SYRCLE’s risk of bias tool for animal studies

R. Hooijmans, Carlijn; M. Rovers, Maroeska; BM de Vries, Rob; Leenaars, Marlies; Ritskes‐Hoitinga, Merel; Langendam, Miranda

doi:10.1186/1471-2288-14-43

Public

SYRCLE’s risk of bias tool for animal studies

Published in BMC Medical Research Methodology • Mar 26, 2014

Authors:

Carlijn R. Hooijmans

Maroeska M. Rovers

Rob BM de Vries

Abstract

BACKGROUND: Systematic Reviews (SRs) of experimental animal studies are not yet common practice, but awareness of the merits of conducting such SRs is steadily increasing. As animal intervention studies differ from randomized clinical trials (RCT) in many aspects, the methodology for SRs of clinical...

Subject

Critical appraisal

Publication bias

Animal testing

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