Cl<sup>−</sup> uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

Yamada, Junko; Okabe, Akihito; Toyoda, Hiroki; Kilb, Werner; J. Luhmann, Heiko; Fukuda, Atsuo

doi:10.1113/jphysiol.2004.062471

Public

Cl− uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1

Published in The Journal of Physiology • Apr 20, 2004

Authors:

Junko Yamada

Akihito Okabe

Hiroki Toyoda

Abstract

GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl(-)](i) in immature neocortical neurones causes GABA(A) receptor activation to be depolarizing. The molecular mechanisms underlying this intracellular Cl(-) accumulation rema...

Subject

Neocortex

Cotransporter

Depolarization

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