Muhammadiyah University Purwokerto

Descriptive statistics are statistics used to analyze data in ways that describe or depict the data that has been collected as it is without intending to generally accepted conclusions or generalizations. Therefore, in order to ensure the validity of results from data obtained three stages required therein or better known as the basic foundation that is; The first variation where statistics works with changing circumstances. The second reduction means that not all of the information that must be processed. Not all people have studied (population), but simply with less samples are representative only. Thirdly, the generalization is to draw general conclusions that apply to members of the population based on representative samples. Through these stages at least, researchers will be able to produce comprehensive data and findings can be justified scientifically. It is therefore essential for researchers to use statistical methods descriptive qualitative research, as a form of research on social phenomena that tend to be captured. Through the ability if a database owned by qualitative descriptive method, it is helpful in making the observations in the form of measures in the form of numbers. Statistik deskriptif adalah statistik yang digunakan untuk menganalisis data dengan cara mendeskripsikan atau menggambarkan data yang telah terkumpul sebagaimana adanya tanpa bermaksud membuat kesimpulan yang berlaku umum atau generalisasi. Oleh karena itu guna menjamin hasil dari kevalidan data yang diperoleh diperlukan tiga tahapan di dalamnya atau lebih dikenal sebagai landasan pokok yaitu; pertama variasi dimana statistik bekerja dengan keadaan yang berubah-ubah. Kedua reduksi artinya tidak seluruh informasi yang harus diolah. Tidak seluruh orang harus diteliti (populasi), melainkan cukup dengan sampel-sampel yang mewakilinya saja. Ketiga, generalisasi yaitu menarik kesimpulan umum yang berlaku untuk anggota-anggota populasinya berdasarkan sampel-sampel yang representatif. Melalui tahapan tersebut paling tidak peneliti akan mampu menghasilkan temuan data yang komprehensif dan dapat dipertanggungjawabkan secara keilmuan. Sebab itu sangat penting bagi peneliti untuk menggunakan metode statistik deskriptif pada penelitian kualitatif, sebagai bentuk penelitian tentang yang cenderung memotret fenomena sosial. Melalui kemampuan olah basis data yang dimiliki oleh metode kualitatif deskriptif, sangatlah membantu dalam melakukan pengamatan dalam bentuk ukuran-ukuran berupa angka-angka.

Currently, most guidelines on drug-drug interaction (DDI) neither consider the potential effect of genetic polymorphism in the strength of the interaction nor do they account for the complex interaction caused by the combination of DDI and drug-gene interaction (DGI) where there are multiple biotransformation pathways, which is referred to as drug-drug-gene interaction (DDGI). In this systematic review, we report the impact of pharmacogenetics on DDI and DDGI in which three major drug-metabolizing enzymes - CYP2C9, CYP2C19 and CYP2D6 - are central. We observed that several DDI and DDGI are highly gene-dependent, leading to a different magnitude of interaction. Precision drug therapy should take pharmacogenetics into account when drug interactions in clinical practice are expected.

Pasien Diabetes Mellitus dapat hidup normal dengan mengendalikan faktor risiko. Tujuan penelitian ini untuk mengetahui faktor risiko Diabetes Mellitus tipe dua. Desain studi non-eksperimental, atau juga bisa disebut dengan observasional, menggunakan desain penelitian cross-sectional. Populasi adalah warga yang berada di wilayah kerja Puskesmas I Wangon. Teknik purposif sampel sebanyak 106 orang dengan pembagian 53 kasus dan 53 kontrol. Analisa data menggunakan uji chi-square. Faktor risiko yang terbukti berpengaruh dengan DM tipe dua di Puskesmas I Wangon adalah faktor genetik dengan keluarga DM (OR=10,938), pola makan tidak sehat, umur ≥45 tahun, IMT obesitas, dan tingkat pendidikan rendah.

Strengthening on Micro, Small and Medium Enterprises (MSMEs) in Indonesia needs to be supported by the use and good information systems management. Therefore, business actors are expected to be able to use a operational strategy supported by the use of information systems. Workshop is one of the complex MSMEs with integrated warehousing and financial reporting. The problem faced at this workshop UMKM is that there is no synchronization between the existing stock of goods and the sales stock, as well as reporting both warehouse reporting and financial reporting. For this reason, this study aims to build a web-based MSME information system for tire & rims workshops. In building this system, researchers used the agile software development method, namely SCRUM. This method is used because the system can adjust to the needs of the product owner, which is always changing and fast in processing. The results of this scrum stage, namely the product log, sprint backlog, sprint and working increment of the software, can resolve all problems that occur with regard to time, scope and cost issues so that in the implementation of making this system application can reduce the system requirements gap during the sprint process. So that the system can be completed in accordance with the requirements needed by the user. By using this workshop's UMKM information system, all sales operational activities can be monitored properly and sales and financial reports can be well structured.

