University of Wuppertal

BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Secondary outcomes included the time to radiologic progression and safety. RESULTS: At the second planned interim analysis, 321 deaths had occurred, and the study was stopped. Median overall survival was 10.7 months in the sorafenib group and 7.9 months in the placebo group (hazard ratio in the sorafenib group, 0.69; 95% confidence interval, 0.55 to 0.87; P<0.001). There was no significant difference between the two groups in the median time to symptomatic progression (4.1 months vs. 4.9 months, respectively, P=0.77). The median time to radiologic progression was 5.5 months in the sorafenib group and 2.8 months in the placebo group (P<0.001). Seven patients in the sorafenib group (2%) and two patients in the placebo group (1%) had a partial response; no patients had a complete response. Diarrhea, weight loss, hand-foot skin reaction, and hypophosphatemia were more frequent in the sorafenib group. CONCLUSIONS: In patients with advanced hepatocellular carcinoma, median survival and the time to radiologic progression were nearly 3 months longer for patients treated with sorafenib than for those given placebo. (ClinicalTrials.gov number, NCT00105443.)

A search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated luminosities of approximately 4.8 fb^-1 collected at sqrt(s) = 7 TeV in 2011 and 5.8 fb^-1 at sqrt(s) = 8 TeV in 2012. Individual searches in the channels H->ZZ^(*)->llll, H->gamma gamma and H->WW->e nu mu nu in the 8 TeV data are combined with previously published results of searches for H->ZZ^(*), WW^(*), bbbar and tau^+tau^- in the 7 TeV data and results from improved analyses of the H->ZZ^(*)->llll and H->gamma gamma channels in the 7 TeV data. Clear evidence for the production of a neutral boson with a measured mass of 126.0 +/- 0.4(stat) +/- 0.4(sys) GeV is presented. This observation, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7x10^-9, is compatible with the production and decay of the Standard Model Higgs boson.

Author(s): Collaboration, The ATLAS; Aad, G; Abat, E; Abdallah, J; Abdelalim, AA; Abdesselam, A; Abdinov, O; Abi, BA; Abolins, M; Abramowicz, H; Acerbi, E; Acharya, BS; Achenbach, R; Ackers, M; Adams, DL; Adamyan, F; Addy, TN; Aderholz, M; Adorisio, C; Adragna, P; Aharrouche, M; Ahlen, SP; Ahles, F; Ahmad, A; Ahmed, H; Aielli, G; Åkesson, PF; Åkesson, TPA; Akimov, AV; Alam, SM; Albert, J; Albrand, S; Aleksa, M; Aleksandrov, IN; Aleppo, M; Alessandria, F; Alexa, C; Alexander, G; Alexopoulos, T; Alimonti, G; Aliyev, M; Allport, PP; Allwood-Spiers, SE; Aloisio, A; Alonso, J; Alves, R; Alviggi, MG; Amako, K; Amaral, P; Amaral, SP; Ambrosini, G; Ambrosio, G; Amelung, C; Ammosov, VV; Amorim, A; Amram, N; Anastopoulos, C; Anderson, B; Anderson, KJ; Anderssen, EC; Andreazza, A; Andrei, V; Andricek, L; Andrieux, M-L; Anduaga, XS; Anghinolfi, F; Antonaki, A; Antonelli, M; Antonelli, S; Apsimon, R; Arabidze, G; Aracena, I; Arai, Y; Arce, ATH; Archambault, JP; Arguin, J-F; Arik, E; Arik, M; Arms, KE; Armstrong, SR; Arnaud, M; Arnault, C; Artamonov, A; Asai, S; Ask, S

Abstract. The present paper reviews existing knowledge with regard to Organic Aerosol (OA) of importance for global climate modelling and defines critical gaps needed to reduce the involved uncertainties. All pieces required for the representation of OA in a global climate model are sketched out with special attention to Secondary Organic Aerosol (SOA): The emission estimates of primary carbonaceous particles and SOA precursor gases are summarized. The up-to-date understanding of the chemical formation and transformation of condensable organic material is outlined. Knowledge on the hygroscopicity of OA and measurements of optical properties of the organic aerosol constituents are summarized. The mechanisms of interactions of OA with clouds and dry and wet removal processes parameterisations in global models are outlined. This information is synthesized to provide a continuous analysis of the flow from the emitted material to the atmosphere up to the point of the climate impact of the produced organic aerosol. The sources of uncertainties at each step of this process are highlighted as areas that require further studies.

