University of Sri Jayewardenepura

Emerging applications such as Internet of Everything, Holographic Telepresence, collaborative robots, and space and deep-sea tourism are already highlighting the limitations of existing fifth-generation (5G) mobile networks. These limitations are in terms of data-rate, latency, reliability, availability, processing, connection density and global coverage, spanning over ground, underwater and space. The sixth-generation (6G) of mobile networks are expected to burgeon in the coming decade to address these limitations. The development of 6G vision, applications, technologies and standards has already become a popular research theme in academia and the industry. In this paper, we provide a comprehensive survey of the current developments towards 6G. We highlight the societal and technological trends that initiate the drive towards 6G. Emerging applications to realize the demands raised by 6G driving trends are discussed subsequently. We also elaborate the requirements that are necessary to realize the 6G applications. Then we present the key enabling technologies in detail. We also outline current research projects and activities including standardization efforts towards the development of 6G. Finally, we summarize lessons learned from state-of-the-art research and discuss technical challenges that would shed a new light on future research directions towards 6G.

Biochar is produced as a charred material with high surface area and abundant functional groups by pyrolysis, which refers to the process of thermochemical decomposition of organic material at elevated temperatures in the absence of oxygen. The carbon component in biochar is relatively stable, and, hence, biochar was originally proposed as a soil amendment to store carbon in the soil. Biochar has multifunctional values that include the use of it for the following purposes: soil amendment to improve soil health, nutrient and microbial carrier, immobilising agent for remediation of toxic metals and organic contaminants in soil and water, catalyst for industrial applications, porous material for mitigating greenhouse gas emissions and odorous compounds, and feed supplement to improve animal health and nutrient intake efficiency and, thus, productivity. This article provides for the first time an overview of the multifunctional values and unintended consequences of biochar applications.

While slow release of chemicals has been widely applied for drug delivery, little work has been done on using this general nanotechnology-based principle for delivering nutrients to crops. In developing countries, the cost of fertilizers can be significant and is often the limiting factor for food supply. Thus, it is important to develop technologies that minimize the cost of fertilizers through efficient and targeted delivery. Urea is a rich source of nitrogen and therefore a commonly used fertilizer. We focus our work on the synthesis of environmentally benign nanoparticles carrying urea as the crop nutrient that can be released in a programmed manner for use as a nanofertilizer. In this study, the high solubility of urea molecules has been reduced by incorporating it into a matrix of hydroxyapatite nanoparticles. Hydroxyapatite nanoparticles have been selected due to their excellent biocompatibility while acting as a rich phosphorus source. In addition, the high surface area offered by nanoparticles allows binding of a large amount of urea molecules. The method reported here is simple and scalable, allowing the synthesis of a urea-modified hydroxyapatite nanohybrid as fertilizer having a ratio of urea to hydroxyapatite of 6:1 by weight. Specifically, a nanohybrid suspension was synthesized by in situ coating of hydroxyapatite with urea at the nanoscale. In addition to the stabilization imparted due to the high surface area to volume ratio of the nanoparticles, supplementary stabilization leading to high loading of urea was provided by flash drying the suspension to obtain a solid nanohybrid. This nanohybrid with a nitrogen weight of 40% provides a platform for its slow release. Its potential application in agriculture to maintain yield and reduce the amount of urea used is demonstrated.

Dengue viral infections are one of the most important mosquito borne diseases in the world. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever (DHF), or dengue shock syndrome. Annually, 100 million cases of dengue fever and half a million cases of DHF occur worldwide. Ninety percent of DHF subjects are children less than 15 years of age. At present, dengue is endemic in 112 countries in the world. No vaccine is available for preventing this disease. Early recognition and prompt initiation of appropriate treatment are vital if disease related morbidity and mortality are to be limited. This review outlines aspects of the epidemiology of dengue infections, the dengue virus and its mosquito vector, clinical features and pathogenesis of dengue infections, and the management and control of these infections.