Hasil penelitian terdahulu tentang profil literasi sains siswa SMP di kota purwokerto menunjukkan bahwa literasi sains siswa dalam aspek konten, konteks, maupun proses masih tergolong rendah. Rendahnya literasi sains menyebabkan siswa menjadi kurang tanggap terhadap perkembangan dan permasalahan yang ada di sekitar lingkungan terutama yang berkaitan dengan fenomena alam, keunggulan lokal daerah, maupun permasalahan yang ada di lingkungan sekitar. Oleh karena itu, perlu dikembangkan sebuah strategi untuk meningkatkan literasi sains siswa menggunakan model pembelajaran berbasis keunggulan lokal. Tujuan penelitian adalah mengetahui bagaimana implementasi pembelajaran berbasis keunggulan lokal yang terintegrasi pada materi pembelajaran biologi beserta peningkatan literasi sains siswa setelah pelaksanaan pembelajaran berbasis keunggulan lokal. Penelitian ini menggunakan metode deskriptif dengan subyek penelitian adalah siswa kelas 10 SMA Negeri 1 Sokaraja. Prosedur penelitian dilakukan melalui empat tahapan, yaitu persiapan, pelaksanaan, pengolahan/ analisis data, dan pelaporan. Penelitian tentang penerapan pembelajaran berbasis keunggulan lokal mendapatkan hasil bahwa terjadi peningkatan literasi sains pada aspek konten, konteks, maupun proses sains siswa. Sebelum diterapkan pembelajaran berbasis keunggulan lokal, kemampuan literasi sains siswa pada aspek konten dan konteks sains termasuk dalam kategori sangat rendah dengan persentase aspek konten 12, 78% dan aspek konteks 28,75%, sedangkan penguasaan aspek proses sains adalah 68,2%. Setelah dilakukan pembelajaran berbasis keunggulan lokal aspek konten sains meningkat menjadi 70,62% dan termasuk dalam kategori baik, konteks sains meningkat menjadi 43, 87% dan termasuk dalam kategori rendah, serta aspek proses sains meningkat menjadi 77, 18% dan termasuk kategori baik. Meskipun peningkatan tersebut belum signifikan, namun dapat disimpulkan bahwa penerapan pembelajaran berbasis keunggulan lokal dapat meningkatkan kemampuan konten, konteks, dan proses sains siswa.

This study aims to analyze the effect of investment knowledge, investment motivation, financial literacy and family environment on the interest in investing in the capital market. This type of research is quantitative. The population of this study were students of the Management Study Program of the Faculty of Economics and Business, Muhammadiyah Purwokerto University in the year 2016 and 2017 with the sample criteria of active students of FEB UMP and those who were / had taken financial management and entrepreneurship courses. Data collection in this study using the questionnaire method. Instrument testing was analyzed using validity test and reliability test. Data analysis techniques used in this study are classic assumptions and multiple linear regression analysis. The results showed that: (1) investment knowledge, investment motivation, and financial literacy simultaneously had a significant effect on investment interest. (2) investment knowledge partially does not affect investment interest. (3) investment motivation partially has a significant effect on investment interest. (4) financial literacy partially has a significant effect on investment interest. (5) the family environment partially has a significant effect on investment interest. keywords: Knowledge, Motivation, Literacy, Environment, Interests.

OBJECTIVE: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin. METHODS: The cytotoxic properties, 50% inhibition concentration (IC50) and its combination with doxorubicin in MCF-7 cell lines resistant to doxorubicin (MCF-7/Dox) cells were determined using MTT assay. Apoptosis induction was examined by double staining assay using ethidium bromide-acridine orange. Immunocytochemistry assay was performed to determine the level and localization of Pgp. RESULTS: Single treatment of hesperidin showed cytotoxic activity on MCF-7/Dox cells with IC50 value of 11 µmol/L. Thus, combination treatment from hesperidin and doxorubicin showed addictive and antagonist effect (CI>1.0). Hesperidin did not increase the apoptotic induction, but decreased the Pgp expressions level when combined with doxorubicin in low concentration. CONCLUSIONS: Hesperidin has cytotoxic effect on MCF-7/Dox cells with IC50 of 11 µmol/L. Hesperidin did not increased the apoptotic induction combined with doxorubicin. Co-chemotherapy application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression.