A no-pair formalism employing external-field projection operators correct to second order in the potential is used to calculate the 1s energies of one-electron atoms and ground-state properties of the bromine and silver atoms in the framework of the multireference double-excitation configuration-interaction (MRD-CI) method. It is found that the relativistic two-component method that has been used reproduces the one-particle energies of the Dirac equation to order (Z\ensuremath{\alpha}${)}^{3}$. The operator is bounded from below and can be used variationally in relativistic electron-structure calculations of many-electron atoms and molecules. The relativistic correction to the total energy recovers 97% of the relativistic correction of the Dirac-Hartree-Fock (DHF) result in the case of the bromine atom and more than 99% in the case of the silver atom. The relativistic correction of the ionization potential of silver has been calculated to be 0.47 eV at the CI level, in good agreement with DHF results, the correlation contribution in the relativistic case being 0.42 eV. The remaining discrepancy of the absolute value of 6.85 eV (DHF 6.34 eV) to experiment (7.57 eV) is attributed to basis-set deficiencies. The corresponding CI value of the electron affinity (relativistic CI value 1.05 eV, nonrelativistic 0.90 eV) is in much better agreement with experiment (1.30 eV). It is found that correlation contribution and relativistic effects are nonadditive.

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P F; F; C A; G; C J W P; T; V M; V A; G M; K Y; V; A L; I O; V N; S V; A G; A; A; A; A; E; W; M J; K K; P; H; R D; K F; A M; Smith, D S; R; M M; S; D; I; R; B A; A; F; Boyd, G R; P; G S; R; M; H; P; J; M; O; M; E; C; E; P; J; C; D; C; De C; De De J B; L; I; A C; L; D; G; S; J; L; P; M; I; M; G G R; P; J M; P; M; L; S; P; J P; D; G; A C; N; L; S; V M; E; D; J J; F; D; K; M; Y; L; T; D; K M; O; T; E; M J; F; K; Y; A L; B H; S; A; B; A; J P; D; G A N; C D; L; M; M; F G; M; V; M G; Yang, Z; A; P; A J; O; N D; de P A; D; P; J; M; C; E; M; J; E J; S M; L M; A; B M; F E W; Hill, J; D; A; D F; B T; C; M; Unel, M; Kirsch, G P; N; W; A; K; J; Lynn, J; A; R B; B; P; J C L; L; G H A; R; A R; Yang, S; G; A; P; F; M; F; S; F; D; M; D; B; Le O; I; F; M; L; A; P; S; F; P; M; M; C; R; M; A; M; G; M; D; A; D A; V; N; M; P T; B C; F F; A; F M; R; H H; F; M; V; E; T; A; V; P; V; A; E; C; F; I; Z; V; J; C; W; G; T; J; J; V; V; V; S; R; Zheng, W; M; J; J; J; M; I; M; P; V; O; A; V; O; M; M; M; M; M; S; M; I; J; L; P; P; J; M; T; L; M; J; V; K; I; J; D; T; P; T; Z; J; Z; V; V; R; S; V; T; K; J; M; V; B; I; V; P; V; Z; J; T; J; Z; Z; P; P; P; R; J; P; D; M; M; P; Z; S; V; I; D; R; J E; M; H; D; M; A; K; G; E; E; A; M; D; L J; A; G; E; M; M; V; L; L P; A S; R; A; Silva, P V M; M A B; C; F; A A; M; J M; F; P; G; P; R; Di Ciaccio, A; B; A; A; R; C; A; P; F; Di S; S; A; E; M; D; A; F; F; F; E; L; C; A; P; C; C; R; A; A; G; De D; De A; De G; Di A; Di A; C; S; P; S; S; E K; F; C; L; F; G; M; A; P; E; E; L; M; S; S; A; E