Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer

C. Turner, Nicholas; Ro, Jungsil; André, Fabrice; Loi, Sherene; Verma, Sunil; Iwata, Hiroji; Harbeck, Nadia; Loibl, Sibylle; Huang Bartlett, Cynthia; Zhang, Ke; Giorgetti, C.; Randolph, Sophia; Koehler, María; Cristofanilli, Massimo

doi:10.1056/nejmoa1505270

Public

Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer

Published in New England Journal of Medicine • Jun 1, 2015

Authors:

Nicholas C. Turner

Jungsil Ro

Fabrice André

Abstract

BACKGROUND: Growth of hormone-receptor-positive breast cancer is dependent on cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), which promote progression from the G1 phase to the S phase of the cell cycle. We assessed the efficacy of palbociclib (an inhibitor of CDK4 and CDK6) and fulvestrant in adv...

Subject

Fulvestrant

Palbociclib

Medicine

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