Sri Venkateswara University

BACKGROUND: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic "Mcy protein" isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. MATERIALS AND METHODS: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. RESULTS: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats. CONCLUSION: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.

Simulated systems are used for modelling and analysis of systems for which an analytical solution is either not accessible or difficult to achieve. Simulation is a highly flexible and adaptable discipline within computer science. Because it is simpler than conventional approaches, which are often challenging, simulation is also chosen as a method of system analysis. Because of this, simulation is an area with extensive application and demand, making it interesting and beneficial to have a chapter dedicated to researching simulation with a case study of modelling a Queuing system.

Salt stress causes decrease in plant growth and productivity by disrupting physiological processes, especially photosynthesis. The accumulation of intracellular sodium ions at salt stress changes the ratio of K : Na, which seems to affect the bioenergetic processes of photosynthesis. Both multiple inhibitory effects of salt stress on photosynthesis and possible salt stress tolerance mechanisms in cyanobacteria and plants are reviewed.

Abstract Four heavy metals (Copper, Cadmium, Lead and Zinc) are monitored in drinking water at twelve important residential areas using DPASV Technique. The results indicate the water to free of heavy metal pollution. The data monitored have been used to compute Heavy metal pollution index (HPI) using weighted arithmetic mean method and the proposed Pollution Index (HPI) seems to be applicable in the assesement of overall water quality with respect to heavy metal pollution.

Emerging technologies such as computer vision and Artificial Intelligence (AI) are estimated to leverage the accessibility of big data for active training and yielding operational real time smart machines and predictable models. This phenomenon of applying vision and learning methods for the improvement of food industry is termed as computer vision and AI driven food industry. This review contributes to provide an insight into state-of-the-art AI and computer vision technologies that can assist farmers in agriculture and food processing. This paper investigates various scenarios and use cases of machine learning, machine vision and deep learning in global perspective with the lens of sustainability. It explains the increasing demand towards the AgTech industry using computer vision and AI which might be a path towards sustainable food production to feed the future. Also, this review tosses some implications regarding challenges and recommendations in inclusion of technologies in real time farming, substantial global policies and investments. Finally, the paper discusses the possibility of using Fourth Industrial Revolution [4.0 IR] technologies such as deep learning and computer vision robotics as a key for sustainable food production.

Germinating seedlings of mung bean ( Phaseolus vulgaris L. cv. K‐16) were treated with different concentrations of cadmium acetate (10, 50 and 100 μ M ). Cd 2+ lowered the chlorophyll and heme levels. The level of lipid peroxides were higher on day 3 than on day 6. However, Cd 2+ treatment significantly enhanced the level of lipid peroxides. Similarly, a dose‐dependent induction of lipoxygenase (EC 1.13.11.12) activity was observed with Cd 2+ treatment. Further, the activities of antioxidant enzymes such as superoxide dismutase (EC 1.15.1.1) and catalase (EC 1.11.1.6) were decreased. Our results suggest that lipoxygenase‐mediated accumulation of lipid peroxides on the one hand and inhibition of free radical scavenging enzymes like superoxide dismutase and catalase on the other caused a pronounced reduction in the chlorophyll and heme levels of the seedlings. The experiments conducted on the effect of Cd 2+ on dark‐grown seedlings did not conform with the result of light‐grown seedlings. Though chlorophyll and heme levels decreased in a dose‐dependent manner, no accumulation of lipid peroxides was observed, suggesting that the inhibition of chlorophyll synthesis by Cd 2+ is achieved both by reaction with constituent biosynthetic enzymes as well as peroxide‐mediated degradation.

