Salisbury University

Abstract Multi-epoch radial velocity measurements of stars can be used to identify stellar, substellar, and planetary-mass companions. Even a small number of observation epochs can be informative about companions, though there can be multiple qualitatively different orbital solutions that fit the data. We have custom-built a Monte Carlo sampler ( The Joker ) that delivers reliable (and often highly multimodal) posterior samplings for companion orbital parameters given sparse radial velocity data. Here we use The Joker to perform a search for companions to 96,231 red giant stars observed in the APOGEE survey (DR14) with ≥3 spectroscopic epochs. We select stars with probable companions by making a cut on our posterior belief about the amplitude of the variation in stellar radial velocity induced by the orbit. We provide (1) a catalog of 320 companions for which the stellar companion’s properties can be confidently determined, (2) a catalog of 4898 stars that likely have companions, but would require more observations to uniquely determine the orbital properties, and (3) posterior samplings for the full orbital parameters for all stars in the parent sample. We show the characteristics of systems with confidently determined companion properties and highlight interesting systems with candidate compact object companions.

INTRODUCTION: Strengthening The Reporting Of Cohort Studies in Surgery (STROCSS) guidelines were developed in 2017 in order to improve the reporting quality of observational studies in surgery and updated in 2019. In order to maintain relevance and continue upholding good reporting quality among observational studies in surgery, we aimed to update STROCSS 2019 guidelines. METHODS: A STROCSS 2021 steering group was formed to come up with proposals to update STROCSS 2019 guidelines. An expert panel of researchers assessed these proposals and judged whether they should become part of STROCSS 2021 guidelines or not, through a Delphi consensus exercise. RESULTS: 42 people (89%) completed the DELPHI survey and hence participated in the development of STROCSS 2021 guidelines. All items received a score between 7 and 9 by greater than 70% of the participants, indicating a high level of agreement among the DELPHI group members with the proposed changes to all the items. CONCLUSION: We present updated STROCSS 2021 guidelines to ensure ongoing good reporting quality among observational studies in surgery.

Abstract Objective : To study the association between upper and lower respiratory viral infections and acute exacerbations of asthma in schoolchildren in the community. Design : Community based 13 month longitudinal study using diary card respiratory symptom and peak expiratory flow monitoring to allow early sampling for viruses. Subjects : 108 Children aged 9-11 years who had reported wheeze or cough, or both, in a questionnaire. Setting : Southampton and surrounding community. Main outcome measures : Upper and lower respiratory viral infections detected by polymerase chain reaction or conventional methods, reported exacerbations of asthma, computer identified episodes of respiratory tract symptoms or peak flow reductions. Results : Viruses were detected in 80% of reported episodes of reduced peak expiratory flow, 80% of reported episodes of wheeze, and in 85% of reported episodes of upper respiratory symptoms, cough, wheeze, and a fall in peak expiratory flow. The median duration of reported falls in peak expiratory flow was 14 days, and the median maximum fall in peak expiratory flow was 81 1/min. The most commonly identified virus type was rhinovirus. Conclusions : This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children. Key messages Key messages In this study common cold viruses were found in 80-85% of reported exacerbations of asthma in children Rhinoviruses, which cause most common colds, accounted for two thirds of viruses detected Analysis of diary cards also showed large numbers of similar but less severe episodes that may also be viral in origin

Losses from environmental hazards have escalated in the past decade, prompting a reorientation of emergency management systems away from simple postevent response. There is a noticeable change in policy, with more emphasis on loss reduction through mitigation, preparedness, and recovery programs. Effective mitigation of losses from hazards requires hazard identification, an assessment of all the hazards likely to affect a given place, and risk-reduction measures that are compatible across a multitude of hazards. The degree to which populations are vulnerable to hazards, however, is not solely dependent upon proximity to the source of the threat or the physical nature of the hazard –social factors also play a significant role in determining vulnerability. This paper presents a method for assessing vulnerability in spatial terms using both biophysical and social indicators. A geographic information system was utilized to establish areas of vulnerability based upon twelve environmental threats and eight social characteristics for our study area, Georgetown County, South Carolina. Our results suggest that the most biophysically vulnerable places do not always spatially intersect with the most vulnerable populations. This is an important finding because it reflects the likely ‘social costs’ of hazards on the region. While economic losses might be large in areas of high biophysical risk, the resident population also may have greater safety nets (insurance, additional financial resources) to absorb and recover from the loss quickly. Conversely, it would take only a moderate hazard event to disrupt the well-being of the majority of county residents (who are more socially vulnerable, but perhaps do not reside in the highest areas of biophysical risks) and retard their longer-term recovery from disasters. This paper advances our theoretical and conceptual understanding of the spatial dimensions of vulnerability. It further highlights the merger of conceptualizations of human environment relationships with geographical techniques in understanding contemporary public policy issues.

