TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation.

Z, Quan; P, Sun; G, Lin; R, Xi

doi:10.1242/jcs.125294

Public

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation.

Shared by NobleBlocks on Jul 10, 2013 • 12:00 AM UTC

Authors:

Quan Z

Sun P

Lin G

Abstract

Tubular sclerosis complex gene products TSC1 and TSC2 have evolutionarily conserved roles in cell growth from Drosophila to mammals. Here we reveal important roles for TSC1/2 in regulating intestinal stem cell (ISC) maintenance and differentiation of the enteroendocrine cell lineage in the Drosophil...

Subject

Drosophila melanogaster

Nutrition

Notch

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