Michelin (Switzerland)

Affordable, stable and earth-abundant photo-electrochemical materials are indispensable for the large-scale implementation of sunlight-driven hydrogen production. Here we present an intrinsically stable and scalable solar water splitting device that is fully based on earth-abundant materials, with a solar-to-hydrogen conversion efficiency of 14.2%. This unprecedented efficiency is achieved by integrating a module of three interconnected silicon heterojunction solar cells that operates at an appropriate voltage to directly power microstructured Ni electrocatalysts. Nearly identical performance levels were also achieved using a customized state-of-the-art proton exchange membrane (PEM) electrolyzer. As silicon heterojunction solar cells and PEM electrolysis systems are commercially viable, easily scalable and have long lifetimes, the devices demonstrated in this report can open a fast avenue toward the industrialization and deployment of cost effective solar-fuel production systems.

Little is known about the magnetic resonance imaging (MRI) appearance of canine meniscal lesions. The aim of this study is to describe the MR appearance of meniscal lesions in dogs with experimentally induced cranial cruciate ligament (CCL) deficiency. The pilot study revealed dogs weighing approximately 10 kg to be too small for meniscal evaluation on low-field MRI. In the main study, dogs weighing approximately 35 kg were used. The left CCL was transected and low-field MRI was performed regularly until 13 months post-surgery. Normal menisci were defined as grade 0. Intrameniscal lesions not reaching any surface corresponded to grade 1 if focal and to grade 2 if linear or diffuse. Grade 3 lesions consisted in linear tears penetrating a meniscal surface. Grade 4 lesions included complex signal changes or meniscal distortion. Between 2 and 13 months post-surgery, all dogs developed grade 4 lesions in the medial meniscus. Most of them corresponded to longitudinal or bucket handle tears on arthroscopy and necropsy. Two dogs showed grade 3 lesions reaching the tibial surface of the lateral meniscus on MRI but not in arthroscopy. Such tears are difficult to evaluate arthroscopically; MRI provides more accurate information about the tibial meniscal surface. Grades 1 and 2 lesions could not be differentiated from presumably normal menisci with our imaging technique. An MRI grading system better adapted to canine lesions has yet to be developed. MRI is a helpful tool for the diagnosis of complete tears in the canine meniscus, especially in larger dogs.

Staphylococcus aureus is a versatile opportunistic pathogen that adapts readily to a variety of different growth conditions. This adaptation requires a rapid regulation of gene expression including the control of mRNA abundance. The CshA DEAD-box RNA helicase was previously shown to be required for efficient turnover of the agr quorum sensing mRNA. Here we show by transcriptome-wide RNA sequencing and microarray analyses that CshA is required for the degradation of bulk mRNA. Moreover a subset of mRNAs is significantly stabilised in absence of CshA. Deletion of the C-terminal extension affects RNA turnover similar to the full deletion of the cshA gene. In accordance with RNA decay data, the C-terminal region of CshA is required for an RNA-independent interaction with components of the RNA degradation machinery. The C-terminal truncation of CshA reduces its ATPase activity and this reduction cannot be compensated at high RNA concentrations. Finally, the deletion of the C-terminal extension does affect growth at low temperatures, but to a significantly lesser degree than the full deletion, indicating that the core of the helicase can assume a partial function and opening the possibility that CshA is involved in different cellular processes.

To investigate the association of metabolic side effects with antipsychotic dose, we conducted a dose-response meta-analysis of randomized controlled trials (RCTs) in which antipsychotics were administered to people with schizophrenia. The primary outcome was mean change in weight. The secondary outcomes were the mean changes in metabolic parameters. MEDLINE, Embase, PubMed, PsyARTICLES, PsycINFO, Cochrane Database of Systematic Reviews, and different trial registries were searched for articles published in English until February 2021. We identified fixed-dose RCTs with first- or second-generation antipsychotics. The quality of RCTs was measured with Cochrane's Risk of Bias tool. We performed a dose-response meta-analysis. We retained 52 RCTs including 22,588 participants. With the exception of aripiprazole long-acting injectable (LAI), all investigated antipsychotics presented significant dose-response associations with weight, from lurasidone with a quasi-parabolic shaped curve (9 studies, estimation of 95% effective dose [ED95; 59.93 mg/d] = 0.53 kg/6 wk) to olanzapine LAI with a curve that continued to increase with the dose (1 study, ED95 [15.05 mg/d] = 4.29 kg/8 wk). All curves could be ordered in 3 different classes of shapes-quasi-parabolic, plateau, and ascending. We found significant dose-response associations for weight and metabolic variables, with a unique signature for each antipsychotic. Weight gain can occur at a relatively low median effective dose, and increasing doses can be associated with greater weight gain for some drugs. Despite several limitations, including the limited number of available studies, our results may provide useful information for preventing weight gain and metabolic disturbance by adapting antipsychotic doses. PROSPERO ID number CRD42021176569.