The Gram-negative bacterium Yersinia pestis is the causative agent of the systemic invasive infectious disease classically referred to as plague, and has been responsible for three human pandemics: the Justinian plague (sixth to eighth centuries), the Black Death (fourteenth to nineteenth centuries) and modern plague (nineteenth century to the present day). The recent identification of strains resistant to multiple drugs and the potential use of Y. pestis as an agent of biological warfare mean that plague still poses a threat to human health. Here we report the complete genome sequence of Y. pestis strain CO92, consisting of a 4.65-megabase (Mb) chromosome and three plasmids of 96.2 kilobases (kb), 70.3 kb and 9.6 kb. The genome is unusually rich in insertion sequences and displays anomalies in GC base-composition bias, indicating frequent intragenomic recombination. Many genes seem to have been acquired from other bacteria and viruses (including adhesins, secretion systems and insecticidal toxins). The genome contains around 150 pseudogenes, many of which are remnants of a redundant enteropathogenic lifestyle. The evidence of ongoing genome fluidity, expansion and decay suggests Y. pestis is a pathogen that has undergone large-scale genetic flux and provides a unique insight into the ways in which new and highly virulent pathogens evolve.

Dental plaque is a structurally- and functionally-organized biofilm. Plaque forms in an ordered way and has a diverse microbial composition that, in health, remains relatively stable over time (microbial homeostasis). The predominant species from diseased sites are different from those found in healthy sites, although the putative pathogens can often be detected in low numbers at normal sites. In dental caries, there is a shift toward community dominance by acidogenic and acid-tolerating species such as mutans streptococci and lactobacilli, although other species with relevant traits may be involved. Strategies to control caries could include inhibition of biofilm development (e.g. prevention of attachment of cariogenic bacteria, manipulation of cell signaling mechanisms, delivery of effective antimicrobials, etc.), or enhancement of the host defenses. Additionally, these more conventional approaches could be augmented by interference with the factors that enable the cariogenic bacteria to escape from the normal homeostatic mechanisms that restrict their growth in plaque and out compete the organisms associated with health. Evidence suggests that regular conditions of low pH in plaque select for mutans streptococci and lactobacilli. Therefore, the suppression of sugar catabolism and acid production by the use of metabolic inhibitors and non-fermentable artificial sweeteners in snacks, or the stimulation of saliva flow, could assist in the maintenance of homeostasis in plaque. Arguments will be presented that an appreciation of ecological principles will enable a more holistic approach to be taken in caries control.

Collaboration with external supply chain entities influences increased internal collaboration, which in turn improves service performance. This relationship may be the key to helping managers understand how best to facilitate behavioral change. The implication is that collaborating with customers and suppliers is a first step toward effective collaboration within the firm.

ABSTRACT Members of the Institutional Investor All‐American Research Team supply more accurate earnings forecasts than other analysts when forecasts are matched by the corporation followed and by the date of brokerage house issuance. This contemporaneous advantage is complemented by a timing advantage; All‐Americans supply forecasts more often than other analysts. Stocks returns immediately following large upward forecast revisions suggest that All‐Americans impact prices more than other analysts. However, there is virtually no difference in returns following large downward revisions. Nevertheless, the collective results suggest a positive relation between reputation and performance, and, assuming that All‐Americans are better paid, pay and performance.