Laccases are blue multicopper oxidases, which catalyze the monoelectronic oxidation of a broad spectrum of substrates, for example, ortho- and para-diphenols, polyphenols, aminophenols, and aromatic or aliphatic amines, coupled with a full, four-electron reduction of O2 to H2O. Hence, they are capable of degrading lignin and are present abundantly in many white-rot fungi. Laccases decolorize and detoxify the industrial effluents and help in wastewater treatment. They act on both phenolic and nonphenolic lignin-related compounds as well as highly recalcitrant environmental pollutants, and they can be effectively used in paper and pulp industries, textile industries, xenobiotic degradation, and bioremediation and act as biosensors. Recently, laccase has been applied to nanobiotechnology, which is an increasing research field, and catalyzes electron transfer reactions without additional cofactors. Several techniques have been developed for the immobilization of biomolecule such as micropatterning, self-assembled monolayer, and layer-by-layer techniques, which immobilize laccase and preserve their enzymatic activity. In this review, we describe the fungal source of laccases and their application in environment protection.

In the present study, iron doped zinc oxide (ZnO:Fe) thin films were prepared by using a simple chemical spray pyrolysis technique by varying the doping concentration in the range, 0–6 at.% at a constant substrate temperature of 400 °C.The effect of Fe-doping concentration on the physical behavior of ZnO thin films were analyzed and discussed. The X-ray diffraction (XRD) patterns exhibited hexagonal wurtzite crystal structure without any secondary phases for all the films irrespective of the doping concentration. However, the preferential orientation changed from (002) to (101) plane with increase of Fe-doping. The Raman spectroscopy studies showed the peaks at 338 cm-1, 438 cm-1 and 574 cm-1 which are the characteristic vibrational modes of ZnO. The scanning electron microscopic (SEM) images showed irregular shaped grains grown over the substrate surface. The X-ray photoelectron spectroscopy (XPS) studies confirmed the presence of Fe in +3 state in ZnO layers. The Fourier transform infrared (FTIR) spectroscopy data revealed the presence of iron in the doped ZnO films by showing the modes related to iron in addition to ZnO. The optical properties revealed that the films with lower Fe-doping concentration (≤ 2 at.%) showed high transmittance and wide band gap than the pure and highly Fe-doped ZnO films. The evaluated band gap showed a red shift upon doping with the energy band gap decreased from 3.24 eV to 3.01 eV for the investigated doping concentration range. The photoluminescence spectra also showed similar optical behavior with quenching of PL signal intensity of the films. Moreover, all the Fe-doped ZnO films showed ferromagnetic behavior at room temperature.

INTRODUCTION: 5-Loxin is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase enzyme. A 90-day, double-blind, randomized, placebo-controlled study was conducted to evaluate the efficacy and safety of 5-Loxin in the treatment of osteoarthritis (OA) of the knee. METHODS: Seventy-five OA patients were included in the study. The patients received either 100 mg (n = 25) or 250 mg (n = 25) of 5-Loxin daily or a placebo (n = 25) for 90 days. Each patient was evaluated for pain and physical functions by using the standard tools (visual analog scale, Lequesne's Functional Index, and Western Ontario and McMaster Universities Osteoarthritis Index) at the baseline (day 0), and at days 7, 30, 60 and 90. Additionally, the cartilage degrading enzyme matrix metalloproteinase-3 was also evaluated in synovial fluid from OA patients. Measurement of a battery of biochemical parameters in serum and haematological parameters, and urine analysis were performed to evaluate the safety of 5-Loxin in OA patients. RESULTS: Seventy patients completed the study. At the end of the study, both doses of 5-Loxin conferred clinically and statistically significant improvements in pain scores and physical function scores in OA patients. Interestingly, significant improvements in pain score and functional ability were recorded in the treatment group supplemented with 250 mg 5-Loxin as early as 7 days after the start of treatment. Corroborating the improvements in pain scores in treatment groups, we also noted significant reduction in synovial fluid matrix metalloproteinase-3. In comparison with placebo, the safety parameters were almost unchanged in the treatment groups. CONCLUSION: 5-Loxin reduces pain and improves physical functioning significantly in OA patients; and it is safe for human consumption. 5-Loxin may exert its beneficial effects by controlling inflammatory responses through reducing proinflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage in OA patients. TRIAL REGISTRATION: ( CLINICAL TRIAL REGISTRATION NUMBER: ISRCTN05212803.).

