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Shizuoka University

UniversityShizuoka, Japan

Research output, citation impact, and the most-cited recent papers from Shizuoka University (Japan). Aggregated across the NobleBlocks index of 300M+ scholarly works.

Total works
34.0K
Citations
1.1M
h-index
264
i10-index
26.5K
Also known as
ShizudaiShizuoka DaigakuShizuoka University静岡大学

Top-cited papers from Shizuoka University

Three-Dimensional Optical Data Storage Using Photochromic Materials
Satoshi Kawata, Yoshimasa Kawata
2000· Chemical Reviews1.5Kdoi:10.1021/cr980073p

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThree-Dimensional Optical Data Storage Using Photochromic MaterialsSatoshi Kawata and Yoshimasa KawataView Author Information Department of Applied Physics, Osaka University, Suita, Osaka, 565-0871, Japan, and Department of Mechanical Engineering, Shizuoka University, Johoku, Hamamatsu, 432-8561, Japan Cite this: Chem. Rev. 2000, 100, 5, 1777–1788Publication Date (Web):April 25, 2000Publication History Received14 June 1999Published online25 April 2000Published inissue 1 May 2000https://pubs.acs.org/doi/10.1021/cr980073phttps://doi.org/10.1021/cr980073presearch-articleACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views9849Altmetric-Citations1285LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Circuits,Lasers,Layers,Light,Molecular structure Get e-Alerts

Ultrafast laser processing of materials: from science to industry
Mangirdas Malinauskas, Albertas Žukauskas, Satoshi Hasegawa, Yoshio Hayasaki +3 more
2016· Light Science & Applications1.3Kdoi:10.1038/lsa.2016.133

Processing of materials by ultrashort laser pulses has evolved significantly over the last decade and is starting to reveal its scientific, technological and industrial potential. In ultrafast laser manufacturing, optical energy of tightly focused femtosecond or picosecond laser pulses can be delivered to precisely defined positions in the bulk of materials via two-/multi-photon excitation on a timescale much faster than thermal energy exchange between photoexcited electrons and lattice ions. Control of photo-ionization and thermal processes with the highest precision, inducing local photomodification in sub-100-nm-sized regions has been achieved. State-of-the-art ultrashort laser processing techniques exploit high 0.1-1 μm spatial resolution and almost unrestricted three-dimensional structuring capability. Adjustable pulse duration, spatiotemporal chirp, phase front tilt and polarization allow control of photomodification via uniquely wide parameter space. Mature opto-electrical/mechanical technologies have enabled laser processing speeds approaching meters-per-second, leading to a fast lab-to-fab transfer. The key aspects and latest achievements are reviewed with an emphasis on the fundamental relation between spatial resolution and total fabrication throughput. Emerging biomedical applications implementing micrometer feature precision over centimeter-scale scaffolds and photonic wire bonding in telecommunications are highlighted.

Reduced HOMO−LUMO Gap as an Index of Kinetic Stability for Polycyclic Aromatic Hydrocarbons
Jun‐ichi Aihara
1999· The Journal of Physical Chemistry A1.1Kdoi:10.1021/jp990092i

A reduced HOMO−LUMO gap, which is defined as the HOMO−LUMO energy separation of a molecule divided by that of the hypothetical polyene reference, can be used as an index of kinetic stability for a variety of polycyclic aromatic hydrocarbons (PAHs). The reduced HOMO−LUMO gap < 1.00 indicates that the HOMO contributes to the decrease in the topological resonance energy. In general, PAHs with reduced HOMO−LUMO gaps < 1.30 are chemically very reactive. Fully benzenoid hydrocarbons are kinetically very stable with very large reduced HOMO−LUMO gaps. Many of the PAH molecules with large reduced HOMO−LUMO gaps are closed-shell substructures of nonmetallic one-dimensional benzenoid polymers.