F; P; R; S; M; H; F; C; N; M; M; L; A; de X; E; M; D; J; A I; Fleischmann, P; A; V; P F; C; S; C; W; E; J F; M; B; C; J P; R; A; D M; P; J; P; J; Z; P; M; D; V V; A; N I; S V; A G; S P; V N; R M; A B; V A; S N; S A; S V; V N; V N; A V; V V; A N; A G; A M; S V; V; V A; M E; A S; V V; A V; M S; A A; G Y; A M; A G; A V; A N; V; A A; V; E A; M; A P; A S; V G; A M; A V; V V; Booth, C N; Booth, P; D; Dawson, I; S D; R; R S; C; R; M C; P; P; N; M; S; D; R; E; K; D R; S; Zhu, H Z; S; P; I; K; M; I; M; V; T; W; U; M; I; R; S; S; S; C; D W; A; A; D; C; R K; K; B; A; D; H K; He, P; J; Y; R; D; A; R; Z; T; Lu, L; P; R R; R; A; Yang, J C; J; P; L; V; V; S; A; V P; S; L G; V P; S Y; F; V A; E; D M; I; A K; S M; B; S; F; L; A; B; R; G; J J; K; A; R L; M; J L; M; A; K J; P; B; Y; E; S; C; C; D; K; S; A; S O; Johansen, M; K E; K; J; D A; T; M; B; S B; J S H; L S; A F; K E; A T; M L; S; S C; Z; S C; D; Z; P K; S; Y; L; T; J; M; E G; H; G; N; G; M; O; Y; E; E; J; Y; Y; E; A; E; K; R; A; H; H; J; P; N; R; M; B; A; White, A; Yu, J; C; K; K; I A; A; A; C; D; I; U; C; S; M; M; N; M; Y; T; T; T; T; H; H; H; H; H; J; I; S; D C; A; P A; L S; B; K K; N K; P; Le C; Ma, L L; F K; J K; R; R S; Rosenbaum, G A; P; P; R J; W; K; Y; Y; T; Y; M; K; H; O; S; J; M; T; T; Y; Y; A; K; K; M; S; K; O; T; K; S; S; J; K; S; Y; A; H; Y; K; K; S H; T; A; Y; K; Y; F; W A; A; S; K; S; B S; D; M; De B; C; M P; H; L; L; C; N; R; E; T; M; M; C J; L; R; J; F; J; S; E; D; F; Segura, F; J; V; J V; M J; C S; C; F; A; 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This paper focuses on Foucault's analysis of two forms of neo-liberalism in his lecture of 1979 at the Collège de France: German post-War liberalism and the liberalism of the Chicago School. Since the course is available only on audio-tapes at the Foucault archive in Paris, the larger part of the text presents a comprehensive reconstruction of the main line of argumentation, citing previously unpublished source material. The final section offers a short discussion of the methodological and theoretical principles underlying the concept of governmentality and the critical political angle it provides for an analysis of contemporary neo-liberalism.

We report on results of an all-sky search for high-energy neutrino events interacting within the IceCube neutrino detector conducted between May 2010 and May 2012. The search follows up on the previous detection of two PeV neutrino events, with improved sensitivity and extended energy coverage down to about 30 TeV. Twenty-six additional events were observed, substantially more than expected from atmospheric backgrounds. Combined, both searches reject a purely atmospheric origin for the 28 events at the 4σ level. These 28 events, which include the highest energy neutrinos ever observed, have flavors, directions, and energies inconsistent with those expected from the atmospheric muon and neutrino backgrounds. These properties are, however, consistent with generic predictions for an additional component of extraterrestrial origin.