The research background is the rapid development of AI which affects various aspects of education. The purpose of this study is to analyze in depth about the opportunities, challenges, threats and obstacles to the implementation of AI in education. The research method used in this study is semy-systematic literature review. The analysis technique used is a meta-narrative approach that includes the process of identifying, analyzing, recognizing patterns and topic-related themes. The results describe that AI opportunities in education are related to the delivery of learning materials, evaluation, management systems, and educational policy making. Meanwhile, the challenges are related to pedagogy, educational frameworks, and literacy. Threats that arise are related to the security of personal data, character building and educational ethics. Finally, obstacles that arise include the high costs required, limited teacher and professional training schemes in preparing AI competencies, and slow changes in curriculum structure and structural level of education.

Biomass is one of abundance resources in the world. Biomass consists of three main materials such as cellulose, hemicelluloses and lignin. Therefore, biomass can be referred to lignocellulosic material. Both the cellulose and hemicelluloses fractions are polymers of sugars, and thereby a potential source of fermentable sugars, or other processes that convert sugars into products. Lignin is a polymer compound which contains of phenolic compounds. Rice husk is one of biomass, which has high contain of lignin. Rice husk has special characteristics because of silica content. The aim of this paper is to analyze lignin and silica extracted during lignin isolation process of rice husk using alkaline hydrogen peroxide. Three main variables such as solvent/solid ratio, concentration of hydrogen peroxide and pH of the mixture are studied. The optimum conditions for lignin isolation are at solvent/solid ratio 9:1 ml/gr, hydrogen peroxide concentration of 1.5%v and pH of the mixture of 11.

Literasi sains menurut PISA (Prgram for international student assessment) adalah kemampuan menggunakan pengetahuan ilmiah, mengidentifikasi pertanyaan dan menggambarkan bukti-bukti yang berdasarkan kesimpulan untuk dapat memahami dan membantu pembuatan kesimpulan tentang alam serta perubahan terhadap alam tersebut akibat aktivitas manusia. Literasi sains bersifat multidimensional. Individu yang “melek sains” adalah orang yang menggunakan konsep sains, keterampilan proses, dan nilai dalam membuat keputusan sehari-hari jika berhubungan dengan orang lain atau dengan lingkungannya, serta memahami interlasi anatara sains, teknologi dan masyarakat, termasuk perkembangan social dan ekonomi. Penelitian ini merupakan penelitian deskriptif, yaitu penelitian yang bertujuan untuk menggambarkan profil capaian literasi sains siswa SMP di kota purwokerto yang ditinjaau dari tigas aspek listerasi sains, yakni konten, proses, dan konteks. Penelitian dilakakukan pada siswa kelas 8 di SMP Negeri 1 Purwokerto, SMP Negeri 8 Purwokerto, dan SMP Muhammadiyah 1 Purwokerto dengan total responden berjumlah 184 siswa. Penelitian dimulai dengan tahap persiapan untuk mendapatkan soal literasi sains tingkat SMP yang valid. Selanjutnya, tahap pengambilan data yang dilakukan dengan mengambil jawaban-jawaban siswa yang mengerjakan soal tes literasi sains selama 90 menit. Tahap terakhir adalah perhitungan presentase capaian per setiap aspek literasi. Hasil penelitian menunjukkan bahwa rata-rata prosentase kemampuan literasi sains siswa SMP di kota purwokerto masih rendah pada 3 aspek literasi sains yaitu aspek konten (53,80%), aspek proses (44,038%) dan aspek konteks (35,088%). Rendahnya salah satu aspek literasi sains akan berpengaruh terhadap aspek literasi sains lainnya. Rendahnya pemahaman konsep siswa terhadap pengetahuan sains akan berdampak pada rendahnya aplikasi sains. Saat ini siswa-siswa di tiga SMP di kota purwokerto yang menjadi subyek penelitian hanya memiliki kemampuan mengingat pengetahuan ilmiah berdasarkan fakta sederhana. Hasil pengukuran literasi sains yang dilakukan pada siswa-siswa SMP di kota purwokerto dapat menjadi acuan dalam memetakan kemampuan sains (IPA) dan kualitas pembelajaran sains (IPA) siswa SMP di kota Purwokerto Kata kunci: profil literasi sains; aspek literasi sains

