Soongsil University

Crystalline solids with extended non-interpenetrating three-dimensional crystal structures were synthesized that support well-defined pores with internal diameters of up to 48 angstroms. The Zn4O(CO2)6 unit was joined with either one or two kinds of organic link, 4,4',4''-[benzene-1,3,5-triyl-tris(ethyne-2,1-diyl)]tribenzoate (BTE), 4,4',44''-[benzene-1,3,5-triyl-tris(benzene-4,1-diyl)]tribenzoate (BBC), 4,4',44''-benzene-1,3,5-triyl-tribenzoate (BTB)/2,6-naphthalenedicarboxylate (NDC), and BTE/biphenyl-4,4'-dicarboxylate (BPDC), to give four metal-organic frameworks (MOFs), MOF-180, -200, -205, and -210, respectively. Members of this series of MOFs show exceptional porosities and gas (hydrogen, methane, and carbon dioxide) uptake capacities. For example, MOF-210 has Brunauer-Emmett-Teller and Langmuir surface areas of 6240 and 10,400 square meters per gram, respectively, and a total carbon dioxide storage capacity of 2870 milligrams per gram. The volume-specific internal surface area of MOF-210 (2060 square meters per cubic centimeter) is equivalent to the outer surface of nanoparticles (3-nanometer cubes) and near the ultimate adsorption limit for solid materials.

Doil Choi and colleagues report the genome sequence of the hot pepper, Capsicum annuum, as well as the resequencing of two cultivated peppers and a wild species, Capsicum chinense. Comparative genomic analysis across Solanaceae provides insights into genome expansion, pungency, ripening and disease resistance in hot peppers. Hot pepper (Capsicum annuum), one of the oldest domesticated crops in the Americas, is the most widely grown spice crop in the world. We report whole-genome sequencing and assembly of the hot pepper (Mexican landrace of Capsicum annuum cv. CM334) at 186.6× coverage. We also report resequencing of two cultivated peppers and de novo sequencing of the wild species Capsicum chinense. The genome size of the hot pepper was approximately fourfold larger than that of its close relative tomato, and the genome showed an accumulation of Gypsy and Caulimoviridae family elements. Integrative genomic and transcriptomic analyses suggested that change in gene expression and neofunctionalization of capsaicin synthase have shaped capsaicinoid biosynthesis. We found differential molecular patterns of ripening regulators and ethylene synthesis in hot pepper and tomato. The reference genome will serve as a platform for improving the nutritional and medicinal values of Capsicum species.

OBJECTIVES: Since the first case of 2019 novel coronavirus (COVID-19) identified on Jan 20, 2020, in South Korea, the number of cases rapidly increased, resulting in 6284 cases including 42 deaths as of Mar 6, 2020. To examine the growth rate of the outbreak, we present the first study to report the reproduction number of COVID-19 in South Korea. METHODS: The daily confirmed cases of COVID-19 in South Korea were extracted from publicly available sources. By using the empirical reporting delay distribution and simulating the generalized growth model, we estimated the effective reproduction number based on the discretized probability distribution of the generation interval. RESULTS: We identified four major clusters and estimated the reproduction number at 1.5 (95% CI: 1.4-1.6). In addition, the intrinsic growth rate was estimated at 0.6 (95% CI: 0.6, 0.7), and the scaling of growth parameter was estimated at 0.8 (95% CI: 0.7, 0.8), indicating sub-exponential growth dynamics of COVID-19. The crude case fatality rate is higher among males (1.1%) compared to females (0.4%) and increases with older age. CONCLUSIONS: Our results indicate an early sustained transmission of COVID-19 in South Korea and support the implementation of social distancing measures to rapidly control the outbreak.

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

With the development of smart grid, residents have the opportunity to schedule their power usage in the home by themselves for the purpose of reducing electricity expense and alleviating the power peak-to-average ratio (PAR). In this paper, we first introduce a general architecture of energy management system (EMS) in a home area network (HAN) based on the smart grid and then propose an efficient scheduling method for home power usage. The home gateway (HG) receives the demand response (DR) information indicating the real-time electricity price that is transferred to an energy management controller (EMC). With the DR, the EMC achieves an optimal power scheduling scheme that can be delivered to each electric appliance by the HG. Accordingly, all appliances in the home operate automatically in the most cost-effective way. When only the real-time pricing (RTP) model is adopted, there is the possibility that most appliances would operate during the time with the lowest electricity price, and this may damage the entire electricity system due to the high PAR. In our research, we combine RTP with the inclining block rate (IBR) model. By adopting this combined pricing model, our proposed power scheduling method would effectively reduce both the electricity cost and PAR, thereby, strengthening the stability of the entire electricity system. Because these kinds of optimization problems are usually nonlinear, we use a genetic algorithm to solve this problem.

