Max Planck Institute for Human Cognitive and Brain Sciences

Although it is being successfully implemented for exploration of the genome, discovery science has eluded the functional neuroimaging community. The core challenge remains the development of common paradigms for interrogating the myriad functional systems in the brain without the constraints of a priori hypotheses. Resting-state functional MRI (R-fMRI) constitutes a candidate approach capable of addressing this challenge. Imaging the brain during rest reveals large-amplitude spontaneous low-frequency (<0.1 Hz) fluctuations in the fMRI signal that are temporally correlated across functionally related areas. Referred to as functional connectivity, these correlations yield detailed maps of complex neural systems, collectively constituting an individual's "functional connectome." Reproducibility across datasets and individuals suggests the functional connectome has a common architecture, yet each individual's functional connectome exhibits unique features, with stable, meaningful interindividual differences in connectivity patterns and strengths. Comprehensive mapping of the functional connectome, and its subsequent exploitation to discern genetic influences and brain-behavior relationships, will require multicenter collaborative datasets. Here we initiate this endeavor by gathering R-fMRI data from 1,414 volunteers collected independently at 35 international centers. We demonstrate a universal architecture of positive and negative functional connections, as well as consistent loci of inter-individual variability. Age and sex emerged as significant determinants. These results demonstrate that independent R-fMRI datasets can be aggregated and shared. High-throughput R-fMRI can provide quantitative phenotypes for molecular genetic studies and biomarkers of developmental and pathological processes in the brain. To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/.

Adaptive goal-directed behavior involves monitoring of ongoing actions and performance outcomes, and subsequent adjustments of behavior and learning. We evaluate new findings in cognitive neuroscience concerning cortical interactions that subserve the recruitment and implementation of such cognitive control. A review of primate and human studies, along with a meta-analysis of the human functional neuroimaging literature, suggest that the detection of unfavorable outcomes, response errors, response conflict, and decision uncertainty elicits largely overlapping clusters of activation foci in an extensive part of the posterior medial frontal cortex (pMFC). A direct link is delineated between activity in this area and subsequent adjustments in performance. Emerging evidence points to functional interactions between the pMFC and the lateral prefrontal cortex (LPFC), so that monitoring-related pMFC activity serves as a signal that engages regulatory processes in the LPFC to implement performance adjustments.

Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.

Language processing is a trait of human species. The knowledge about its neurobiological basis has been increased considerably over the past decades. Different brain regions in the left and right hemisphere have been identified to support particular language functions. Networks involving the temporal cortex and the inferior frontal cortex with a clear left lateralization were shown to support syntactic processes, whereas less lateralized temporo-frontal networks subserve semantic processes. These networks have been substantiated both by functional as well as by structural connectivity data. Electrophysiological measures indicate that within these networks syntactic processes of local structure building precede the assignment of grammatical and semantic relations in a sentence. Suprasegmental prosodic information overtly available in the acoustic language input is processed predominantly in a temporo-frontal network in the right hemisphere associated with a clear electrophysiological marker. Studies with patients suffering from lesions in the corpus callosum reveal that the posterior portion of this structure plays a crucial role in the interaction of syntactic and prosodic information during language processing.

A new framework for the understanding of functional relationships between perception and action is discussed. According to this framework, perceived events and planned actions share a common representational domain (common-coding approach). Supporting evidence from two classes of experimental paradigms is presented: induction paradigms and interference paradigms. Induction paradigms study how certain stimuli induce certain actions by virtue of similarity. Evidence from two types of induction tasks is reviewed: sensorimotor synchronisation and spatial compatibility tasks. Interference paradigms study the mutual interference between the perception of ongoing events and the preparation and control of ongoing action. Again, evidence from two types of such tasks is reviewed, implying interference in either direction. It is concluded that the evidence available supports the common coding principle. A further general principle emerging from these studies is the action effect principle that is, the principle that cognitive representations of action effects play a critical role in the planning and control of these actions.

Abstract Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight 1 . Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories 2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones 3 , showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.

