The King's College

Abstract A description of the ab initio quantum chemistry package GAMESS is presented. Chemical systems containing atoms through radon can be treated with wave functions ranging from the simplest closed‐shell case up to a general MCSCF case, permitting calculations at the necessary level of sophistication. Emphasis is given to novel features of the program. The parallelization strategy used in the RHF, ROHF, UHF, and GVB sections of the program is described, and detailed speecup results are given. Parallel calculations can be run on ordinary workstations as well as dedicated parallel machines. © John Wiley & Sons, Inc.

I. Comments on the four discussions in the previous issue of points in the General Theory, 209. — II. Certain definite points on which the writer diverges from previous theories, 212. — The theory of interest restated, 215. — Uncertainties and fluctuations of investment, 217. — III. Demand and Supply for output as a whole, 219. — The output of capital goods and of consumption, 221.

Measuring Behaviour is a guide to the principles and methods of quantitative studies of behaviour, with an emphasis on techniques of direct observation, recording and analysis. Numerous textbooks describe and analyse human and animal behaviour, but none provides a comprehensive review of the principles and techniques of its measurement. Those undertaking this task for the first time are often bemused by the apparent difficulty of the job facing them - how will they accurately and systematically record all that is happening? The purpose of this book is to provide this basic knowledge in a succinct and easily understood form. This concise review of methodology includes a comprehensive annotated bibliography. Written with ,brevity and clarity, Measuring Behaviour is intended, above all, as a practical guide-book.

BACKGROUND: Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. METHODS: We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, in pediatric health centers across the United States. The case definition included six criteria: serious illness leading to hospitalization, an age of less than 21 years, fever that lasted for at least 24 hours, laboratory evidence of inflammation, multisystem organ involvement, and evidence of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse-transcriptase polymerase chain reaction (RT-PCR), antibody testing, or exposure to persons with Covid-19 in the past month. Clinicians abstracted the data onto standardized forms. RESULTS: We report on 186 patients with MIS-C in 26 states. The median age was 8.3 years, 115 patients (62%) were male, 135 (73%) had previously been healthy, 131 (70%) were positive for SARS-CoV-2 by RT-PCR or antibody testing, and 164 (88%) were hospitalized after April 16, 2020. Organ-system involvement included the gastrointestinal system in 171 patients (92%), cardiovascular in 149 (80%), hematologic in 142 (76%), mucocutaneous in 137 (74%), and respiratory in 131 (70%). The median duration of hospitalization was 7 days (interquartile range, 4 to 10); 148 patients (80%) received intensive care, 37 (20%) received mechanical ventilation, 90 (48%) received vasoactive support, and 4 (2%) died. Coronary-artery aneurysms (z scores ≥2.5) were documented in 15 patients (8%), and Kawasaki's disease-like features were documented in 74 (40%). Most patients (171 [92%]) had elevations in at least four biomarkers indicating inflammation. The use of immunomodulating therapies was common: intravenous immune globulin was used in 144 (77%), glucocorticoids in 91 (49%), and interleukin-6 or 1RA inhibitors in 38 (20%). CONCLUSIONS: Multisystem inflammatory syndrome in children associated with SARS-CoV-2 led to serious and life-threatening illness in previously healthy children and adolescents. (Funded by the Centers for Disease Control and Prevention.).

Journal Article Collapse: How Societies Choose to Fail or Succeed Get access Collapse: How Societies Choose to Fail or Succeed. By Jared Diamond. New York: Viking, 2005. 575 pp. Cloth $29.95. Neal Bukeavich Neal Bukeavich King's College Search for other works by this author on: Oxford Academic Google Scholar ISLE: Interdisciplinary Studies in Literature and Environment, Volume 13, Issue 1, Winter 2006, Pages 249–250, https://doi.org/10.1093/isle/13.1.249 Published: 01 January 2006

Rheumatoid arthritis is a common chronic inflammatory and destructive arthropathy that cannot be cured and that has substantial personal, social, and economic costs. The long-term prognosis is poor: 80 percent of affected patients are disabled after 20 years,1 and life expectancy is reduced by an average of 3 to 18 years.2 The medical cost of rheumatoid arthritis averages $5,919 per case per year in the United States3 and approximately £2,600 per case per year in the United Kingdom.4 Current slow-acting antirheumatic drugs have limited efficacy and many side effects. Moreover, they do not improve the long-term prognosis of rheumatoid arthritis. . . .

