Analysis of shared heritability in common disorders of the brain

Anttila, Verneri; Bulik‐Sullivan, Brendan; K. Finucane, Hilary; K. Walters, Raymond; Brás, José; E. Duncan, Laramie; Escott‐Price, Valentina; J. Falcone, Guido; Gormley, Padhraig; Malik, Rainer; A. Patsopoulos, Nikolaos; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; H. Lee, Phil; Turley, Patrick; Grenier‐Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine; Letenneur, Luc; Hannequin, Didier; Amouyel, Philippe; Boland, Anne; Deleuze, Jean‐François; Duron, Emmanuelle; N. Vardarajan, Badri; Reitz, Christiane; Goate, Alison; J. Huentelman, Matthew; Ilyas Kamboh, M.; B. Larson, Eric; Rogaeva, Ekaterina; St George‐Hyslop, Peter; Håkonarson, Håkon; A. Kukull, Walter; A. Farrer, Lindsay; L. Barnes, Lisa; G. Beach, Thomas; Yesim Demirci, F.; Head, Elizabeth; M. Hulette, Christine; A. Jicha, Gregory; S.K. Kauwe, John; A. Kaye, Jeffrey; B. Leverenz, James; I. Levey, Allan; P. Lieberman, Andrew; Shane Pankratz, V.; W. Poon, Wayne; F. Quinn, Joseph; J. Saykin, Andrew; S. 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Neale, Benjamin

doi:10.1126/science.aap8757

Public

Analysis of shared heritability in common disorders of the brain

Published in Science • Jun 21, 2018

Authors:

Verneri Anttila

Brendan Bulik‐Sullivan

Hilary K. Finucane

Abstract

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and ...

Subject

Heritability

Genome-wide association study

Missing heritability problem

Research Assistant

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