Es wird von drei Experimenten berichtet, die zeigen, daß Individuen subjektiv erlebtes Erinnerungsvermögen als Information bei der Bewertung der Bedeutung des Erinnerten benutzen. Besonders diejenigen Testpersonen, die sich an Situationen erinnern sollten, in denen sie sich positiv verhielten und sich wohlfühlten, schätzten sich im Rückblick positiver ein als Personen, die sich Situationen ins Gedächtnis rufen sollten, in denen sie sich nicht positiv verhielten und sich unsicher fühlten. Dieser Effekt der Wertigkeit der Erinnerung bestand jedoch nur bei denjenigen Testpersonen, die sich an sechs Beispiele der betreffenden Wertigkeit erinnern sollten, was ihnen leichtfiel. Wenn sich die Personen an zwölf Beispiele erinnern sollten, was sie schwierig fanden, kehrte sich die Wirkung der Wertigkeit ins Gegenteil um. In diesem Fall berichteten die Testpersonen eher von einem positiven Gefühl bei der Erinnerung an Beispiele negativen als an Beispiele positiven Verhaltens. Offensichtlich kamen sie zu dem Schluß, daß die Verhaltensweisen, an die sie sich erinnerten, nicht häufig oder typisch sein konnten, wenn sie nur schwierig ins Gedächtnis zu rufen waren (Experimente 1 und 2). In Übereinstimmung mit dieser Interpretation wurde die Wirkung des erlebten Erinnerungsvermögens ausgeschaltet, wenn die Testpersonen ihre subjektiven Erfahrungen irrigerweise auf die Wirkung vorübergehender äußerer Einflüsse zurückführen konnten (Experiment 3). Diskutiert werden die Konsequenzen für das Wirken besonders der Verfügbarkeitsheuristik und der Funktionen subjektiver Erfahrungen als Information im allgemeinen. (ICAübers)

The tendency to mimic and synchronize with others is well established. Although mimicry has been shown to lead to affiliation between co-actors, the effect of interpersonal synchrony on affiliation remains an open question. The authors investigated the relationship by having participants match finger movements with a visual moving metronome. In Experiment 1, affiliation ratings were examined based on the extent to which participants tapped in synchrony with the experimenter. In Experiment 2, synchrony was manipulated. Affiliation ratings were compared for an experimenter who either (a) tapped to a metronome that was synchronous to the participant's metronome, (b) tapped to a metronome that was asynchronous, or (c) did not tap. As hypothesized, in both studies, the degree of synchrony predicted subsequent affiliation ratings. Experiment 3 found that the affiliative effects were unique to interpersonal synchrony.

