L. N. Gumilyov Eurasian National University

Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world's rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focused on the process-based understanding of hydrological variability and causality at all space and time scales. Increased attention to environmental change drives a new emphasis on understanding how change propagates across interfaces within the hydrological system and across disciplinary boundaries. In particular, the expansion of the human footprint raises a new set of questions related to human interactions with nature and water cycle feedbacks in the context of complex water management problems. We hope that this reflection and synthesis of the 23 unsolved problems in hydrology will help guide research efforts for some years to come.

It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

CO(2) sensing is of great societal implications, as CO(2) is a component of gas mixtures from many natural and anthropogenic processes with huge impacts on globe climate and human well-being. Herein we report a CO(2) assay scheme over a wide concentration range, utilizing a fluorogen with an aggregation-induced emission feature and a liquid with tunable polarity and viscosity. The CO(2) sensing process is specific, quantitative, and interferent tolerant.

Abstract Domestication of horses fundamentally transformed long-range mobility and warfare 1 . However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling 2–4 at Botai, Central Asia around 3500 bc 3 . Other longstanding candidate regions for horse domestication, such as Iberia 5 and Anatolia 6 , have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 bc , synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association 7 between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 bc 8,9 driving the spread of Indo-European languages 10 . This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium bc Sintashta culture 11,12 .

We demonstrate that there appear finite-time future singularities in $f(T)$ gravity with $T$ being the torsion scalar. We reconstruct a model of $f(T)$ gravity with realizing the finite-time future singularities. In addition, it is explicitly shown that a power-law-type correction term ${T}^{\ensuremath{\beta}}$ ($\ensuremath{\beta}>1$) such as a ${T}^{2}$ term can remove the finite-time future singularities in $f(T)$ gravity. Moreover, we study $f(T)$ models with realizing inflation in the early universe, the $\ensuremath{\Lambda}\mathrm{CDM}$ model, little rip cosmology and pseudo-rip cosmology. It is demonstrated that the disintegration of bound structures for little rip and pseudo-rip cosmologies occurs in the same way as in gravity with corresponding dark energy fluid. We also discuss that the time-dependent matter instability in the star collapse can occur in $f(T)$ gravity. Furthermore, we explore thermodynamics in $f(T)$ gravity and illustrate that the second law of thermodynamics can be satisfied around the finite-time future singularities for the universe with the temperature inside the horizon being the same as that of the apparent horizon.

: The main purpose of this work is to study the effectiveness of using FeCeOx nanocomposites doped with Nb2O5 for the purification of aqueous solutions from manganese. X-ray diffraction, energy–dispersive analysis, scanning electron microscopy, vibrational magnetic spectroscopy, and mössbauer spectroscopy were used as research methods. It is shown that an increase in the dopant concentration leads to the transformation of the shape of nanoparticles from spherical to cubic and rhombic, followed by an increase in the size of the nanoparticles. The spherical shape of the nanoparticles is characteristic of a structure consisting of a mixture of two phases of hematite (Fe2O3) and cerium oxide CeO2. The cubic shape of nanoparticles is typical for spinel-type FeNbO4 structures, the phase contribution of which increases with increasing dopant concentration. It is shown that doping leads not only to a decrease in the concentration of manganese in model solutions, but also to an increase in the efficiency of adsorption from 11% to 75%.

