Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Kawai, Taro; Takeuchi, Osamu; Fujita, Takashi; Inoue, Jun‐ichiro; F. Mühlradt, Peter; Sato, Shintaro; Hoshino, Katsuaki; Akira, Shizuo

doi:10.4049/jimmunol.167.10.5887

Public

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

Published in The Journal of Immunology • Nov 1, 2001

Authors:

Taro Kawai

Osamu Takeuchi

Takashi Fujita

Abstract

Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR) 4, a member of the TLR family that participates in pathogen recognition. TLRs recruit a cytoplasmic protein, MyD88, upon pathogen recognition, mediating its function for immune responses. Two major p...

Subject

TLR2

TLR4

Lipopolysaccharide

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