Effect of phenylpiperidine opioid antagonists on food consumption and weight gain of the obese Zucker rat.

WN, Shaw; CH, Mitch; JD, Leander; DM, Zimmerman

doi:10.1016/s0022-3565(25)12485-3

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Effect of phenylpiperidine opioid antagonists on food consumption and weight gain of the obese Zucker rat.

Shared by NobleBlocks on Apr 1, 1990 • 12:00 AM UTC

Authors:

Shaw WN

Mitch CH

Leander JD

Abstract

Meal-fed Zucker rats were used to determine the acute and chronic s.c. effect of certain trans-3,4-dimethyl-4-phenylpiperidines (opioid antagonists) on food consumption. In acute studies, the active compounds suppressed food intake significantly of lean and obese meal-fed Zucker rats. LY117413 was t...

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