A characterization of tame automorphisms of the algebra <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper A equals upper F left-bracket x 1 comma x 2 comma x 3 right-bracket"> <mml:semantics> <mml:mrow> <mml:mi>A</mml:mi> <mml:mo>=</mml:mo> <mml:mi>F</mml:mi> <mml:mo stretchy="false">[</mml:mo> <mml:msub> <mml:mi>x</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mo>,</mml:mo> <mml:msub> <mml:mi>x</mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mo>,</mml:mo> <mml:msub> <mml:mi>x</mml:mi> <mml:mn>3</mml:mn> </mml:msub> <mml:mo stretchy="false">]</mml:mo> </mml:mrow> <mml:annotation encoding="application/x-tex">A=F[x_1,x_2,x_3]</mml:annotation> </mml:semantics> </mml:math> </inline-formula> of polynomials in three variables over a field <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper F"> <mml:semantics> <mml:mi>F</mml:mi> <mml:annotation encoding="application/x-tex">F</mml:annotation> </mml:semantics> </mml:math> </inline-formula> of characteristic <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="0"> <mml:semantics> <mml:mn>0</mml:mn> <mml:annotation encoding="application/x-tex">0</mml:annotation> </mml:semantics> </mml:math> </inline-formula> is obtained. In particular, it is proved that the well-known Nagata automorphism is wild. It is also proved that the tame and the wild automorphisms of <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper A"> <mml:semantics> <mml:mi>A</mml:mi> <mml:annotation encoding="application/x-tex">A</mml:annotation> </mml:semantics> </mml:math> </inline-formula> are algorithmically recognizable.

Abstract\nDark energy cosmology is considered in a modified Gauss-Bonnet model of gravity with and without a scalar field. It is shown that these generalizations of General Relativity endow it with a very rich cosmological structure: it may naturally lead to an effective cosmological constant, quintessence or phantom cosmic acceleration, with the possibility to describe the transition from a decelerating to an accelerating phase explicitly. It is demonstrated here that these modified GB and scalar-GB theories are perfectly viable as cosmological models. They can describe the ?CDM cosmological era without any need for a cosmological constant. Specific properties of these theories of gravity in different particular cases, such as the de Sitter one, are studied.

(x = 2, 3, 4, and 5) as strongly exchange-coupled nanosized ferrites were fabricated using a one-pot sol⁻gel combustion method (citrate sol-gel method). The X-ray diffraction (XRD) powder patterns of the products confirmed the occurrence of pure, exchange-coupled ferrites. Frequency dependencies of the microwave characteristics (MW) were investigated using a co-axial method. The non-linear behavior of the MW with the composition transformation may be due to different degrees of Fe ion oxidation on the spinel/hexaferrite grain boundaries and strong exchange coupling during the hard and soft phases.

Mimetic gravity is a Weyl-symmetric extension of General Relativity, related to the latter by a singular disformal transformation, wherein the appearance of a dust-like perfect fluid can mimic cold dark matter at a cosmological level. Within this framework, it is possible to provide a unified geometrical explanation for dark matter, the late-time acceleration, and inflation, making it a very attractive theory. In this review, we summarize the main aspects of mimetic gravity, as well as extensions of the minimal formulation of the model. We devote particular focus to the reconstruction technique, which allows the realization of any desired expansionary history of the universe by an accurate choice of potential or other functions defined within the theory (as in the case of mimetic<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>f</mml:mi><mml:mo stretchy="false">(</mml:mo><mml:mi>R</mml:mi><mml:mo stretchy="false">)</mml:mo></mml:math>gravity). We briefly discuss cosmological perturbation theory within mimetic gravity. As a case study within which we apply the concepts previously discussed, we study a mimetic Hořava-like theory, of which we explore solutions and cosmological perturbations in detail. Finally, we conclude the review by discussing static spherically symmetric solutions within mimetic gravity and apply our findings to the problem of galactic rotation curves. Our review provides an introduction to mimetic gravity, as well as a concise but self-contained summary of recent findings, progress, open questions, and outlooks on future research directions.

In order to apply holography and entropy relations to the whole universe, which is a gravitational and thus nonextensive system, for consistency one should use the generalized definition for the universe horizon entropy, namely Tsallis nonextensive entropy. We formulate Tsallis holographic dark energy, which is a generalization of standard holographic dark energy quantified by a new dimensionless parameter $\delta$, possessing the latter as a particular sub-case. We provide a simple differential equation for the dark energy density parameter, as well as an analytical expression for its equation-of-state parameter. In this scenario the universe exhibits the usual thermal history, namely the successive sequence of matter and dark-energy epochs, before resulting in a complete dark energy domination in the far future. Additionally, the dark energy equation-of-state parameter presents a rich behavior and, according to the value of $\delta$, it can be quintessence-like, phantom-like, or experience the phantom-divide crossing before or after the present time. Finally, we confront the scenario with Supernovae type Ia and Hubble parameter observational data, and we show that the agreement is very good, with $\delta$ preferring a value slightly larger than its standard value 1.

