Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( <i>USF2</i> ) knockout mice

Nicolas, Gaël; Bennoun, Myriam; Devaux, Isabelle; Beaumont, Carole; Grandchamp, Bernard; Kahn, Axel; Vaulont, Sophie

doi:10.1073/pnas.151179498

Public

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

Published in Proceedings of the National Academy of Sciences • Jul 10, 2001

Authors:

Gaël Nicolas

Myriam Bennoun

Isabelle Devaux

Abstract

We previously reported the disruption of the murine gene encoding the transcription factor USF2 and its consequences on glucose-dependent gene regulation in the liver. We report here a peculiar phenotype of Usf2(-/-) mice that progressively develop multivisceral iron overload; plasma iron overcomes ...

Subject

Hepcidin

Knockout mouse

Hemochromatosis

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