Cooperatively between catalytic sites in the mechanism of action of beef heart mitochondrial adenosine triphosphatase.

Grubmeyer, Charles; S. Penefsky, Harvey

doi:10.1016/s0021-9258(19)69515-3

Public

Cooperatively between catalytic sites in the mechanism of action of beef heart mitochondrial adenosine triphosphatase.

Published in Journal of Biological Chemistry • Apr 1, 1981

Authors:

Charles Grubmeyer

Harvey S. Penefsky

Abstract

Occupancy of only one of two hydrolytic sites on beef heart mitochondrial ATPase (F1) by the radioactive ATP analog, 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-[gamma-32P]-triphosphate (TNP-[gamma-32P]ATP) is associated with a low rate of hydrolysis of the substrate even under conditions otherwise ...

Subject

Adenosine triphosphatase

Mechanism (biology)

Action (physics)

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