Microplastics are well known for vector transport of hydrophobic organic contaminants, and there are growing concerns regarding their potential adverse effects on ecosystems and human health. However, recent studies focussing on hydrophilic compounds, such as pharmaceuticals and personal care products (PPCPs), have shown that the compounds ability to be adsorbed onto plastic surfaces. The extensive use of PPCPs has led to their ubiquitous presence in the environment resulting in their cooccurrence with microplastics. The partitioning between plastics and PPCPs and their fate through vector transport are determined by various physicochemical characteristics and environmental conditions of specific matrices. Although the sorption capacities of microplastics for different PPCP compounds have been investigated extensively, these findings have not yet been synthesized and analyzed critically. The specific objectives of this review were to synthesize and critically assess the various factors that affect the adsorption of hydrophilic compounds such as PPCPs on microplastic surfaces and their fate and transport in the environment. The review also focuses on environmental factors such as pH, salinity, and dissolved organics, and properties of polymers and PPCP compounds, and the relationships with sorption dynamics and mechanisms. Furthermore, the ecotoxicological effects of PPCP-sorbed microplastics on biota and human health are also discussed.

This paper seeks to provide simplified general reflections in respect of green human resource management (green HRM) that is a novel concept at least in Sri Lankan context and indeed has a great potential to serve the individual, society and business. The paper has its focus on seven aspects such as meaning of green, reasons for greening, meaning of green HRM, importance of green HRM, green human resource requirements, greening of HRM functions and the findings of some green HRM research studies. It is hoped that the paper has some utility for generating an interest within potential researchers and for gaining a conceptual understanding of green HRM.

INTRODUCTION: Type 2 diabetes is reaching pandemic levels and young-onset type 2 diabetes is becoming increasingly common. Erectile dysfunction (ED) is a common and distressing complication of diabetes. The pathophysiology and management of diabetic ED is significantly different to nondiabetic ED. AIM: To provide an update on the epidemiology, risk factors, pathophysiology, and management of diabetic ED. METHOD: Literature for this review was obtained from Medline and Embase searches and from relevant text books. MAIN OUTCOME MEASURES: A comprehensive review on epidemiology, risk factors, pathophysiolgy, and management of diabetic ED. RESULTS: Large differences in the reported prevalence of ED from 35% to 90% among diabetic men could be due to differences in methodology and population characteristics. Advancing age, duration of diabetes, poor glycaemic control, hypertension, hyperlipidemia, sedentary lifestyle, smoking, and presence of other diabetic complications have been shown to be associated with diabetic ED in cross-sectional studies. Diabetic ED is multifactorial in aetiology and is more severe and more resistant to treatment compared with nondiabetic ED. Optimized glycaemic control, management of associated comorbidities and lifestyle modifications are essential in all patients. Psychosexual and relationship counseling would be beneficial for men with such coexisting problems. Hypogonadism, commonly found in diabetes, may need identification and treatment. Maximal doses of phosphodiesterase type 5 (PDE5) inhibitors are often needed. Transurethral prostaglandins, intracavenorsal injections, vacuum devices, and penile implants are the available therapeutic options for nonresponders to PDE5 inhibitors and for whom PDE5 inhibitors are contraindicated. Premature ejaculation and reduced libido are conditions commonly associated with diabetic ED and should be identified and treated. CONCLUSIONS: Aetiology of diabetic ED is multifactorial although the relative significance of these factors are not clear. A holistic approach is needed in the management of diabetic ED.

