Liaoning University

We study the process ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}$ at a center-of-mass energy of 4.260 GeV using a $525\text{ }\text{ }{\mathrm{pb}}^{\ensuremath{-}1}$ data sample collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross section is measured to be $(62.9\ifmmode\pm\else\textpm\fi{}1.9\ifmmode\pm\else\textpm\fi{}3.7)\text{ }\text{ }\mathrm{pb}$, consistent with the production of the $Y(4260)$. We observe a structure at around $3.9\text{ }\text{ }\mathrm{GeV}/{c}^{2}$ in the ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}J/\ensuremath{\psi}$ mass spectrum, which we refer to as the ${Z}_{c}(3900)$. If interpreted as a new particle, it is unusual in that it carries an electric charge and couples to charmonium. A fit to the ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}J/\ensuremath{\psi}$ invariant mass spectrum, neglecting interference, results in a mass of $(3899.0\ifmmode\pm\else\textpm\fi{}3.6\ifmmode\pm\else\textpm\fi{}4.9)\text{ }\text{ }\mathrm{MeV}/{c}^{2}$ and a width of $(46\ifmmode\pm\else\textpm\fi{}10\ifmmode\pm\else\textpm\fi{}20)\text{ }\text{ }\mathrm{MeV}$. Its production ratio is measured to be $R=(\ensuremath{\sigma}\mathbf{(}{e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{Z}_{c}(3900{)}^{\ensuremath{\mp}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}\mathbf{)}/\ensuremath{\sigma}({e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}))=(21.5\ifmmode\pm\else\textpm\fi{}3.3\ifmmode\pm\else\textpm\fi{}7.5)%$. In all measurements the first errors are statistical and the second are systematic.

Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear, and additional diagnostic and therapeutic strategies for MDD still are needed. The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD. Even it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD, thus in recent years, great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies, further revealing the disease features of MDD. Furthermore, some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention, some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive symptoms. In this work, we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD, preventive approaches and therapeutic medicines, as well as the related clinical trials.

In recent years, two-dimensional atomic-level thickness crystal materials have attracted widespread interest such as graphene, hexagonal boron nitride (h-BN), silicene, germanium, black phosphorus (BP), transition metal sulfides and so on.

Circular RNAs (circRNAs) are a class of single-stranded, covalently closed RNA molecules with a variety of biological functions. Studies have shown that circRNAs are involved in a variety of biological processes and play an important role in the development of various complex diseases, so the identification of circRNA-disease associations would contribute to the diagnosis and treatment of diseases. In this review, we summarize the discovery, classifications and functions of circRNAs and introduce four important diseases associated with circRNAs. Then, we list some significant and publicly accessible databases containing comprehensive annotation resources of circRNAs and experimentally validated circRNA-disease associations. Next, we introduce some state-of-the-art computational models for predicting novel circRNA-disease associations and divide them into two categories, namely network algorithm-based and machine learning-based models. Subsequently, several evaluation methods of prediction performance of these computational models are summarized. Finally, we analyze the advantages and disadvantages of different types of computational models and provide some suggestions to promote the development of circRNA-disease association identification from the perspective of the construction of new computational models and the accumulation of circRNA-related data.

The rapid advance of mild aqueous zinc-ion batteries (ZIBs) is driving the development of the energy storage system market. But the thorny issues of Zn anodes, mainly including dendrite growth, hydrogen evolution, and corrosion, severely reduce the performance of ZIBs. To commercialize ZIBs, researchers must overcome formidable challenges. Research about mild aqueous ZIBs is still developing. Various technical and scientific obstacles to designing Zn anodes with high stripping efficiency and long cycling life have not been resolved. Moreover, the performance of Zn anodes is a complex scientific issue determined by various parameters, most of which are often ignored, failing to achieve the maximum performance of the cell. This review proposes a comprehensive overview of existing Zn anode issues and the corresponding strategies, frontiers, and development trends to deeply comprehend the essence and inner connection of degradation mechanism and performance. First, the formation mechanism of dendrite growth, hydrogen evolution, corrosion, and their influence on the anode are analyzed. Furthermore, various strategies for constructing stable Zn anodes are summarized and discussed in detail from multiple perspectives. These strategies are mainly divided into interface modification, structural anode, alloying anode, intercalation anode, liquid electrolyte, non-liquid electrolyte, separator design, and other strategies. Finally, research directions and prospects are put forward for Zn anodes. This contribution highlights the latest developments and provides new insights into the advanced Zn anode for future research.

