Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

M. Davis, Nicole; M. Proctor, Diana; Holmes, Susan; A. Relman, David; J. Callahan, Benjamin

doi:10.1186/s40168-018-0605-2

Public

Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data

Published in Microbiome • Dec 1, 2018

Authors:

Nicole M. Davis

Diana M. Proctor

Susan Holmes

Abstract

BACKGROUND: The accuracy of microbial community surveys based on marker-gene and metagenomic sequencing (MGS) suffers from the presence of contaminants-DNA sequences not truly present in the sample. Contaminants come from various sources, including reagents. Appropriate laboratory practices can redu...

Subject

Metagenomics

Biology

Computational biology

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