High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Boutet, Sébastien; Lomb, Lukas; J. Williams, Garth; R. M. Barends, Thomas; Aquila, Andrew; Bruce Doak, R.; Weierstall, Uwe; P. DePonte, Daniel; Steinbrener, Jan; L. Shoeman, Robert; Messerschmidt, M.; Barty, Anton; A. White, Thomas; Kassemeyer, Stephan; A. Kirian, Richard; Seibert, M.; Montanez, P.; Kenney, C.; Herbst, Ryan; Hart, Philip; Pines, J.; Haller, G.; M. Grüner, Sol; T. Philipp, Hugh; W. Täte, Mark; S. Hromalik, Marianne; J. Koerner, Lucas; van Bakel, Niels; Morse, John; Ghonsalves, W.; Arnlund, David; J. Bogan, Michael; Caleman, Carl; Fromme, Raimund; Y. Hampton, Christina; S. Hunter, Mark; C. Johansson, Linda; Katona, Gergely; Kupitz, Christopher; Liang, Mengning; V. Martin, Andrew; Nass, Karol; Redecke, Lars; Stellato, Francesco; Tı̂mneanu, Nicuşor; Wang, Dingjie; A. Zatsepin, Nadia; W. Schafer, Donald; Defever, James; Neutze, Richard; Fromme, Petra; C. H. Spence, John; N. Chapman, Henry; Schlichting, Ilme

doi:10.1126/science.1217737

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High-Resolution Protein Structure Determination by Serial Femtosecond Crystallography

Published in Science • Jun 1, 2012

Authors:

Sébastien Boutet

Lukas Lomb

Garth J. Williams

Abstract

Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XF...

Subject

Femtosecond

Protein crystallization

Crystallography

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