We study ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{h}_{c}$ at center-of-mass energies from 3.90 to 4.42 GeV by using data samples collected with the BESIII detector operating at the Beijing Electron Positron Collider. The Born cross sections are measured at 13 energies and are found to be of the same order of magnitude as those of ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}$ but with a different line shape. In the ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{h}_{c}$ mass spectrum, a distinct structure, referred to as ${Z}_{c}(4020)$, is observed at $4.02\text{ }\text{ }\mathrm{GeV}/{c}^{2}$. The ${Z}_{c}(4020)$ carries an electric charge and couples to charmonium. A fit to the ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{h}_{c}$ invariant mass spectrum, neglecting possible interferences, results in a mass of $(4022.9\ifmmode\pm\else\textpm\fi{}0.8\ifmmode\pm\else\textpm\fi{}2.7)\text{ }\text{ }\mathrm{MeV}/{c}^{2}$ and a width of $(7.9\ifmmode\pm\else\textpm\fi{}2.7\ifmmode\pm\else\textpm\fi{}2.6)\text{ }\text{ }\mathrm{MeV}$ for the ${Z}_{c}(4020)$, where the first errors are statistical and the second systematic. The difference between the parameters of this structure and the ${Z}_{c}(4025)$ observed in the ${D}^{*}{\overline{D}}^{*}$ final state is within $1.5\ensuremath{\sigma}$, but whether they are the same state needs further investigation. No significant ${Z}_{c}(3900)$ signal is observed, and upper limits on the ${Z}_{c}(3900)$ production cross sections in ${\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{h}_{c}$ at center-of-mass energies of 4.23 and 4.26 GeV are set.

Cancer stem cells (CSCs) are a subpopulation of tumor cells that possess unique self-renewal activity and mediate tumor initiation and propagation. The PI3K/Akt/mTOR signaling pathway can be considered as a master regulator for cancer. More and more recent studies have shown the links between PI3K/Akt/mTOR signaling pathway and CSC biology. Herein, we provide a comprehensive review on the role of signaling components upstream and downstream of PI3K/Akt/mTOR signaling in CSC. In addition, we also summarize various classes of small molecule inhibitors of PI3K/Akt/mTOR signaling pathway and their clinical potential in CSC. Overall, the current available data suggest that the PI3K/Akt/mTOR signaling pathway could be a promising target for development of CSC-target drugs.

Abstract The discovery of monolayer superconductors bears consequences for both fundamental physics and device applications. Currently, the growth of superconducting monolayers can only occur under ultrahigh vacuum and on specific lattice-matched or dangling bond-free substrates, to minimize environment- and substrate-induced disorders/defects. Such severe growth requirements limit the exploration of novel two-dimensional superconductivity and related nanodevices. Here we demonstrate the experimental realization of superconductivity in a chemical vapour deposition grown monolayer material—NbSe 2 . Atomic-resolution scanning transmission electron microscope imaging reveals the atomic structure of the intrinsic point defects and grain boundaries in monolayer NbSe 2 , and confirms the low defect concentration in our high-quality film, which is the key to two-dimensional superconductivity. By using monolayer chemical vapour deposited graphene as a protective capping layer, thickness-dependent superconducting properties are observed in as-grown NbSe 2 with a transition temperature increasing from 1.0 K in monolayer to 4.56 K in 10-layer.