BACKGROUND: Stunting is affected by various factors from mother and child. Previous studies assessed only one or more influencing variables. Unfortunately, nor the significant influence of maternal and child factors nor the indicators contributing to maternal and child factors that affect the stunting incidence have ever been analyzed. PURPOSE: This study analyzed the effect of maternal and child factors on stunting and the significant indicators that shape the maternal and child factors that impact stunting. METHODS: This was a case-control study. Overall, 132 stunted children and 132 nonstunted children in Purbalingga Regency, Central Java Province, participated in the research. Direct interviews and medical record reviews were conducted to assess the studied variables. The research data were tested using the partial least squares structural equation with a formative model. RESULTS: Maternal factors directly affected the occurrence of stunting (t=3.527, P<0.001) with an effect of 30.3%. Maternal factors also contributed a significant indirect effect on stunting through child factors (t=4.762, P<0.001) with an effect of 28.2%. Child factors affected the occurrence of stunting (t= 5.749, P<0.001) with an effect of 49.8%. The child factor was influenced by maternal factor with an effect of 56.7% (t=10.014, P<0.001). The moderation analysis results demonstrated that maternal and child factors were moderate predictive variables of stunting occurrence. CONCLUSION: Child factors have more significant and direct effects on stunting than maternal factors but are greatly affected by them.

The aim of this study is to examine the effect of financial literacy and financial experience on SMEs financial behavior in Indonesia.The dependent variable is financial behavior while independent variables are financial literacy and financial experience. There are four control variables used, namely company size, business length, age and education level of SME owner. The respondent sample is 42 owners of SMEs in Purwokerto Selatan. This study used multiple regression analysis. The results showed that financial literacy has no effect on financial behavior. Financial experience has a positive effect on financial behavior. While among four control variables, only company size has a significant negative effect on financial behavior. Three control variables have no significant effect on financial behavior. The implication of this study, SME owners have good financial experience will increase financial behavior. Therefore, it is very important to improve the financial experience of SME owners

Introduction: The preoperative phase is an important period in which to prevent surgical site infections (SSIs). Prophylactic antibiotic use helps to reduce SSI rates, leading to reductions in hospitalization time and cost. In clinical practice, besides effectiveness and safety, the selection of prophylactic antibiotic agents should also consider the evidence with regard to costs and microbiological results. This review assessed the current research related to the use of antibiotics for SSI prophylaxis from an economic perspective and the underlying epidemiology of microbiological findings. Methods: A literature search was carried out through PubMed and Embase databases from 1 January 2006 to 31 August 2017. The relevant studies which reported the use of prophylactic antibiotics, SSI rates and costs were included for analysis. The causing pathogens for SSIs were categorized by sites of the surgery. The quality of reporting on each included study was assessed with the “Consensus on Health Economic Criteria” (CHEC). Results: We identified 20 eligible full-text studies that met our inclusion criteria were subsequently assessed, resulting in a reporting quality scored on the CHEC list averaging 13.03 (8-18.5). Of the included studies, 14 were trial-based studies, and the others were model-based studies. The SSI rates ranged from 0 to 71.1% with costs amounting to US$480-22,130. Twenty-four bacteria were identified as causative agents of SSIs. Gram negatives were the dominant causes of SSIs especially in general surgery, neurosurgery, cardiothoracic surgery and obstetric cesarean sections. Conclusions: Varying results were reported in the studies reviewed. Yet, information from both trial-based and model-based costing studies could be considered in the clinical implementation of proper and efficient use of prophylactic antibiotics to prevent SSIs and antimicrobial resistance. Nevertheless, the findings of economics and microbiology from the included studies have reported diverse results.

AbstractMany studies have been conducted to investigate teachers' knowledge and beliefs and they confirmed that knowledge and beliefs are an influential factor in teachers' decision making in the classroom. However, little research has been undertaken to investigate how teachers' knowledge and beliefs in influence the implementation of language policy. This study aims at investigating primary school teachers' knowledge and beliefs about the English program in primary schools in Indonesia, focusing on their pedagogical knowledge and how it influences the way they teach English when English is positioned as a local content subject in the curriculum The study reveals that in the absence of official curriculum teachers are required to draw on their existing knowledge and beliefs but the existing knowledge and beliefs of teachers in Indonesia are often not well developed. With no curriculum to guide their teaching, teachers' rely on textbooks. They consider that the textbook can be regarded as a substitute for a curriculum because the textbook contains information about the themes, the objectives of teaching, materials, and exercises. That is, textbooks have many of the features that teachers said were important in curriculum as guides for teaching.Keywords: teachers' knowledgeteachers' beliefsEnglish language teachingprimary schoolsclassroom decision making