This book analyses changes which have occurred in the organization and management of the UK public services over the last 15 years, looking particularly at the restructured NHS. The authors present an up to date analysis around three main themes: 1. the transfer of private sector models to the public sector 2. the management of change in the public sector 3. management reorganization and role change In doing so they examine to what extent a New Public Management has emerged and ask whether this is a parochial UK development or of wider international significance. This is a topical and important issue in management training, professional and policy circles. Important analytic themes include: an analysis of the nature of the change process in the UK public services: characterisation of quasi markets; the changing role of local Boards and possible adaptation by professional groupings. The book also addresses the important and controversial question of accountability, and contributes to the development of a general theory of the New Public Management.

1. Multi-female groups of primates fall into two main classes, (a) female-bonded (FB) and (b) non-female-bonded (non-FB). A model is presented to account for the evolution of FB groups in terms of ecological pressures on female relationships. 2. The model suggests that FB groups have evolved as a result of competition for high-quality food patches containing a limited number of feeding sites. Groups are viewed as being based on cooperative relationships among females. These relationships are beneficial because cooperators act together to supplant others from preferred food patches. 3. Ecological data support the model for most FB species, but not for Theropithecus gelada or Colobus guereza, whose foods are not found in high-quality patches with limited feeding sites. Non-FB species conform to expectation, either because they do not use high-quality patches, or because feeding competition has disruptive effects during periods of food scarcity. 4. The behaviour of females differs as expected between FB and non-FB species in group movements and in inter-group interactions; in both contexts females are more involved in FB species. 5. Multi-male groups tend to be found in non-territorial FB species. The presence of several males per group is suggested to benefit females by raising the competitive ability of the group in inter-group interactions. 6. Competitive relationships among females are more strongly marked in FB groups than in non-FB groups. The model suggests that relationships in most FB groups are ultimately related to feeding competition.

Journal Article A Model of Economic Growth Get access Nicholas Kaldor Nicholas Kaldor King’s College, Cambridge Search for other works by this author on: Oxford Academic Google Scholar The Economic Journal, Volume 67, Issue 268, 1 December 1957, Pages 591–624, https://doi.org/10.2307/2227704 Published: 01 December 1957

A Theoretical model consists of certain hypotheses concerning the causal inter-relationship between various magnitudes or forces and the sequence in which they react on each other. We all agree that the basic requirement of any model is that it should be capable of explaining the characteristic features of the economic process as we find them in reality. It is no good starting off a model with the kind of abstraction which initially excludes the influence of forces which are mainly responsible for the behaviour of the economic variables under investigation; and upon finding that the theory leads to results contrary to what we observe in reality, attributing this contrary movement to the compensating (or more than compensating) influence of residual factors that have been assumed away in the model. In dealing with capital accumulation and economic growth, we are only too apt to begin by assuming a ‘given state of knowledge’ (that is to say, absence of technical progress) and the absence of ‘uncertainty’, and content ourselves with saying that these two factors — technical progress and uncertainty — must have been responsible for the difference between theoretical expectation and the recorded facts of experience. The interpretative value of this kind of theory must of necessity be extremely small.

Beginning with a long and extensively rewritten introduction surveying the predecessors of the Presocratics, this book traces the intellectual revolution initiated by Thales in the sixth century BC to its culmination in the metaphysics of Parmenides and the complex physical theories of Anaxagoras and the Atomists in the fifth century it is based on a selection of some six hundred texts, in Greek and a close English translation which in this edition is given more prominence. These provide the basis for a detailed critical study of the principal individual thinkers of the time. Besides serving as an essential text for undergraduate and graduate courses in Greek philosophy and in the history of science, this book will appeal to a wide range of readers with interests in philosophy, theology, the history of ideas and of the ancient world, and indeed to anyone who wants an authoritative account of the Presocratics.

PART ONE: CHALLENGES AND AMBIGUITIES OF BUSINESS RESEARCH 1. Introduction 2. Research in business PART TWO: THE RESEARCH PROCESS 3. The Process Perspective 4. Research Problems 5. Research Design 6. Measurements 7. Data sources 8. Data Collection 9. Sampling in empirical research 10. Preparation and analysis of data PART THREE: IMPLEMENTATION 11. Quantitative data analysis 12. Qualitative Data analysis 13. Writing the final report