We report a measurement of the branching fraction ratios $R({D}^{(*)})$ of $\overline{B}\ensuremath{\rightarrow}{D}^{(*)}{\ensuremath{\tau}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}}$ relative to $\overline{B}\ensuremath{\rightarrow}{D}^{(*)}{\ensuremath{\ell}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\ell}}$ (where $\ensuremath{\ell}=e$ or $\ensuremath{\mu}$) using the full Belle data sample of $772\ifmmode\times\else\texttimes\fi{}{10}^{6}B\overline{B}$ pairs collected at the $\mathrm{\ensuremath{\Upsilon}}(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy ${e}^{+}{e}^{\ensuremath{-}}$ collider. The measured values are $R(D)=0.375\ifmmode\pm\else\textpm\fi{}0.064(\text{stat})\ifmmode\pm\else\textpm\fi{}0.026(\text{syst})$ and $R({D}^{*})=0.293\ifmmode\pm\else\textpm\fi{}0.038(\text{stat})\ifmmode\pm\else\textpm\fi{}0.015(\text{syst})$. The analysis uses hadronic reconstruction of the tag-side $B$ meson and purely leptonic $\ensuremath{\tau}$ decays. The results are consistent with earlier measurements and do not show a significant deviation from the standard model prediction.

Flash memory is being rapidly deployed as data storage for mobile devices such as PDAs, MP3 players, mobile phones, and digital cameras, mainly because of its low electronic power, nonvolatile storage, high performance, physical stability, and portability. One disadvantage of flash memory is that prewritten data cannot be dynamically overwritten. Before overwriting prewritten data, a time-consuming erase operation on the used blocks must precede, which significantly degrades the overall write performance of flash memory. In order to solve this “erase-before-write” problem, the flash memory controller can be integrated with a software module, called “flash translation layer (FTL).” Among many FTL schemes available, the log block buffer scheme is considered to be optimum. With this scheme, a small number of log blocks, a kind of write buffer, can improve the performance of write operations by reducing the number of erase operations. However, this scheme can suffer from low space utilization of log blocks. In this paper, we show that there is much room for performance improvement in the log buffer block scheme, and propose an enhanced log block buffer scheme, called FAST (full associative sector translation). Our FAST scheme improves the space utilization of log blocks using fully-associative sector translations for the log block sectors. We also show empirically that our FAST scheme outperforms the pure log block buffer scheme.

Pressure-sensitive electronic skin composed of a hierarchical structural array exhibits outstanding linear and high sensitivity in the pressure range exerted by gentle touch. By virtue of monolayer graphene acting as electrode material, this device can be operated with low voltage. Especially, its high transparency enables an accurate placement of the device on the target position when it is used for health monitoring.

A strategy based on assembling metal ions and organic carboxylate links has been applied for the design and synthesis of a new class of porous, truncated tetrahedral and heterocuboidal polyhedra, whose pore size and functionality can be systematically varied. The synthesis of this series of metal-organic polyhedra (MOPs) employs sulfate-capped oxygen-centered iron-carboxylate trimers, Fe3O(CO2)3(-)(SO4)3, as rigid nodes separated by linear (phenyl, biphenyl, terphenyl, and tetrahydropyrene) or trigonal (benzenetriphenyl) links to yield five highly crystalline polyhedra of general formula [NH2(CH3)2]8[Fe12O4(-)(SO4)12(link)x(py)12].G (x = 6 for linear or 4 for trigonal, py = pyridine, G = guests). In this series, the size of each polyhedron has been varied from 20.0 to 28.5 A (on edge), and the corresponding pore diameter from 7.3 to 13.3 A. Gas sorption isotherms were measured for three members of this series to reveal significant uptake of gases (N2, Ar, CO2, H2, CH4) and benzene and exhibit Type I sorption behavior that is indicative of permanent porosity. The apparent surface areas for these compounds range from 387 to 480 m(2)/g.

A transparent and stretchable all-graphene multifunctional electronic-skin sensor matrix is developed. Three different functional sensors are included in this matrix: humidity, thermal, and pressure sensors. These are judiciously integrated into a layer-by-layer geometry through a simple lamination process.