The intranasal inoculation of volunteers with living partially attenuated strains of influenza A and B viruses offers a new opportunity to determine the protective effect of serum haemagglutin-inhibiting antibody against a strictly homologous virus, under conditions where the time and dosage of the infective challenge can be controlled, the scoring of proven infections can be more precise and higher rates of infection can be achieved than in most natural epidemics.In 1032 adult volunteers, whose serum HI antibody titre was determined immediately before virus challenge, there was a consistent inverse quantitative relationship between the HI titre and the likelihood of infection. The PD 50 (50% protective dose) of HI antibody was 1/18-1/36, but an unusual finding was that volunteers with no detectable pre-challenge antibody often seem to be less susceptible to infection than those with pre-challenge antibody in low titre.In one group of volunteers challenged with an influenza B strain there was no evidence that pre-challenge antibody titres against viral neuraminidase had any significant protective effect against challenge infection.

During the time, 3.2 ×109 years, that life has been present on Earth, the physical and chemical conditions of most of the planetary surface have never varied from those most favourable for life. The geological record reads that liquid water was always present and that the pH was never far from neutral. During this same period, however, the Earth's radiation environment underwent large changes. As the sun moved along the course set by the main sequence of stars its output will have increased at least 30% and possibly 100%. It may also have fluctuated in brightness over periods of a few million years. At the same time hydrogen was escaping to space from the Earth and so causing progressive changes in the chemical environment. This in turn through atmospheric compositional changes could have affected the Earth's radiation balance. It may have been that these physical and chemical changes always by blind chance followed the path whose bounds are the conditions favouring the continued existence of life. This paper offers an alternative explanation that, early after life began it acquired control of the planetary environment and that this homeostasis by and for the biosphere has persisted ever since. Historic and contemporary evidence and arguments for this hypothesis will be presented.DOI: 10.1111/j.2153-3490.1974.tb01946.x

To provide high resolution local, regional, national, and global estimates of annual mangrove forest levels from 2000 through to 2012 with the goal of driving mangrove research questions pertaining to biodiversity, carbon, climate change, functionality, food security, livelihoods, fisheries support, and conservation that have been impeded until now by a lack of suitable data. We synthesize the Global Forest Change database, the Terrestrial Ecosystems of the World database, and Mangrove Forests of the World database to extract mangrove forest cover at high spatial and temporal resolutions. We then use the new database to monitor mangrove cover at the global, national, and protected area levels. Countries showing relatively high levels of mangrove loss include Myanmar, Malaysia, Cambodia, Indonesia, and Guatemala. Indonesia remains by far the largest mangrove-holding nation containing between 26 percent and 28 percent of the global mangrove inventory with a deforestation rate of between 0.26 percent and 0.63 percent annually.Global mangrove deforestation continues but at a much reduced rate of between 0.16 percent and 0.39 percent annually. Southeast Asia is a region of concern with mangrove deforestation rates between 3.58 percent and 7.86 percent during the analysis period, this in a region containing almost half of the entire global mangrove forest inventory. The global mangrove deforestation pattern from 2000 to 2012 is one of decreasing rates of deforestation, with many nations essentially stable, with the exception of the largest mangrove-holding region of Southeast Asia.

Abstract Aim To provide high‐resolution local, regional, national and global estimates of annual mangrove forest area from 2000 through to 2012 with the goal of driving mangrove research questions pertaining to biodiversity, carbon stocks, climate change, functionality, food security, livelihoods, fisheries support and conservation that have been impeded until now by a lack of suitable data. Location Global, covering 99% of all mangrove forests. Methods We synthesized the Global Forest Change database, the Terrestrial Ecosystems of the World database and the Mangrove Forests of the World database to extract mangrove forest cover at high spatial and temporal resolutions. We then used the new database to monitor mangrove cover at the global, national and protected area scales. Results Countries showing relatively high amounts of mangrove loss include Myanmar, Malaysia, Cambodia, Indonesia and Guatemala. Indonesia remains by far the largest mangrove‐holding nation, containing between 26% and 29% of the global mangrove inventory with a deforestation rate of between 0.26% and 0.66% per year. We have made our new database, CGMFC‐21, freely available. Main conclusions Global mangrove deforestation continues but at a much reduced rate of between 0.16% and 0.39% per year. Southeast Asia is a region of concern with mangrove deforestation rates between 3.58% and 8.08%, this in a region containing half of the entire global mangrove forest inventory. The global mangrove deforestation pattern from 2000 to 2012 is one of decreasing rates of deforestation, with many nations essentially stable, with the exception of the largest mangrove‐holding region of Southeast Asia. We provide a standardized spatial dataset that monitors mangrove deforestation globally at high spatio‐temporal resolutions. These data can be used to drive the mangrove research agenda, particularly as it pertains to monitoring of mangrove carbon stocks and the establishment of baseline local mangrove forest inventories required for payment for ecosystem service initiatives.