Current tests for nonlinearity compare a time series to the null hypothesis of a Gaussian linear stochastic process. For this restricted null assumption, random surrogates can be constructed which are constrained by the linear properties of the data. We propose a more general null hypothesis allowing for nonlinear rescalings of a Gaussian linear process. We show that such rescalings cannot be accounted for by a simple amplitude adjustment of the surrogates which leads to spurious detection of nonlinearity. An iterative algorithm is proposed to make appropriate surrogates which have the same autocorrelations as the data and the same probability distribution.

We describe the implementation of methods of nonlinear time series analysis which are based on the paradigm of deterministic chaos. A variety of algorithms for data representation, prediction, noise reduction, dimension and Lyapunov estimation, and nonlinearity testing are discussed with particular emphasis on issues of implementation and choice of parameters. Computer programs that implement the resulting strategies are publicly available as the TISEAN software package. The use of each algorithm will be illustrated with a typical application. As to the theoretical background, we will essentially give pointers to the literature. (c) 1999 American Institute of Physics.

A new method for estimating the Kolmogorov entropy directly from a time signal is proposed and tested on examples. The method should prove valuable for characterizing experimental chaotic signals.Received 6 May 1983DOI:https://doi.org/10.1103/PhysRevA.28.2591©1983 American Physical Society

The dynamics of the interaction of a single Rydberg atom with a single mode of an electromagnetic field in a superconducting cavity was investigated. Velocity-selected atoms were used and the evolution of the atomic inversion as atom and field exchange energy was observed. The quantum collapse and revival predicted by the Jaynes-Cummings model were demonstrated experimentally for the first time. The evaluation of the dynamic behavior of the atoms allows us to determine the statistics of the few photons in the cavity.

A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is m_{H}=125.09±0.21 (stat)±0.11 (syst) GeV.

This paper gives an overview of medium-voltage (MV) multilevel converters with a focus on achieving minimum harmonic distortion and high efficiency at low switching frequency operation. Increasing the power rating by minimizing switching frequency while still maintaining reasonable power quality is an important requirement and a persistent challenge for the industry. Existing solutions are discussed and analyzed based on their topologies, limitations, and control techniques. As a preferred option for future research and application, an inverter configuration based on three-level building blocks to generate five-level voltage waveforms is suggested. This paper shows that such an inverter may be operated at a very low switching frequency to achieve minimum on-state and dynamic device losses for highly efficient MV drive applications while maintaining low harmonic distortion.

from the atmosphere. Herein, we review innovative technologies that offer solutions achieving carbon (C) neutrality and sustainable development, including those for renewable energy production, food system transformation, waste valorization, C sink conservation, and C-negative manufacturing. The wealth of knowledge disseminated in this review could inspire the global community and drive the further development of innovative technologies to mitigate climate change and sustainably support human activities.

Before we apply nonlinear techniques, e.g. those inspired by chaos theory, to dynamical phenomena occurring in nature, it is necessary to first ask if the use of such advanced techniques is justified by the data. While many processes in nature seem very unlikely a priori to be linear, the possible nonlinear nature might not be evident in specific aspects of their dynamics. The method of surrogate data has become a very popular tool to address such a question. However, while it was meant to provide a statistically rigorous, foolproof framework, some limitations and caveats have shown up in its practical use. In this paper, recent efforts to understand the caveats, avoid the pitfalls, and to overcome some of the limitations, are reviewed and augmented by new material. In particular, we will discuss specific as well as more general approaches to constrained randomisation, providing a full range of examples. New algorithms will be introduced for unevenly sampled and multivariate data and for surrogate spike trains. The main limitation, which lies in the interpretability of the test results, will be illustrated through instructive case studies. We will also discuss some implementational aspects of the realisation of these methods in

