Gauhati University

Abstract At sufficiently high temperature and energy density, nuclear matter undergoes a transition to a phase in which quarks and gluons are not confined: the quark–gluon plasma (QGP) 1 . Such an exotic state of strongly interacting quantum chromodynamics matter is produced in the laboratory in heavy nuclei high-energy collisions, where an enhanced production of strange hadrons is observed 2,3,4,5,6 . Strangeness enhancement, originally proposed as a signature of QGP formation in nuclear collisions 7 , is more pronounced for multi-strange baryons. Several effects typical of heavy-ion phenomenology have been observed in high-multiplicity proton–proton (pp) collisions 8,9 , but the enhanced production of multi-strange particles has not been reported so far. Here we present the first observation of strangeness enhancement in high-multiplicity proton–proton collisions. We find that the integrated yields of strange and multi-strange particles, relative to pions, increases significantly with the event charged-particle multiplicity. The measurements are in remarkable agreement with the p–Pb collision results 10,11 , indicating that the phenomenon is related to the final system created in the collision. In high-multiplicity events strangeness production reaches values similar to those observed in Pb–Pb collisions, where a QGP is formed.

The United Nations General Assembly agreed and approved in September 2015 the document ‘2030 Agenda for Sustainable Development’, which contains a set of measures aiming to balance economic progress and protection of the environment, whilst at the same time remain aware of the need to address the many disparities still seen between industrialised and developing countries. The Agenda document consists of 17 Sustainable Development Goals (SDGs), which among many other tasks, intend to eradicate poverty and create better health conditions in both developed and developing countries. But despite the need for and the relevance of the SDGs, it is unclear how they may help to address present and future sustainability challenges. Based on the need to shed some light on such a relationship, this paper describes each of the SDGs, and offers an analysis of the extent to which their implementation may offer support to ongoing attempts to handle some of the pressing problems seen in pursuing sustainable development. Three case studies are presented to show in practice how best the SDGs can be handled. The paper concludes that the process of implementing the SDGs offers unrivalled opportunities to advance equal opportunity and foster economic empowerment, helping countries to promote the cause of sustainable development in their territories, hence benefiting their populations.

Bromination is one of the most important transformations in organic synthesis and can be carried out using bromine and many other bromo compounds. Use of molecular bromine in organic synthesis is well-known. However, due to the hazardous nature of bromine, enormous growth has been witnessed in the past several decades for the development of solid bromine carriers. This review outlines the use of bromine and different bromo-organic compounds in organic synthesis. The applications of bromine, a total of 107 bromo-organic compounds, 11 other brominating agents, and a few natural bromine sources were incorporated. The scope of these reagents for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, ring-opening reactions, substitution, rearrangement, hydrolysis, catalysis, etc. has been described briefly to highlight important aspects of the bromo-organic compounds in organic synthesis.

The worsening energy crisis, growing environmental consciousness, and the detrimental consequences of climate change, prompted governments to reduce carbon footprints. One of the approaches involved is adopting green energy technology to charge electric vehicles (EVs). The US Department of Energy estimates that EVs may effectively use 60% of the input energy while driving, twice as much as traditional fossil fuel-based vehicles. Although EVs are tremendously efficient, the amount of greenhouse gas emissions they can reduce relies on the source of electricity needed to power them. To summarize the role of RE as a viable charging alternative, in this study, we analyze four essential elements of EV charging infrastructure, RE-enabled smart charging approaches, utility interest and associated challenges and opportunities. First, the existing RE sources employed for EV charging are discussed with their global adoption, advantages and drawbacks and the leading countries. Second, we presented a thorough investigation of energy storage technologies, charging systems, related power electronics, and smart grid integration to facilitate the adoption of RE in EVs. Third, we discussed in-depth the many industry-implemented smart charging approaches with RE in light of the most recent global trend in EV energy usage. Finally, given the inherent challenges associated with realizing the sustainable transition, we discuss the technological challenges and opportunities related to grid integration, renovation, standardization, maintenance, network security and resource optimization. The authors believe this manuscript will serve as an information cornerstone for all the involved parties and scientific communication to gain a deeper understanding and contribute.

The updated concepts on the nature of π–π interactions and their use in various fields ranging from crystal engineering to materials science to biochemistry are discussed. This is the opening paper for the Crystal Growth & Design virtual special issue on “π···π Stacking in Crystal Engineering: Fundamentals and Applications”.