Advances in neuroimaging technologies and analytics have enabled the discovery of gradients in microstructure, connectivity, gene expression, and function in the human cerebral cortex. The notion that functional processing hierarchies are confined to sensorimotor systems is challenged by recent descriptions of global hierarchies, extending throughout transmodal association areas. An innovative line of research has uncovered a cortical hierarchy in the temporal domain that accounts for spatially distributed functional specialization. Recent advances in mapping cortical areas in the human brain provide a basis for investigating the significance of their spatial arrangement. Here we describe a dominant gradient in cortical features that spans between sensorimotor and transmodal areas. We propose that this gradient constitutes a core organizing axis of the human cerebral cortex, and describe an intrinsic coordinate system on its basis. Studying the cortex with respect to these intrinsic dimensions can inform our understanding of how the spectrum of cortical function emerges from structural constraints. Recent advances in mapping cortical areas in the human brain provide a basis for investigating the significance of their spatial arrangement. Here we describe a dominant gradient in cortical features that spans between sensorimotor and transmodal areas. We propose that this gradient constitutes a core organizing axis of the human cerebral cortex, and describe an intrinsic coordinate system on its basis. Studying the cortex with respect to these intrinsic dimensions can inform our understanding of how the spectrum of cortical function emerges from structural constraints. For more than a century, neuroscientists have studied the cerebral cortex by delineating individual cortical areas (see Glossary) and mapping their function [1Vogt C. Vogt O. Allgemeinere ergebnisse unserer hirnforschung.J. Psychol. Neurol. 1919; 25: 279-468Google Scholar]. This agenda has substantially advanced in recent years, as automated parcellation methods improve and data sets of unprecedented size and quality become available [2Amunts K. Zilles K. Architectonic mapping of the human brain beyond Brodmann.Neuron. 2015; 88: 1086-1107Abstract Full Text Full Text PDF PubMed Scopus (230) Google Scholar, 3Glasser M.F. et al.A multi-modal parcellation of human cerebral cortex.Nature. 2016; 536: 171-178Crossref PubMed Scopus (1992) Google Scholar, 4Eickhoff S.B. et al.Topographic organization of the cerebral cortex and brain cartography.Neuroimage. 2017; (Published online February 20, 2017)https://doi.org/10.1016/j.neuroimage.2017.02.018Crossref Scopus (82) Google Scholar]. Nevertheless, our understanding of how the complex structure of the cerebral cortex emerges and gives rise to its elaborate functions remains fragmentary. To complement the description of individual cortical areas, we propose an inquiry into the significance of their spatial arrangement, asking the basic question: Why are cortical areas located where they are? Early formulations of this question date to theories from classical neuroanatomy [1Vogt C. Vogt O. Allgemeinere ergebnisse unserer hirnforschung.J. Psychol. Neurol. 1919; 25: 279-468Google Scholar, 5Brockhaus H. Die cyto-und myeloarchitektonik des cortex claustralis und des claustrum beim menschen.J. Psychol. Neurol. 1940; 49: 249-348Google Scholar, 6Sanides F. Die Architektonik des Menschlichen Stirnhirns. Springer, 1962Crossref Google Scholar, 7Pandya D. et al.Cerebral Cortex: Architecture, Connections, and the Dual Origin Concept. Oxford University Press, 2015Crossref Google Scholar]. They state that the spatial layout of cortical areas is not arbitrary, but a consequence of developmental mechanisms, shaped through evolutionary selection. The location of an area among its neighbors thus provides insight into its microstructural characteristics [6Sanides F. Die Architektonik des Menschlichen Stirnhirns. Springer, 1962Crossref Google Scholar], its connections to other parts of the brain [7Pandya D. et al.Cerebral Cortex: Architecture, Connections, and the Dual Origin Concept. Oxford University Press, 2015Crossref Google Scholar], and eventually its position in global processing hierarchies [8Mesulam M.M. From sensation to cognition.Brain. 1998; 121: 1013-1052Crossref PubMed Scopus (2101) Google Scholar]. Consider, for example, the well-researched visual system of the macaque monkey [9Felleman D.J. Van Essen D.C. Distributed hierarchical processing in the primate cerebral cortex.Cereb. Cortex. 1991; 1: 1-47Crossref PubMed Scopus (5448) Google Scholar, 10Markov N.T. et al.A weighted and directed interareal connectivity matrix for macaque cerebral cortex.Cereb. Cortex. PubMed Scopus Google Scholar]. the visual visual features are and with from other areas are on their of microstructural and the of their connections as H. in the of Neurol. PubMed Scopus Google Scholar]. 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Vogt O. Allgemeinere ergebnisse unserer hirnforschung.J. Psychol. Neurol. 1919; 25: 279-468Google Scholar, 5Brockhaus H. Die cyto-und myeloarchitektonik des cortex claustralis und des claustrum beim menschen.J. Psychol. Neurol. 1940; 49: 249-348Google Scholar, 6Sanides F. Die Architektonik des Menschlichen Stirnhirns. Springer, 1962Crossref Google Scholar, 7Pandya D. et al.Cerebral Cortex: Architecture, Connections, and the Dual Origin Concept. 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Zilles K. Architectonic mapping of the human brain beyond Brodmann.Neuron. 2015; 88: 1086-1107Abstract Full Text Full Text PDF PubMed Scopus (230) Google Scholar, 4Eickhoff S.B. et al.Topographic organization of the cerebral cortex and brain cartography.Neuroimage. 2017; (Published online February 20, 2017)https://doi.org/10.1016/j.neuroimage.2017.02.018Crossref Scopus (82) Google Scholar]. a cortical area is from parts of the cortex on a connectivity and to the description of cortical and organization to the size and of and their in of the cortical K. in des cortical areas in of how the cortical and their can in their on and their areas a on and of a that can to for example, the a between the description of cortical and organization to the of and their in and in the cortical [1Vogt C. Vogt O. Allgemeinere ergebnisse unserer hirnforschung.J. Psychol. 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Goal-directed behavior requires the continuous monitoring and dynamic adjustment of ongoing actions. Here, we report a direct coupling between the event-related electroencephalogram (EEG), functional magnetic resonance imaging (fMRI), and behavioral measures of performance monitoring in humans. By applying independent component analysis to EEG signals recorded simultaneously with fMRI, we found the single-trial error-related negativity of the EEG to be systematically related to behavior in the subsequent trial, thereby reflecting immediate behavioral adjustments of a cognitive performance monitoring system. Moreover, this trial-by-trial EEG measure of performance monitoring predicted the fMRI activity in the rostral cingulate zone, a brain region thought to play a key role in processing of response errors. We conclude that investigations of the dynamic coupling between EEG and fMRI provide a powerful approach for the study of higher order brain functions.

