Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Shrine, Nick; G. Izquierdo, Abril; Chen, Jing; Packer, Richard; J. Hall, Robert; L. Guyatt, Anna; Batini, Chiara; Thompson, Rebecca; Pavuluri, Chandan; Malik, Vidhi; D. Hobbs, Brian; Moll, Matthew; Kim, Wonji; Tal‐Singer, Ruth; Bakke, Per; A. Fawcett, Katherine; John, Catherine; Coley, Kayesha; Nicole Piga, Noemi; Pozarickij, Alfred; Lin, Kuang; Y. Millwood, Iona; Chen, Zhengming; Li, Liming; Kadoorie Biobank Collaborative Group, China; Wijnant, Sara; Lahousse, Lies; Brusselle, Guy; G. Uitterlinden, André; Manichaikul, Ani; C. Oelsner, Elizabeth; S. Rich, Stephen; Graham Barr, R.; M. Kerr, Shona; Vitart, Véronique; R. Brown, Michael; Wielscher, Matthias; Imboden, Medea; Jeong, Ayoung; M. Bartz, Traci; A. Gharib, Sina; Flexeder, Claudia; Karrasch, Stefan; Gieger, Christian; Peters, Annette; Stubbe, Beate; Hu, Xiaowei; E. Ortega, Victor; A. Meyers, Deborah; R. Bleecker, Eugene; Gabriel, Stacey; Gupta, Namrata; V. Smith, Albert; Luan, Jian’an; Zhao, Jinghua; Falkmo Hansen, Ailin; Langhammer, Arnulf; J. Willer, Cristen; Bhatta, Laxmi; J. Porteous, David; H. Smith, Blair; Campbell, Archie; Sofer, Tamar; Lee, Jiwon; L. Daviglus, Martha; Yu, Bing; Lim, Elise; Xu, Hanfei; O'connor, George; Thareja, Gaurav; Albagha, Omar; I. Ismail, Said; Al‐Muftah, Wadha; Badji, Radja; Mbarek, Hamdi; Darwish, Dima; Fadl, Tasnim; Yasin, Heba; Ennaifar, Maryem; G. Abdel‐latif, Rania; Alkuwari, Fatima; Arshad Alvi, Muhammad; Al‐Sarraj, Yasser; Saad, Chadi; Althani, Asmaa; and Sample Preparation, Biobank; Fethnou, Eleni; Qafoud, Fatima; Alkhayat, Eiman; Afifi, Nahla; and Genotyping group, Sequencing; Tomei, Sara; Liu, Wei; Lorenz, Stephan; Bioinformatics Core, Applied; Syed, Najeeb; Almabrazi, Hakeem; Rehaman Vempalli, Fazulur; Temanni, Ramzi; Management and Computing Infrastructure group, Data; Abu Saqri, Tariq; Khatib, Mohammedhusen; Hamza, Mehshad; Abu Zaid, Tariq; El Khouly, Ahmed; Pathare, Tushar; Poolat, Shafeeq; Al‐Ali, Rashid; Al Khodor, Souhaila; Al‐Shafai, Mashael; Badii, Ramin; Chouchane, Lotfi; Estivill, Xavier; A. Fakhro, Khalid; Mokrab, Younes; V. Jithesh, Puthen; Tatari-Calderone, Zohreh; Suhre, Karsten; Granell, Raquel; Faquih, Tariq; S. Hiemstra, Pieter; M. Slats, Annelies; H. Mullin, Benjamin; Hui, Jennie; James, Alan; Beilby, John; Patasova, Karina; G. Hysi, Pirro; Koskela, Jukka; B. Wyss, Annah; Jin, Jianping; Sikdar, Sinjini; Kyeong Lee, Mi; May-Wilson, Sebastian; Pirastu, Nicola; A. Kentistou, Katherine; K. Joshi, Peter; R. H. J. Timmers, Paul; T. Williams, Alexander; C. Free, Robert; Wang, Xueyang; L. Morrison, John; D. Gilliland, Frank; Chen, Zhanghua; A. Wang, Carol; E. Foong, Rachel; E. Harris, Sarah; Taylor, Adele; Redmond, Paul; P. Cook, James; Mahajan, Anubha; Lind, Lars; Palviainen, Teemu; Lehtimäki, Terho; T. Raitakari, Olli; Kaprio, Jaakko; Rantanen, Taina; H. Pietiläinen, Kirsi; R. Cox, Simon; E. Pennell, Craig; L. Hall, Graham; James Gauderman, W.; E. Brightling, Christopher; F. Wilson, James; Vasankari, Tuula; Laitinen, Tarja; Salomaa, Veikko; O. Mook‐Kanamori, Dennis; J. Timpson, Nicholas; Zeggini, Eleftheria; Dupuis, Josée; Hayward, Caroline; Brumpton, Ben; Langenberg, Claudia; Weiß, Stefan; Homuth, Georg; Oliver Schmidt, Carsten; Probst‐Hensch, Nicole; Järvelin, Marjo‐Riitta; C. Morrison, Alanna; Polašek, Ozren; Rudan, Igor; Lee, Joo‐Hyeon; Sayers, Ian; L. Rawlins, Emma; Dudbridge, Frank; K. Silverman, Edwin; P. Strachan, David; Walters, Robin; P. Morris, Andrew; J. London, Stephanie; H. Cho, Michael; V. Wain, Louise; P. Hall, Ian; D. Tobin, Martin

doi:10.1038/s41588-023-01314-0

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk | NobleBlocks