Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Mestre, Humberto; Tithof, Jeffrey; Du, Ting; Song, Wei; Peng, Weiguo; M. Sweeney, Amanda; E. Olveda, Genaro; H. Thomas, John; Nedergaard, Maiken; H. Kelley, Douglas

doi:10.1038/s41467-018-07318-3

Public

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Published in Nature Communications • Nov 13, 2018

Authors:

Humberto Mestre

Jeffrey Tithof

Ting Du

Abstract

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but this has never been quantitatively shown. We used particle tracking to quantify CSF flow velocities in PVSs of live mice...

Subject

Pulsatile flow

Backflow

Cerebrospinal fluid

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