Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, Marco; J. Rowan, Andrew; Horswell, Stuart; Larkin, James; Endesfelder, David; Grönroos, Eva; Martinez, Pierre; Matthews, Nicholas; Stewart, Aengus; Tarpey, Patrick; Varela, Ignacio; Phillimore, Benjamin; Begum, Sharmin; Q. McDonald, Neil; Butler, Adam; Jones, David; Raine, Keiran; Latimer, Calli; R. Santos, Cláudio; Nohadani, Mahrokh; C. Eklund, Aron; Spencer‐Dene, Bradley; Clark, Graham; Pickering, Lisa; Stamp, Gordon; Gore, Martin; Szállási, Zoltán; Downward, Julian; Andrew Futreal, P.; Swanton, Charles

doi:10.1056/nejmoa1113205

Public

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Published in New England Journal of Medicine • Mar 7, 2012

Authors:

Marco Gerlinger

Andrew J. Rowan

Stuart Horswell

Abstract

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy ...

Subject

Computational biology

Evolutionary biology

Biology

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