High Prevalence of KatG Ser315Thr Substitution among Isoniazid-Resistant <i>Mycobacterium tuberculosis</i> Clinical Isolates from Northwestern Russia, 1996 to 2001

Mokrousov, Igor; Narvskaya, Olga; Otten, Tatiana; Limeschenko, Elena; Steklova, Lidia; Vyshnevskiy, Boris

doi:10.1128/aac.46.5.1417-1424.2002

Public

High Prevalence of KatG Ser315Thr Substitution among Isoniazid-Resistant Mycobacterium tuberculosis Clinical Isolates from Northwestern Russia, 1996 to 2001

Published in Antimicrobial Agents and Chemotherapy • May 1, 2002

Authors:

Igor Mokrousov

Olga Narvskaya

Tatiana Otten

Abstract

A total of 204 isoniazid (INH)-resistant strains of Mycobacterium tuberculosis isolated from different patients in the northwestern region of Russia from 1996 to 2001 were screened by a PCR-restriction fragment length polymorphism (RFLP) assay. This assay uses HapII cleavage of an amplified fragment...

Subject

Genotype

Isoniazid

Mycobacterium tuberculosis

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