Southeast University

Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as "smart" mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.

OBJECTIVE: To evaluate the efficacy and safety of tadalafil monotherapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). METHODS: A comprehensive search was done to identify randomized controlled trials comparing the efficacy and safety of tadalafil for LUTS/BPH with placebos. Meta-analytical techniques were applied to evaluate the differences in the study results. RESULTS: Eight studies were identified and analyzed. Compared with placebo, tadalafil was associated with significant improvements in the International Prostate Symptom Score (IPSS) (mean difference = -2.19, p < 0.00001) and the International Index of Erectile Function (IIEF) score (mean difference = +4.66, p < 0.00001), despite the concomitant presence of erectile dysfunction. Significant differences were also observed in the IPSS irritative and obstructive subscores, IPSS quality of life index and BPH impact index. After pooling four doses (2.5, 5, 10 and 20 mg), tadalafil failed to produce a significant outcome in maximal urinary flow rate (Qmax) (mean difference = +0.26 ml/s, p = 0.14), but 5 mg of tadalafil significantly improved Qmax (mean difference = +0.63 ml/s, p = 0.04). No significant difference was detected in the incidence of serious adverse events (risk ratio = 1.00, p = 1.00) after tadalafil treatment. CONCLUSIONS: Tadalafil showed good efficacy and safety for improving LUTS and erectile dysfunction in men with BPH, and 5 mg of tadalafil significantly improved Qmax.

Metamaterials are artificial structures that are usually described by effective medium parameters on the macroscopic scale, and these metamaterials are referred to as ‘analog metamaterials’. Here, we propose ‘digital metamaterials’ through two steps. First, we present ‘coding metamaterials’ that are composed of only two types of unit cells, with 0 and π phase responses, which we name ‘0’ and ‘1’ elements, respectively. By coding ‘0’ and ‘1’ elements with controlled sequences (i.e., 1-bit coding), we can manipulate electromagnetic (EM) waves and realize different functionalities. The concept of coding metamaterials can be extended from 1-bit coding to 2-bit coding or higher. In 2-bit coding, four types of unit cells, with phase responses of 0, π/2, π, and 3π/2, are required to mimic the ‘00’, ‘01’, ‘10’ and ‘11’ elements, respectively. The 2-bit coding has greater freedom than 1-bit coding for controlling EM waves. Second, we propose a unique metamaterial particle that has either a ‘0’ or ‘1’ response controlled by a biased diode. Based on this particle, we present ‘digital metamaterials’ with unit cells that possess either a ‘0’ or ‘1’ state. Using a field-programmable gate array, we realize digital control over the digital metamaterial. By programming different coding sequences, a single digital metamaterial has the ability to manipulate EM waves in different manners, thereby realizing ‘programmable metamaterials’. The above concepts and physical phenomena are confirmed through numerical simulations and experiments using metasurfaces. Smart materials offering great freedom in manipulating electromagnetic radiation have been developed. This exciting new concept was realized by Tie Jun Cui and co-workers at the Southeast University, China, who developed digital metamaterials consisting of two kinds of unit cells whose different phase responses allow them to act as ‘0’ and ‘1’ bits. These cells can be judiciously arranged in sequences to enable controlled manipulation of electromagnetic waves. This is one-bit coding; higher-bit coding is possible by employing more kinds of unit cells. The researchers developed a metamaterial cell whose binary response can be controlled by a biased diode. By using a field-programmable gate array, they demonstrated that this digital metamaterial can be programmed. Such metamaterials are attractive for controlling radiation beams in antennas and for realizing other ‘smart’ metamaterials.

Multi-label learning studies the problem where each example is represented by a single instance while associated with a set of labels simultaneously. During the past decade, significant amount of progresses have been made toward this emerging machine learning paradigm. This paper aims to provide a timely review on this area with emphasis on state-of-the-art multi-label learning algorithms. Firstly, fundamentals on multi-label learning including formal definition and evaluation metrics are given. Secondly and primarily, eight representative multi-label learning algorithms are scrutinized under common notations with relevant analyses and discussions. Thirdly, several related learning settings are briefly summarized. As a conclusion, online resources and open research problems on multi-label learning are outlined for reference purposes.