Penelitian ini berlandaskan masalah yang ada di sekolah. Masalah ditemukan berdasarkan hasil observasi dan analisis media pembelajaran yang ada di sekolah. Pembelajaran berjalan dengan baik jika dalam proses pembelajaran ditunjang dengan sarana dan prasarana penunjang yang memadai, salah satunya yaitu penggunaan media pembelajaran. Tujuan penelitian ini untuk menghasilkan media pembelajaran Articulate Storyline kurikulum 2013 berbasis kompetensi peserta didik abad 21 tema 7 kelas IV sekolah dasar. Jenis penelitian yang digunakan adalah penelitian dan pengembangan (R&amp;D) dengan model 4D yang dikembangkan oleh Thiagarajan. Teknik pengumpulan data melalui tes dan non tes. Hasil penelitian ini menunjukan bahwa media pembelajaran dapat dijadikan sebagai penunjang proses pembelajaran. Media pembelajaran memperoleh nilai rata-rata hasil validator 4,23 dengan predikat sangat baik. Media pembelajaran Artikulate Storyline tema 7 dengan model TPS (think, pair and square) dapat meningkatkan kompetensi 4C (critical thinking and problem solving, creative and inovative, collaborative, and comunicative) sesuai dengan tuntutan pembelajaran abad 21. Respon guru terhadap media pembelajaran nilai scor rata-rata 4,73 dengan predikat sangat baik. Respon peserta didik terhadap media pembelajaran mendapatkan nilai scor rata-rata 4,6 dengan predikat sangat baik

Purpose This study aims to determine the direct effect of entrepreneurial orientation on family business performance. This study also discusses the role of family involvement as a mediating variable and the role of gender as a moderating variable in the relationship between entrepreneurial orientation and family business performance. Design/methodology/approach A total of 328 hotels in Yogyakarta, Indonesia, were selected as samples by the convenience sampling method. Primary data is collected through structured questionnaires that are delivered by themselves to key people in the hotel such as owners, directors and key staff (HRD, financial, relationship). Hypotheses are tested by structural equation modeling procedures using AMOS 22.0. Sobel test is used to determine the indirect effect of the mediation variable. Findings The results showed that entrepreneurial orientation had no significant effect on family business performance. Family involvement acts as a full mediation in the relationship between entrepreneurial orientation and family business performance. Gender acts as a moderating variable that can strengthen the relationship between entrepreneurial orientation and family business performance. The results showed support for previous research. Research limitations/implications The results of the study cannot conclude the national family business because it adopts convenience sampling and the sampling area is limited in Yogyakarta. Future research can use a larger sample. This study only researches hotels managed by family businesses, so it is not feasible to conclude for family businesses in general. Future research may choose to use several types of family businesses so that more varied results can be obtained. Future research could also compare hotels managed by family businesses with non-family businesses. The results also found that in addition to gender roles, respondent heterogeneity was an important component in the study of social identity. Therefore, research examining the influence of different cultures on the relationship between entrepreneurial orientation and family business performance should be an extraordinary topic for future study. Other results from this study also indicate that there is a role for religion in improving hotel performance. Future research is needed to further explore Islamic business modeling for family businesses. Practical implications This finding has significant implications that can help family businesses in developing strategies that are suitable for business management. Entrepreneurial orientation occupies a strategic position in developing sustainable competitive advantage in the family business of the tourism sector especially the hotel business in Yogyakarta for the better. Besides, the results of the study also showed that entrepreneurial orientation had no significant effect on performance. This relationship becomes significant when combined with active family involvement. This finding also shows that entrepreneurial orientation has the potential to have a more beneficial effect because of the active involvement of the family in helping with business management, alleviating business-related problems, and having a significant influence when the family also acts as management. Social implications Research findings indicate the role of gender in strengthening the relationship between entrepreneurial orientation and family business performance. This provides a good position for women in the social environment to show achievement. To place women on the side of gender equality and justice in the family business in Indonesia. By opening wider access for Indonesian women in the realm of business management, expanding women's participation in a family business, increasing the role of control for women, and increasing women's knowledge and skills to increase the benefits in managing family businesses so that they have sustainable resilience in the face of global competition. Originality/value The results of this study provide a new model in providing an overview of the direct and indirect roles (mediating and moderating) in the assessment of family business performance. This study uses three variables which are important in performance appraisal, namely entrepreneurial orientation (independent variable), family involvement (mediating variable) and gender (moderating variable). Where research that combines these four variables, directly and indirectly, has never been done before.