BACKGROUND AND PURPOSE: Post hoc analyses of randomized controlled clinical trials evaluating mechanical thrombectomy have suggested that admission-to-groin-puncture (ATG) delays are associated with reduced reperfusion rates. Purpose of this analysis was to validate this association in a real-world cohort and to find associated factors and confounders for prolonged ATG intervals. METHODS: Patients included into the BEYOND-SWIFT cohort (Bernese-European Registry for Ischemic Stroke Patients Treated Outside Current Guidelines With Neurothrombectomy Devices Using the Solitaire FR With the Intention for Thrombectomy; https://www.clinicaltrials.gov; Unique identifier: NCT03496064) were analyzed (n=2386). Association between baseline characteristics and ATG was evaluated using mixed linear regression analysis. The effect of increasing symptom-onset-to-admission and ATG intervals on successful reperfusion (defined as Thrombolysis in Cerebral Infarction [TICI] 2b-3) was evaluated using logistic regression analysis adjusting for potential confounders. RESULTS: Median ATG was 73 minutes. Prolonged ATG intervals were associated with the use of magnetic resonance imaging (+19.1 [95% CI, +9.1 to +29.1] minutes), general anesthesia (+12.1 [95% CI, +3.7 to +20.4] minutes), and borderline indication criteria, such as lower National Institutes of Health Stroke Scale, late presentations, or not meeting top-tier early time window eligibility criteria (+13.8 [95% CI, +6.1 to +21.6] minutes). There was a 13% relative odds reduction for TICI 2b-3 (adjusted odds ratio [aOR], 0.87 [95% CI, 0.79-0.96]) and TICI 2c/3 (aOR, 0.87 [95% CI, 0.79-0.95]) per hour ATG delay, while the reduction of TICI 2b-3 per hour increase symptom-onset-to-admission was minor (aOR, 0.97 [95% CI, 0.94-0.99]) and inconsistent regarding TICI 2c/3 (aOR, 0.99 [95% CI, 0.97-1.02]). After adjusting for identified factors associated with prolonged ATG intervals, the association of ATG delay and lower rates of TICI 2b-3 remained tangible (aOR, 0.87 [95% CI, 0.76-0.99]). CONCLUSIONS: There is a great potential to reduce ATG, and potential targets for improvement can be deduced from observational data. The association between in-hospital delay and reduced reperfusion rates is evident in real-world clinical data, underscoring the need to optimize in-hospital workflows. Given the only minor association between symptom-onset-to-admission intervals and reperfusion rates, the causal relationship of this association warrants further research. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT03496064.

The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected in E. californica could be hypothesized to act at GABAA receptors, which are widely expressed in the brain mainly at the inhibitory interneurons. Electrophysiological studies on a recombinant α 1 β 2 γ 2 GABAA receptor showed no effect of N-methyllaurotetanine at concentrations lower than 30 μM. However, (S)-reticuline behaved as positive allosteric modulator at the α 3, α 5, and α 6 isoforms of GABAA receptors. The depressant properties of aerial parts of E. californica are assigned to chloride-current modulation by (S)-reticuline at the α 3 β 2 γ 2 and α 5 β 2 γ 2 GABAA receptors. Interestingly, α 1, α 3, and α 5 were not significantly affected by (R)-reticuline, 1,2-tetrahydroreticuline, codeine, and morphine-suspected (S)-reticuline metabolites in the rodent brain.

Abstract The main factors for reducing the consumption of a vehicle are reduction of curb weight, air drag and increase in the drivetrain efficiency. Highly efficient drivetrains can be developed based on PEFC technology and curb weight may be limited by an innovative vehicle construction. In this paper, data on consumption and efficiency of a four‐place passenger vehicle with a curb weight of 850 kg and an H 2 /O 2 fed PEFC/Supercap hybrid electric powertrain are presented. Hydrogen consumption in the New European Driving Cycle is 0.67 kg H 2 /100 km, which corresponds to a gasoline equivalent consumption of 2.5 l/100 km. When including the energy needed to supply pure oxygen, the calculated consumption increases from 0.67 to 0.69–0.79 kg H 2 /100 km, depending on the method of oxygen production.