We investigate inflation within $$f(R,\phi )$$ -theories, where a dynamical scalar field is coupled to gravity. A class of models which can support early-time acceleration with the emerging of an effective cosmological constant at high curvature is studied. The dynamics of the field allow for exit from inflation leading to the correct amount of inflation in agreement with cosmological data. Furthermore, the spectral index and tensor-to-scalar ratio of the models are carefully analyzed. A generalization of the theory to incorporate dark matter in the context of mimetic gravity, and further extensions of the latter, are also discussed.

Recent studies on water retention behaviour of biochar amended soil rarely considers the effect of pyrolysis temperature and also feedstock type into account. It is well known that pyrolysis temperature and feedstock type influences the physical and chemical properties of biochar due to stagewise decomposition of structure and chemical bonds. Further, soil density, which is in a loose state (in agricultural applications) and dense (in geo-environmental engineering applications) can also influence water retention behaviour of biochar amended soils. The major objective of this study is to investigate the water retention properties of soil amended with three different biochars in both loose and dense state. The biochars, i.e. water hyacinth biochar (WHB), chicken manure biochar (CMB) and wood biochar (WB) were produced in-house at different pyrolysis temperature. After then, biochars at 5% and 10% (w/w%) were amended to the soil. Water retention behaviour (soil suction and gravimetric water content) was studied under drying and wetting cycle simulated by varying relative humidity (RH, 50-90%). Results show that 10% WHB produced at 300 °C were found to possess highest water retention. CMB is found to possess higher water retention than WB for 10% amendment ratio. In general, the addition of three biochars (at both 300 °C and 600 °C) at 10% (w/w) significantly improved the water retention at all suction ranges in both loose and dense compaction state as compared to that of the bare soil. The adsorption (wetting) and desorption (drying) capacity of biochar amended soils is constant at corresponding RH.

The growth of industrialization, which is forced to use non-renewable energy sources, leads to an increase in environmental pollution. Therefore, it is necessary not only to reduce the use of fossil fuels to meet energy needs but also to replace it with cleaner fuels. Production of hydrogen by splitting water is considered one of the most promising ways to use solar energy. TiO2 is an amphoteric oxide that occurs naturally in several modifications. This review summarizes recent advances of doped TiO2-based photocatalysts used in hydrogen production and the degradation of organic pollutants in water. An intense scientific and practical interest in these processes is aroused by the fact that they aim to solve global problems of energy conservation and ecology.

Magnetic Fe3O4 nanoparticles (NPs) and their surface modification with therapeutic substances are of great interest, especially drug delivery for cancer therapy, including boron-neutron capture therapy (BNCT). In this paper, we present the results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane (APTMS) iron oxide NPs. Fourier transform infrared spectroscopy with Attenuated total reflectance accessory (ATR-FTIR) and energy-dispersive X-ray analysis confirmed the change of the element content of NPs after modification and formation of new bonds between Fe3O4 NPs and the attached molecules. Transmission (TEM) and scanning electron microscopy (SEM) showed Fe3O4 NPs’ average size of 18.9 nm. Phase parameters were studied by powder X-ray diffraction (XRD), and the magnetic behavior of Fe3O4 NPs was elucidated by Mössbauer spectroscopy. The colloidal and chemical stability of NPs was studied using simulated body fluid (phosphate buffer—PBS). Modified NPs have shown excellent stability in PBS (pH = 7.4), characterized by XRD, Mössbauer spectroscopy, and dynamic light scattering (DLS). Biocompatibility was evaluated in-vitro using cultured mouse embryonic fibroblasts (MEFs). The results show us an increasing of IC50 from 0.110 mg/mL for Fe3O4 NPs to 0.405 mg/mL for Fe3O4-Carborane NPs. The obtained data confirm the biocompatibility and stability of synthesized NPs and the potential to use them in BNCT.