Autophagy causes the breakdown of damaged proteins and organelles to their constituent components. The phosphatidylinositol 3-kinase (PI3K) pathway played an important role in regulating the autophagic response of cells in response to changing reactive oxygen species (ROS) levels. The PI3K α catalytic subunit inhibits autophagy, while its β catalytic subunit promotes autophagy in response to changes in ROS levels. The downstream Akt protein acts against autophagy initiation in response to increases in ROS levels under nutrient-rich conditions. Akt acts by activating a mechanistic target of the rapamycin complex 1 (mTORC1) and by arresting autophagic gene expression. The AMP-activated protein kinase (AMPK) protein counteracts the Akt actions. mTORC1 and mTORC2 inhibit autophagy under moderate ROS levels, but under high ROS levels, mTORC2 can promote cellular senescence via autophagy. Phosphatase and tensin homolog (PTEN) protein are the negative regulators of the PI3K pathway, and it has proautophagic activities. Studies conducted on cells treated with flavonoids and ionizing radiation showed that the moderate increase in ROS levels in the flavonoid-treated groups corresponded with higher PTEN levels and lowered Akt levels leading to a higher occurrence of autophagy. In contrast, higher ROS levels evoked by ionizing radiation caused a lowering of the incidence of autophagy.

Stochastic Processes Queueing Systems: General Concepts Birth-and-Death Queueing Systems: Exponential Models Non-Birth-and-Death Queueing Systems: Markovian Models Network of Queues Non-Markovian Queueing Systems Queues with General Arrival Time and Service Time Distributions 333 Miscellaneous Topics

The agricultural crops are often affected by the scarcity of fresh water. Seasonal drought is a major constraint on Northeast Indian agriculture. Almost 80% of the agricultural land in this region is acidic and facing severe drought during the winter period. Apart from classical breeding and transgenic approaches, the application of plant-growth-promoting bacteria (PGPB) is an alternative strategy for improving plant fitness under stressful conditions. The 1-aminocyclopropane-1-carboxylate (ACC) deaminase-producing PGPB offer drought stress tolerance by regulating plant ethylene levels. The aim of the present study was to evaluate the consortium effect of three ACC-deaminase producing rhizobacteria - Ochrobactrum pseudogrignonenseRJ12, Pseudomonas sp.RJ15 and Bacillus subtilisRJ46 on drought stress alleviation in Vigna mungo L. and Pisum sativum L. Consortium treatment significantly increase seed germination percentage, root length, shoot length, and dry weight of treated plants. An elevated production of reactive oxygen species scavenging enzymes and cellular osmolytes; higher leaf chlorophyll content; increase in relative water content and root recovery intension were observed after consortium treatment in comparison with the uninoculated plants under drought conditions. The consortium treatment decreased the ACC accumulation and down-regulated ACC-oxidase gene expression. This consortium could be an effective bio-formulator for crop health improvement in drought-affected acidic agricultural fields.

Production and spillage of petroleum hydrocarbons which is the most versatile energy resource causes disastrous environmental pollution. Elevated oil degrading performance from microorganisms is demanded for successful microbial remediation of those toxic pollutants. The employment of biosurfactant-producing and hydrocarbon-utilizing microbes enhances the effectiveness of bioremediation as biosurfactant plays a key role by making hydrocarbons bio-available for degradation. The present study aimed the isolation of a potent biosurfactant producing indigenous bacteria which can be employed for crude oil remediation, along with the characterization of the biosurfactant produced during crude oil biodegradation. A potent bacterial strain Pseudomonas aeruginosa PG1 (identified by 16s rDNA sequencing) was isolated from hydrocarbon contaminated soil that could efficiently produce biosurfactant by utilizing crude oil components as the carbon source, thereby leading to the enhanced degradation of the petroleum hydrocarbons. Strain PG1 could degrade 81.8% of total petroleum hydrocarbons (TPH) after 5 weeks of culture when grown in mineral salt media (MSM) supplemented with 2% (v/v) crude oil as the sole carbon source. GCMS analysis of the treated crude oil samples revealed that P. aeruginosa PG1 could potentially degrade various hydrocarbon contents including various PAHs present in the crude oil. Biosurfactant produced by strain PG1 in the course of crude oil degradation, promotes the reduction of surface tension (ST) of the culture medium from 51.8 mN m-1 to 29.6 mN m-1, with the critical micelle concentration (CMC) of 56 mg L-1. FTIR, LC-MS and SEM-EDS studies revealed that the biosurfactant is a rhamnolipid comprising of both mono and di rhamnolipid congeners. The biosurfactant did not exhibit any cytotoxic effect to mouse L292 fibroblastic cell line, however, strong antibiotic activity against some pathogenic bacteria and fungus was observed.