Abstract The exploration for groundwater in hard rock terrains is a complex task. To overcome this complexity, the integrated approach based on advanced applications of remote sensing and geographical information systems (GIS) lends itself as an efficient and effective result-oriented method for studying the development and management of water resources. Chittoor area, comprised of a hard rock terrain, is located in the drought-prone Rayalaseema region of Andhra Pradesh, India. Using remote sensing and GIS technology, groundwater potential zones, along with zones of water quality suitable for domestic purposes, were delineated and classified. Results indicated that, for the town of Chittoor, 1.64% of the area was classified to have very high groundwater potential, with groundwater quality suitable or moderately suitable for domestic purposes; and 31.68% of the area was classified as high potential, with over 31% being suitable or moderately suitable. Most (62.05%) of the area is of moderate groundwater potential, with groundwater quality mostly suitable or moderately suitable for domestic purposes. Résumé La recherche d'eaux souterraines dans des sites à roches dures est une tâche complexe. Face à cette complexité, l'approche intégrée basée sur des applications avancées de télédétection et de système d'information géographique (SIG) permet de proposer une méthode efficace et efficiente pour étudier le développement et la gestion des ressources en eau. La zone de Chittoor, présentant un substrat de roches dures, se situe dans la région sensible aux sécheresses de Rayalaseema en Andhra Pradesh, en Inde. Les zones de potentiel en eaux souterraines ainsi que les zones où la qualité d'eau est compatible avec les usages domestiques ont été délimitées et classifiées en utilisant la télédétection et la technologie SIG. Les résultats indiquent que, pour la ville de Chittoor, un peu moins de 2% de la zone ont été classifiés avec un très fort potentiel en eaux souterraines, bien que moins de 1% seulement soit valable ou presque valable pour les usages domestiques; et que 31.68% de la zone aient été classifiés avec un fort potentiel, avec plus de 31% valables ou presque valables. La plupart (62.05%) de la zone présente un potentiel en eaux souterraines modéré, avec une qualité d'eau essentiellement valable et modérément valable pour les usages domestiques. Keywords: groundwater potential zonesgroundwater qualityremote sensingGISAndhra PradeshIndiaMots clefs: zones de potentiel en eaux souterrainesqualité d'eaux souterrainestélédétectionSIGAndhra PradeshInde

The solar photovoltaic (PV) cell is a prominent energy harvesting device that reduces the strain in the conventional energy generation approach and endorses the prospectiveness of renewable energy. Thus, the exploration in this ever-green field is worth the effort. From the power conversion efficiency standpoint of view, PVs are consistently improving, and when analyzing the potential areas that can be advanced, more and more exciting challenges are encountered. One such crucial challenge is to increase the photon availability for PV conversion. This challenge is solved using two ways. First, by suppressing the reflection at the interface of the solar cell, and the other way is to enhance the optical pathlength inside the cell for adequate absorption of the photons. Our review addresses this challenge by emphasizing the various strategies that aid in trapping the light in the solar cells. These strategies include the usage of antireflection coatings (ARCs) and light-trapping structures. The primary focus of this study is to review the ARCs from a PV application perspective based on various materials, and it highlights the development of ARCs from more than the past three decades covering the structure, fabrication techniques, optical performance, features, and research potential of ARCs reported. More importantly, various ARCs researched with different classes of PV cells, and their impact on its efficiency is given a special attention. To enhance the optical pathlength, and thus the absorption in solar PV devices, an insight about the advanced light-trapping techniques that deals with the concept of plasmonics, spectral modification, and other prevailing innovative light-trapping structures approaching the Yablonovitch limit is discussed. An extensive collection of information is presented as tables under each core review section. Further, we take a step forward to brief the effects of ageing on ARCs and their influence on the device performance. Finally, we summarize the review of ARCs on the basis of structures, materials, optical performance, multifunctionality, stability, and cost-effectiveness along with a master table comparing the selected high-performance ARCs with perfect AR coatings. Also, from the discussed significant challenges faced by ARCs and future outlook; this work directs the researchers to identify the area of expertise where further research analysis is needed in near future.

