop peri-implantitis. MATERIALS AND METHODS: The functional risk assessment diagram was constructed incorporating eight parameters, each with documented evidence for an association with peri-implantitis. RESULTS: The eight vectors of the diagram include (1) assessment of a history of periodontitis (2) percentage of sites with bleeding on probing (BOP) (3) number of teeth/implants with probing depths (PD) ≥5 mm (4) the ratio of periodontal bone loss (evaluated from a radiograph) divided by the patient's age (5) periodontitis susceptibility as described by the staging and grading categories from the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases (Journal of Periodontology, 89 Suppl 1, S159-S172, 2018) (6) the frequency/compliance with supportive periodontal therapy (7) the distance in mm from the restorative margin of the implant-supported prosthesis to the marginal bone crest and (8) prosthesis-related factors including cleanability and fit of the implant-supported prosthesis. CONCLUSION: The combination of these factors in a risk assessment tool, IDRA, may be useful in identifying individuals at risk for development of peri-implantitis.

The Spionidae of southeastern Australia are described.Intertidal and subtidal collections come mostly from Victoria, New South Wales and southern Queensland.A few records from West Australia, South Australia, Tasmania and the Great Barrier Reef (Queensland) are also included.A total of 68 species in 19 genera have been identified.These include 4 new genera and 43 new species, with new synonyms and generic emendations also proposed.The genera with pointed prostomia include Scolelepis (9 species, 8 being new), Aonides (1 species) and Dispio (1 new species).Australospio trifida gen.et.sp.nov. is a unique spionid with both a distally pointed prostomium and lateral prostomial horns.The genera with frontal or lateral prostomial horns include Malacoceros (3 species, 2 being new), Rhynchospio (2 new species) and Scolecolepides (1 new species).The definition of Rhynchospio is expanded to include those species with branchiae free from dorsal lamellae.Laonice includes 3 new species, with 1 being a simultaneous hermaphrodite.Spiophanes includes 3 species, Spio with 3 species (2 being new) and Microspio with 1 new species.The genera of the Prionospio-compXex are reviewed and revised to include: Parapriono- spio (1 species), Orthoprionospio gen.nov.(1 new species), Streblospio (not represented) and Prionospio (9 species, 5 being new).A generic revision of the Poly dora-comp\ex is presented with 6 genera recognized: Boccardia (3 species), Carazziella gen.nov.(4 new species), Polydora (15 species, 8 being new), Boccardiella gen.nov.(2 species, 1 being new), Tripolydora (not represented) and Pseu- dopolydora (5 species, 2 being new).Polydorella is synonymized with Pseudopolydora.Approximately I of the species reported herein are endemic to Australia; the remainder are species with more cosmopolitan distributions.We consider it to be increasingly difficult to 6a.Hooded hooks bidentate (Fig. 3d-e); maintain 2 subgencric or generic (see Fauparapodia and branchiae of middle chald, 1 977a) categories based on such tenuous and posterior setigers vesiculate (Fig. and variable characteristics.Although we re-3c) S. phyllobranchia gret lumping such a large group of species b.Hooded hooks multidentate (Fig. under one genus, we believe it to be the better 4h; 5c); parapodia and branchiae not course, pending a re-evaluation of the taxo- vesiculate 7 nomic characteristics of Scolelepis.A similar n n n , t • , , position was adopted by Light (1977).^?™" c > e P^norfy elevated mo fo- The reader is referred to Pettibone (1963) i'°% ^^"JF?n™! and Foster (1971) for historical and revision- S^JS'SSS T A t ary clarification of the genus Scolelepis, and l^l^t £ °> i^l r for lists and keys to the tpecies.Eighteen spe- h %» £? 3t tipS Fl g ' f C " d) , 5 " °?*** cies are listed as valid by Pettibone (1 963).Wu b ' £™f .PJ^S < m ' and Chen (1964), Hartmann-Schroder (1965), PO^ed not fohose (Fig. 5a-b); su- Foster (1971), Bcllan and Lagardere (1971 P en °r dorsal capillary setae with Gibbs (1971); (1972), and Day (1973) have dc- T^J^K^t T I Spm°US scribed additional species.In our study, we Jff/ 1 f (Flg ; **** branchiae corn- have identified 9 species belonging to Scdlele- pletely fuS ° d t0 d°rSal ,araeIIae S ' towra pis, of which 8 are new to science.^a.Posterior notopodia with acicular spines (Fig. 8g) in addition to capil- KEY TO SPECIES OF SCOLELEPIS FROM lary setae; area posterior to caruncle southeastern Australia with nuchal papilla and raised rec- 1 a.Notosetae present on setiger 1 2 tangular patch (Fig. 7 a-b) S. viridis b.Notosetae absent from setiger 1 5 8b .Posterior notopodia without acicular 2a.Caruncle posteriorly free from dorsum 3 spines, with capillary setae only; car- b.Caruncle attached to dorsum 4 uncle with rounded lobe; nuchal pa- 3a.Setiger 1 with notopodial lamella in P 11 . 1 * located posterior to caruncle presetal position (Fig. 6a-b); hooded ( F' §-9 a-b) S. victoriensis hooks multidentate, beginning in c ....... .neuropodia of setiger 15-90 (Fig Scolelepis Iamelhcincta sp.nov.6g-f) S. precirriseta (Figure 1) b.Setiger 1 with notopodial lamella in Material examined: QUEENSLAND.Heron Island, DOStsetal nositinn CFio ?iV hnnApA sandy shore -NE of is1and > mid-low tide levels (1 EvEw ° f ?, f I ' specimen.AM W13000).