We study inflation induced by (power-low) scalar curvature corrections to General Relativity. The class of inflationary scalar potentials $V(\ensuremath{\sigma})\ensuremath{\sim}\text{exp}[n\ensuremath{\sigma}]$, $n$ general parameter, is investigated in the Einstein frame, and the corresponding actions in the Jordan frame are derived. We found the conditions for which these potentials are able to reproduce viable inflation according to the last cosmological data and lead to large scalar curvature corrections that emerge only at a mass scale larger than the Planck mass. The cosmological constant may appear or be set equal to zero in the Jordan frame action without changing the behavior of the model during inflation. Moreover, polynomial corrections to General Relativity are analyzed in detail. When de Sitter space-time emerges as an exact solution of the models, it is necessary to use perturbative equations in the Jordan framework to study their dynamics during the inflation. In this case, we demonstrate that the Ricci scalar decreases after a correct amount of inflation, making the models consistent with the observable evolution of the Universe.

A depth-resolved Raman spectroscopy technique was used to study the residual stress profiles in polycrystalline silicon nitride that was irradiated with Xe (167 MeV, 1 × 1011 cm−2 ÷ 4.87 × 1013 cm−2) and Bi (710 MeV, 1 × 1011 cm−2 ÷ 1 × 1013 cm−2) ions. It was shown that both the compressive and tensile stress fields were formed in the irradiated specimen, separated by a buffer zone that was located at a depth that coincided with the thickness of layer, amorphized due to multiple overlapping track regions. The compressive stresses were registered in a subsurface region, while at a greater depth, the tensile stresses were recorded and their levels reached the maximum value at the end of ion range. The size of the amorphous layer was evaluated from the dose dependence of the full width at half maximum (FWHM) (FWHM of the dominant 204 cm−1 line in the Raman spectra and scanning electron microscopy.

Abstract We construct a holographic dark energy scenario based on Kaniadakis entropy, which is a generalization of Boltzmann-Gibbs entropy that arises from relativistic statistical theory and is characterized by a single parameter K which quantifies the deviations from standard expressions, and we use the future event horizon as the Infrared cutoff. We extract the differential equation that determines the evolution of the effective dark energy density parameter, and we provide analytical expressions for the corresponding equation-of-state and deceleration parameters. We show that the universe exhibits the standard thermal history, with the sequence of matter and dark-energy eras, while the transition to acceleration takes place at $$z\approx 0.6$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mi>z</mml:mi> <mml:mo>≈</mml:mo> <mml:mn>0.6</mml:mn> </mml:mrow> </mml:math> . Concerning the dark-energy equation-of-state parameter we show that it can have a rich behavior, being quintessence-like, phantom-like, or experience the phantom-divide crossing in the past or in the future. Finally, in the far future dark energy dominates completely, and the asymptotic value of its equation of state depends on the values of the two model parameters.

The big bang singularity could be understood as a breakdown of Einstein's general relativity at very high energies. By adopting this viewpoint, other theories that implement Einstein cosmology at high energies might solve the problem of the primeval singularity. One of them is loop quantum cosmology (LQC) with a small cosmological constant that models a universe moving along an ellipse, which prevents singularities like the big bang or the big rip, in the phase space $(H,\ensuremath{\rho})$, where $H$ is the Hubble parameter and $\ensuremath{\rho}$ the energy density of the universe. Using LQC one considers a model universe filled by radiation and matter where, due to the cosmological constant, there are a de Sitter and an anti--de Sitter solution. This means that one obtains a bouncing nonsingular universe which is in the contracting phase at early times. After leaving this phase, i.e., after bouncing, it passes trough a radiation- and matter-dominated phase and finally at late times it expands in an accelerated way (current cosmic acceleration). This model does not suffer from the horizon and flatness problems as in big bang cosmology, where a period of inflation that increases the size of our universe in more than 60 e-folds is needed in order to solve both problems. The model has two mechanisms to avoid these problems: the evolution of the universe through a contracting phase and a period of super inflation ($\stackrel{\ifmmode \dot{}\else \textperiodcentered \fi{}}{H}&gt;0$).