Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Ossenkoppele, Rik; Pichet Binette, Alexa; Groot, Colin; Smith, Ruben; Strandberg, Olof; Palmqvist, Sebastian; Stomrud, Erik; Tideman, Pontus; Ohlsson, Tomas; Jögi, Jonas; A. Johnson, Keith; A. Sperling, Reisa; Doré, Vincent; L. Masters, Colin; C. Rowe, Christopher; Visser, Denise; N. M. van Berckel, Bart; M. van der Flier, Wiesje; L. Baker, Suzanne; J. Jagust, William; J. Wiste, Heather; C. Petersen, Ronald; R. Jack, Clifford; Hansson, Oskar

doi:10.1038/s41591-022-02049-x

Public

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

Published in Nature Medicine • Nov 1, 2022

Authors:

Rik Ossenkoppele

Alexa Pichet Binette

Colin Groot

Abstract

Abstract A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer’s disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In ...

Subject

Hazard ratio

Dementia

Cognitive decline

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