MOTIVATION: RNA-seq has been extensively used for transcriptome study. Quality control (QC) is critical to ensure that RNA-seq data are of high quality and suitable for subsequent analyses. However, QC is a time-consuming and complex task, due to the massive size and versatile nature of RNA-seq data. Therefore, a convenient and comprehensive QC tool to assess RNA-seq quality is sorely needed. RESULTS: We developed the RSeQC package to comprehensively evaluate different aspects of RNA-seq experiments, such as sequence quality, GC bias, polymerase chain reaction bias, nucleotide composition bias, sequencing depth, strand specificity, coverage uniformity and read distribution over the genome structure. RSeQC takes both SAM and BAM files as input, which can be produced by most RNA-seq mapping tools as well as BED files, which are widely used for gene models. Most modules in RSeQC take advantage of R scripts for visualization, and they are notably efficient in dealing with large BAM/SAM files containing hundreds of millions of alignments. AVAILABILITY AND IMPLEMENTATION: RSeQC is written in Python and C. Source code and a comprehensive user's manual are freely available at: http://code.google.com/p/rseqc/.

Disturbance-observer-based control (DOBC) and related methods have been researched and applied in various industrial sectors in the last four decades. This survey, at first time, gives a systematic and comprehensive tutorial and summary on the existing disturbance/uncertainty estimation and attenuation techniques, most notably, DOBC, active disturbance rejection control, disturbance accommodation control, and composite hierarchical antidisturbance control. In all of these methods, disturbance and uncertainty are, in general, lumped together, and an observation mechanism is employed to estimate the total disturbance. This paper first reviews a number of widely used linear and nonlinear disturbance/uncertainty estimation techniques and then discusses and compares various compensation techniques and the procedures of integrating disturbance/uncertainty compensation with a (predesigned) linear/nonlinear controller. It also provides concise tutorials of the main methods in this area with clear descriptions of their features. The application of this group of methods in various industrial sections is reviewed, with emphasis on the commercialization of some algorithms. The survey is ended with the discussion of future directions.

autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Non-orthogonal multiple access (NOMA) is an essential enabling technology for the fifth-generation (5G) wireless networks to meet the heterogeneous demands on low latency, high reliability, massive connectivity, improved fairness, and high throughput. The key idea behind NOMA is to serve multiple users in the same resource block, such as a time slot, subcarrier, or spreading code. The NOMA principle is a general framework, and several recently proposed 5G multiple access schemes can be viewed as special cases. This survey provides an overview of the latest NOMA research and innovations as well as their applications. Thereby, the papers published in this special issue are put into the context of the existing literature. Future research challenges regarding NOMA in 5G and beyond are also discussed.

This paper reviews some main results and progress in distributed multi-agent coordination, focusing on papers published in major control systems and robotics journals since 2006. Distributed coordination of multiple vehicles, including unmanned aerial vehicles, unmanned ground vehicles, and unmanned underwater vehicles, has been a very active research subject studied extensively by the systems and control community. The recent results in this area are categorized into several directions, such as consensus, formation control, optimization, and estimation. After the review, a short discussion section is included to summarize the existing research and to propose several promising research directions along with some open problems that are deemed important for further investigations.

Federated learning (FL), as a type of distributed machine learning, is capable of significantly preserving clients’ private data from being exposed to adversaries. Nevertheless, private information can still be divulged by analyzing uploaded parameters from clients, e.g., weights trained in deep neural networks. In this paper, to effectively prevent information leakage, we propose a novel framework based on the concept of differential privacy (DP), in which artificial noise is added to parameters at the clients’ side before aggregating, namely, noising before model aggregation FL (NbAFL). First, we prove that the NbAFL can satisfy DP under distinct protection levels by properly adapting different variances of artificial noise. Then we develop a theoretical convergence bound on the loss function of the trained FL model in the NbAFL. Specifically, the theoretical bound reveals the following three key properties: 1) there is a tradeoff between convergence performance and privacy protection levels, i.e., better convergence performance leads to a lower protection level; 2) given a fixed privacy protection level, increasing the number <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> of overall clients participating in FL can improve the convergence performance; and 3) there is an optimal number aggregation times (communication rounds) in terms of convergence performance for a given protection level. Furthermore, we propose a <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> -client random scheduling strategy, where <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1\leq K&lt; N$ </tex-math></inline-formula> ) clients are randomly selected from the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> overall clients to participate in each aggregation. We also develop a corresponding convergence bound for the loss function in this case and the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> -client random scheduling strategy also retains the above three properties. Moreover, we find that there is an optimal <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$K$ </tex-math></inline-formula> that achieves the best convergence performance at a fixed privacy level. Evaluations demonstrate that our theoretical results are consistent with simulations, thereby facilitating the design of various privacy-preserving FL algorithms with different tradeoff requirements on convergence performance and privacy levels.