Abstract Efficiency is the key parameter for the application of fuel cells in automotive applications. The efficiency of a hydrogen/oxygen polymer electrolyte fuel cell system is analyzed and compared to hydrogen/air systems. The analysis is performed for the tank to electric power chain. Furthermore, the additional energy required for using pure oxygen as a second fuel is analyzed and included in the calculation. The results show that if hydrogen is produced from primary fossil energy carriers, such as natural gas and pure oxygen needs to be obtained by a conventional process; the fuel to electric current efficiency is comparable for hydrogen/oxygen and hydrogen/air systems. However, if hydrogen and oxygen are produced by the splitting of water, i.e., by electrolysis or by a thermochemical process, the fuel to electric current efficiency for the hydrogen/oxygen system is clearly superior.

Summary While early Neolithic populations in Europe were largely descended from early Aegean farmers, there is also evidence of episodic gene flow from local Mesolithic hunter-gatherers into early Neolithic communities. Exactly how and where this occurred is still unknown. Here we report direct evidence for admixture between the two groups at the Danube Gorges in Serbia. Analysis of palaeogenomes recovered from skeletons revealed that second-generation mixed individuals were buried amidst individuals whose ancestry was either exclusively Aegean Neolithic or exclusively local Mesolithic. The mixed ancestry is also reflected in a corresponding mosaic of grave goods. With its deep sequence of occupation and its unique dwellings that suggest at least semi-sedentary occupation since the late Mesolithic, the area of the Danube Gorges has been at the center of the debate about the contribution of Mesolithic societies to the Neolithisation of Europe. As suggested by our data, which were processed exclusively with uncertainty-aware bioinformatic tools, it may have been precisely in such contexts that close interactions between these societies were established, and Mesolithic ancestry and cultural elements were assimilated.

Abstract Between the nineteenth and early twentieth centuries, large-scale afforestation projects were undertaken in the Swiss Prealps. The Swiss stone pine ( Pinus cembra L.), an emblematic alpine tree with important economic potential, conservation value and ecological relevance, was one of the species used in these afforestation efforts. We investigated the distribution and site characteristics of all known natural populations and planted stands in the canton of Fribourg (Switzerland). Between 1885 and 1952, artificial afforestation was carried out in the mountainous regions of the canton of Fribourg. Nearly 450,000 seedlings of P. cembra were planted. One century later, only approximately 650 trees survived (0.15% of all planted trees). Moreover, no natural regeneration can be observed in the afforested stands. Since no known harvest activities were undertaken in these planted stands, the whole afforestation campaign of P. cembra in the canton of Fribourg can be described as a failure. Possible causes are investigated and discussed. In this region, P. cembra occurs naturally only in particular microrefugia with markedly rough topography. We argue that the lack of knowledge or consideration of the ecology of the species at a local scale can be an important factor leading to this failure. In the actual context of large-scale afforestation projects anticipating and mitigating the negative effects of global warming, our study highlights the importance of a precise understanding of species ecology and regional conditions.

Signal transmission from the human retina to visual cortex and connectivity of visual brain areas are relatively well understood. How specific visual perceptions transform into corresponding long-term memories remains unknown. Here, I will review recent Blood Oxygenation Level-Dependent functional Magnetic Resonance Imaging (BOLD fMRI) in humans together with molecular biology studies (animal models) aiming to understand how the retinal image gets transformed into so-called visual (retinotropic) maps. The broken object paradigm has been chosen in order to illustrate the complexity of multisensory perception of simple objects subject to visual--rather than semantic--type of memory encoding. The author explores how amygdala projections to the visual cortex affect the memory formation and proposes the choice of experimental techniques needed to explain our massive visual memory capacity. Maintenance of the visual long-term memories is suggested to require recycling of GluR2-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR) and β(2)-adrenoreceptors at the postsynaptic membrane, which critically depends on the catalytic activity of the N-ethylmaleimide-sensitive factor (NSF) and protein kinase PKMζ.