BACKGROUND: The efficacy and safety of thromboprophylaxis in patients with acute medical illnesses who may be at risk for venous thromboembolism have not been determined in adequately designed trials. METHODS: In a double-blind study, we randomly assigned 1102 hospitalized patients older than 40 years to receive 40 mg of enoxaparin, 20 mg of enoxaparin, or placebo subcutaneously once daily for 6 to 14 days. Most patients were not in an intensive care unit. The primary outcome was venous thromboembolism between days 1 and 14, defined as deep-vein thrombosis detected by bilateral venography (or duplex ultrasonography) between days 6 and 14 (or earlier if clinically indicated) or documented pulmonary embolism. The duration of follow-up was three months. RESULTS: The primary outcome could be assessed in 866 patients. The incidence of venous thromboembolism was significantly lower in the group that received 40 mg of enoxaparin (5.5 percent [16 of 291 patients]) than in the group that received placebo (14.9 percent [43 of 288 patients]) (relative risk, 0.37; 97.6 percent confidence interval, 0.22 to 0.63; P< 0.001). The benefit observed with 40 mg of enoxaparin was maintained at three months. There was no significant difference in the incidence of venous thromboembolism between the group that received 20 mg of enoxaparin (43 of 287 patients [15.0 percent]) and the placebo group. The incidence of adverse effects did not differ significantly between the placebo group and either enoxaparin group. By day 110, 50 patients had died in the placebo group (13.9 percent), 51 had died in the 20-mg group (14.7 percent), and 41 had died in the 40-mg group (11.4 percent); the differences were not significant. CONCLUSIONS: Prophylactic treatment with 40 mg of enoxaparin subcutaneously per day safely and effectively reduces the risk of venous thromboembolism in patients with acute medical illnesses.

In the last 10 years a consensus has developed that the symptoms of psychosis may be better understood by linking the steps between the phenomenological experiences and social, psychological and neurobiological levels of explanation. Cognitive models of psychosis are an important link in this chain. They provide a psychological description of the phenomena from which hypotheses concerning causal processes can be derived and tested; social, individual, and neurobiological factors can then be integrated via their impact on these cognitive processes. In this paper, we set out the cognitive processes that we think lead to the formation and maintenance of the positive symptoms of psychosis and we attempt to integrate into our model research in social factors. If this model proves useful, a fuller integration with the findings of biological research will be required (Frith, 1992).

BACKGROUND: Apalutamide is an inhibitor of the ligand-binding domain of the androgen receptor. Whether the addition of apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression-free survival and overall survival as compared with placebo plus ADT among patients with metastatic, castration-sensitive prostate cancer has not been determined. METHODS: In this double-blind, phase 3 trial, we randomly assigned patients with metastatic, castration-sensitive prostate cancer to receive apalutamide (240 mg per day) or placebo, added to ADT. Previous treatment for localized disease and previous docetaxel therapy were allowed. The primary end points were radiographic progression-free survival and overall survival. RESULTS: A total of 525 patients were assigned to receive apalutamide plus ADT and 527 to receive placebo plus ADT. The median age was 68 years. A total of 16.4% of the patients had undergone prostatectomy or received radiotherapy for localized disease, and 10.7% had received previous docetaxel therapy; 62.7% had high-volume disease, and 37.3% had low-volume disease. At the first interim analysis, with a median of 22.7 months of follow-up, the percentage of patients with radiographic progression-free survival at 24 months was 68.2% in the apalutamide group and 47.5% in the placebo group (hazard ratio for radiographic progression or death, 0.48; 95% confidence interval [CI], 0.39 to 0.60; P<0.001). Overall survival at 24 months was also greater with apalutamide than with placebo (82.4% in the apalutamide group vs. 73.5% in the placebo group; hazard ratio for death, 0.67; 95% CI, 0.51 to 0.89; P = 0.005). The frequency of grade 3 or 4 adverse events was 42.2% in the apalutamide group and 40.8% in the placebo group; rash was more common in the apalutamide group. CONCLUSIONS: In this trial involving patients with metastatic, castration-sensitive prostate cancer, overall survival and radiographic progression-free survival were significantly longer with the addition of apalutamide to ADT than with placebo plus ADT, and the side-effect profile did not differ substantially between the two groups. (Funded by Janssen Research and Development; TITAN ClinicalTrials.gov number, NCT02489318.).

Abstract 1. Introduction.— 1·0. The object of this paper is to develop methods where by the differential equations of physics may be applied more freely than hitherto in the approximate form of difference equations to problems concerning irregular bodies. Though very different in method, it is in purpose a continuation of a former paper by the author, on a “Freehand Graphic Way of Determining Stream Lines and Equipotentials” (‘Phil. Mag.,’February, 1908; also ‘Proc. Physical Soc.,’ London, vol. xxi.). And all that was there said, as to the need for new methods, may be taken to apply here also. In brief, analytical methods are the foundation of the whole subject, and in practice they are the most accurate when they will work, but in the integration of partial equations, with reference to irregular-shaped boundaries, their field of application is very limited.