Thousands of novel transcripts have been identified using deep transcriptome sequencing. This discovery of large and 'hidden' transcriptome rejuvenates the demand for methods that can rapidly distinguish between coding and noncoding RNA. Here, we present a novel alignment-free method, Coding Potential Assessment Tool (CPAT), which rapidly recognizes coding and noncoding transcripts from a large pool of candidates. To this end, CPAT uses a logistic regression model built with four sequence features: open reading frame size, open reading frame coverage, Fickett TESTCODE statistic and hexamer usage bias. CPAT software outperformed (sensitivity: 0.96, specificity: 0.97) other state-of-the-art alignment-based software such as Coding-Potential Calculator (sensitivity: 0.99, specificity: 0.74) and Phylo Codon Substitution Frequencies (sensitivity: 0.90, specificity: 0.63). In addition to high accuracy, CPAT is approximately four orders of magnitude faster than Coding-Potential Calculator and Phylo Codon Substitution Frequencies, enabling its users to process thousands of transcripts within seconds. The software accepts input sequences in either FASTA- or BED-formatted data files. We also developed a web interface for CPAT that allows users to submit sequences and receive the prediction results almost instantly.

This paper studies unmanned aerial vehicle (UAV)-enabled wireless communication, where a rotary-wing UAV is dispatched to communicate with multiple ground nodes (GNs). We aim to minimize the total UAV energy consumption, including both propulsion energy and communication related energy, while satisfying the communication throughput requirement of each GN. To this end, we first derive a closed-form propulsion power consumption model for rotary-wing UAVs, and then formulate the energy minimization problem by jointly optimizing the UAV trajectory and communication time allocation among GNs, as well as the total mission completion time. The problem is difficult to be optimally solved, as it is non-convex and involves infinitely many variables over time. To tackle this problem, we first consider the simple fly-hover-communicate design, where the UAV successively visits a set of hovering locations and communicates with one corresponding GN while hovering at each location. For this design, we propose an efficient algorithm to optimize the hovering locations and durations, as well as the flying trajectory connecting these hovering locations, by leveraging the travelling salesman problem with neighborhood and convex optimization techniques. Next, we consider the general case, where the UAV also communicates while flying. We propose a new path discretization method to transform the original problem into a discretized equivalent with a finite number of optimization variables, for which we obtain a high-quality suboptimal solution by applying the successive convex approximation technique. The numerical results show that the proposed designs significantly outperform the benchmark schemes.

IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

Abstract The fifth generation (5G) wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized, such as mass connectivity, ultra-reliability, and guaranteed low latency. However, 5G will not meet all requirements of the future in 2030 and beyond, and sixth generation (6G) wireless communication networks are expected to provide global coverage, enhanced spectral/energy/cost efficiency, better intelligence level and security, etc. To meet these requirements, 6G networks will rely on new enabling technologies, i.e., air interface and transmission technologies and novel network architecture, such as waveform design, multiple access, channel coding schemes, multi-antenna technologies, network slicing, cell-free architecture, and cloud/fog/edge computing. Our vision on 6G is that it will have four new paradigm shifts. First, to satisfy the requirement of global coverage, 6G will not be limited to terrestrial communication networks, which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle (UAV) communication networks, thus achieving a space-air-ground-sea integrated communication network. Second, all spectra will be fully explored to further increase data rates and connection density, including the sub-6 GHz, millimeter wave (mmWave), terahertz (THz), and optical frequency bands. Third, facing the big datasets generated by the use of extremely heterogeneous networks, diverse communication scenarios, large numbers of antennas, wide bandwidths, and new service requirements, 6G networks will enable a new range of smart applications with the aid of artificial intelligence (AI) and big data technologies. Fourth, network security will have to be strengthened when developing 6G networks. This article provides a comprehensive survey of recent advances and future trends in these four aspects. Clearly, 6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears.

Fifth generation (5G) mobile communication systems have entered the stage of commercial deployment, providing users with new services, improved user experiences as well as a host of novel opportunities to various industries. However, 5G still faces many challenges. To address these challenges, international industrial, academic, and standards organizations have commenced research on sixth generation (6G) wireless communication systems. A series of white papers and survey papers have been published, which aim to define 6G in terms of requirements, application scenarios, key technologies, etc. Although ITU-R has been working on the 6G vision and it is expected to reach a consensus on what 6G will be by mid-2023, the related global discussions are still wide open and the existing literature has identified numerous open issues. This paper first provides a comprehensive portrayal of the 6G vision, technical requirements, and application scenarios, covering the current common understanding of 6G. Then, a critical appraisal of the 6G network architecture and key technologies is presented. Furthermore, existing testbeds and advanced 6G verification platforms are detailed for the first time. In addition, future research directions and open challenges are identified to stimulate the on-going global debate. Finally, lessons learned to date concerning 6G networks are discussed.