The biotechnological production of fragrances is a recent trend that has expanded rapidly in the last two decades. Vanillin is the second most popular flavoring agent after saffron and is extensively used in various applications, e.g., as a food additive in food and beverages and as a masking agent in various pharmaceutical formulations. It is also considered a valuable product for other applications, such as metal plating and the production of other flavoring agents, herbicides, ripening agents, antifoaming agents, and personal and home-use products (such as in deodorants, air fresheners, and floor-polishing agents). In general, three types of vanillin, namely natural, biotechnological, and chemical/synthetic, are available on the market. However, only natural and nature-identical (biotechnologically produced from ferulic acid only) vanillins are considered as food-grade additives by most food-safety control authorities worldwide. In the present review, we summarize recent trends in fermentation technology for vanillin production and discuss the importance of the choice of raw materials for the economically viable production of vanillin. We also describe the key enzymes used in the biotechnological production of vanillin as well as their underlying genes. Research to advance our understanding of the molecular regulation of different pathways involved in vanillin production from ferulic acid is still ongoing. The enhanced knowledge is expected to offer new opportunities for the application of metabolic engineering to optimize the production of nature-identical vanillin. © 2018 Society of Chemical Industry.

The process of adsorption is considered to be one of the best water treatment technologies around the world. Different heavy metals, due to their toxic and hazardous nature, are possibly the most widespread groundwater contaminants imposing a serious threat to human health. In this review, an attempt has been made to discuss the use of two common clay materials, namely kaolinite and montmorillonite, along with their modified forms for heavy metal removal on the basis of published reports (2008 onwards). The modifications of clays have been attempted by the process of pillaring, intercalation, acid/base activation, functionalization, etc. The adsorption of toxic metals, viz., As, Cd, Cr, Co, Cu, Fe, Pb, Mn, Ni, Zn, etc., has been studied predominantly. Montmorillonite and its modified forms have much higher metal adsorption capacity compared to that of kaolinite as well as modified-kaolinite. The modification often boosted the adsorption capacities of the clays, however, reverse trends are also reported in some cases.

The Kolong River of Nagaon district, Assam has been facing serious degradation leading to its current moribund condition due to a drastic human intervention in the form of an embankment put across it near its take-off point from the Brahmaputra River in the year 1964. The blockage of the river flow was adopted as a flood control measure to protect its riparian areas, especially the Nagaon town, from flood hazard. The river, once a blooming distributary of the mighty Brahmaputra, had high navigability and rich riparian biodiversity with a well established agriculturally productive watershed. However, the present status of Kolong River is highly wretched as a consequence of the post-dam effects thus leaving it as stagnant pools of polluted water with negligible socio-economic and ecological value. The Central Pollution Control Board, in one of its report has placed the Kolong River among 275 most polluted rivers of India. Thus, this study is conducted to analyze the seasonal water quality status of the Kolong River in terms of water quality index (WQI). The WQI scores shows very poor to unsuitable quality of water samples in almost all the seven sampling sites along the Kolong River. The water quality is found to be most deteriorated during monsoon season with an average WQI value of 122.47 as compared to pre-monsoon and post-monsoon season having average WQI value of 85.73 and 80.75, respectively. Out of the seven sampling sites, Hatimura site (S1) and Nagaon Town site (S4) are observed to be the most polluted sites.

The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines.

The ALICE Collaboration at the LHC has measured the J/ and photoproduction at mid-rapidity in ultra-peripheral Pb-Pb collisions at s NN = 2.76 TeV. The charmonium is identified via its leptonic decay for events where the hadronic activity is required to be minimal. The analysis is based on an event sample corresponding to an integrated luminosity of about 23 b -1 . The cross section for coherent and incoherent J/ production in the rapidity interval -0.9 < y < 0.9, are d coh J/ /dy = 2.38 +0.34 -0.24 (sta + sys) mb and d inc J/ /dy = 0.98 +0.19 -0.17 (sta + sys) mb, respectively. The results are compared to theoretical models for J/ production and the coherent cross section is found to be in good agreement with those models incorporating moderate nuclear gluon shadowing at Bjorkenx around 10 -3 , such as EPS09 parametrization. In addition the cross section for the process e + e -has been measured and found to be in agreement with models implementing QED at leading order.

