Rutgers Sexual and Reproductive Health and Rights

Many problems of recent interest in statistics and machine learning can be posed in the framework of convex optimization. Due to the explosion in size and complexity of modern datasets, it is increasingly important to be able to solve problems with a very large number of features or training examples. As a result, both the decentralized collection or storage of these datasets as well as accompanying distributed solution methods are either necessary or at least highly desirable. In this review, we argue that the alternating direction method of multipliers is well suited to distributed convex optimization, and in particular to large-scale problems arising in statistics, machine learning, and related areas. The method was developed in the 1970s, with roots in the 1950s, and is equivalent or closely related to many other algorithms, such as dual decomposition, the method of multipliers, Douglas–Rachford splitting, Spingarn's method of partial inverses, Dykstra's alternating projections, Bregman iterative algorithms for ℓ1 problems, proximal methods, and others. After briefly surveying the theory and history of the algorithm, we discuss applications to a wide variety of statistical and machine learning problems of recent interest, including the lasso, sparse logistic regression, basis pursuit, covariance selection, support vector machines, and many others. We also discuss general distributed optimization, extensions to the nonconvex setting, and efficient implementation, including some details on distributed MPI and Hadoop MapReduce implementations.

BACKGROUND: Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence regarding the comparison of the two procedures in patients who are at low risk. METHODS: We randomly assigned patients with severe aortic stenosis and low surgical risk to undergo either TAVR with transfemoral placement of a balloon-expandable valve or surgery. The primary end point was a composite of death, stroke, or rehospitalization at 1 year. Both noninferiority testing (with a prespecified margin of 6 percentage points) and superiority testing were performed in the as-treated population. RESULTS: At 71 centers, 1000 patients underwent randomization. The mean age of the patients was 73 years, and the mean Society of Thoracic Surgeons risk score was 1.9% (with scores ranging from 0 to 100% and higher scores indicating a greater risk of death within 30 days after the procedure). The Kaplan-Meier estimate of the rate of the primary composite end point at 1 year was significantly lower in the TAVR group than in the surgery group (8.5% vs. 15.1%; absolute difference, -6.6 percentage points; 95% confidence interval [CI], -10.8 to -2.5; P<0.001 for noninferiority; hazard ratio, 0.54; 95% CI, 0.37 to 0.79; P = 0.001 for superiority). At 30 days, TAVR resulted in a lower rate of stroke than surgery (P = 0.02) and in lower rates of death or stroke (P = 0.01) and new-onset atrial fibrillation (P<0.001). TAVR also resulted in a shorter index hospitalization than surgery (P<0.001) and in a lower risk of a poor treatment outcome (death or a low Kansas City Cardiomyopathy Questionnaire score) at 30 days (P<0.001). There were no significant between-group differences in major vascular complications, new permanent pacemaker insertions, or moderate or severe paravalvular regurgitation. CONCLUSIONS: Among patients with severe aortic stenosis who were at low surgical risk, the rate of the composite of death, stroke, or rehospitalization at 1 year was significantly lower with TAVR than with surgery. (Funded by Edwards Lifesciences; PARTNER 3 ClinicalTrials.gov number, NCT02675114.).

Two studies investigated the tendency of people to be unrealistically optimistic about future life events. In Study 1, 258 college students estimated how much their own chances of experiencing 42 events differed from the chances of their classmates. Overall, they rated their own chances to be above average for posi-tive events and below average for negative events, ps<.001. Cognitive and motivational considerations led to predictions that degree of desirability, per-ceived probability, personal experience, perceived controllability, and stereotype salience would influence the amount of optimistic bias evoked by different events. All predictions were supported, although the pattern of effects differed for positive and negative events. Study 2 tested the idea that people are un-realistically optimistic because they focus on factors that improve their own chances of achieving desirable outcomes and fail to realize that others may have just as many factors in their favor. Students listed the factors that they thought influenced their own chances of experiencing eight future events. When such lists were read by a second group of students, the amount of unrealistic opti-mism shown by this second group for the same eight events decreased signifi-cantly, although it was not eliminated. According to popular belief, people tend to think they are invulnerable. They expect others to be victims of misfortune, not them-selves. Such ideas imply not merely a hopeful outlook on life, but an error in judgment that can be labeled unrealistic optimism. It is usually impossible to demonstrate that an individual's optimistic expectations about the future are unrealistic. An individual might be quite correct in asserting that his or her chances of experiencing a negative event are less than average. On a group basis, however, it is relatively easy to test for an optimistic bias. If all people claim their changes of ex-periencing a negative event are less than