L’apprentissage organisationnel en gestion de crise est crucial pour le décideur, et notamment pour les cadres supérieurs dont la conception intuitive de la gestion de crise est plus structurelle et organisationnelle que basée sur les compétences générales, la prise de décision ou les perspectives émotionnelles. En tant que technique supérieure de cartographie de l’ensemble du processus décisionnel des gestionnaires, la carte cognitive permet de déterminer la séquence optimale des activités d’apprentissage. De telles cartes peuvent être utilisées comme représentations fiables de l’acquisition des connaissances. Nous avons mobilisé différents modes d’apprentissage en présentiel et en distanciel via l’usage des jeux sérieux. À travers des sessions d’apprentissage de la gestion de crise dans une multinationale industrielle nous démontrons que ce ne sont pas les leviers eux-mêmes qui conduisent à l’acquisition réelle des connaissances mais plutôt l’enchaînement des actions d’apprentissage successives. Ces conclusions permettent aux organisations de mieux adapter les actions pratiques de gestion et les investissements d’apprentissage nécessaires pour accroître les compétences des équipes de gestion en matière de gestion de crise.

Abstract The Asian longhorned beetle Anoplophora glabripennis (Motschulsky) (Coleoptera: Cerambycidae) is one of the most dangerous xylophagous pests affecting broadleaf trees in the world. Eradication programmes are undertaken in non‐native regions, requiring extensive resources and involving high costs. An adapted strategy must be set up to optimize the ratio cost/probability of success. We developed a method to generate a risk index of A. glabripennis presence at a local scale, in the surrounding area of an infestation, using field observations (counts of adult insects, exit holes and infested trees). The method, mathematically based on the bivariate symmetric Laplace distribution, has thus reasonable input requirements. The output risk map is easy to interpret and can be directly used by decision‐makers. We used our approach in three infestations in Switzerland. The risk map represented well the insect pressure (beetle population density). We highlighted the fact that survey boundaries, commonly chosen using constant distances from the infestation, should be selected regarding the spatial distribution of the insect pressure, to prioritize monitoring activities. The risk map provides a helpful instrument for advanced survey planning after a first overview, for example to decide which area and which host trees should be inspected for infestations.

Dow and Rosen’s work in 1965 formed an intellectual framework for compressive strength of unidirectional composites. Compressive strength was explained in terms of micro-buckling, in which filaments are beams on an elastic foundation. While groundbreaking, the discrepancy between model predictions and observed compressive strength is well known. This study builds on Dow and Rosen’s model specifically with respect to the dominant shear mode instability. A new method that accounts for matrix thermal residual strain, matrix compressive and shear stresses, with associated reductions in tangent modulus due to matrix non-linearity, is proposed. The method is validated using a specific test case, which is conducted to precisely account for microscopic fiber alignment and matrix non-linearity. Accordingly, a method of measuring and accounting for a continuum of fiber misalignment is developed. Predictions are compared to literature values, with variations in fiber modulus, matrix modulus, and volume fraction. Good agreement is shown, both in terms of trend and magnitude. The approach successfully preserves initial in-plane shear stiffness, while showing that in-plane shear stiffness decreases significantly as compressive stress increases.

Abstract Throughout the last centuries, the structure and genetic composition of forests have been strongly affected by forest management. Over 30% of European forests are artificially regenerated, very often using translocated forest reproductive material, among these species the Swiss stone pine ( Pinus cembra L.). In the late nineteenth and early twentieth centuries, the species was largely used for artificial afforestation in the northern Alps. However, only a few planted trees have survived. Therefore, we aimed to evaluate if the historical afforestation of P. cembra in the northwestern Swiss Alps relied on allochthonous material. We sampled 12 sites, genotyping 11 nuclear microsatellites, to infer the spatial genetic structure of regional populations, to test for genetic differences between natural and planted stands, and to infer potential source regions of planted stands using reference samples covering the entire Alps. Population genetic structure analysis allowed us to distinguish planted from natural stands and to determine that forest reproductive material used for plantations was not of regional origin. We found similar levels of genetic diversity between natural and planted stands. Assignment tests revealed that reproductive material for planting was translocated to the study area from two source regions, i.e., near the border of Switzerland and Austria, and further to the East, between Austria and Italy. Our study shows how genetic tools may inform about historical transfer of forest reproductive material, which still may affect the population genetic make-up of regional occurrences, e.g., because of reduced natural regeneration.