Solar<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi>B</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>8</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>and hep Neutrino Measurements from 1258 Days of Super-Kamiokande Data
Satoshi Fukuda, Y. Fukuda, M. Ishitsuka, Y. Itow +4 more
2001· Physical Review Letters1.0Kdoi:10.1103/physrevlett.86.5651

Solar neutrino measurements from 1258 days of data from the Super-Kamiokande detector are presented. The measurements are based on recoil electrons in the energy range 5.0--20.0 MeV. The measured solar neutrino flux is $2.32\ifmmode\pm\else\textpm\fi{}0.03(\mathrm{stat}{)}_{\ensuremath{-}0.07}^{+0.08}(\mathrm{syst})\ifmmode\times\else\texttimes\fi{}{10}^{6}{\mathrm{cm}}^{\ensuremath{-}2}{\mathrm{s}}^{\ensuremath{-}1}$, which is $45.1\ifmmode\pm\else\textpm\fi{}0.5(\mathrm{stat}{)}_{\ensuremath{-}1.4}^{+1.6}(\mathrm{syst})%$ of that predicted by the BP2000 SSM. The day vs night flux asymmetry $({\ensuremath{\Phi}}_{n}\ensuremath{-}{\ensuremath{\Phi}}_{d})/{\ensuremath{\Phi}}_{\mathrm{average}}$ is $0.033\ifmmode\pm\else\textpm\fi{}0.022(\mathrm{stat}{)}_{\ensuremath{-}0.012}^{+0.013}(\mathrm{syst})$. The recoil electron energy spectrum is consistent with no spectral distortion. For the hep neutrino flux, we set a $90%$ C.L. upper limit of $40\ifmmode\times\else\texttimes\fi{}{10}^{3}{\mathrm{cm}}^{\ensuremath{-}2}{\mathrm{s}}^{\ensuremath{-}1}$, which is 4.3 times the BP2000 SSM prediction.

The physics of traffic jams
Takashi Nagatani
2002· Reports on Progress in Physics974doi:10.1088/0034-4885/65/9/203

Traffic flow is a kind of many-body system of strongly interacting vehicles. Traffic jams are a typical signature of the complex behaviour of vehicular traffic. Various models are presented to understand the rich variety of physical phenomena exhibited by traffic. Analytical and numerical techniques are applied to study these models. Particularly, we present detailed results obtained mainly from the microscopic car-following models. A typical phenomenon is the dynamical jamming transition from the free traffic (FT) at low density to the congested traffic at high density. The jamming transition exhibits the phase diagram similar to a conventional gas-liquid phase transition: the FT and congested traffic correspond to the gas and liquid phases, respectively. The dynamical transition is described by the time-dependent Ginzburg-Landau equation for the phase transition. The jamming transition curve is given by the spinodal line. The metastability exists in the region between the spinodal and phase separation lines. The jams in the congested traffic reveal various density waves. Some of these density waves show typical nonlinear waves such as soliton, triangular shock and kink. The density waves are described by the nonlinear wave equations: the Korteweg-de-Vries (KdV) equation, the Burgers equation and the Modified KdV equation. Subjects like the traffic flow such as bus-route system and pedestrian flow are touched as well. The bus-route system with many buses exhibits the bunching transition where buses bunch together with proceeding ahead. Such dynamic models as the car-following model are proposed to investigate the bunching transition and bus delay. A recurrent bus exhibits the dynamical transition between the delay and schedule-time phases. The delay transition is described in terms of the nonlinear map. The pedestrian flow also reveals the jamming transition from the free flow at low density to the clogging at high density. Some models are presented to study the pedestrian flow. When the clogging occurs, the pedestrian flow shows the scaling behaviour.