The research was qualitative research aimed to find out the effect of green accounting application toward profitability. The independent variables in this research were environmental performance and environmental disclosure, while the dependent variable was profitability. The research objects were the mining companies registered in Indonesia Stock Exchange within 2013-2015 period. This research used 54 samples. The sampling technique was purposive sampling,while the data analysis techniques were descriptive statistic, classic assumption test, multipleregression analysis, and hypothesis test with significance level (á) of 0,05. The research resultshowed that the environmental performance did not positively affect profitability with the significance value of 0,129 &gt; 0,05 and the environmental disclosure did not positively affect profitability with the significance value of 0,715 &gt; 0,05.Ke ywords: environmental disclosure, green accounting, environmental performance, profitability.

Penelitian ini bertujuan untuk menguji pengaruh dewan direksi, dewan komisaris independen, dan dewan pengawas syariah terhadap kinerja keuangan perbankan syariah indonesia. Kinerja keuangan diproksikan menggunakan ROA, populasi dalam penelitian ini adalah perbankan syariah yang terdaftar di Otoritas Jasa Keuangan (OJK) di Indonesia yang beroperasi pada tahun 2017-2019. Teknik pengambilan sampel menggunakan teknik purposive sampling, dan diperoleh 42 sampel. Metode analisis yang digunakan unutk menguji hipotesis adalah regresi linear berganda. Hasil penelitian ini menunjukan bahwa dewan direksi tidak berpengaruh terhadap kinerja keuangan, dewan komisaris independen berpengaruh positif terhadap kinerja keuangan, sedangkan dewan pengawas syariah tidak berpengaruh terhadap kinerja keuangan. Kata Kunci: Dewan Direksi, Dewan Komisari Independen, Dewan Pengawas Syariah dan Kinerja Keuangan.

In the ever-evolving landscape of education, integrating innovative technologies can enhance the learning experience for students. ChatGPT, a cutting-edge language processing tool developed by OpenAI, offers exciting possibilities for teaching writing. This advanced AI model can be a powerful asset in the classroom, providing students with valuable resources and support as they develop their writing skills. Seventy-three college students participated in the quasi-experiment. The findings demonstrate that AI chatbot-based instruction reduces students' anxiety about learning English writing. AI chatbots offer instant feedback, allowing students to correct errors immediately. This quick feedback loop can prevent students from ruminating over their mistakes, thus reducing anxiety. With AI chatbot, students can learn at their own pace. They can take time to understand concepts, practice writing, and receive feedback without feeling rushed. This flexibility can alleviate the pressure of strict deadlines in traditional classroom settings. The findings imply teachers to implement chatbot-based learning in the classroom.

INTRODUCTION: The COVID-19 outbreak first occurred in China and has developed throughout the world, including Indonesia. The Indonesian government reports that up to May 22, 2020 there have been 21,430 confirmed cases. The purpose of this study is to describe the epidemiology, clinical symptoms and comorbidities of COVID-19 as well as the various government interventions to reduce the rate of incidence. METHODOLOGY: A retrospective cohort study was designed. The population in this study is based data from the official Indonesian government website run by the Task Force for the Acceleration of Handling COVID-19. The sample was observed b March 2 to April 24, 2020. The total sample included 8,211 cases of patients diagnosed with COVID-19, among these 1,002 recovered and 689 died. Data analysis used percentages from various recorded epidemiological variables. RESULTS: The results showed that COVID-19 epidemiological features were mostly observed in men (56.5%) and patients of productive age (31-59 of age) by 57.5%; most deaths were recorded in patients aged > 60 years (43.6%). The most recurrent clinical symptom was cough (77.8%), the most recurrent comorbidity was hypertension (52.4%), and the province with the highest COVID-19 incidence was DKI Jakarta (34.3%). CONCLUSIONS: The combination of common sources and propagated source was observed during the COVID-19 outbreak in Indonesia. Special attention should be given to protecting vulnerable populations such as children, health care providers, and the elderly. The community is expected to participate in preventing the transmission of COVID-19 by complying with health protocols.