Uptake, metabolism and efflux of l-alpha-acetylmethadol (LAAM) by rat lung tissue.

DH, Lau; GL, Henderson

doi:10.1016/s0022-3565(25)31307-8

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Uptake, metabolism and efflux of l-alpha-acetylmethadol (LAAM) by rat lung tissue.

Shared by NobleBlocks on Jul 1, 1978 • 12:00 AM UTC

Authors:

Lau DH

Henderson GL

Abstract

The uptake, metabolism and efflux of the longacting narcotic analgesic l-alpha-[2-3H]acetylmethadol ([3H]LAAM) were studied using rat lung tissue slices. Uptake of [3H]LAAM by lung slices incubated in 1 micrometer [3H]LAAM in Krebs-Ringer phosphate buffer was rapid for the first 10 minutes, slow the...

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