In recent years, there are a large number of recommendation algorithms proposed in the literature, from traditional collaborative filtering to deep learning algorithms. However, the concerns about how to standardize open source implementation of recommendation algorithms continually increase in the research community. In the light of this challenge, we propose a unified, comprehensive and efficient recommender system library called RecBole (pronounced as [rEk'[email protected]]), which provides a unified framework to develop and reproduce recommendation algorithms for research purpose. In this library, we implement 73 recommendation models on 28 benchmark datasets, covering the categories of general recommendation, sequential recommendation, context-aware recommendation and knowledge-based recommendation. We implement the RecBole library based on PyTorch, which is one of the most popular deep learning frameworks. Our library is featured in many aspects, including general and extensible data structures, comprehensive benchmark models and datasets, efficient GPU-accelerated execution, and extensive and standard evaluation protocols. We provide a series of auxiliary functions, tools, and scripts to facilitate the use of this library, such as automatic parameter tuning and break-point resume. Such a framework is useful to standardize the implementation and evaluation of recommender systems. The project and documents are released at https://recbole.io/.

Received March 14, 2005; revised manuscript received May 4, 2005; accepted May 4, 2005 We report what is believed to be the first experimental demonstration of two-photon correlated imaging with true thermal light from a hollow cathode lamp. The coherence time of the source is much shorter than that of previous experiments using random scattered light from a laser. A two-pinhole mask was used as object, and the corresponding thin lens equation was well satisfied. Since thermal light sources are easier to obtain and measure than entangled light, it is conceivable that they may be used in special imaging applications.

We presented a new aptasensor for mycotoxins, which was based on multiplexed fluorescence resonance energy transfer (FRET) between multicolor upconversion fluorescent nanoparticles (UCNPs) as donors and graphene oxide (GO) as the entire and effective acceptor. BaY0.78F5:Yb0.2, Er0.02 and BaY0.78F5:Yb0.7, Tm0.02 upconversion nanoparticles were synthesized and functionalized, respectively, with immobilized ochratoxin A (OTA)-aptamers and fumonisin B1 (FB1)-aptamers. On the basis of the strong π–π stacking effect between the nucleobases of the aptamers and the sp2 atoms of GO, the aptamer modified-UCNPs can be brought in close proximity to the GO surface. The strong upconversion fluorescence both of BaY0.78F5:Yb0.2, Er0.02 and BaY0.78F5:Yb0.2, Tm0.02 can be completely quenched by the GO, because of a good overlap between the fluorescence emission of multicolor UCNPs and the absorption spectrum of GO. In contrast, in the presence of OTA and FB1, the aptamers preferred to bind to their corresponding mycotoxins, which led to changes in the formation of aptamers, and therefore, aptamer modified-UCNPs were far away from the GO surface. Our study results showed that the fluorescence intensity of BaYF5:Yb Er and BaYF5:Yb Tm were related to the concentration of OTA and FB1. We therefore developed a sensitive and simple platform for the simultaneous detection of OTA and FB1 with multicolor UCNPs and GO as the FRET pair. The aptasensor provided a linear range from 0.05 to 100 ng·mL–1 for OTA and 0.1 to 500 ng·mL–1 for FB1; the detection limit of OTA was 0.02 ng·mL–1 and FB1 was 0.1 ng·mL–1. As a practical application, the aptasensor was used to monitor OTA and FB1 level in naturally contaminated maize samples with the results consistent with that of a classic ELISA method. More importantly, the novel multiplexed FRET was established for the first time based on multiplexed energy donors to the entire energy acceptor; this work was expected to open up a new field of FRET system applications for various targets.

Two excited state proton transfer mechanisms of 3-hydroxyisoquinoline (3HIQ) in cyclohexane and acetic acid (ACID) were investigated based on the time-dependent density functional theory (TDDFT), suggesting a different double-proton transfer mechanism from the one proposed previously (J. Phys. Chem. B, 1998, 102, 1053). Instead of the formation of keto-enol complexes for 3HIQ self-association in cyclohexane, our theoretical results predicted that 3HIQ self-association exists in two forms: the normal form (enol/enol) and the tautomer form (keto/keto) in cyclohexane. A high barrier (37.023 kcal mol(-1)) between the 3HIQ enol monomer and 3HIQ keto monomer form indicated that the 3HIQ keto monomer in the ground state should not exist. In addition, the constructed potential energy surfaces of the ground state and excited state have been used to explain the proton transfer process. Upon optical excitation, the enol/enol form is excited to the first excited state, then transfers one proton, in turn, transition to the ground state to transfer another proton. A relatively low barrier (8.98 kcal mol(-1)) demonstrates two stable structures in the ground state. In view of the acetic acid solvent effect, two protons of 3HIQ/ACID transfer along the dihydrogen bonds in the first excited state, which is a different transfer mechanism to 3HIQ self-association. In addition, the proton transfer process provides a possible explanation for the fluorescence quenching observed.

