The Janus kinases (Jaks)

Yamaoka, Kunihiro; Saharinen, Pipsa; Pesu, Marko; Holt, Vance; Silvennoinen, Olli; J. O’Shea, John

doi:10.1186/gb-2004-5-12-253

Public

The Janus kinases (Jaks)

Published in Genome biology • Nov 30, 2004

Authors:

Kunihiro Yamaoka

Pipsa Saharinen

Marko Pesu

Abstract

The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kina...

Subject

Janus kinase

Biology

Tyrosine kinase 2

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