Soil contamination by potentially toxic elements (PTEs) has led to adverse environmental impacts. In this review, we discussed remediation of PTEs contaminated soils through immobilization techniques using different soil amendments with respect to type of element, soil, and amendment, immobilization efficiency, underlying mechanisms, and field applicability. Soil amendments such as manure, compost, biochar, clay minerals, phosphate compounds, coal fly ash, and liming materials are widely used as immobilizing agents for PTEs. Among these soil amendments, biochar has attracted increased interest over the past few years because of its promising surface properties. Integrated application of appropriate amendments is also recommended to maximize their use efficiency. These amendments can reduce PTE bioavailability in soils through diverse mechanisms such as precipitation, complexation, redox reactions, ion exchange, and electrostatic interaction. However, soil properties such as soil pH, and clay, sesquioxides and organic matter content, and processes, such as sorption/desorption and redox processes, are the key factors governing the amendments' efficacy for PTEs immobilization in soils. Selecting proper immobilizing agents can yield cost-effective remediation techniques and fulfill green and sustainable remediation principles. Furthermore, long-term stability of immobilized PTE compounds and the environmental impacts and cost effectiveness of the amendments should be considered before application.

The description of solids at a microscopic level is complex, involving the interaction of a huge number of its constituents, such as ions or electrons. It is impossible to solve the corresponding many-body problems analytically or numerically, although much insight can be gained from the analysis of simplified models. An important example is the Hubbard model, which describes interacting electrons in narrow energy bands, and which has been applied to problems as diverse as high-Tc superconductivity, band magnetism, and the metal-insulator transition. This 2005 book presents a coherent, self-contained account of the exact solution of the Hubbard model in one dimension. The early chapters will be accessible to beginning graduate students with a basic knowledge of quantum mechanics and statistical mechanics. The later chapters address more advanced topics, and are intended as a guide for researchers to some of the more topical results in the field of integrable models.

During the last few years, transition metal oxides (TMO) such as molybdenum tri-oxide (MoO(3) ), vanadium pent-oxide (V(2) O(5) ) or tungsten tri-oxide (WO(3) ) have been extensively studied because of their exceptional electronic properties for charge injection and extraction in organic electronic devices. These unique properties have led to the performance enhancement of several types of devices and to a variety of novel applications. TMOs have been used to realize efficient and long-term stable p-type doping of wide band gap organic materials, charge-generation junctions for stacked organic light emitting diodes (OLED), sputtering buffer layers for semi-transparent devices, and organic photovoltaic (OPV) cells with improved charge extraction, enhanced power conversion efficiency and substantially improved long term stability. Energetics in general play a key role in advancing device structure and performance in organic electronics; however, the literature provides a very inconsistent picture of the electronic structure of TMOs and the resulting interpretation of their role as functional constituents in organic electronics. With this review we intend to clarify some of the existing misconceptions. An overview of TMO-based device architectures ranging from transparent OLEDs to tandem OPV cells is also given. Various TMO film deposition methods are reviewed, addressing vacuum evaporation and recent approaches for solution-based processing. The specific properties of the resulting materials and their role as functional layers in organic devices are discussed.

The cost-effective production of flexible electronic components will profit considerably from the development of solution-processable, organic semiconductor materials. Particular attention is focused on soluble semiconductors for organic field-effect transistors (OFETs). The hitherto differentiation between "small molecules" and polymeric materials no longer plays a role, rather more the ability to process materials from solution to homogeneous semiconducting films with optimal electronic properties (high charge-carrier mobility, low threshold voltage, high on/off ratio) is pivotal. Key classes of materials for this purpose are soluble oligoacenes, soluble oligo- and polythiophenes and their respective copolymers, and oligo- and polytriarylamines. In this context, micro- or nanocrystalline materials have the general advantage of somewhat higher charge-carrier mobilities, which, however, could be offset in the case of amorphous, glassy materials by simpler and more reproducible processing.