Large capital investment, extended R&D cycle, and high uncertainties characterize green innovations. Consequently, financial risks easily emerge during firms’ green innovation process. This study utilizes data from Chinese A-share listed companies from 2011 to 2019 to examine the effects of digital finance on firms’ green innovation. The findings reveal that digital finance exerts significant and positive influence on green innovation. Digital finance institutions alleviate information asymmetry in the green innovation market through digital technologies such as big data analysis of firm behavior to directly promote firms’ innovation behavior. The internal mechanism analysis reveals that digital finance indirectly promotes green innovation by improving the quality of firms’ environmental information disclosure and reducing financial constraints. The heterogeneity analysis indicates that the promotional effect of digital finance on green innovation is more prominent in larger and state-owned enterprises.

Transformations within container-molecules provide a good alternative between traditional homogeneous and heterogeneous catalysis, as the containers themselves can be regarded as single molecular nanomicelles. We report here the designed-synthesis of a water-soluble redox-active supramolecular Pd4L2 cage and its application in the encapsulation of aromatic molecules and polyoxometalates (POMs) catalysts. Compared to the previous known Pd6L4 cage, our results show that replacement of two cis-blocked palladium corners with p-xylene bridges through pyridinium bonds formation between the 2,4,6-tri-4-pyridyl-1,3,5-triazine (TPT) ligands not only provides reversible redox-activities for the new Pd4L2 cage, but also realizes the expansion and subdivision of its internal cavity. An increased number of guests, including polyaromatics and POMs, can be accommodated inside the Pd4L2 cage. Moreover, both conversion and product selectivity (sulfoxide over sulfone) have also been much enhanced in the desulfurization reactions catalyzed by the POMs@Pd4L2 host–guest complexes. We expect that further photochromic or photoredox functions are possible taking advantage of this new generation of organo-palladium cage.

We observe a narrow enhancement near $2{m}_{p}$ in the invariant mass spectrum of $p\overline{p}$ pairs from radiative $J/\ensuremath{\psi}\ensuremath{\rightarrow}\ensuremath{\gamma}p\overline{p}$ decays. No similar structure is seen in $J/\ensuremath{\psi}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}p\overline{p}$ decays. The results are based on an analysis of a $58\ifmmode\times\else\texttimes\fi{}{10}^{6}$ event sample of $J/\ensuremath{\psi}$ decays accumulated with the BESII detector at the Beijing electron-positron collider. The enhancement can be fit with either an $S$- or $P$-wave Breit-Wigner resonance function. In the case of the $S$-wave fit, the peak mass is below $2{m}_{p}$ at $M={1859}_{\ensuremath{-}10}^{+3}\text{ }{\mathrm{(}\mathrm{s}\mathrm{t}\mathrm{a}\mathrm{t}\mathrm{)}}_{\ensuremath{-}25}^{+5}\mathrm{(}\mathrm{s}\mathrm{y}\mathrm{s}\mathrm{t}\mathrm{)}\text{ }\text{ }\mathrm{M}\mathrm{e}\mathrm{V}/{c}^{2}$ and the total width is $\ensuremath{\Gamma}<30\text{ }\text{ }\mathrm{M}\mathrm{e}\mathrm{V}/{c}^{2}$ at the 90% confidence level. These mass and width values are not consistent with the properties of any known particle.