1. Rapid Maxillary Expansion is a comparatively simple, conservative method of treating impaired nasal respiration. 2. It can be used from 4 years to 25 or 30 years of age, but the younger the patient the better the long term results. 3. The medical indications are a combination of poor nasal airway, septal deformity, recurrent ear or nasal infection, allergic rhinitis and asthma, and prior to septoplasty. 4. The dental indications are mainly unilateral or bilateral cross bite, class III (prognathoid) malocclusion, maxillary compression, and cleft palate. 5. The dental contra-indications are normal occlusion in the permanent dentition and to a lesser degree severe class II occlusion and micromandible. 6. In selected cases, it produces a change of over 80 percent from mouth to nose breathing. In this series of 310 consecutive cases 87 percent were greatly improved, 9 percent had a fair result and 4 percent a poor result. 7. It also gives considerable improvement in colds and respiratory infection, nasal allergy and many cases of asthma. The improvement in health and confidence and concentration in over 30 percent of cases is particularly pleasing. 8. The rationale of Rapid Maxillary Expansion can be explained by the maxillary moulding theory of production of septal and facial deformities.

An accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high reexcision rates without resorting to the removal of excess healthy tissue. Optical coherence microelastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to microscale variations of the mechanical properties of tissue. As the tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the microscale, involved regions of fresh, unstained tissue. OCME is based on the use of optical coherence tomography (OCT) to measure tissue deformation in response to applied mechanical compression. In this feasibility study on 58 ex vivo samples from patients undergoing mastectomy or wide local excision, we demonstrate the performance of OCME as a means to visualize tissue microarchitecture in benign and malignant human breast tissues. Through a comparison with corresponding histology and OCT images, OCME is shown to enable ready visualization of features such as ducts, lobules, microcysts, blood vessels, and arterioles and to identify invasive tumor through distinctive patterns in OCME images, often with enhanced contrast compared with OCT. These results lay the foundation for future intraoperative studies. Cancer Res; 75(16); 3236-45. ©2015 AACR.

The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain conditions, depending on dosage (serum concentration), duration of treatment and interactions among individual elements. We review the beneficial and toxic effects of key elements on bone homeostasis.

The increasing number of international students enrolled in Australian universities over the last decade has met with a corresponding concern that many non-English-speaking background (NESB) students experience considerable difficulty in their courses. Consequently, concerns about admission procedures have been raised regarding how English language proficiency (ELP) is determined for NESB students (both domestic and international). In addition to standardised ELP tests, some universities accept other forms of evidence, such as the completion of English-medium courses. This large-scale quantitative study analysed data on 5675 undergraduate and postgraduate students available from one university's database over a three-year period to ascertain if its ELP requirements were sufficient to ensure the academic progress of adequate numbers of these students. The best evidence for potential academic success was found to be standardised tests while students submitting other forms of ELP evidence tended to have more difficulties.

THIS case is reported as being of interest from three points of view:(1) Multiple primary malignant tumours are themselves rare in children.(2) Two primary tumours of different pathological nature occurring in the same orbit at different times are very rare.(3) New primary tumours occurring in areas treated by radiotherapy for a different type of tumour are rare.The case concerns a schoolgirl who died at the age of 10 years from a meningioma arising in the roof of the orbit 6 years after surgical removal of a tumour of the optic nerve, gliomatous (astrocytoma) in nature.The orbit was treated with deep x-ray therapy after removal of the first tumour.Case Report History.-Alittle girl, born in 1942, was noticed at the age of 3 to screw up her.left eye when looking at anything.She was taken to the Princess Margaret Hospital for Children and approximately a year later a tumour of the left optic nerve was removed through a Kronlein approach, the eyeball being left in situ and the tumour being apparently excised completely.Although the tumour was thought to have been completely removed and was reported by the pathologist as an astrocytoma, deep x-ray therapy was given to prevent possible recurrence.Deep therapy was begun in April, 1946, over a 7 x 7-cm.field including the whole orbit and optic foramen.In 2 weeks a dose of 3,300 r spread over ten applications had been given, with an estimated tissue dose of 2,500 r at the optic foramen.During May, June, August, September, October, and December, 1946, and January, February, and April, 1947, single monthly doses totalling 6,500 r (tissue dose 5,500 r) were given.A large x-ray burn, involving thecornea and conjunctiva and producing telangiectases of the lids, resulted.She was treated for the corneal ulcer which healed with obliteration of the fornices, adhesion of the lids to the globe and keratinization of the corneal epithelium.Eyebrow and eyelashes were permanently destroyed-Recent Developments.-Shewas seen for the first time by one of us (P.C.Y.) in 1950, and at intervals until June, 1951.She remained well until this time when her mother noticed a swelling above the left supra-orbital margin.She was readmitted to the Princess Margaret Hospital and a portion of the swelling was removed for biopsy.The section showed a meningioma, and she was transferred to the Neuro-Surgical Unit of the Royal Perth Hospital.When presented to this Unit the child was suffering from a meningioma arising from the dura over the left frontal lobe.The tumour had invaded and destroyed a considerable portion of the adjacent frontal bone and presented as a soft swelling immedi- ately beneath the skin above the left supra-orbital ridge.Tomographic studies demonstra- ted a large, roughly circular hiatus in the supra-orbital margin, and the anterior part of the frontal bone.