The objective of this review is to explore green human resource management practices of organisations based on the existent literature. In this emerging field, it has been generally observed that the existent literature has to be extended further from the perspective of functions of Human Resource Management (HRM). It reveals that much of the past research focused on a few functions of HRM such as recruitment, training and development, performance evaluation and reward management in integrating environmental management with HRM though HRM has more potential and scope in improving organisation’s environmental performance. Hence, this review incorporates diverse functions of HRM to explore the respective green HRM practices under those functions. The findings of the review have identified and highlighted several green HRM practices under the 12 functions of HRM such as job design, job analysis, human resource planning, recruitment, selection, induction, performance evaluation, training and development, reward management, discipline management, health and safety management and employee relations. The contribution of this paper lies in extending the scope and depth of green HRM in materializing sustainable environmental performance of organisations.

Plant pathogens cause severe losses or damage to crops worldwide and thereby significantly reduce the quality and quantity of agricultural commodities. World tendencies are shifting towards reducing the usage of chemically synthesized pesticides, while various biocontrol methods, strategies and approaches are being used in plant disease management. Fungal antagonists play a significant role in controlling plant pathogens and diseases and they are used as Biocontrol Agents (BCAs) throughout the world. This review provides a comprehensive list of fungal BCAs used against fungal plant pathogens according to modern taxonomic concepts, and clarifies their phylogenetic relationships because thewrong names are frequently used in the literature of biocontrol. Details of approximately 300 fungal antagonists belonging to 13 classes and 113 genera are listed together with the target pathogens and corresponding plant diseases. Trichoderma is identified as the genus with greatest potential comprising 25 biocontrol agents that have been used against a number of plant fungal diseases. In addition to Trichoderma , nine genera are recognized as significant comprising five or more known antagonistic species, namely, Alternaria , Aspergillus , Candida , Fusarium , Penicillium , Pichia , Pythium , Talaromyces , and Verticillium . A phylogenetic analysis based on partial sequences of the 28S nrRNA gene (LSU) of fungal antagonists was performed to establish their phylogenetic relationships.

Trace elements (TEs) may have toxic effects to plants and humans; thus, countries and organizations impose maximum allowable regulation limits of their concentrations in soils. Usually such limits are placed in different categories according to soil use, soil properties or based on both attributes. However, some countries have regulation limits irrespective of differentiation in soil properties. In this review, we aimed at collecting TE regulation limits in soils from major countries and organizations around the globe, and critiquing them by assessing potential human health risks in the case of soils attaining the maximum allowable values. We explored the soil-to-human pathway and differentiated among three major exposures from TEs, i.e., residential, industrial and agricultural. We observed the existence of problems concerning TE regulation limits, among which the fact that limits across countries do not regulate the same TEs, not even a minimum number of TEs. This indicates that countries do not seem to agree on which regulation limits of TEs pose a high risk. Also, these regulation limits do not take into account TE mobility to neighbouring environment interphases such as plant, especially edible, and water matrices. Moreover, limits for same TEs are vastly diverse across countries; this indicates that those countries have conflicting information concerning TE-related health risks. Subsequently, we addressed this problem of diversity by quantifying resultant risks; we did that by calculating human health risk indices, taking into consideration the cases in which the highest allowable TE limits are attained in soil. Arsenic limits were found to generate a relatively high hazard quotient (HQi, accounting for human intake over the maximum allowable oral reference dose for that same TE), indicating that its risk tends to be underestimated. Other TE limits, such as those of Cd, Cu, Ni, Pb, and Zn typically result in low HQi, meaning that limits in their cases are rather overprotective. Our approach reveals the need of reducing diversity in regulation limits by drafting soil legislations of worldwide validity, since risks are common across countries. We suggest that new directions should strategically tend to (a) reduce limits of TEs with underestimated contribution to health risk (such as As), (b) cautiously increase limits of TEs that currently cause minor health risks, (c) quantify TE risks associated with uptake to edible plants and potable water, and (d) consider multi-element contamination cases, where risks are cumulatively enhanced due to TE synergism.