A mycoplasma-encoded purine nucleoside phosphorylase (designated PNP_Hyor) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine and 6-aminopurine nucleosides was observed, with adenosine the preferred natural substrate (<i>K</i>_m = 61 <i>µ</i>M). Several cytostatic purine nucleoside analogs proved to be susceptible to PNP_Hyor-mediated phosphorolysis, and a markedly decreased or increased cytostatic activity was observed in <i>Mycoplasma hyorhinis</i>–infected human breast carcinoma MCF-7 cell cultures (MCF-7.Hyor), depending on the properties of the released purine base. We demonstrated an ∼10-fold loss of cytostatic activity of cladribine in MCF-7.Hyor cells and observed a rapid and complete phosphorolysis of this drug when it was exposed to the supernatant of mycoplasma-infected cells. This conversion (inactivation) could be prevented by a specific PNP inhibitor. These findings correlated well with the high efficiency of PNP_Hyor-catalyzed phosphorolysis of cladribine to its less toxic base 2-chloroadenine (<i>K</i>_m = 80 <i>µ</i>M). In contrast, the cytostatic activity of nucleoside analogs carrying a highly toxic purine base and being a substrate for PNP_Hyor, but not human PNP, was substantially increased in MCF-7.Hyor cells (∼130-fold for fludarabine and ∼45-fold for 6-methylpurine-2′-deoxyriboside). Elimination of the mycoplasma from the tumor cell cultures or selective inhibition of PNP_Hyor by a PNP inhibitor restored the cytostatic activity of the purine-based nucleoside drugs. Since several studies suggest a high and preferential colonization or association of tumor tissue in cancer patients with different prokaryotes (including mycoplasmas), the data presented here may be of relevance for the optimization of purine nucleoside–based anticancer drug treatment.

Measuring Behaviour is a guide to the principles and methods of quantitative studies of behaviour, with an emphasis on techniques of direct observation, recording and analysis. In this new edition, all sections have been updated and revised, some have been expanded and others introduced for the first time. Aimed primarily at undergraduate and graduate students in biology and psychology who are about to embark upon behavioural research projects, this book provides a concise review of methodology that will also be of interest to scientists of all disciplines in which behaviour is measured. Written with brevity and clarity, it is intended, above all, as a practical guide book.

BACKGROUND: Apalutamide, a competitive inhibitor of the androgen receptor, is under development for the treatment of prostate cancer. We evaluated the efficacy of apalutamide in men with nonmetastatic castration-resistant prostate cancer who were at high risk for the development of metastasis. METHODS: We conducted a double-blind, placebo-controlled, phase 3 trial involving men with nonmetastatic castration-resistant prostate cancer and a prostate-specific antigen doubling time of 10 months or less. Patients were randomly assigned, in a 2:1 ratio, to receive apalutamide (240 mg per day) or placebo. All the patients continued to receive androgen-deprivation therapy. The primary end point was metastasis-free survival, which was defined as the time from randomization to the first detection of distant metastasis on imaging or death. RESULTS: A total of 1207 men underwent randomization (806 to the apalutamide group and 401 to the placebo group). In the planned primary analysis, which was performed after 378 events had occurred, median metastasis-free survival was 40.5 months in the apalutamide group as compared with 16.2 months in the placebo group (hazard ratio for metastasis or death, 0.28; 95% confidence interval [CI], 0.23 to 0.35; P<0.001). Time to symptomatic progression was significantly longer with apalutamide than with placebo (hazard ratio, 0.45; 95% CI, 0.32 to 0.63; P<0.001). The rate of adverse events leading to discontinuation of the trial regimen was 10.6% in the apalutamide group and 7.0% in the placebo group. The following adverse events occurred at a higher rate with apalutamide than with placebo: rash (23.8% vs. 5.5%), hypothyroidism (8.1% vs. 2.0%), and fracture (11.7% vs. 6.5%). CONCLUSIONS: Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo. (Funded by Janssen Research and Development; SPARTAN ClinicalTrials.gov number, NCT01946204 .).

Giddens's analysis of the writings of Marx, Durkheim and Weber has become the classic text for any student seeking to understand the three thinkers who established the basic framework of contemporary sociology. The first three sections of the book, based on close textual examination of the original sources, contain separate treatments of each writer. The author demonstrates the internal coherence of their respective contributions to social theory. The concluding section discusses the principal ways in which Marx can be compared with the other two authors, and discusses misconceptions of some conventional views on the subject.