Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Liew, Felicity; Efstathiou, Claudia; Fontanella, Sara; Richardson, Matthew; Saunders, Ruth; Swieboda, Dawid; K. Sidhu, Jasmin; Ascough, Stephanie; C. Moore, Shona; Mohamed, Noura; Nunag, Jose; King, Clara; C. Leavy, Olivia; Elneima, Omer; J. C. McAuley, Hamish; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; C. Harris, Victoria; Houchen-Wolloff, Linzy; J. Greening, Neil; I. Lone, Nazir; Thorpe, Matthew; A. Roger Thompson, A.; L. Rowland-Jones, Sarah; B. Docherty, Annemarie; D. Chalmers, James; Ho, Ling-Pei; Horsley, Alexander; Raman, Betty; Poinasamy, Krisnah; Marks, Michael; Min Kon, Onn; S. Howard, Luke; G. Wootton, Daniel; K. Quint, Jennifer; I. de Silva, Thushan; Ho, Antonia; Chiu, Christopher; M. Harrison, Ewen; Greenhalf, William; Kenneth Baillie, J.; G. Semple, Malcolm; Turtle, Lance; A. Evans, Rachael; V. Wain, Louise; Brightling, Christopher; S. Thwaites, Ryan; J. M. Openshaw, Peter; collaborative group, PHOSP-COVID; Abel, Kathryn; Adamali, H.; Adeloye, Davies; Adeyemi, Oluwaseun; Adrego, Rita; Aguilar Jimenez, Laura; Ahmad, Shanaz; Ahmad Haider, N.; Ahmed, Rubina; Ahwireng, Nyarko; Ainsworth, Mark; Alamoudi, Asma; Ali, Mariam; Aljaroof, M.; Allan, Louise; Allen, Richard; Allerton, Lisa; Allsop, Lynne; Marie Allt, Ann; Almeida, Paula; Al-Sheklly, Bashar; Altmann, Danny; Alvarez Corral, Maria; Amoils, Shannon; Anderson, David; Antoniades, Charalambos; Arbane, Gill; Maria Arias, Ava; Armour, Cherie; Armstrong, Lisa; Armstrong, Natalie; Arnold, David; Arnold, H.; Ashish, A.; Ashworth, Andrew; Ashworth, M.; Aslani, Shahab; Assefa-Kebede, Hosanna; Atkin, Paul; Atkin, Catherine; Aul, Raminder; Aung, Hnin; Austin, Liam; Avram, Cristina; Avramidis, Nikos; Ayoub, A.; Babores, Marta; Baggott, Rhiannon; Bagshaw, J.; Baguley, David; Bailey, Elisabeth; Kenneth Baillie, J.; Bain, Steve; Bakali, Majda; Bakau, M.; Baldry, E.; Baldwin, Molly; Baldwin, David; Ballard, Clive; Banerjee, Amita; Bang, Dongchun; E. Barker, R.; Barman, Laura; Barran, Perdita; Barratt, Shaney; Barrett, Fiona; Basire, Donna; Basu, Neil; Bates, Michelle; Bates, A.; Batterham, R.; Baxendale, Helen; Baxter, Gabrielle; Bayes, Hannah; Beadsworth, M.; Beckett, Paul; Beggs, M.; Begum, M.; Beirne, Paul; Bell, Murdina; Bell, Robert; Bennett, Kaytie; Beranova, Eva; Bermperi, Areti; Berridge, Anthony; Berry, Colin; Betts, Sarah; Bevan, Emily; Bhui, Kamaldeep; Bingham, Michelle; Birchall, K.; Bishop, Lettie; Bisnauthsing, Karen; Blaikely, John; Bloss, Angela; Bolger, Annette; Bolton, Charlotte; Bonnington, J.; Botkai, A.; Bourne, Charlotte; Bourne, Michelle; Bramham, Kate; Brear, Lucy; Breen, G.; Breeze, Jonathon; Breeze, Katie; Briggs, Andrew; Bright, E.; Brill, Simon; Brindle, K.; Broad, Lauren; Broadley, Andrew; Brookes, Claire; Broome, Mattew; Brown, Vanessa; Brown, M.; Brown, Jo; Brown, J.; Brown, Ammani; Brown, Angela; Brown, M.; Brown, Jeremy; Brugha, Terry; Brunskill, Nigel; Buch, M.; Buckley, Phil; Bularga, Anda; Bullmore, Ed; Bunker, Jenny; Burden, L.; Burdett, Tracy; Burn, David; Burns, G.; Burns, A.; Busby, John; Butcher, Robyn; Butt, Al-Tahoor; Byrne, S.; Cairns, P.; C. Calder, P.; Calvelo, Ellen; Carborn, H.; Card, Bethany; Carr, Caitlin; Carr, Liesel; Carson, G.; Carter, Penny; Casey, Anna; Cassar, M.; Cavanagh, Jonathon

doi:10.1038/s41590-024-01778-0

Public

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Shared by NobleBlocks on Apr 1, 2024 • 12:00 AM UTC

Authors:

Felicity Liew

Claudia Efstathiou

Sara Fontanella

Abstract

Abstract One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood 1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitaliz...

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