Proper treatment of nonbonded interactions is essential for the accuracy of molecular dynamics (MD) simulations, especially in studies of lipid bilayers. The use of the CHARMM36 force field (C36 FF) in different MD simulation programs can result in disagreements with published simulations performed with CHARMM due to differences in the protocols used to treat the long-range and 1-4 nonbonded interactions. In this study, we systematically test the use of the C36 lipid FF in NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM. A wide range of Lennard-Jones (LJ) cutoff schemes and integrator algorithms were tested to find the optimal simulation protocol to best match bilayer properties of six lipids with varying acyl chain saturation and head groups. MD simulations of a 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) bilayer were used to obtain the optimal protocol for each program. MD simulations with all programs were found to reasonably match the DPPC bilayer properties (surface area per lipid, chain order parameters, and area compressibility modulus) obtained using the standard protocol used in CHARMM as well as from experiments. The optimal simulation protocol was then applied to the other five lipid simulations and resulted in excellent agreement between results from most simulation programs as well as with experimental data. AMBER compared least favorably with the expected membrane properties, which appears to be due to its use of the hard-truncation in the LJ potential versus a force-based switching function used to smooth the LJ potential as it approaches the cutoff distance. The optimal simulation protocol for each program has been implemented in CHARMM-GUI. This protocol is expected to be applicable to the remainder of the additive C36 FF including the proteins, nucleic acids, carbohydrates, and small molecules.

The discovery of the enhancement of Raman scattering by molecules adsorbed on nanostructured metal surfaces is a landmark in the history of spectroscopic and analytical techniques. Significant experimental and theoretical effort has been directed toward understanding the surface-enhanced Raman scattering (SERS) effect and demonstrating its potential in various types of ultrasensitive sensing applications in a wide variety of fields. In the 45 years since its discovery, SERS has blossomed into a rich area of research and technology, but additional efforts are still needed before it can be routinely used analytically and in commercial products. In this Review, prominent authors from around the world joined together to summarize the state of the art in understanding and using SERS and to predict what can be expected in the near future in terms of research, applications, and technological development. This Review is dedicated to SERS pioneer and our coauthor, the late Prof. Richard Van Duyne, whom we lost during the preparation of this article.

In 590 for-profit and nonprofit firms from the National Organizations Survey, we found positive associations between human resource management (HRM) practices, such as training and staffing selectivity, and perceptual firm performance measures. Results also suggest methodological issues for consideration in examinations of the relationship between HRM systems and firm performance.

Many innovative approaches to education such as problem-based learning (PBL) and inquiry learning (IL) situate learning in problem-solving or investigations of complex phenomena. Kirschner, Sweller, and Clark (2006) Kirschner, P. A., Sweller, J. and Clark, R. E. 2006. Why minimal guidance during instruction does not work: An analysis of the failure of constructivist, discovery, problem-based, experiential, and inquiry-based teaching. Educational Psychologist., 41: 75–86. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar] grouped these approaches together with unguided discovery learning. However, the problem with their line of argument is that IL and PBL approaches are highly scaffolded. In this article, we first demonstrate that Kirschner et al. have mistakenly conflated PBL and IL with discovery learning. We then present evidence demonstrating that PBL and IL are powerful and effective models of learning. Far from being contrary to many of the principles of guided learning that Kirschner et al. discussed, both PBL and IL employ scaffolding extensively thereby reducing the cognitive load and allowing students to learn in complex domains. Moreover, these approaches to learning address important goals of education that include content knowledge, epistemic practices, and soft skills such as collaboration and self-directed learning.

The causal logic behind many arguments in historical institutionalism emphasizes the enduring impact of choices made during critical junctures in history. These choices close off alternative options and lead to the establishment of institutions that generate self-reinforcing path-dependent processes. Despite the theoretical and practical importance of critical junctures, however, analyses of path dependence often devote little attention to them. The article reconstructs the concept of critical junctures, delimits its range of application, and provides methodological guidance for its use in historical institutional analyses. Contingency is the key characteristic of critical junctures, and counterfactual reasoning and narrative methods are necessary to analyze contingent factors and their impact. Finally, the authors address specific issues relevant to both cross-sectional and longitudinal comparisons of critical junctures.

In virtually all published literature wherein closure between gravimetric and chemical measurements is tested, the concentration of particulate organics is estimated by multiplying the measured concentration of organic carbon (micrograms carbon/cubic meter air) by a factor of 1.2 -1.4.This factor, which is an estimate of the average molecular weight per carbon weight for the organic aerosol, stems from very limited theoretical and laboratory studies conducted during the 1970s.This investigation suggests that 1.4 is the lowest reasonable estimate for the organic molecular weight per carbon weight for an urban aerosol and that 1.4 does not accurately represent the average organic molecular weight per carbon weight for a nonurban aerosol.Based on the current evaluation, ratios of 1.6 § 0.2 for urban aerosols and 2.1 § 0.2 for nonurban aerosols appear to be more accurate.Measurements are recommended.Literature values also suggest that 1.2 g/cm 3 is a reasonable estimate for the organic aerosol density.This quantity is needed to convert between geometric and aerodynamic size distributions (e.g., to predict aerosol optical properties and understand cloud nucleating properties).