The pseudorapidity density of charged particles, $d{N}_{\mathrm{ch}}/d\ensuremath{\eta}$, at midrapidity in Pb-Pb collisions has been measured at a center-of-mass energy per nucleon pair of $\sqrt{{s}_{NN}}=5.02\text{ }\text{ }\mathrm{TeV}$. For the 5% most central collisions, we measure a value of $1943\ifmmode\pm\else\textpm\fi{}54$. The rise in $d{N}_{\mathrm{ch}}/d\ensuremath{\eta}$ as a function of $\sqrt{{s}_{NN}}$ is steeper than that observed in proton-proton collisions and follows the trend established by measurements at lower energy. The increase of $d{N}_{\mathrm{ch}}/d\ensuremath{\eta}$ as a function of the average number of participant nucleons, $⟨{N}_{\text{part}}⟩$, calculated in a Glauber model, is compared with the previous measurement at $\sqrt{{s}_{NN}}=2.76\text{ }\text{ }\mathrm{TeV}$. A constant factor of about 1.2 describes the increase in $d{N}_{\mathrm{ch}}/d\ensuremath{\eta}$ from $\sqrt{{s}_{NN}}=2.76$ to 5.02 TeV for all centrality classes, within the measured range of 0%--80% centrality. The results are also compared to models based on different mechanisms for particle production in nuclear collisions.

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists' attention to exploring the green synthesis of AuNPs by exploiting plants' secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy.

The degree of contamination in the sediments of the Dikrong river, for the metals Al, Fe, Ti, Mn, Zn, Cu, Cr, Ni and Pb, has been evaluated using Enrichment ratio (ER), Pollution load index (PLI) and Geo-accumulation index (Igeo). The sediments have been found to be contaminated with Cu and Pb which has been attributed mainly to dispersion from the mineralized zone of the upper catchment area since no major industrial establishments are present in the area.

Betalains are accepted food additives derived from vacuoles of plants belonging to about 17 families in the order Caryophyllales. These pigments are composed of a nitrogenous core structure, betalamic acid [4-(2-oxoethylidene)-1,2,3,4-tetrahydropyridine-2,6-dicarboxylic acid]. Betalamic acid condenses with imino compounds (cyclo-DOPA and/or its glucosyl derivatives) or amines and/or their derivatives to form violet betacyanins (for example, betanin) and yellow betaxanthins (for example, indicaxanthin), respectively. Till date, structures of 75 betalains have been elucidated from plants under the order Caryophyllales. The extracted betalains are safe to consume and they act as micronutrients in the body. In vitro studies to highlight radical-scavenging activity, cell culture studies to assess cytotoxicity and absorption of betalains, and proven clinical efficacies are compiled in this review. The literature on biological activity has not been analyzed for a synthesis of safety, clinical efficacy, and bioavailability to arrive at the concentrations required for the purported health benefits. Most betalains are under-utilized in pharmaceutical and cosmetic preparations due to poor stability and lack of scientific reports highlighting their superior tinctorial strength including flourescence, water solubility, and functional value alongside their bioavailability. This is the first comprehensive review on the dietary safety, biological activity and bioavailability of betalains. Based on this review, for future debate and input from health professionals, a human daily intake of betanin and indicaxanthin can be proposed at 100 and 50 mg, respectively.

Production of charged pions, kaons and protons at large transverse momenta

The intrinsic biodegradability of hydrocarbons and the distribution of proficient degrading microorganisms in the environment are very crucial for the implementation of bioremediation practices. Among others, one of the most favorable methods that can enhance the effectiveness of bioremediation of hydrocarbon-contaminated environment is the application of biosurfactant producing microbes. In the present study, the biodegradation capacities of native bacterial consortia toward total petroleum hydrocarbons (TPH) with special emphasis to poly aromatic hydrocarbons were determined. The purpose of the study was to isolate TPH degrading bacterial strains from various petroleum contaminated soil of Assam, India and develop a robust bacterial consortium for bioremediation of crude oil of this native land. From a total of 23 bacterial isolates obtained from three different hydrocarbons contaminated samples five isolates, namely KS2, PG1, PG5, R1, and R2 were selected as efficient crude oil degraders with respect to their growth on crude oil enriched samples. Isolates KS2, PG1, and R2 are biosurfactant producers and PG5, R1 are non-producers. Fourteen different consortia were designed involving both biosurfactant producing and non-producing isolates. Consortium 10, which comprises two Bacillus strains namely, Bacillus pumilus KS2 and B. cereus R2 (identified by 16s rRNA sequencing) has shown the best result in the desired degradation of crude oil. The consortium showed degradation up to 84.15% of TPH after 5 weeks of incubation, as revealed from gravimetric analysis. FTIR (Fourier transform infrared) and GCMS (Gas chromatography-mass spectrometer) analyses were correlated with gravimetric data which reveals that the consortium has removed a wide range of petroleum hydrocarbons in comparison with abiotic control including different aliphatic and aromatic hydrocarbons.