Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

Kunjachan, Sijumon; Pola, Robert; Gremse, Felix; Theek, Benjamin; Ehling, Josef; Moeckel, Diana; Hermanns‐Sachweh, Benita; Pechar, Michal; Ulbrich, Karel; E. Hennink, Wim; Storm, Gert; Lederle, Wiltrud; Kießling, Fabian; Lammers, Twan

doi:10.1021/nl404391r

Public

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

Published in Nano Letters • Jan 14, 2014

Authors:

Sijumon Kunjachan

Robert Pola

Felix Gremse

Abstract

Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-related surface receptors are key features of tumor blood vessels. As a consequence, EPR-mediated passive and Arg-Gly-Asp (RGD) and Asn-Gly-Arg (NGR) based active tumor targeting have received considerable attention...

Subject

Nanocarriers

In vivo

Ex vivo

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