Abstract In recent years a set of new ‘postempiricist’ approaches to public policy, drawing on discursive analysis and participatory deliberative practices, have come to challenge the dominant technocratic, empiricist models in policy analysis. In this book, Frank Fischer brings together this work for the first time and critically examines its implications for the field of public policy studies. He describes the theoretical, methodological and political dimensions of this emerging approach to policy research. The book includes a discussion of the social construction of policy problems, the role of interpretation and narrative analysis in policy inquiry, the dialectics of policy argumentation, and the uses of participatory policy analysis. After an introductory chapter, ten further chapters are arranged in four parts: Part I, Public Policy and the Discursive Construction of Reality (two chapters), introduces the re-emergence of interest in ideas and discourse. It then turns to the postempiricist or constructionist view of social reality, presenting public policy as a discursive construct that turns on multiple interpretations. Part II, Public Policy as Discursive Politics (two chapters), examines more specifically the nature of discursive politics and discourse theory and illustrates through a particular disciplinary debate the theoretical, methodological, and political implications of such a conceptual reframing of policy inquiry. Part III, Discursive Policy Inquiry: Resituating Empirical Analysis (four chapters), offers a postempiricist methodology for policy inquiry based on the logic of practical discourse, and explores specific methodological perspectives pertinent to such an orientation, in particular the role of interpretation in policy analysis, narrative policy analysis, and the dialectics of policy argumentation. Part IV, Deliberative Governance (two chapters), discusses the participatory implications of such a method and the role of the policy analyst as facilitator of citizen deliberation .

ABSTRACT The paper recommends an acceptable methodology for recording electrodermal activity which reflects a consensus of experts in the field. These recommendations are presented with a minimum of technical discussion in order to maximize their usefulness to investigators who are not specialists in this area. For most purposes, skin conductance (SC) is to be preferred over skin potential (SP). It is recommended that SC be recorded from palmar sites with silver‐silver chloride electrodes and an electrode paste consisting of a sodium chloride electrolyte in a neutral ointment cream medium. The area of contact with the skin should be controlled and time allowed for stabilization of the skin‐electrode paste interface. Electrode bias potentials and polarization should be monitored during use. Signal conditioning is achieved by the application of a constant 0.5 volt across the electrodes and measurement of the resultant current flow by amplifying the voltage developed across a small resistor in series with the skin. The measurement of the amplitude‐or even the detection‐of small responses requires some form of tonic level control, permitting an adjustment of the tonic level. A circuit is provided for signal conditioning and tonic level control. SP can be recorded with the same electrodes and electrode paste, unless the results are to be related to the British work on SP level, in which case the original potassium chloride electrolyte in an agar medium should be used. SP recordings require that one of the electrodes be placed over an inactive reference site, preferably over the ulnar bone near the elbow. No external voltage is applied, but some form of tonic level control may be needed. Electrodes need to be checked for bias potentials but not polarization.

Denitrification is a critical process regulating the removal of bioavailable nitrogen (N) from natural and human-altered systems. While it has been extensively studied in terrestrial, freshwater, and marine systems, there has been limited communication among denitrification scientists working in these individual systems. Here, we compare rates of denitrification and controlling factors across a range of ecosystem types. We suggest that terrestrial, freshwater, and marine systems in which denitrification occurs can be organized along a continuum ranging from (1) those in which nitrification and denitrification are tightly coupled in space and time to (2) those in which nitrate production and denitrification are relatively decoupled. In aquatic ecosystems, N inputs influence denitrification rates whereas hydrology and geomorphology influence the proportion of N inputs that are denitrified. Relationships between denitrification and water residence time and N load are remarkably similar across lakes, river reaches, estuaries, and continental shelves. Spatially distributed global models of denitrification suggest that continental shelf sediments account for the largest portion (44%) of total global denitrification, followed by terrestrial soils (22%) and oceanic oxygen minimum zones (OMZs; 14%). Freshwater systems (groundwater, lakes, rivers) account for about 20% and estuaries 1% of total global denitrification. Denitrification of land-based N sources is distributed somewhat differently. Within watersheds, the amount of land-based N denitrified is generally highest in terrestrial soils, with progressively smaller amounts denitrified in groundwater, rivers, lakes and reservoirs, and estuaries. A number of regional exceptions to this general trend of decreasing denitrification in a downstream direction exist, including significant denitrification in continental shelves of N from terrestrial sources. Though terrestrial soils and groundwater are responsible for much denitrification at the watershed scale, per-area denitrification rates in soils and groundwater (kg N x km(-2) x yr(-1)) are, on average, approximately one-tenth the per-area rates of denitrification in lakes, rivers, estuaries, continental shelves, or OMZs. A number of potential approaches to increase denitrification on the landscape, and thus decrease N export to sensitive coastal systems exist. However, these have not generally been widely tested for their effectiveness at scales required to significantly reduce N export at the whole watershed scale.

