Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Ju, Yi; Shi Lee, Wen; H. Pilkington, Emily; G. Kelly, Hannah; Li, Shiyao; J. Selva, Kevin; M. Wragg, Kathleen; Subbarao, Kanta; H. O. Nguyen, Thi; C. Rowntree, Louise; F. Allen, Lilith; Bond, Katherine; A. Williamson, Deborah; P. Truong, Nghia; Plebanski, Magdalena; Kedzierska, Katherine; Mahanty, Siddhartha; W. Chung, Amy; Caruso, Frank; K. Wheatley, Adam; A. Juno, Jennifer; J. Kent, Stephen

doi:10.1021/acsnano.2c04543

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Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Published in ACS Nano • Jun 27, 2022

Authors:

Yi Ju

Wen Shi Lee

Emily H. Pilkington

Abstract

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) mRNA vaccines for SARS-CoV-2 contain small amounts of PEG, but it is not known whether PEG antibodies are enhanced by vaccination and what their impact is on particle-immu...

Subject

Vaccination

Reactogenicity

Antibody

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