We report on a study of the process ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{(D{\overline{D}}^{*})}^{\ensuremath{\mp}}$ at $\sqrt{s}=4.26\text{ }\text{ }\mathrm{GeV}$ using a $525\text{ }\mathrm{pb}{}^{\ensuremath{-}1}$ data sample collected with the BESIII detector at the BEPCII storage ring. A distinct charged structure is observed in the ${(D{\overline{D}}^{*})}^{\ensuremath{\mp}}$ invariant mass distribution. When fitted to a mass-dependent-width Breit-Wigner line shape, the pole mass and width are determined to be ${M}_{\mathrm{pole}}=\phantom{\rule{0ex}{0ex}}\mathbf{(}3883.9\ifmmode\pm\else\textpm\fi{}1.5\phantom{\rule{0.333em}{0ex}}(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}4.2\phantom{\rule{0.333em}{0ex}}(\mathrm{syst})\mathbf{)}\text{ }\text{ }\mathrm{MeV}/{c}^{2}$ and ${\mathrm{\ensuremath{\Gamma}}}_{\mathrm{pole}}=\mathbf{(}24.8\ifmmode\pm\else\textpm\fi{}3.3\phantom{\rule{0.333em}{0ex}}(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}11.0\phantom{\rule{0.333em}{0ex}}(\mathrm{syst})\mathbf{)}\text{ }\text{ }\mathrm{MeV}$. The mass and width of the structure, which we refer to as ${Z}_{c}(3885)$, are $2\ensuremath{\sigma}$ and $1\ensuremath{\sigma}$, respectively, below those of the ${Z}_{c}(3900)\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}J/\ensuremath{\psi}$ peak observed by BESIII and Belle in ${\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}J/\ensuremath{\psi}$ final states produced at the same center-of-mass energy. The angular distribution of the $\ensuremath{\pi}{Z}_{c}(3885)$ system favors a ${J}^{P}={1}^{+}$ quantum number assignment for the structure and disfavors ${1}^{\ensuremath{-}}$ or ${0}^{\ensuremath{-}}$. The Born cross section times the $D{\overline{D}}^{*}$ branching fraction of the ${Z}_{c}(3885)$ is measured to be ${\ensuremath{\sigma}\mathbf{(}{e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\phantom{\rule{0ex}{0ex}}{\ensuremath{\pi}}^{\ifmmode\pm\else\textpm\fi{}}{Z}_{c}(3885)}^{\ensuremath{\mp}}\mathbf{)}\ifmmode\times\else\texttimes\fi{}{\mathcal{B}\mathbf{(}{Z}_{c}(3885)}^{\ensuremath{\mp}}\ensuremath{\rightarrow}{(D{\overline{D}}^{*})}^{\ensuremath{\mp}}\mathbf{)}=\mathbf{(}83.5\ifmmode\pm\else\textpm\fi{}6.6\phantom{\rule{0.333em}{0ex}}(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}22.0\phantom{\rule{0.333em}{0ex}}(\mathrm{syst})\mathbf{)}\text{ }\text{ }\text{ }\mathrm{pb}$. Assuming the ${Z}_{c}(3885)\ensuremath{\rightarrow}D{\overline{D}}^{*}$ signal reported here and the ${Z}_{c}(3900)\ensuremath{\rightarrow}\ensuremath{\pi}J/\ensuremath{\psi}$ signal are from the same source, the partial width ratio $(\mathrm{\ensuremath{\Gamma}}({Z}_{c}(3885)\ensuremath{\rightarrow}D{\overline{D}}^{*})/\mathrm{\ensuremath{\Gamma}}({Z}_{c}(3900)\ensuremath{\rightarrow}\ensuremath{\pi}J/\ensuremath{\psi}))=6.2\ifmmode\pm\else\textpm\fi{}1.1\phantom{\rule{0.333em}{0ex}}(\mathrm{stat})\phantom{\rule{0.333em}{0ex}}\ifmmode\pm\else\textpm\fi{}2.7\phantom{\rule{0.333em}{0ex}}(\mathrm{syst})$ is determined.

The root economics spectrum (RES), a common hypothesis postulating a tradeoff between resource acquisition and conservation traits, is being challenged by conflicting relationships between root diameter, tissue density (RTD) and root nitrogen concentration (RN). Here, we analyze a global trait dataset of absorptive roots for over 800 plant species. For woody species (but not for non-woody species), we find nonlinear relationships between root diameter and RTD and RN, which stem from the allometric relationship between stele and cortical tissues. These nonlinear relationships explain how sampling bias from different ends of the nonlinear curves can result in conflicting trait relationships. Further, the shape of the relationships varies depending on evolutionary context and mycorrhizal affiliation. Importantly, the observed nonlinear trait relationships do not support the RES predictions. Allometry-based nonlinearity of root trait relationships improves our understanding of the ecology, physiology and evolution of absorptive roots.

