Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

Ghannam, Soufiane; Pène, Jérôme; Torcy-Moquet, Gabriel; Jørgensen, Christian; Yssel, Hans

doi:10.4049/jimmunol.0902007

Public

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

Published in The Journal of Immunology • May 29, 2010

Authors:

Soufiane Ghannam

Jérôme Pène

Gabriel Torcy-Moquet

Abstract

Mesenchymal stem cells (MSCs) exert immunomodulatory properties via the inhibition of T cell activation and proliferation. Because of the deleterious role of Th17 cells in the pathogenesis of inflammatory disease, we investigated whether proinflammatory cytokines could modify the expression of adhes...

Subject

Mesenchymal stem cell

Phenotype

Cell biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!