In the present article, the problem of boundary layer flow of MHD electrically conducting fluid past a cone and a wedge with non-uniform heat source/sink along with Cattaneo-Christov heat flux is investigated numerically. At first, the flow equations are converted into ODE via appropriate self similarity transforms and the resulting equations are solved with the assistance of R.-K. and Newton’s methods. The influence of several dimensionless parameters on velocity and temperature fields in addition to the friction factor and reduced heat transfer coefficient has been examined with the support of graphs and numerical values. The heat transfer phenomenon in the flow caused by the cone is excessive when compared to the wedge flow. Also, the thermal and momentum boundary layers are not the same for the flow over a cone and wedge. Keywords: MHD, Non-uniform heat source/sink, Cattaneo-Christov heat flux, Cone and wedge

INTRODUCTION: Alzheimer's disease is a type of dementia, and till now there is no suitable drug available for the complete cure of this disease. Now-a-days Probiotics, Lactobacillus strains play a therapeutic role in cognitive disorders through Gut-Brain Axis communication. AIM: MTCC1325 against D-Galactose-induced Alzheimer's disease in albino rats. MATERIALS AND METHODS: MTCC1325 for 60 days. During the experimentation, both morphometric and behavioural aspects were studied. Later we have examined histopathological changes and estimated cholinergic levels in selected brain regions of all experimental groups of rats including control on selected days. RESULTS: alone. CONCLUSION: MTCC1325 might have anti-Alzheimer properties against D-Galactose induced Alzheimer's disease.

This comprehensive review paper examines the technological advancements towards smart energy management in smart cities. It provides an overview of the concept of smart energy management, the challenges faced by cities in managing their energy consumption, and the need for technological advancements to overcome these challenges. The advancements are categorized based on their applications, such as smart grids, smart buildings, and smart transportation, and their benefits are discussed, including increased efficiency, reduced costs, and better sustainability. The paper also presents case studies of successful implementation of smart energy management technologies and discusses the challenges faced during implementation and how they were overcome. In addition, the paper highlights potential research areas and emerging technologies, including block chain, edge computing, IoT, big data analytics, energy harvesting technologies, machine learning, and distributed energy resources (DERs). The importance of technological advancements for smart energy management in smart cities is emphasized, and recommendations for future research and development in the field are provided. Overall, this review paper contributes to the ongoing development of smart cities and provides valuable insights for researchers, industry professionals, and policymakers working towards a more sustainable future.

Food security is the main path to develop the socioeconomic status in any country in the world to defeat malnutrition. The present scenario in an under developed countries are still facing this problem. Hence the human nutrition deficiencies focus on the importance of animal protein in their regular diet. To overcome this problem, fisheries contribute a significant amount of animal protein to the diets of people worldwide. The aquatic animals are the highly nutritious and cheapest protein sources, which serves as a valuable supplement in diets by providing essential vitamins, proteins, micronutrients, and minerals, for the poor people. Aquaculture is playing a vital role in the developing countries in national economic development, and global food supply. Food and agricultural organization (FAO) declared that this aquaculture has the continuous potentiality to create a developmental goals for the country economy and better human welfare.

In recent times, nanoparticles are attributed to green nanotechnology methods to know the synergistic biological activities. To accomplish this phenomenon, present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) by using Syzygium alternifolium stem bark, characterized those NPs using expository tools and to elucidate high prioritized antimicrobial and anticancer activities. Synthesized particles exhibited a color change pattern upon synthesis and affirmed its respective broad peak at 285 nm which was analyzed through UV–vis spectroscopy. FT-IR study confirmed that phenols and primary amines were mainly involved in capping and stabilization of nanoparticles. DLS and Zeta potential studies revealed narrow size of particles with greater stability. XRD studies revealed the crystallographic nature of particles with 17.2 nm average size. Microscopic analysis by using TEM revealed that particle size range from 5–13 nm and most of them were spherical in shape, non-agglomerated and poly-dispersed in condition. Antimicrobial studies of particles showed highest inhibitory activity against E. coli and T. harzianum among bacterial and fungal strains, respectively. The scope of this study is extended by examining anticancer activity of CuO NPs. This study exhibited potential anticancer activity towards MDA-MB-231 human breast cancer lines. Overall, these examinations relate that the S. alternifolium is described as efficient well-being plant and probabilistically for the design and synthesis of nanoparticles for human health. This study paves a way to better understand antimicrobial and anticancer therapeutic drug potentials of nanoparticles to design and analysis of pharmaceuticals by in vivo and in vitro approaches.