Electrocatalytic water splitting is regarded as the most effective pathway to generate green energy-hydrogen-which is considered as one of the most promising clean energy solutions to the world's energy crisis and climate change mitigation. Although electrocatalytic water splitting has been proposed for decades, large-scale industrial hydrogen production is hindered by high electricity cost, capital investment, and electrolysis media. Harsh conditions (strong acid/alkaline) are widely used in electrocatalytic mechanism studies, and excellent catalytic activities and efficiencies have been achieved. However, the practical application of electrocatalytic water splitting in harsh conditions encounters several obstacles, such as corrosion issues, catalyst stability, and membrane technical difficulties. Thus, the research on water splitting in mild conditions (neutral/near neutral), even in natural seawater, has aroused increasing attention. However, the mechanism in mild conditions or natural seawater is not clear. Herein, different conditions in electrocatalytic water splitting are reviewed and the effects and proposed mechanisms in the three conditions are summarized. Then, a comparison of the reaction process and the effects of the ions in different electrolytes are presented. Finally, the challenges and opportunities associated with direct electrocatalytic natural seawater splitting and the perspective are presented to promote the progress of hydrogen production by water splitting.

Motivation: A large number of resources have been devoted to exploring the associations between microRNAs (miRNAs) and diseases in the recent years. However, the experimental methods are expensive and time-consuming. Therefore, the computational methods to predict potential miRNA-disease associations have been paid increasing attention. Results: In this paper, we proposed a novel computational model of Bipartite Network Projection for MiRNA-Disease Association prediction (BNPMDA) based on the known miRNA-disease associations, integrated miRNA similarity and integrated disease similarity. We firstly described the preference degree of a miRNA for its related disease and the preference degree of a disease for its related miRNA with the bias ratings. We constructed bias ratings for miRNAs and diseases by using agglomerative hierarchical clustering according to the three types of networks. Then, we implemented the bipartite network recommendation algorithm to predict the potential miRNA-disease associations by assigning transfer weights to resource allocation links between miRNAs and diseases based on the bias ratings. BNPMDA had been shown to improve the prediction accuracy in comparison with previous models according to the area under the receiver operating characteristics (ROC) curve (AUC) results of three typical cross validations. As a result, the AUCs of Global LOOCV, Local LOOCV and 5-fold cross validation obtained by implementing BNPMDA were 0.9028, 0.8380 and 0.8980 ± 0.0013, respectively. We further implemented two types of case studies on several important human complex diseases to confirm the effectiveness of BNPMDA. In conclusion, BNPMDA could effectively predict the potential miRNA-disease associations at a high accuracy level. Availability and implementation: BNPMDA is available via http://www.escience.cn/system/file?fileId=99559. Supplementary information: Supplementary data are available at Bioinformatics online.

We study the process e(+)e(-) -> (D* (D) over bar*)(+/-)pi(-/+) at a center-of-mass energy of 4.26 GeV using a 827 pb(-1) data sample obtained with the BESIII detector at the Beijing Electron Positron Collider. Based on a partial reconstruction technique, the Born cross section is measured to be (137 +/- 9 +/- 15) pb. We observe a structure near the (D* (D) over bar*)(+/-) threshold in the pi(-/+) recoil mass spectrum, which we denote as the Z(c)(+/-) (4025). The measured mass and width of the structure are (4026.3 +/- 2.6 +/- 3.7) MeV/c(2) and (24.8 +/- 5.6 +/- 7.7) MeV, respectively. Its production ratio sigma(e(+)e(-) -> Z(c)(+/-)(4025)pi(-/+)-> (D* (D) over bar*)(+/-)pi(-/+)/sigma(e(+)e(-) -> (D* (D) over bar*)(+/-)pi(-/+) is determined to be 0.65 +/- 0.09 +/- 0.06. The first uncertainties are statistical and the second are systematic.