Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

K. Somineni, Hari; Nagpal, Sini; Venkateswaran, Suresh; J. Cutler, David; T. Okou, David; Haritunians, Talin; L. Simpson, Claire; Begum, Ferdouse; W. Datta, Lisa; Quiros, Antonio; Seminerio, Jenifer; Mengesha, Emebet; Steven Alexander, J.; N. Baldassano, Robert; Dudley‐Brown, Sharon; K. Cross, Raymond; Dassopoulos, Themistocles; A. Denson, Lee; Dhere, Tanvi; Iskandar, Heba; W. Dryden, Gerald; K. Hou, Jason; Z. Hussain, Sunny; S. Hyams, Jeffrey; L. Isaacs, Kim; A. Kader, Howard; D. Kappelman, Michael; Katz, Jeffry; Kellermayer, Richárd; F. Kuemmerle, John; Lazarev, Mark; Li, Ellen; Mannon, Peter; E. Moulton, Dedrick; D. Newberry, Rodney; Patel, Ashish; Pekow, Joel; A. Saeed, Shehzad; F. Valentine, John; Wang, Ming‐Hsi; L. McCauley, Jacob; T. Abreu, María; Jester, Traci; Molle‐Rios, Zarela; Palle, Sirish; Scherl, Ellen; H. Kwon, John; D. Rioux, John; H. Duerr, Richard; S. Silverberg, Mark; E. Zwick, Michael; Stevens, Christine; J. Daly, Mark; H. Cho, Judy; Gibson, Greg; McGovern, Dermot; R. Brant, Steven; Kugathasan, Subra

doi:10.1016/j.ajhg.2021.02.001

Public

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease

Published in The American Journal of Human Genetics • Feb 17, 2021

Authors:

Hari K. Somineni

Sini Nagpal

Suresh Venkateswaran

Abstract

Whether or not populations diverge with respect to the genetic contribution to risk of specific complex diseases is relevant to understanding the evolution of susceptibility and origins of health disparities. Here, we describe a large-scale whole-genome sequencing study of inflammatory bowel disease...

Subject

Inflammatory bowel disease

Genetic architecture

Genome

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