TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

A. Kujubu, Dean; S. Fletcher, Bradley; Varnum, Brian; W. Lim, Robert; R. Herschman, Harvey

doi:10.1016/s0021-9258(18)98774-0

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TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Published in Journal of Biological Chemistry • Jul 1, 1991

Authors:

Dean A. Kujubu

Bradley S. Fletcher

Brian Varnum

Abstract

TIS10 is a primary response gene whose cDNA was cloned as a result of its rapid, superinducible expression in Swiss 3T3 cells in response to 12-O-Tetradecanoylphorbol-13-acetate. The 5'-untranslated region of the 3.9-kilobase TIS10 message contains only 124 nucleotides, whereas the 3'-untranslated r...

Subject

Molecular biology

Untranslated region

Complementary DNA

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