Au centre de cet article, l’idée que les prostituées « indigènes », parce qu’elles se trouvent au croisement de l’ordre et du désordre, de la conformité et de la déviance, du permis et de l’interdit, sont des êtres de l’hybridation. Bien que sous contrôle d’un système réglementariste extrêmement répressif, les prostituées « indigènes » ne se contentent pas, en effet, de se situer dans un « entre deux » mais proposent une synthèse inédite qui touche l’ensemble de leur vie quotidienne : leurs pratiques religieuses, médicales, corporelles, sexuelles, linguistiques… Ce faisant, elles donnent à voir leur extraordinaire capacité d’adaptation mais aussi la richesse et la complexité d’une société « en mouvement » qui se recompose au contact de la colonisation.

Pourquoi un Clio sur la prostitution ? Le dbat politique et social actuel s'y prtait, bien sr Mais au-del des questions du prsent, auxquelles on ne peut rester indiffrentE, l'aboutissement de plusieurs travaux de jeunes chercheuses et chercheurs nous a incites raliser ce dossier, qui vient enrichir une bibliographie plutt maigre, en France. S'inscrivant dans le vaste domaine de l'histoire de la sexualit, elle peine, en effet, rebondir aprs les tudes magistrales d'Alain Corbin et de Michel Foucault. Elle occupe d'ailleurs une place mineure dans l'histoire des femmes, d'o l'intrt de ce numro de Clio 2 La bibliographie franaise -dont un rcent et symbolique dossier sur Le commerce du sexe dans L'Histoire en 2002 -se rsume quelques titres de rfrence et de rares spcialistes : Jacques Rossiaud, Alain Corbin et Jacques Sol notamment. Cette particularit ne se limite pas au champ franais mais concerne aussi les tudes sur l'histoire de la prostitution et de la sexualit non occidentale : Jean Bottero pour la Msopotamie, Robert Van Gulik pour la Chine ancienne, Christian Henriot pour Shanghai au XIXe et au XXe sicles Comme si, en France, les historiennes s'inscrivant dans l'histoire des femmes s'taient dtournes du sujet ? Ce qui a de quoi surprendre si l'on en juge l'abondance que connat, en ce domaine, la production angloamricaine o les spcialistes de la question sont extrmement nombreuses. Les travaux historiques sur la prostitution couvrent d'ailleurs un large panel thmatique et gographique. L'Europe mais aussi le monde non occidental (Luise White sur l'Afrique ; Eileen Findlay, Donna Guy et Katherine Bliss sur l'Amrique latine ; Katharine Moon et Gail Hershatter sur l'Asie) y sont bien reprsents. L'essentiel de la production traite de l'histoire contemporaine occidentale (la recherche sur les Etats-Unis et le Canada tant tout particulirement dveloppe), mais l'histoire mdivale (Richard Trexler, Ruth Mazo Karras) et l'histoire ancienne ne sont pas absentes (Thomas Mac Ginn, Catharine Edwards, James Davidson). La bibliographie en franais parat limite quelques tudes de qualit traitant surtout de la police des moeurs (Marie Erica Bnabou, Jill Harsin et Jean-Marc Berlire) et du rglementarisme, de l'abolitionnisme (opposition toute rglementation de la prostitution) et de la traite des femmes (voir Edward Bristow). La prostitution n'apparat pas comme un thme important de ditorial

A simple method of compressive strength measurement of a continuously pultruded unidirectional glass-vinyl ester rod is developed. Measured compressive strength was quite high. Compared to a unidirectional composite laminate of the same composition, compressive strength values were doubled. The study shows that glass fiber composites have the potential for high compressive strength. This potential is reached with excellent fiber alignment and suitable matrix characteristics. Results of both laminate and pultruded composites are shown to be consistent with model predictions, with the primary delineating factor being fiber alignment.

Le présent article présente une approche innovatrice dans le traitement de la schizophrénie, soit des rencontres didactiques en groupe pour les parents de schizophrènes. L'article explicite la structure de ces rencontres et les avantages qu'on y trouve en vue d'aider les autres professionnels de la santé mentale à utiliser éventuellement des interventions similaires.

The globalization phenomenon, among other things, turned technics, tools and technologies available to individuals who, until recently, were merely subjugated by the interest of those actors whom dominate the global financial and economical fluxes. It is assumed that the same technologies used by these hegemonic actors can be harnessed to disseminate alternatives that subvert the domination logic, spreading seeds carrying potential social innovations. From this thought, the present article presents seeding as a possible metadesign action, in the strategic design domain, to reach this positively subversive purpose. Anticipating a possible obstacle, it reflects on the role of subjectivity as a cognitive basis on which the seeds can anchor, unleashing the innovation process.