Antimony (Sb) is introduced into soils, sediments, and aquatic environments from various sources such as weathering of sulfide ores, leaching of mining wastes, and anthropogenic activities. High Sb concentrations are toxic to ecosystems and potentially to public health via the accumulation in food chain. Although Sb is poisonous and carcinogenic to humans, the exact mechanisms causing toxicity still remain unclear. Most studies concerning the remediation of soils and aquatic environments contaminated with Sb have evaluated various amendments that reduce Sb bioavailability and toxicity. However, there is no comprehensive review on the biogeochemistry and transformation of Sb related to its remediation. Therefore, the present review summarizes: (1) the sources of Sb and its geochemical distribution and speciation in soils and aquatic environments, (2) the biogeochemical processes that govern Sb mobilization, bioavailability, toxicity in soils and aquatic environments, and possible threats to human and ecosystem health, and (3) the approaches used to remediate Sb-contaminated soils and water and mitigate potential environmental and health risks. Knowledge gaps and future research needs also are discussed. The review presents up-to-date knowledge about the fate of Sb in soils and aquatic environments and contributes to an important insight into the environmental hazards of Sb. The findings from the review should help to develop innovative and appropriate technologies for controlling Sb bioavailability and toxicity and sustainably managing Sb-polluted soils and water, subsequently minimizing its environmental and human health risks.

The adsorption of nitrogen dioxide on gamma aluminium oxide (gamma-Al(2)O(3)) and alpha iron oxide (alpha-Fe(2)O(3)) particle surfaces under various conditions of relative humidity, presence of molecular oxygen and UV light has been investigated. X-Ray photoelectron spectroscopy (XPS) is used to monitor the different surface species that form under these environmental conditions. Adsorption of NO(2) on aluminum oxide particle surfaces results primarily in the formation of surface nitrate, NO(3)(-) with an oxidation state of +5, as indicated by a peak with binding energy of 407.3 eV in the N1s region. An additional minority species, sensitive to the presence of relative humidity and molecular oxygen, is also observed in the N1s region with lower binding energy of 405.9 eV. This peak is assigned to a surface species in the +4 oxidation state. When irradiated with UV light, other species form on the surface. These surface-bound photochemical products all have lower binding energy, between 400 and 402 eV, indicating reduced nitrogen species in the range of N oxidations states spanning +1 to -1. Co-adsorbed water decreases the amount of these reduced surface-bound products while the presence of molecular oxygen completely suppresses the formation of all reduced nitrogen species on aluminum oxide particle surfaces. For NO(2) on iron oxide particle surfaces, photoreduction is enhanced relative to gamma-Al(2)O(3) and surface bound photoreduced species are observed under all environmental conditions. Complementing the experimental data, N1s core electron binding energies (CEBEs) were calculated using DFT for a number of nitrogen-containing species in the gas phase and adsorbed on an Al(8)O(12) cluster. A range of CEBEs is calculated for various nitrogen species in different adsorption modes and oxidation states. These calculated values are discussed in light of the peaks observed in the XPS N1s region and the possible species that form following NO(2) adsorption and photoreaction on metal oxide particle surfaces under different conditions of relative humidity, presence of molecular oxygen and UV light.

In this paper, we study the evolution of hourly oil price volatility. Using multiple measures of oil price volatility, we conclude that volatility increased following the onset of COVID-19. After controlling for conventional predictors of oil price volatility, we show that COVID-19 cases and deaths led to an increase in daily oil price volatility by between 8% and 22%. Our results pass a battery of robustness tests.

