8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

C. Cheng, Keith; S Cahill, D; Kasai, Hiroshi; Nishimura, S.; A. Loeb, Lawrence

doi:10.1016/s0021-9258(18)48474-8

Public

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Published in Journal of Biological Chemistry • Jan 1, 1992

Authors:

Keith C. Cheng

D S Cahill

Hiroshi Kasai

Abstract

Mutations caused by oxidative DNA damage may contribute to human disease. A major product of that damage is 8-hydroxyguanine (oh8Gua). Because of differences in experimental design, the base pairing specificity of oh8G in vivo is not completely resolved. Here, oh8dGTP and DNA polymerase were used in...

Subject

Oxidative phosphorylation

DNA

Chemistry

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