The Infrared Astronomical Mission AKARI
Hiroshi Murakami, Hajime Baba, P. D. Barthel, D. L. Clements +4 more
2007· Publications of the Astronomical Society of Japan856doi:10.1093/pasj/59.sp2.s369

Abstract AKARI, the first Japanese satellite dedicated to infrared astronomy, was launched on 2006 February 21, and started observations in May of the same year. AKARI has a 68.5 cm cooled telescope, together with two focal-plane instruments, which survey the sky in six wavelength bands from mid–to far-infrared. The instruments also have a capability for imaging and spectroscopy in the wavelength range 2-180$\mu$m in the pointed observation mode, occasionally inserted into a continuous survey operation. The in-orbit cryogen lifetime is expected to be one and a half years. The All-Sky Survey will cover more than 90% of the whole sky with a higher spatial resolution and a wider wavelength coverage than that of the previous IRAS all-sky survey. Point-source catalogues of the All-Sky Survey will be released to the astronomical community. Pointed observations will be used for deep surveys of selected sky areas and systematic observations of important astronomical targets. These will become an additional future heritage of this mission.

Measurement of atmospheric neutrino oscillation parameters by Super-Kamiokande I
Y. Ashie, J. Hosaka, K. Ishihara, Y. Itow +4 more
2005· Physical review. D. Particles, fields, gravitation, and cosmology/Physical review. D, Particles, fields, gravitation, and cosmology821doi:10.1103/physrevd.71.112005

We present a combined analysis of fully-contained, partially-contained and upward-going muon atmospheric neutrino data from a 1489 d exposure of the Super-Kamiokande detector. The data samples span roughly five decades in neutrino energy, from 100 MeV to 10 TeV. A detailed Monte Carlo comparison is described and presented. The data is fit to the Monte Carlo expectation, and is found to be consistent with neutrino oscillations of ${\ensuremath{\nu}}_{\ensuremath{\mu}}\ensuremath{\leftrightarrow}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ with ${sin}^{2}2\ensuremath{\theta}&gt;0.92$ and $1.5\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}&lt;\ensuremath{\Delta}{m}^{2}&lt;3.4\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}\text{ }\text{ }{\mathrm{eV}}^{2}$ at 90% confidence level.

ZnO diode fabricated by excimer-laser doping
Toru Aoki, Yoshinori Hatanaka, D. C. Look
2000· Applied Physics Letters714doi:10.1063/1.126599

A ZnO diode was fabricated by using a laser-doping technique to form a p-type ZnO layer on an n-type ZnO substrate. A zinc-phosphide compound, used as a phosphorous source, was deposited on the ZnO wafer and subjected to excimer-laser pulses. The current–voltage characteristics showed a diode characteristic between the phosphorous-doped p-layer and the n-type substrate. Moreover, light emission, with a band-edge component, was observed by forward current injection at 110 K.

Tau Neutrinos Favored over Sterile Neutrinos in Atmospheric Muon Neutrino Oscillations
Satoshi Fukuda, Y. Fukuda, M. Ishitsuka, Y. Itow +4 more
2000· Physical Review Letters698doi:10.1103/physrevlett.85.3999

The previously published atmospheric neutrino data did not distinguish whether muon neutrinos were oscillating into tau neutrinos or sterile neutrinos, as both hypotheses fit the data. Using data recorded in 1100 live days of the Super-Kamiokande detector, we use three complementary data samples to study the difference in zenith angle distribution due to neutral currents and matter effects. We find no evidence favoring sterile neutrinos, and reject the hypothesis at the 99% confidence level. On the other hand, we find that oscillation between muon and tau neutrinos suffices to explain all the results in hand.

Constraints on Neutrino Oscillations Using 1258 Days of Super-Kamiokande Solar Neutrino Data
Satoshi Fukuda, Y. Fukuda, M. Ishitsuka, Y. Itow +4 more
2001· Physical Review Letters650doi:10.1103/physrevlett.86.5656

We report the result of a search for neutrino oscillations using precise measurements of the recoil electron energy spectrum and zenith angle variations of the solar neutrino flux from 1258 days of neutrino-electron scattering data in Super-Kamiokande. The absence of significant zenith angle variation and spectrum distortion places strong constraints on neutrino mixing and mass difference in a flux-independent way. Using the Super-Kamiokande flux measurement in addition, two allowed regions at large mixing are found.