The study investigated the anti-inflammatory activity of the hydro methanolic extract of six leafy vegetables, namely Cassia auriculata, Passiflora edulis, Sesbania grandiflora, Olax zeylanica, Gymnema lactiferum, and Centella asiatica. The anti-inflammatory activity of methanolic extracts of leafy vegetables was evaluated using four in vitro-based assays: hemolysis inhibition, proteinase inhibition, protein denaturation inhibition, and lipoxygenase inhibition. Results showed that the percent inhibition of hemolysis from these leaf extracts (25–100 µg/mL dry weight basis (DW)) was within the range from 5.4% to 14.9%, and the leaves of P. edulis and O. zeylanica showed a significantly higher (p < 0.05) inhibition levels. Percent inhibition of protein denaturation of these leafy types was within the range of 36.0–61.0%, and the leaf extract of C. auriculata has exhibited a significantly higher (p < 0.05) inhibition level. Proteinase inhibitory activity of these leaf extracts was within the range of 20.2–25.9%. The lipoxygenase inhibition was within the range of 3.7–36.0%, and the leaf extract of G. lactiferum showed an improved ability to inhibit lipoxygenase activity. In conclusion, results revealed that all the studied leaves possess anti-inflammatory properties at different levels, and this could be due to the differences in the composition and concentration of bioactive compounds.

Abstract To date, non-pharmacological interventions (NPI) have been the mainstay for controlling the coronavirus disease-2019 (COVID-19) pandemic. While NPIs are effective in preventing health systems overload, these long-term measures are likely to have significant adverse economic consequences. Therefore, many countries are currently considering to lift the NPIs—increasing the likelihood of disease resurgence. In this regard, dynamic NPIs, with intervals of relaxed social distancing, may provide a more suitable alternative. However, the ideal frequency and duration of intermittent NPIs, and the ideal “break” when interventions can be temporarily relaxed, remain uncertain, especially in resource-poor settings. We employed a multivariate prediction model, based on up-to-date transmission and clinical parameters, to simulate outbreak trajectories in 16 countries, from diverse regions and economic categories. In each country, we then modelled the impacts on intensive care unit (ICU) admissions and deaths over an 18-month period for following scenarios: (1) no intervention, (2) consecutive cycles of mitigation measures followed by a relaxation period, and (3) consecutive cycles of suppression measures followed by a relaxation period. We defined these dynamic interventions based on reduction of the mean reproduction number during each cycle, assuming a basic reproduction number ( R 0 ) of 2.2 for no intervention, and subsequent effective reproduction numbers ( R ) of 0.8 and 0.5 for illustrative dynamic mitigation and suppression interventions, respectively. We found that dynamic cycles of 50-day mitigation followed by a 30-day relaxation reduced transmission, however, were unsuccessful in lowering ICU hospitalizations below manageable limits. By contrast, dynamic cycles of 50-day suppression followed by a 30-day relaxation kept the ICU demands below the national capacities. Additionally, we estimated that a significant number of new infections and deaths, especially in resource-poor countries, would be averted if these dynamic suppression measures were kept in place over an 18-month period. This multi-country analysis demonstrates that intermittent reductions of R below 1 through a potential combination of suppression interventions and relaxation can be an effective strategy for COVID-19 pandemic control. Such a “schedule” of social distancing might be particularly relevant to low-income countries, where a single, prolonged suppression intervention is unsustainable. Efficient implementation of dynamic suppression interventions, therefore, confers a pragmatic option to: (1) prevent critical care overload and deaths, (2) gain time to develop preventive and clinical measures, and (3) reduce economic hardship globally.

The dengue virus can infect many cell types and cause diverse clinical and pathological effects. We describe clinical and experimental observations that suggest that liver involvement occurs during dengue infections, and we outline the possible role played by host immune responses in this process.

