An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

Kuo, George; L Choo, Q; Alter, Harrison; Gitnick, Gary; G. Redeker, Allan; H Purcell, R; Miyamura, Tatsuo; L. Dienstag, Jules; J Alter, M; E. Stevens, Cladd; E. Tegtmeier, Gary; Bonino, Ferruccio; Colombo, Massimo; Lee, W.-S.; Kuo, C.; Berger, Karin; R. Shuster, Jeffrey; R. Overby, Lacy; W. Bradley, Daniel; Houghton, Michael

doi:10.1126/science.2496467

Public

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

Published in Science • Apr 21, 1989

Authors:

George Kuo

Q L Choo

Harrison Alter

Abstract

A specific assay has been developed for a blood-borne non-A, non-B hepatitis (NANBH) virus in which a polypeptide synthesized in recombinant yeast clones of the hepatitis C virus (HCV) is used to capture circulating viral antibodies. HCV antibodies were detected in six of seven human sera that were ...

Subject

Medicine

Antibody

Hepatitis C virus

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