Size effect on the ferroelectric phase transition in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">PbTiO</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>ultrafine particles
Kenji Ishikawa, Kazutoshi Yoshikawa, Nagaya Okada
1988· Physical review. B, Condensed matter640doi:10.1103/physrevb.37.5852

We report a size effect on the ferroelectric phase transition in ${\mathrm{PbTiO}}_{3}$ ultrafine particles. The samples were synthesized by an alkoxide method. The size was determined by x-ray analysis with the aid of Scherrer's equation. When the particle size is less than 50 nm, the transition temperature ${T}_{c}$, determined by Raman scattering, decreases from its bulk value (500 \ifmmode^\circ\else\textdegree\fi{}C) as the size decreases. The temperature ${T}_{c}$ is described by an empirical expression, ${T}_{c}$=500-588.5/(D-12.6) (\ifmmode^\circ\else\textdegree\fi{}C), where D is the average particle size (nm).

Klebsormidium flaccidum genome reveals primary factors for plant terrestrial adaptation
Koichi Hori, Fumito Maruyama, Takatomo Fujisawa, Tomoaki Togashi +4 more
2014· Nature Communications618doi:10.1038/ncomms4978

The colonization of land by plants was a key event in the evolution of life. Here we report the draft genome sequence of the filamentous terrestrial alga Klebsormidium flaccidum (Division Charophyta, Order Klebsormidiales) to elucidate the early transition step from aquatic algae to land plants. Comparison of the genome sequence with that of other algae and land plants demonstrate that K. flaccidum acquired many genes specific to land plants. We demonstrate that K. flaccidum indeed produces several plant hormones and homologues of some of the signalling intermediates required for hormone actions in higher plants. The K. flaccidum genome also encodes a primitive system to protect against the harmful effects of high-intensity light. The presence of these plant-related systems in K. flaccidum suggests that, during evolution, this alga acquired the fundamental machinery required for adaptation to terrestrial environments. Plant colonization of land is an important evolutionary event. Here, the authors sequence the genome of a filamentous terrestrial alga and, through a comparative analysis with related algae and land plant species, provide insight into how aquatic algae adapted to terrestrial environments.

Evidence for an Oscillatory Signature in Atmospheric Neutrino Oscillations
Y. Ashie, J. Hosaka, K. Ishihara, Y. Itow +4 more
2004· Physical Review Letters614doi:10.1103/physrevlett.93.101801

Muon neutrino disappearance probability as a function of neutrino flight length $L$ over neutrino energy $E$ was studied. A dip in the $L/E$ distribution was observed in the data, as predicted from the sinusoidal flavor transition probability of neutrino oscillation. The observed $L/E$ distribution constrained ${\ensuremath{\nu}}_{\ensuremath{\mu}}\ensuremath{\leftrightarrow}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ neutrino oscillation parameters; $1.9\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}&lt;\ensuremath{\Delta}{m}^{2}&lt;3.0\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}3}\text{ }\text{ }{\mathrm{e}\mathrm{V}}^{2}$ and ${sin}^{2}2\ensuremath{\theta}&gt;0.90$ at 90% confidence level.

The Impact of Covid-19 to Indonesian Education and Its Relation to the Philosophy of “Merdeka Belajar”
Azmil Abidah, Hasan Nuurul Hidaayatullaah, Roy Martin Simamora, Daliana Fehabutar +1 more
2020· Studies in Philosophy of Science and Education570doi:10.46627/sipose.v1i1.9

The Covid-19 pandemic is now beginning to spread to the world of education. The Ministry of Education and Culture (MOEC) is currently based on official information, ready with all scenarios, including encouraging online learning for students. This article is a kind of position paper—it clearances one side of a debatable opinion about a hot issue. The aim of a position paper is to persuade the reader that our opinion is valid and defensible. In regards to our position as researchers, then, the point of view is separated into four parts: The philosophy of “Merdeka Belajar”, physical distancing, social distancing and self-quarantine, digital learning in Indonesia to face Covid-19, ‘Merdeka Belajar’, digital learning, Covid-19, and authors’ view.