Robot Hands and the Mechanics of Manipulation explores several aspects of the basic mechanics of grasping, pushing, and in general, manipulating objects. It makes a significant contribution to the understanding of the motion of objects in the presence of friction, and to the development of fine position and force controlled articulated hands capable of doing useful work. In the book's first section, kinematic and force analysis is applied to the problem of designing and controlling articulated hands for manipulation. The analysis of the interface between fingertip and grasped object then becomes the basis for the specification of acceptable hand kinematics. A practical result of this work has been the development of the Stanford/JPL robot hand - a tendon-actuated, 9 degree-of-freedom hand which is being used at various laboratories around the country to study the associated control and programming problems aimed at improving robot dexterity. Chapters in the second section study the characteristics of object motion in the presence of friction. Systematic exploration of the mechanics of pushing leads to a model of how an object moves under the combined influence of the manipulator and the forces of sliding friction. The results of these analyses are then used to demonstrate verification and automatic planning of some simple manipulator operations. Matthew T. Mason is Assistant Professor of Computer Science at Carnegie-Mellon University, and coeditor of Robot Motion (MIT Press 1983). J. Kenneth Salisbury, Jr. is a Research Scientist at MIT's Artificial Intelligence Laboratory, and president of Salisbury Robotics, Inc. Robot Hands and the Mechanics of Manipulation is 14th in theArtificial Intelligence Series, edited by Patrick Henry Winston and Michael Brady.

Intertidal mangrove forests are a dynamic ecosystem experiencing rapid changes in extent and habitat quality over geological history, today and into the future. Climate and sea level have drastically altered mangrove distribution since their appearance in the geological record ∼75 million years ago (Mya), through to the Holocene. In contrast, contemporary mangrove dynamics are driven primarily by anthropogenic threats, including pollution, overextraction, and conversion to aquaculture and agriculture. Deforestation rates have declined in the past decade, but the future of mangroves is uncertain; new deforestation frontiers are opening, particularly in Southeast Asia and West Africa, despite international conservation policies and ambitious global targets for rehabilitation. In addition, geological and climatic processes such as sea-level rise that were important over geological history will continue to influence global mangrove distribution in the future. Recommendations are given to reframe mangrove conservation, with a view to improving the state of mangroves in the future.

The significance of the change in direction dispersion on applying the fold test in palaeomagnetism is used as the criterion for deciding whether or not the fold test has statistical significance. A set of tables is compiled which can be used for quick application of the test.

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsRobert KirschRobert Kirsch is an instructor of philosophy at Salisbury University in Maryland, USA. He focuses on applying critical political theory to economic and fiscal policies of advanced industrial democracies, especially sovereign debt markets.

OBJECTIVE: To establish the incidence and aetiology of infectious intestinal disease in the community and presenting to general practitioners. Comparison with incidence and aetiology of cases reaching national laboratory based surveillance. DESIGN: Population based community cohort incidence study, general practice based incidence studies, and case linkage to national laboratory surveillance. SETTING: 70 general practices throughout England. PARTICIPANTS: 459 975 patients served by the practices. Community surveillance of 9776 randomly selected patients. MAIN OUTCOME MEASURES: Incidence of infectious intestinal disease in community and reported to general practice. RESULTS: 781 cases were identified in the community cohort, giving an incidence of 19.4/100 person years (95% confidence interval 18.1 to 20.8). 8770 cases presented to general practice (3.3/100 person years (2.94 to 3.75)). One case was reported to national surveillance for every 1.4 laboratory identifications, 6.2 stools sent for laboratory investigation, 23 cases presenting to general practice, and 136 community cases. The ratio of cases in the community to cases reaching national surveillance was lower for bacterial pathogens (salmonella 3.2:1, campylobacter 7.6:1) than for viruses (rotavirus 35:1, small round structured viruses 1562:1). There were many cases for which no organism was identified. CONCLUSIONS: Infectious intestinal disease occurs in 1 in 5 people each year, of whom 1 in 6 presents to a general practitioner. The proportion of cases not recorded by national laboratory surveillance is large and varies widely by microorganism. Ways of supplementing the national laboratory surveillance system for infectious intestinal diseases should be considered.

