Cell-Free DNA to Detect Heart Allograft Acute Rejection

Agbor-Enoh, Sean; Shah, Palak; Tunc, Ilker; Hsu, Steven; Russell, Stuart; Feller, Erika; Shah, Keyur; E. Rodrigo, Maria; S. Najjar, Samer; Kong, Hyesik; Pirooznia, Mehdi; Fideli, Ulgen; Bikineyeva, Alfiya; Marishta, Argit; Bhatti, Kenneth; Yang, Yanqin; Mutebi, Cedric; Yu, Kai; Kyoo Jang, Moon; Marboe, Charles; J. Berry, Gerald; A. Valantine, Hannah; the GRAfT Investigators, For

doi:10.1161/circulationaha.120.049098

Public

Cell-Free DNA to Detect Heart Allograft Acute Rejection

Published in Circulation • Jan 13, 2021

Authors:

Sean Agbor-Enoh

Palak Shah

Ilker Tunc

Abstract

BACKGROUND: After heart transplantation, endomyocardial biopsy (EMBx) is used to monitor for acute rejection (AR). Unfortunately, EMBx is invasive, and its conventional histological interpretation has limitations. This is a validation study to assess the performance of a sensitive blood biomarker-pe...

Subject

Medicine

Receiver operating characteristic

Heart transplantation

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