In the original version of this manuscript, an error was introduced on pp352. '2.7nb:1.6nb' has been corrected to '2.4nb:1.3nb' in the current online and printed version. doi:10.1093/ptep/ptz106.

is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB and activator protein-1. This review discusses recent studies regarding molecular mechanisms by which ginsenosides play critical roles in inflammatory responses and diseases, and provides evidence showing their potential to prevent and treat inflammatory diseases.

Metal-organic polyhedra and frameworks (MOPs and MOFs) were prepared by linking square units M2(CO2)4 (M = Cu and Zn) with a variety of organic linkers designed to control the dimensionality (periodicity) and topology of the resulting structures. We describe the preparation, characterization, and crystal structures of 5 new MOPs and 11 new MOFs (termed MOP-14, -15, -17, -23, -24 and MOF-114, -115, -116, -117, -118, -119, -222, -601, -602, -603, -604) and show how their structures are related to the shape and functionality of the building blocks. The gas uptake behaviors of MOP-23 and MOF-601 to -603 are also presented as evidence that these structures have permanent porosity and rigid architectures.

High quality MOF-5 crystals of 5-25 mum in size were prepared for the first time using a sonochemical method in substantially reduced synthesis time (ca. 30 min) compared with conventional solvothermal synthesis (24 h).

We address the issue of how to provide basic quality of service (QoS) in optical burst-switched WDM networks with limited fiber delay lines (FDLs). Unlike existing buffer-based QoS schemes, the novel offset-time-based QoS scheme we study in this paper does not mandate any buffer for traffic isolation, but nevertheless can take advantage of FDLs to improve the QoS. This makes the proposed QoS scheme suitable for the next generation optical Internet. The offset times required for class isolation when making wavelength and FDL reservations are quantified, and the upper and lower bounds on the burst loss probability are analyzed. Simulations are also conducted to evaluate the QoS performance in terms of burst loss probability and queuing delay. We show that with limited FDLs, the offset-time-based QoS scheme can be very efficient in supporting basic QoS.

IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE: To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS: Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.

The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.

We investigated the electronic structures of the 5d Ruddlesden-Popper series Sr n+1Ir nO3n+1 (n=1, 2, and infinity) using optical spectroscopy and first-principles calculations. As 5d orbitals are spatially more extended than 3d or 4d orbitals, it has been widely accepted that correlation effects are minimal in 5d compounds. However, we observed a Mott insulator-metal transition with a change of bandwidth as we increased n. In addition, the artificially synthesized perovskite SrIrO3 showed a very large mass enhancement of about 6, indicating that it was in a correlated metallic state.

We report on nanoscale strain gradients in ferroelectric HoMnO(3) epitaxial thin films, resulting in a giant flexoelectric effect. Using grazing-incidence in-plane x-ray diffraction, we measured strain gradients in the films, which were 6 or 7 orders of magnitude larger than typical values reported for bulk oxides. The combination of transmission electron microscopy, electrical measurements, and electrostatic calculations showed that flexoelectricity provides a means of tuning the physical properties of ferroelectric epitaxial thin films, such as domain configurations and hysteresis curves.

We report the first measurement of the $\ensuremath{\tau}$ lepton polarization ${P}_{\ensuremath{\tau}}({D}^{*})$ in the decay $\overline{B}\ensuremath{\rightarrow}{D}^{*}{\ensuremath{\tau}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}}$ as well as a new measurement of the ratio of the branching fractions $R({D}^{*})=\mathcal{B}(\overline{B}\ensuremath{\rightarrow}{D}^{*}{\ensuremath{\tau}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\tau}})/\mathcal{B}(\overline{B}\ensuremath{\rightarrow}{D}^{*}{\ensuremath{\ell}}^{\ensuremath{-}}{\overline{\ensuremath{\nu}}}_{\ensuremath{\ell}})$, where ${\ensuremath{\ell}}^{\ensuremath{-}}$ denotes an electron or a muon, and the $\ensuremath{\tau}$ is reconstructed in the modes ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ and ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{\ensuremath{\rho}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$. We use the full data sample of $772\ifmmode\times\else\texttimes\fi{}1{0}^{6}\text{ }\text{ }B\overline{B}$ pairs recorded with the Belle detector at the KEKB electron-positron collider. Our results, ${P}_{\ensuremath{\tau}}({D}^{*})=\ensuremath{-}0.38\ifmmode\pm\else\textpm\fi{}0.51{(\text{stat})}_{\ensuremath{-}0.16}^{+0.21}(\text{syst})$ and $R({D}^{*})=0.270\ifmmode\pm\else\textpm\fi{}0.035{(\text{stat})}_{\ensuremath{-}0.025}^{+0.028}(\text{syst})$, are consistent with the theoretical predictions of the standard model.