Catalytic reaction between PVA-capped AgNPs and hydrogen peroxide, and the corresponding LSPR optical absorbance spectra as a function of time.

Land use/land cover (LU/LC) changes were determined in an urban area, Tirupati, from 1976 to 2003 by using Geographical Information Systems (GISs) and remote sensing technology. These studies were employed by using the Survey of India topographic map 57 O/6 and the remote sensing data of LISS III and PAN of IRS ID of 2003. The study area was classified into eight categories on the basis of field study, geographical conditions, and remote sensing data. The comparison of LU/LC in 1976 and 2003 derived from toposheet and satellite imagery interpretation indicates that there is a significant increase in built-up area, open forest, plantation, and other lands. It is also noted that substantial amount of agriculture land, water spread area, and dense forest area vanished during the period of study which may be due to rapid urbanization of the study area. No mining activities were found in the study area in 1976, but a small addition of mining land was found in 2003.

The mammalian abasic endonuclease, APE1, has two distinct roles in the repair of oxidative DNA damage and in gene regulation. Here we show that both functions are essential for cell survival. Deletion of the APE1 gene causes embryonic lethality in mice, and no nullizygous embryo fibroblasts have been isolated. We have now established nullizygous embryo fibroblast lines from APE1(-/-) mouse embryos that are transgenic with the "floxed" human APE1 (hAPE1) gene. Removal of hAPE1 by Cre expression through nuclear microinjection elicited apoptosis in these cells within 24 h, which was blocked by coinjection of the wild-type hAPE1 gene. In contrast, mutant hAPE1 alleles, lacking either the DNA repair or acetylation-mediated gene regulatory function, could not prevent apoptosis, although the combination of these two mutants complemented APE deficiency induced by Cre. These results indicate that distinct and separable functions of APE1 are both essential for mammalian cells even in vitro and provide the evidence that mammalian cells, unlike yeast or Escherichia coli, absolutely require APE for survival, presumably to protect against spontaneous oxidative DNA damage.

Zinc oxide (ZnO) nanoparticles (NPs) anchored to carbon nanofiber (CNF) hybrids were synthesized using a facile coprecipitation method. This report demonstrates an effective strategy to intrinsically improve the conductivity and supercapacitive performance of the hybrids by inducing oxygen vacancies. Oxygen deficiency-related defect analyses were performed qualitatively as well as quantitatively using Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. All of the analyses clearly indicate an increase in oxygen deficiencies in the hybrids with an increase in the vacuum-annealing temperature. The nonstoichiometric oxygen vacancy is mainly induced via the migration of the lattice oxygen into interstitial sites at elevated temperature (300 °C), followed by diffusion into the gaseous phase with further increase in the annealing temperature (600 °C) in an oxygen-deficient atmosphere. This induction of oxygen vacancy is corroborated by diffuse reflectance spectroscopy, which depicts the oxygen-vacancy-induced bandgap narrowing of the ZnO NPs within the hybrids. At a current density of 3 A g(-1), the hybrid electrode exhibited higher energy density (119.85 Wh kg(-1)) and power density (19.225 kW kg(-1)) compared to a control ZnO electrode (48.01 Wh kg(-1) and 17.687 kW kg(-1)). The enhanced supercapacitive performance is mainly ascribed to the good interfacial contact between CNF and ZnO, high oxygen deficiency, and fewer defects in the hybrid. Our results are expected to provide new insights into improving the electrochemical properties of various composites/hybrids.