Given the potential risk of X-ray radiation to the patient, low-dose CT has attracted a considerable interest in the medical imaging field. Currently, the main stream low-dose CT methods include vendor-specific sinogram domain filtration and iterative reconstruction algorithms, but they need to access raw data, whose formats are not transparent to most users. Due to the difficulty of modeling the statistical characteristics in the image domain, the existing methods for directly processing reconstructed images cannot eliminate image noise very well while keeping structural details. Inspired by the idea of deep learning, here we combine the autoencoder, deconvolution network, and shortcut connections into the residual encoder-decoder convolutional neural network (RED-CNN) for low-dose CT imaging. After patch-based training, the proposed RED-CNN achieves a competitive performance relative to the-state-of-art methods in both simulated and clinical cases. Especially, our method has been favorably evaluated in terms of noise suppression, structural preservation, and lesion detection.

Reconfigurable intelligent surfaces (RISs) comprised of tunable unit cells have recently drawn significant attention due to their superior capability in manipulating electromagnetic waves. In particular, RIS-assisted wireless communications have the great potential to achieve significant performance improvement and coverage enhancement in a cost-effective and energy-efficient manner, by properly programming the reflection coefficients of the unit cells of RISs. In this article, free-space path loss models for RIS-assisted wireless communications are developed for different scenarios by studying the physics and electromagnetic nature of RISs. The proposed models, which are first validated through extensive simulation results, reveal the relationships between the free-space path loss of RIS-assisted wireless communications and the distances from the transmitter/receiver to the RIS, the size of the RIS, the near-field/far-field effects of the RIS, and the radiation patterns of antennas and unit cells. In addition, three fabricated RISs (metasurfaces) are utilized to further corroborate the theoretical findings through experimental measurements conducted in a microwave anechoic chamber. The measurement results match well with the modeling results, thus validating the proposed free-space path loss models for RISs, which may pave the way for further theoretical studies and practical applications in this field.

We develop a novel deep learning framework to achieve highly accurate machine fault diagnosis using transfer learning to enable and accelerate the training of deep neural network. Compared with existing methods, the proposed method is faster to train and more accurate. First, original sensor data are converted to images by conducting a Wavelet transformation to obtain time-frequency distributions. Next, a pretrained network is used to extract lower level features. The labeled time-frequency images are then used to fine-tune the higher levels of the neural network architecture. This paper creates a machine fault diagnosis pipeline and experiments are carried out to verify the effectiveness and generalization of the pipeline on three main mechanical datasets including induction motors, gearboxes, and bearings with sizes of 6000, 9000, and 5000 time series samples, respectively. We achieve state-of-the-art results on each dataset, with most datasets showing test accuracy near 100%, and in the gearbox dataset, we achieve significant improvement from 94.8% to 99.64%. We created a repository including these datasets located at mlmechanics.ics.uci.edu.

Droplet microfluidics generates and manipulates discrete droplets through immiscible multiphase flows inside microchannels. Due to its remarkable advantages, droplet microfluidics bears significant value in an extremely wide range of area. In this review, we provide a comprehensive and in-depth insight into droplet microfluidics, covering fundamental research from microfluidic chip fabrication and droplet generation to the applications of droplets in bio(chemical) analysis and materials generation. The purpose of this review is to convey the fundamentals of droplet microfluidics, a critical analysis on its current status and challenges, and opinions on its future development. We believe this review will promote communications among biology, chemistry, physics, and materials science.

Unmanned aerial vehicles (UAVs) have found numerous applications and are expected to bring fertile business opportunities in the next decade. Among various enabling technologies for UAVs, wireless communication is essential and has drawn significantly growing attention in recent years. Compared to the conventional terrestrial communications, UAVs' communications face new challenges due to their high altitude above the ground and great flexibility of movement in the 3-D space. Several critical issues arise, including the line-of-sight (LoS) dominant UAV-ground channels and induced strong aerial-terrestrial network interference, the distinct communication quality-of-service (QoS) requirements for UAV control messages versus payload data, the stringent constraints imposed by the size, weight, and power (SWAP) limitations of UAVs, as well as the exploitation of the new design degree of freedom (DoF) brought by the highly controllable 3-D UAV mobility. In this article, we give a tutorial overview of the recent advances in UAV communications to address the above issues, with an emphasis on how to integrate UAVs into the forthcoming fifth-generation (5G) and future cellular networks. In particular, we partition our discussion into two promising research and application frameworks of UAV communications, namely UAV-assisted wireless communications and cellular-connected UAVs, where UAVs are integrated into the network as new aerial communication platforms and users, respectively. Furthermore, we point out promising directions for future research.