This study investigates self-presentation strategies among online dating participants, exploring how participants manage their online presentation of self in order to accomplish the goal of finding a romantic partner. Thirty-four individuals active on a large online dating site participated in telephone interviews about their online dating experiences and perceptions. Qualitative data analysis suggests that participants attended to small cues online, mediated the tension between impression management pressures and the desire to present an authentic sense of self through tactics such as creating a profile that reflected their “ideal self,” and attempted to establish the veracity of their identity claims. This study provides empirical support for Social Information Processing theory in a naturalistic context while offering insight into the complicated way in which “honesty” is enacted online.

Shirk, J. L., H. L. Ballard, C. C. Wilderman, T. Phillips, A. Wiggins, R. Jordan, E. McCallie, M. Minarchek, B. V. Lewenstein, M. E. Krasny, and R. Bonney. 2012. Public participation in scientific research: a framework for deliberate design. Ecology and Society 17(2): 29. https://doi.org/10.5751/ES-04705-170229

This study examined the impact of a realistic merger preview, a program of realistic communications, on employees of an organization that had just announced a merger. Employees in one plant received the preview and those in another received limited information. Results based on four collections of data indicated that the preview reduced dysfunctional outcomes of the merger. Those effects continued over the duration of the study and, in some cases, measured attributes returned to levels comparable to their levels before the merger was announced. We discuss implications for organizations contemplating mergers or acquisitions and for researchers interested in such activities.

This research assessed the causes and consequences of job insecurity using a new theory-based measure incorporating recent conceptual arguments. We also compared the measure's reliability and const...

Resilience in human development is defined in relation to positive adaptation in the context of significant adversity, emphasizing a developmental systems approach. A brief history and glossary on the central concepts of resilience research in developmental science are provided, and the fundamental models and strategies guiding the research are described. Major findings of the first four decades of research are summarized in terms of protective and promotive factors consistently associated with resilience in diverse situations and populations of young people. These factors—such as self-regulation skills, good parenting, community resources, and effective schools—suggest that resilience arises from ordinary protective processes, common but powerful, that protect human development under diverse conditions. The greatest threats posed to children may be adversities that damage or undermine these basic human protective systems. Implications of these findings for theory and practice are discussed, highlighting three strategies of fostering resilience, focused on reducing risk, building strengths or assets, and mobilizing adaptive systems that protect and restore positive human development. The concluding section outlines future directions of resilience research and its applications, including rapidly growing efforts to integrate research and prevention efforts across disciplines, from genetics to ecology, and across level of analysis, from molecules to media.

Abstract This article summarizes the results and conclusions reached in studies of the relationships between race and gender diversity and business performance carried out in four large firms by a research consortium known as the Diversity Research Network. These researchers were asked by the BOLD Initiative to conduct this research to test arguments regarding the “business case” for diversity. Few positive or negative direct effects of diversity on performance were observed. Instead a number of different aspects of the organizational context and some group processes moderated diversity‐performance relationships. This suggests a more nuanced view of the “business case” for diversity may be appropriate. © 2003 Wiley Periodicals, Inc.

Core-shell nanoparticles (CSNs) are a class of nanostructured materials that have recently received increased attention owing to their interesting properties and broad range of applications in catalysis, biology, materials chemistry and sensors. By rationally tuning the cores as well as the shells of such materials, a range of core-shell nanoparticles can be produced with tailorable properties that can play important roles in various catalytic processes and offer sustainable solutions to current energy problems. Various synthetic methods for preparing different classes of CSNs, including the Stöber method, solvothermal method, one-pot synthetic method involving surfactants, etc., are briefly mentioned here. The roles of various classes of CSNs are exemplified for both catalytic and electrocatalytic applications, including oxidation, reduction, coupling reactions, etc.

Most management problems involve multilevel phenomena, yet most management research uses a single level of analysis. A micro or a macro lens alone yields incomplete understanding at either level. Multilevel research addresses the levels of theory, measurement, and analysis required to fully examine research questions. This forum presents multilevel research on bribery, national identity, team boundary spanning, professional role identity, organizational citizenship, interorganizational exchanges, and divestitures. To enrich the impact of future management research, we recommend (1) applying multilevel designs to existing models (2) considering bottom-up effects, (3) collaborating across disciplines on multidisciplinary topics, and (4) addressing major real-world problems via multilevel approaches.