Abstract A constant concern of management information systems (MIS) researchers and practitioners has been improving user satisfaction with the information services function (USISF). Due to the growth of end‐user computing, decentralization, and alternative sources of supply, an organization's information services function (ISF) is now faced with serving customers that possess substantial discretion in their use and purchase of information systems (IS) services. This increasingly market‐oriented environment demands sensitivity to IS customers' expectations and perceived value of ISF services. One important source of guidance in such an IS management environment is to look at marketing literature for frameworks that may permit the ISF to more effectively determine and convey the value of their services. Recognizing the need to improve existing MIS measures of user satisfaction with the ISF, this study adapts the SERVQUAL measure from marketing to provide more specific information about user satisfaction with the information service function. It was found that, while the three original dimensions of the traditional user information satisfaction (UIS) measure remain strong predictors of overall ISF user satisfaction, two aspects of IS service quality, “reliability” and “empathy,” are also significant predictors. The results suggest that the original dimensions of UIS may not be comprehensive enough to capture the more detailed dimensions of ISF service quality in SERVQUAL, and that the reliability and empathy dimensions of service quality may be needed to supplement the traditional UIS measure in determining user satisfaction with the information services function. Implications for research and practice resulting from these findings are discussed.

Vaccination has had a major impact on the control of infectious diseases. However, there are still many infectious diseases for which the development of an effective vaccine has been elusive. In many cases the failure to devise vaccines is a consequence of the inability of vaccine candidates to evoke appropriate immune responses. This is especially true where cellular immunity is required for protective immunity and this problem is compounded by the move toward devising sub-unit vaccines. Over the past decade nanoscale size (<1000 nm) materials such as virus-like particles, liposomes, ISCOMs, polymeric, and non-degradable nanospheres have received attention as potential delivery vehicles for vaccine antigens which can both stabilize vaccine antigens and act as adjuvants. Importantly, some of these nanoparticles (NPs) are able to enter antigen-presenting cells by different pathways, thereby modulating the immune response to the antigen. This may be critical for the induction of protective Th1-type immune responses to intracellular pathogens. Their properties also make them suitable for the delivery of antigens at mucosal surfaces and for intradermal administration. In this review we compare the utilities of different NP systems for the delivery of sub-unit vaccines and evaluate the potential of these delivery systems for the development of new vaccines against a range of pathogens.

1. The mechanism of the anti-nutritive activities of soluble non-starch polysaccharides (NSPs) in broiler diets was investigated with emphasis on the inter-relationship between viscosity and fermentation along the gut. Isolated soluble NSP were added to a control diet to effect high gut viscosity, and in vivo depolymerisation of the NSP was achieved using a commercial glycanase. 2. Addition of soluble NSPs significantly (P < 0.01) increased gut viscosity, reduced the AME of the diet and depressed the growth and FCE of the birds. Enzyme supplementation of the NSP-enriched diet reversed the adverse effects, increasing (P < 0.01) weight gain, FCE and AME. Comparisons of the viscosities (mPa) in birds fed on the NSP-enriched diet and the same diet supplemented with enzyme were respectively: 11.9 v. 2.3 in the duodenum; 78.3 v. 4.4 in the jejunum and 409.3 v. 10.8 in the ileum. 3. Caecal volatile fatty acid concentration was markedly (P < 0.01) elevated by enzyme supplementation, whereas ileal fermentation was inhibited. 4. Microscopic examination revealed that, among birds fed on the NSP-enriched diet, there had been extensive small intestinal fermentation, which was eliminated by the enzyme supplementation. 5. Addition of a synthetic antibiotic (Amoxil) had no beneficial effects. 6. The current study demonstrated that increased fermentation occurs in the small intestine when a large amount of viscous NSPs is present in the diet and this is detrimental to the performance and well-being of poultry.