Cl<sup>−</sup> uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
Junko Yamada, Akihito Okabe, Hiroki Toyoda, Werner Kilb +2 more
2004· The Journal of Physiology556doi:10.1113/jphysiol.2004.062471

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(-)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(-) accumulation remain controversial. Therefore, the GABA reversal potential (E(GABA)) or [Cl(-)](i) in early postnatal rat neocortical neurones was measured by the gramicidin-perforated patch-clamp method, and the relative expression levels of the cation-Cl(-) cotransporter mRNAs (in the same cells) were examined by semiquantitative single-cell multiplex RT-PCR to look for statistical correlations with [Cl(-)](i). The mRNA expression levels were positively (the Cl(-) accumulating Na(+),K(+)-2Cl(-) cotransporter NKCC1) or negatively (the Cl(-) extruding K(+)-Cl(-) cotransporter KCC2) correlated with [Cl(-)](i). NKCC1 mRNA expression was high in early postnatal days, but decreased during postnatal development, whereas KCC2 mRNA expression displayed the opposite pattern. [Cl(-)](i) and NKCC1 mRNA expression were each higher in cortical plate (CP) neurones than in the presumably older layer V/VI pyramidal neurones in a given slice. The pharmacological effects of bumetanide on E(GABA) were consistent with the different expression levels of NKCC1 mRNA. These data suggest that NKCC1 may play a pivotal role in the generation of GABA-mediated depolarization in immature CP cells, while KCC2 promotes the later maturation of GABAergic inhibition in the rat neocortex.

A Simple Screening Method for Antioxidants and Isolation of Several Antioxidants Produced by Marine Bacteria from Fish and Shellfish
Tomohiro Takao, Futoshi Kitatani, Naoharu Watanabe, Akihito Yagi +1 more
1994· Bioscience Biotechnology and Biochemistry539doi:10.1271/bbb.58.1780

Journal Article A Simple Screening Method for Antioxidants and Isolation of Several Antioxidants Produced by Marine Bacteria from Fish and Shellfish Get access Tomohiro Takao, Tomohiro Takao Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Futoshi Kitatani, Futoshi Kitatani Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Naoharu Watanabe, Naoharu Watanabe Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Akihito Yagi, Akihito Yagi Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Kanzo Sakata Kanzo Sakata Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 836 Ohya, Shizuoka 422, JapanResearch Laboratory of Marine Biological Science, Faculty of Agriculture, Shizuoka University, Mochimune, Shizuoka 421–01, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 58, Issue 10, 1 January 1994, Pages 1780–1783, https://doi.org/10.1271/bbb.58.1780 Published: 01 January 1994 Article history Published: 01 January 1994 Received: 25 February 1994

Global estimates of shark catches using trade records from commercial markets
Shelley Clarke, Murdoch K. McAllister, E.J. Milner‐Gulland, G.P. Kirkwood +4 more
2006· Ecology Letters527doi:10.1111/j.1461-0248.2006.00968.x

Despite growing concerns about overexploitation of sharks, lack of accurate, species-specific harvest data often hampers quantitative stock assessment. In such cases, trade studies can provide insights into exploitation unavailable from traditional monitoring. We applied Bayesian statistical methods to trade data in combination with genetic identification to estimate by species, the annual number of globally traded shark fins, the most commercially valuable product from a group of species often unrecorded in harvest statistics. Our results provide the first fishery-independent estimate of the scale of shark catches worldwide and indicate that shark biomass in the fin trade is three to four times higher than shark catch figures reported in the only global data base. Comparison of our estimates to approximated stock assessment reference points for one of the most commonly traded species, blue shark, suggests that current trade volumes in numbers of sharks are close to or possibly exceeding the maximum sustainable yield levels.