the heuristics-and-biases approach to statistical reasoning is and is not about. At issue is the imposition of unnecessarily narrow norms of sound reasoning that are used to diagnose so-called cognitive illusions and the continuing reliance on vague heuristics that explain everything and nothing. D. Kahneman and A. Tversky (1996) incorrectly asserted that Gigerenzer simply claimed that frequency formats make all cognitive illusions disappear. In contrast, Gigerenzer has proposed and tested models that actually predict when frequency judgments are valid and when they are not. The issue is not whether or not. or how often, cognitive illusions disappear. The focus should be rather the construction of detailed models of cognitive processes that explain when and why they disappear. A postscript responds to Kahneman and Tversky&amp;apos;s (1996) postscript. I welcome Kahneman and Tversky&amp;apos;s (1996) reply to my critique (e.g., Gigerenzer, 1991, 1994; Gigerenzer &amp;amp; Murray, 1987) and hope this exchange will encourage a rethinking of research strategies. I emphasize research strategies, rather than specific empirical results or even explanations of those results, because I believe that this debate is fundamentally about what

The present study used pleasant and unpleasant music to evoke emotion and functional magnetic resonance imaging (fMRI) to determine neural correlates of emotion processing. Unpleasant (permanently dissonant) music contrasted with pleasant (consonant) music showed activations of amygdala, hippocampus, parahippocampal gyrus, and temporal poles. These structures have previously been implicated in the emotional processing of stimuli with (negative) emotional valence; the present data show that a cerebral network comprising these structures can be activated during the perception of auditory (musical) information. Pleasant (contrasted to unpleasant) music showed activations of the inferior frontal gyrus (IFG, inferior Brodmann's area (BA) 44, BA 45, and BA 46), the anterior superior insula, the ventral striatum, Heschl's gyrus, and the Rolandic operculum. IFG activations appear to reflect processes of music-syntactic analysis and working memory operations. Activations of Rolandic opercular areas possibly reflect the activation of mirror-function mechanisms during the perception of the pleasant tunes. Rolandic operculum, anterior superior insula, and ventral striatum may form a motor-related circuitry that serves the formation of (premotor) representations for vocal sound production during the perception of pleasant auditory information. In all of the mentioned structures, except the hippocampus, activations increased over time during the presentation of the musical stimuli, indicating that the effects of emotion processing have temporal dynamics; the temporal dynamics of emotion have so far mainly been neglected in the functional imaging literature.

Evidence from macaque monkey tracing studies suggests connectivity-based subdivisions within the precuneus, offering predictions for similar subdivisions in the human. Here we present functional connectivity analyses of this region using resting-state functional MRI data collected from both humans and macaque monkeys. Three distinct patterns of functional connectivity were demonstrated within the precuneus of both species, with each subdivision suggesting a discrete functional role: (i) the anterior precuneus, functionally connected with the superior parietal cortex, paracentral lobule, and motor cortex, suggesting a sensorimotor region; (ii) the central precuneus, functionally connected to the dorsolateral prefrontal, dorsomedial prefrontal, and multimodal lateral inferior parietal cortex, suggesting a cognitive/associative region; and (iii) the posterior precuneus, displaying functional connectivity with adjacent visual cortical regions. These functional connectivity patterns were differentiated from the more ventral networks associated with the posterior cingulate, which connected with limbic structures such as the medial temporal cortex, dorsal and ventromedial prefrontal regions, posterior lateral inferior parietal regions, and the lateral temporal cortex. Our findings are consistent with predictions from anatomical tracer studies in the monkey, and provide support that resting-state functional connectivity (RSFC) may in part reflect underlying anatomy. These subdivisions within the precuneus suggest that neuroimaging studies will benefit from treating this region as anatomically (and thus functionally) heterogeneous. Furthermore, the consistency between functional connectivity networks in monkeys and humans provides support for RSFC as a viable tool for addressing cross-species comparisons of functional neuroanatomy.

Although anecdotes that creative thoughts often arise when one is engaged in an unrelated train of thought date back thousands of years, empirical research has not yet investigated this potentially critical source of inspiration. We used an incubation paradigm to assess whether performance on validated creativity problems (the Unusual Uses Task, or UUT) can be facilitated by engaging in either a demanding task or an undemanding task that maximizes mind wandering. Compared with engaging in a demanding task, rest, or no break, engaging in an undemanding task during an incubation period led to substantial improvements in performance on previously encountered problems. Critically, the context that improved performance after the incubation period was associated with higher levels of mind wandering but not with a greater number of explicitly directed thoughts about the UUT. These data suggest that engaging in simple external tasks that allow the mind to wander may facilitate creative problem solving.

