von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome

Furlan, Miha; Robles, Rodolfo; Galbusera, Miriam; Remuzzi, Giuseppe; A. Kyrle, Paul; Brenner, B.; Krause, Manuela; Scharrer, I.; Aumann, V.; Mittler, U.; Solenthaler, Max; Lämmle, Bernhard

doi:10.1056/nejm199811263392202

Public

von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome

Published in New England Journal of Medicine • Nov 26, 1998

Authors:

Miha Furlan

Rodolfo Robles

Miriam Galbusera

Abstract

BACKGROUND: Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet clumping with similar signs and symptoms. Unusually large multimers of von Willebrand factor, capable of agglutinating circulating platelets under high shear stress, occur...

Subject

Thrombotic thrombocytopenic purpura

Medicine

Von Willebrand factor

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