Accumulation of Carotenoids and Expression of Carotenoid Biosynthetic Genes during Maturation in Citrus Fruit
Masaya Kato, Yoshinori Ikoma, Hikaru Matsumoto, Minoru Sugiura +2 more
2004· PLANT PHYSIOLOGY524doi:10.1104/pp.103.031104

The relationship between carotenoid accumulation and the expression of carotenoid biosynthetic genes during fruit maturation was investigated in three citrus varieties, Satsuma mandarin (Citrus unshiu Marc.), Valencia orange (Citrus sinensis Osbeck), and Lisbon lemon (Citrus limon Burm.f.). We cloned the cDNAs for phytoene synthase (CitPSY), phytoene desaturase (CitPDS), zeta-carotene (car) desaturase (CitZDS), carotenoid isomerase (CitCRTISO), lycopene beta-cyclase (CitLCYb), beta-ring hydroxylase (CitHYb), zeaxanthin (zea) epoxidase (CitZEP), and lycopene epsilon-cyclase (CitLCYe) from Satsuma mandarin, which shared high identities in nucleotide sequences with Valencia orange, Lisbon lemon, and other plant species. With the transition of peel color from green to orange, the change from beta,epsilon-carotenoid (alpha-car and lutein) accumulation to beta,beta-carotenoid (beta-car, beta-cryptoxanthin, zea, and violaxanthin) accumulation was observed in the flavedos of Satsuma mandarin and Valencia orange, accompanying the disappearance of CitLCYe transcripts and the increase in CitLCYb transcripts. Even in green fruit, high levels of beta,epsilon-carotenoids and CitLCYe transcripts were not observed in the juice sacs. As fruit maturation progressed in Satsuma mandarin and Valencia orange, a simultaneous increase in the expression of genes (CitPSY, CitPDS, CitZDS, CitLCYb, CitHYb, and CitZEP) led to massive beta,beta-xanthophyll (beta-cryptoxanthin, zea, and violaxanthin) accumulation in both the flavedo and juice sacs. The gene expression of CitCRTISO was kept low or decreased in the flavedo during massive beta,beta-xanthophyll accumulation. In the flavedo of Lisbon lemon and Satsuma mandarin, massive accumulation of phytoene was observed with a decrease in the transcript level for CitPDS. Thus, the carotenoid accumulation during citrus fruit maturation was highly regulated by the coordination of the expression among carotenoid biosynthetic genes. In this paper, the mechanism leading to diversity in beta,beta-xanthophyll compositions between Satsuma mandarin and Valencia orange was also discussed on the basis of the substrate specificity of beta-ring hydroxylase and the balance of expression between upstream synthesis genes (CitPSY, CitPDS, CitZDS, and CitLCYb) and downstream synthesis genes (CitHYb and CitZEP).

Halichondrins - antitumor polyether macrolides from a marine sponge
Yoshimasa Hiratå, Daisuke Uemura
1986· Pure and Applied Chemistry511doi:10.1351/pac198658050701

Abstract

The amphioxus genome illuminates vertebrate origins and cephalochordate biology
Linda Z. Holland, Ricard Albalat, Kaoru Azumi, Èlia Benito‐Gutiérrez +4 more
2008· Genome Research511doi:10.1101/gr.073676.107

Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we intensively searched for particular genes, gene families, and conserved noncoding elements in the sequenced genome of the cephalochordate Branchiostoma floridae, commonly called amphioxus or lancelets. Special attention was given to homeobox genes, opsin genes, genes involved in neural crest development, nuclear receptor genes, genes encoding components of the endocrine and immune systems, and conserved cis-regulatory enhancers. The amphioxus genome contains a basic set of chordate genes involved in development and cell signaling, including a fifteenth Hox gene. This set includes many genes that were co-opted in vertebrates for new roles in neural crest development and adaptive immunity. However, where amphioxus has a single gene, vertebrates often have two, three, or four paralogs derived from two whole-genome duplication events. In addition, several transcriptional enhancers are conserved between amphioxus and vertebrates--a very wide phylogenetic distance. In contrast, urochordate genomes have lost many genes, including a diversity of homeobox families and genes involved in steroid hormone function. The amphioxus genome also exhibits derived features, including duplications of opsins and genes proposed to function in innate immunity and endocrine systems. Our results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.