Empathy--the ability to share the feelings of others--is fundamental to our emotional and social lives. Previous human imaging studies focusing on empathy for others' pain have consistently shown activations in regions also involved in the direct pain experience, particularly anterior insula and anterior and midcingulate cortex. These findings suggest that empathy is, in part, based on shared representations for firsthand and vicarious experiences of affective states. Empathic responses are not static but can be modulated by person characteristics, such as degree of alexithymia. It has also been shown that contextual appraisal, including perceived fairness or group membership of others, may modulate empathic neuronal activations. Empathy often involves coactivations in further networks associated with social cognition, depending on the specific situation and information available in the environment. Empathy-related insular and cingulate activity may reflect domain-general computations representing and predicting feeling states in self and others, likely guiding adaptive homeostatic responses and goal-directed behavior in dynamic social contexts.

Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.

This third edition provides translations of all chapters of the most recent fifth German edition of Motivation and Action, including several entirely new chapters. It provides comprehensive coverage of the history of motivation, and introduces up-to-date theories and new research findings. Early sections provide a broad introduction to, and deep understanding of, the field of motivation psychology, mapping out different perspectives and research traditions. Subsequent chapters examine major themes of human motivation, including achievement, affiliation, and power motivation as well as the fundamentals of motivation psychology, such as motivated and goal oriented behaviors, implicit and explicit motives, and the regulation of development. In addition, the book discusses the roles of motivation in three practical fields: school and college, the workplace, and sports. Topics featured in this text include: Social Relationships and its effects on sexual or intimacy motivation. Conscious and unconscious motivators of behavior. Drives and incentives in the fields of achievement, intimacy, sociability and power. How the biochemistry and structures of our brain shapes motivated behavior. How to engage in intentional goal-directed behavior. The potential and limits of motivation and self-direction in shaping our lives. Motivation and Action, Third Edition, is a must-have resource for undergraduate and graduate students as well as researchers in the fields of motivation psychology, cognitive psychology, and social psychology, as well as personality psychology and agency.

An event-related functional magnetic resonance imaging (fMRI) paradigm was used to specify those brain areas supporting the processing of sentence-level semantic and syntactic information. Hemodynamic responses were recorded while participants listened to correct, semantically incorrect and syntactically incorrect sentences. Both anomalous conditions recruited larger portions of the superior temporal region than correct sentences. Processing of semantic violations relied primarily on the mid-portion of the superior temporal region bilaterally and the insular cortex bilaterally, whereas processing of syntactic violations specifically involved the anterior portion of the left superior temporal gyrus, the left posterior frontal operculum adjacent to Broca's area and the putamen in the left basal ganglia. A comparison of the two anomalous conditions revealed higher levels of activation for the syntactic over the semantic condition in the left basal ganglia and for the semantic over the syntactic condition in the mid-portion of the superior temporal gyrus, bilaterally. These data indicate that both semantic and syntactic processes are supported by a temporo-frontal network with distinct areas specialized for semantic and syntactic processes.

The focus of this chapter is on the course of action, which is understood to be a temporal, horizontal path starting with a person's desires and ending with the evaluation of the achieved action outcome. The phenomena of choosing an action goal, initiating the appropriate actions, and executing these actions are assumed to be situated in between. This comprehensive perspective conceives of the course of action as a number of consecutive, distinct segments or phases. It raises questions concerning how people choose action goals, plan and enact their execution, and eaaluate thek efforts. The concept of mind-set is employed to find answers to these questions in terms of the cognitive processes or orientations that allow for easy completion of the different action phases.

The present study investigated different aspects of auditory language comprehension. The sentences which were presented as connected speech were either correct or incorrect including a semantic error (selectional restriction), a morphological error (verb inflection), or a syntactic error (phrase structure). After each sentence, a probe word was presented auditorily, and subjects had to decide whether this word was part of the preceding sentence or not. Event-related brain potentials (ERPs) were recorded from 7 scalp electrodes. The ERPs evoked by incorrect sentences differed significantly from the correct ones as a function of error type. Semantic anomalies evoked a 'classical' N400 pattern. Morphological errors elicited a pronounced negativity between 300 and 600 ms followed by a late positivity. Syntactic errors, in contrast, evoked an early negativity peaking around 180 ms followed by a negativity around 400 ms. The early negativity was only significant over the left anterior electrode. The present data demonstrate that linguistic errors of different categories evoke different ERP patterns. They indicate that with using connected speech as input, different aspects of language comprehension processes cannot only be described with respect to their temporal structure, but eventually also with respect to possible brain systems subserving these processes.