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular leak typically becomes clinically evident 3-6 days after the onset of illness, which is known as the critical phase. This critical phase follows the period of peak viraemia, and lasts for 24-48 hr and usually shows rapid and complete reversal, suggesting that it is likely to occur as a result of inflammatory mediators, rather than infection of the endothelium. Cytokines such as tumour necrosis factor-α, which are known to be elevated in the critical phase of dengue, are likely to be contributing factors. Dengue NS1, a soluble viral protein, has also been shown to disrupt the endothelial glycocalyx and thus contribute to vascular leak, although there appears to be a discordance between the timing of NS1 antigenaemia and occurrence of vascular leak. In addition, many inflammatory lipid mediators are elevated in acute dengue viral infection such as platelet activating factor (PAF) and leukotrienes. Furthermore, many other inflammatory mediators such as vascular endothelial growth factor and angiopoietin-2 have been shown to be elevated in patients with dengue haemorrhagic fever, exerting their action in part by inducing the activity of phospholipases, which have diverse inflammatory effects including generation of PAF. Platelets have also been shown to significantly contribute to endothelial dysfunction by production of interleukin-1β through activation of the NLRP3 inflammasome and also by inducing production of inflammatory cytokines by monocytes. Drugs that block down-stream immunological mediator pathways such as PAF may also be beneficial in the treatment of severe disease.

Pharmaceutical and personal care products (PPCPs) are considered as emerging contaminants (ECs) in the environment due to their known or suspected adverse ecological effects and human health risks. Wastewater, compost, and manure application release PPCPs into the agricultural soil systems. Since the plants can take up such ECs, they are considered as a primary window of human exposure to the PPCPs via the route of consumption of contaminated plants. This may lead to deleterious human health effects. However, as PPCPs are of various kinds, differential uptake and bioaccumulation in the plant have recently received research interest. Therefore, the present article reviewed the occurrence of PPCPs as antibiotics, anti-inflammatory drugs, hormones, cytostatic drugs, contrast media, β-blockers, blood lipid regulators, antiepileptic drugs, antimicrobials, ultra-violet filters, preservatives, insect repellents, and synthetic musks in the environment by assembling the literature. Moreover, plant uptake and translocation under the realistic and greenhouse condition, and the factors influencing the uptake and translocation through the plants are explicitly demonstrated in this review. Also, the human risk connected with the consumption of the contaminated plants and the research gap areas were investigated with future perspectives.

Lam., which is commonly known as jackfruit is a tropical climacteric fruit, belonging to Moraceae family, is native to Western Ghats of India and common in Asia, Africa, and some regions in South America. It is known to be the largest edible fruit in the world. Jackfruit is rich in nutrients including carbohydrates, proteins, vitamins, minerals, and phytochemicals. Both the seeds and the flesh of jackfruit are consumed as curries and boiled forms, while the flesh in fully ripen stage can be eaten directly as a fruit. Several countries have developed different food products such as jam, jellies, marmalades, and ice creams using pureed jackfruit. The several parts of jack tree including fruits, leaves, and barks have been extensively used in traditional medicine due to its anticarcinogenic, antimicrobial, antifungal, anti-inflammatory, wound healing, and hypoglycemic effects. Despite all these benefits, unfortunately, the fruit is underutilized in commercial scale processing in regions where it is grown. The aim of this review is to disseminate the knowledge on nutritional and health benefits of jackfruit, in order to promote utilization of jackfruit for commercial scale food production.

BACKGROUND: It is widely acknowledged that there is a global divide on health care and health research known as the 10/90 divide. METHODS: A retrospective survey of articles published in the BMJ, Lancet, NEJM, Annals of Internal Medicine & JAMA in a calendar year to examine the contribution of the developing world to medical literature. We categorized countries into four regions: UK, USA, Other Euro-American countries (OEAC) and (RoW). OEAC were European countries other than the UK but including Australia, New Zealand and Canada. RoW comprised all other countries. RESULTS: The average contribution of the RoW to the research literature in the five journals was 6.5%. In the two British journals 7.6% of the articles were from the RoW; in the three American journals 4.8% of articles were from RoW. The highest proportion of papers from the RoW was in the Lancet (12%). An analysis of the authorship of 151 articles from RoW showed that 104 (68.9%) involved authorship with developed countries in Europe or North America. There were 15 original papers in these journals with data from RoW but without any authors from RoW. CONCLUSIONS: There is a marked under-representation of countries in high-impact general medical journals. The ethical implications of this inequity and ways of reducing it are discussed.