Abstract 2468: Chronic Treatment Of Hypertensive Patients With The At1 Receptor Blocker Losartan Results In Sufficient Serum Levels Of The Metabolite Exp3179 Exhibiting Pparγ-stimulating Properties

Kappert, Kai; Tsuprykov, Oleg; Kaufmann, Jan; Ott, Ingo; Goebel, Matthias; Nirmala Bähr, Ilse; Häβle, Paul-Laszlo; Gust, Ronald; Fleck, Eckart; Unger, Thomas; Stawowy, Philipp; Kintscher, Ulrich

doi:10.1161/circ.118.suppl_18.s_731-c

Public

Abstract 2468: Chronic Treatment Of Hypertensive Patients With The At1 Receptor Blocker Losartan Results In Sufficient Serum Levels Of The Metabolite Exp3179 Exhibiting Pparγ-stimulating Properties

Published in Circulation • Oct 28, 2008

Authors:

Kai Kappert

Oleg Tsuprykov

Jan Kaufmann

Abstract

The losartan metabolite EXP3174 exhibits angiotensin II receptor 1 (AT1R)-blocking properties, whereas the metabolite EXP3179 potently induces the activity of the insulin-sensititzing peroxisome proliferator-activated receptor γ (PPARγ) as a partial agonist in vitro.. We investigated, whether hypert...

Subject

Losartan

Medicine

Internal medicine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!